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The map label for this gene is groEL [H]

Identifier: 89897840

GI number: 89897840

Start: 33407

End: 35041

Strand: Direct

Name: groEL [H]

Synonym: CF0033

Alternate gene names: 89897840

Gene position: 33407-35041 (Clockwise)

Preceding gene: 89897839

Following gene: 89897841

Centisome position: 2.86

GC content: 41.71

Gene sequence:

>1635_bases
GTGTCTAAAATATTTAAGAATCGATTAGAAGGACTTAGCGCATTAAATCGAGGCGTGAGAGCTTTAGCTAAGGCCGTTAC
CACAACTTTAGGGCCTCAAGGCTCCCATGTTGTTATCAAAAAAGATCACTCCCCTCCCTATGTTACAAAACATGGTGCTT
CAATAGCTAAGGAGATCTCTTTAGCAGATGCTTTTGAAAATACTGGTTTAAAATTTGCCGGTGAAGTTGCTTTACAAACA
GACTTGCAGGTAGGAGACGGATCTACCACAGCTGTGATATTGACAGATGCTTTATTCTCTTCGGGGCTCAAAGGTGTTGC
TGTTGGATTGGATCCCTTAGAGATAAAACAGGGAATTCATCTTGCCGGAGAAATGTTAGATAAAGAGCTTACTAAGCTTG
CGGTTAAAAGGAAGCCAGCTGAAGACTCTTTTCATATAGCCACTACCTCAGCCAACAATGACCCGGCTATTGGCAAAATT
ATATCCGATGCCATAGCAGCTGTTGGTGTGGAGGGCGTATTCTCTATAAAATTGGGAACGGGAGAAGAAACCACTCTAGA
GGCTTCGTCTCATGTAGGGTTTAATTCAGGATACTTATCTCCGTACTTCGTAACGCATCCAGAGACTATGGAAGTCATCT
ATGAGGATGCTTCTATTTTATTGTGTAATCAGAAACTATCCTGTTTGAATCAATCGTTTATTCATTTTTTAGACCAAACT
TTTCAGACGAGTCGAGCTCCTCTAATTATTATTGCTGAGGATTTTGATCCTCAGCTTCTATCTATATTAATAGTGAACAA
ACTTAGGGCAAATCTTCCCGTATGTGCGATAAAAGCCCCAGGATTCGGTGAACGGCGTAGAGAGATTTTAGAAGACATCG
CTATTTTAACAGGAGCCACTCTTGTTGGTGATCTGTTGGGACTTTCCTTAGATGAGAGTAATTTAGATGCTCTTGGGCAC
GTAGGGAAAATTATCATAGGGCAGGACACAACTGTTTTATCCGAAGGGAAAGGCGATCGGGAAAGCATAGATCGTCGTAT
CGATTACTTGCGGCAGGCAATTATTCATAGTTCGTCTGAGATGGATACTCAGGACTTGGAAAGGCGCTTGGCGAGGTTTG
TCGGAGGAATGGCTCAAATATACATAGGAGCTTCATCAGAAAGAGAATTTAAAGAGAAGAAAGCTCGCTTAGAAGGTGTT
TTAAAAGCGACTAGAGCCGCATTTAAAGAAGGTTGTCTCCCAGGGGGAGGCTCTGCTTTAGCTCGCGTAGTGTCTATTGT
AAAAATCCCCGATCAACTACCTAAGGGGGTAATGTTTGGCTGTAAGTGCATGCTTCAATCTGCAGAAGCACCTCTTAGAG
TTATAGCAACAAATTGTGGAAAAGCTCCTGAAAGTGTGGTAGATACGGTTCTGTCACATGCAGATCCTTGTTTTGGATAT
AATTGTATTACCGATACTTTTGAAAATTTAATTGCTTCGGGAGTGTGTGACGCGCTCTCAGTGATTAAATTTATTTTGAA
ACGTTCGATTTCCATTGCTTGCTTATTGTTGACCAGTTCATTTGTTATCGTAGAATCTTCTGAAGGCACGCAAGACTCTC
AACACCCAGATTCCCCTCTTTCCGATGATTGTTAA

Upstream 100 bases:

>100_bases
TTTCTCAAGATTCGACTGTTTGACAGGAATTTTTGATGTTTCTATAAGCGACCTTGTAGGGGCGCCTTATCCCCGGAGTC
CGGGAGAGACATTTAAAAAC

Downstream 100 bases:

>100_bases
CATCAAATAATTTTTGCATGGTGTTAAAAACAGTTTTATCTTTTCATCTTAGAACGATCTTTTTTTCATAAGATAGGGAG
AAAAACTTGATCATTTGGTC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MSKIFKNRLEGLSALNRGVRALAKAVTTTLGPQGSHVVIKKDHSPPYVTKHGASIAKEISLADAFENTGLKFAGEVALQT
DLQVGDGSTTAVILTDALFSSGLKGVAVGLDPLEIKQGIHLAGEMLDKELTKLAVKRKPAEDSFHIATTSANNDPAIGKI
ISDAIAAVGVEGVFSIKLGTGEETTLEASSHVGFNSGYLSPYFVTHPETMEVIYEDASILLCNQKLSCLNQSFIHFLDQT
FQTSRAPLIIIAEDFDPQLLSILIVNKLRANLPVCAIKAPGFGERRREILEDIAILTGATLVGDLLGLSLDESNLDALGH
VGKIIIGQDTTVLSEGKGDRESIDRRIDYLRQAIIHSSSEMDTQDLERRLARFVGGMAQIYIGASSEREFKEKKARLEGV
LKATRAAFKEGCLPGGGSALARVVSIVKIPDQLPKGVMFGCKCMLQSAEAPLRVIATNCGKAPESVVDTVLSHADPCFGY
NCITDTFENLIASGVCDALSVIKFILKRSISIACLLLTSSFVIVESSEGTQDSQHPDSPLSDDC

Sequences:

>Translated_544_residues
MSKIFKNRLEGLSALNRGVRALAKAVTTTLGPQGSHVVIKKDHSPPYVTKHGASIAKEISLADAFENTGLKFAGEVALQT
DLQVGDGSTTAVILTDALFSSGLKGVAVGLDPLEIKQGIHLAGEMLDKELTKLAVKRKPAEDSFHIATTSANNDPAIGKI
ISDAIAAVGVEGVFSIKLGTGEETTLEASSHVGFNSGYLSPYFVTHPETMEVIYEDASILLCNQKLSCLNQSFIHFLDQT
FQTSRAPLIIIAEDFDPQLLSILIVNKLRANLPVCAIKAPGFGERRREILEDIAILTGATLVGDLLGLSLDESNLDALGH
VGKIIIGQDTTVLSEGKGDRESIDRRIDYLRQAIIHSSSEMDTQDLERRLARFVGGMAQIYIGASSEREFKEKKARLEGV
LKATRAAFKEGCLPGGGSALARVVSIVKIPDQLPKGVMFGCKCMLQSAEAPLRVIATNCGKAPESVVDTVLSHADPCFGY
NCITDTFENLIASGVCDALSVIKFILKRSISIACLLLTSSFVIVESSEGTQDSQHPDSPLSDDC
>Mature_543_residues
SKIFKNRLEGLSALNRGVRALAKAVTTTLGPQGSHVVIKKDHSPPYVTKHGASIAKEISLADAFENTGLKFAGEVALQTD
LQVGDGSTTAVILTDALFSSGLKGVAVGLDPLEIKQGIHLAGEMLDKELTKLAVKRKPAEDSFHIATTSANNDPAIGKII
SDAIAAVGVEGVFSIKLGTGEETTLEASSHVGFNSGYLSPYFVTHPETMEVIYEDASILLCNQKLSCLNQSFIHFLDQTF
QTSRAPLIIIAEDFDPQLLSILIVNKLRANLPVCAIKAPGFGERRREILEDIAILTGATLVGDLLGLSLDESNLDALGHV
GKIIIGQDTTVLSEGKGDRESIDRRIDYLRQAIIHSSSEMDTQDLERRLARFVGGMAQIYIGASSEREFKEKKARLEGVL
KATRAAFKEGCLPGGGSALARVVSIVKIPDQLPKGVMFGCKCMLQSAEAPLRVIATNCGKAPESVVDTVLSHADPCFGYN
CITDTFENLIASGVCDALSVIKFILKRSISIACLLLTSSFVIVESSEGTQDSQHPDSPLSDDC

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=517, Percent_Identity=35.3965183752418, Blast_Score=320, Evalue=3e-87,
Organism=Homo sapiens, GI31542947, Length=517, Percent_Identity=35.3965183752418, Blast_Score=320, Evalue=3e-87,
Organism=Escherichia coli, GI1790586, Length=512, Percent_Identity=41.015625, Blast_Score=389, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17555558, Length=517, Percent_Identity=36.3636363636364, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI193210679, Length=203, Percent_Identity=33.0049261083744, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323288, Length=528, Percent_Identity=35.9848484848485, Blast_Score=333, Evalue=5e-92,
Organism=Drosophila melanogaster, GI24641193, Length=510, Percent_Identity=37.2549019607843, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24641191, Length=510, Percent_Identity=37.2549019607843, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI45550936, Length=510, Percent_Identity=36.078431372549, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI45550132, Length=510, Percent_Identity=36.078431372549, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI45550935, Length=510, Percent_Identity=36.078431372549, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI17864606, Length=516, Percent_Identity=34.4961240310078, Blast_Score=303, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24584129, Length=525, Percent_Identity=28.952380952381, Blast_Score=202, Evalue=5e-52,
Organism=Drosophila melanogaster, GI19921262, Length=525, Percent_Identity=28.952380952381, Blast_Score=202, Evalue=5e-52,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58182; Mature: 58051

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIFKNRLEGLSALNRGVRALAKAVTTTLGPQGSHVVIKKDHSPPYVTKHGASIAKEIS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCHHHHHHHH
LADAFENTGLKFAGEVALQTDLQVGDGSTTAVILTDALFSSGLKGVAVGLDPLEIKQGIH
HHHHHHCCCCEEECCEEEEEEEEECCCCCEEEEEEHHHHHCCCCEEEECCCHHHHHHHHH
LAGEMLDKELTKLAVKRKPAEDSFHIATTSANNDPAIGKIISDAIAAVGVEGVFSIKLGT
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECC
GEETTLEASSHVGFNSGYLSPYFVTHPETMEVIYEDASILLCNQKLSCLNQSFIHFLDQT
CCCCEEECCCCCCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
FQTSRAPLIIIAEDFDPQLLSILIVNKLRANLPVCAIKAPGFGERRREILEDIAILTGAT
HHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
LVGDLLGLSLDESNLDALGHVGKIIIGQDTTVLSEGKGDRESIDRRIDYLRQAIIHSSSE
HHHHHHCCCCCCCCHHHHHCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
MDTQDLERRLARFVGGMAQIYIGASSEREFKEKKARLEGVLKATRAAFKEGCLPGGGSAL
CCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ARVVSIVKIPDQLPKGVMFGCKCMLQSAEAPLRVIATNCGKAPESVVDTVLSHADPCFGY
HHHHHHHHCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCC
NCITDTFENLIASGVCDALSVIKFILKRSISIACLLLTSSFVIVESSEGTQDSQHPDSPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCEEEEECCCCCCCCCCCCCCC
SDDC
CCCC
>Mature Secondary Structure 
SKIFKNRLEGLSALNRGVRALAKAVTTTLGPQGSHVVIKKDHSPPYVTKHGASIAKEIS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEECCCHHHHHHHH
LADAFENTGLKFAGEVALQTDLQVGDGSTTAVILTDALFSSGLKGVAVGLDPLEIKQGIH
HHHHHHCCCCEEECCEEEEEEEEECCCCCEEEEEEHHHHHCCCCEEEECCCHHHHHHHHH
LAGEMLDKELTKLAVKRKPAEDSFHIATTSANNDPAIGKIISDAIAAVGVEGVFSIKLGT
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECC
GEETTLEASSHVGFNSGYLSPYFVTHPETMEVIYEDASILLCNQKLSCLNQSFIHFLDQT
CCCCEEECCCCCCCCCCCCCCEEEECCHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
FQTSRAPLIIIAEDFDPQLLSILIVNKLRANLPVCAIKAPGFGERRREILEDIAILTGAT
HHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
LVGDLLGLSLDESNLDALGHVGKIIIGQDTTVLSEGKGDRESIDRRIDYLRQAIIHSSSE
HHHHHHCCCCCCCCHHHHHCCCEEEECCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
MDTQDLERRLARFVGGMAQIYIGASSEREFKEKKARLEGVLKATRAAFKEGCLPGGGSAL
CCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ARVVSIVKIPDQLPKGVMFGCKCMLQSAEAPLRVIATNCGKAPESVVDTVLSHADPCFGY
HHHHHHHHCHHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCC
NCITDTFENLIASGVCDALSVIKFILKRSISIACLLLTSSFVIVESSEGTQDSQHPDSPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCEEEEECCCCCCCCCCCCCCC
SDDC
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]