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The map label for this gene is holA [H]

Identifier: 89257146

GI number: 89257146

Start: 1828587

End: 1829564

Strand: Direct

Name: holA [H]

Synonym: FTL_1898

Alternate gene names: 89257146

Gene position: 1828587-1829564 (Clockwise)

Preceding gene: 89257143

Following gene: 89257147

Centisome position: 96.44

GC content: 30.67

Gene sequence:

>978_bases
ATGGAATTAAGTTATTTTGAGCTACTCCAAAAAAATGATCTCACCGCCTATAAACTTTTTATCATAACAGGTGATGAACC
TCTACAAAAACACAATACTATTGAAAAAATAACTAATCAGTTTAAAACTAAAAATTTTGAAATAAGCTATCATGATTTAA
GTGAACAAAATATAGATGTTTTGTATAACGAAGTTGATAGTCTTAGCCTATTTAGTATTGATAAATTTATTCAATTCAAT
TTTGATAAGCCCCCACAAAAAAAACTCCAACAAACATTAGTTGACAAGCTTATAAATGATGATGATAACGTTTACTTGCT
TGTTTTTAGTGGTATGAAAAAGCAAAATACCTCAGCAAAGTGGTTTCAAAGCTTAGAGCATAAAGCTATTCATATTCGCA
TTTTTCAACCAAATTTAGATAATGCCATAAATATTATAGATTATGAAACACAACAACTCGGCTTAAGTCTGACAAAAGAA
GCTACACAGCTCTTAGCGCTAAAAACCGAGGGAAATTTGATAGCAACAAAACAAATCTTAAAATTACTCTCACGCCAAGA
TAGCCGAGTCTTTGATGAAAATACAATTCGTCCTTTTCTACATGAGCACGCCAATTTTGACGTATTTGATCTTTCTGAAG
CAATTCTCTCTCAGCATAAAAGCAAAGCACTAAAGATACTTAATAGCATCCTGAACGAAAATGATAAGCCTCCTCTTGTA
CTCTGGGCCCTAAAAAGAGAATTAAGAATACTCTCCCAACTAAAAAACACTCAAATAACTTATCATCAAAAAATATTTAA
AGATAACAATATTTGGTCAGCTAAACAGAAATTTTATATTAGTTTAGCGAATAAGCTTAGTCCTAAAAAAATTTCAGCAG
GACTGGAAAAATGCCTTGATACTGACCTATGTATCAAAGGTGCAAGAAAAGGCAATATTCAGCTTAAACTTAATGAAATT
GTTTTTGATATTTTCTAA

Upstream 100 bases:

>100_bases
AACTAACTTTTTCATAATTAAACCTCTTTTGATTTCTTATATGCTAAACAGTATAGTAAACTAACTGTGATATATAACAA
TAGCTAAAAGTTTTAATATT

Downstream 100 bases:

>100_bases
ATACACTATCTAAGATTTTTGCTAAATTTTAATGACAACTGTAATAGTAGCATTTACTTTTTTTAGACAATTGATATCAT
TAAACAGAATTAACCAATGT

Product: DNA polymerase III, delta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MELSYFELLQKNDLTAYKLFIITGDEPLQKHNTIEKITNQFKTKNFEISYHDLSEQNIDVLYNEVDSLSLFSIDKFIQFN
FDKPPQKKLQQTLVDKLINDDDNVYLLVFSGMKKQNTSAKWFQSLEHKAIHIRIFQPNLDNAINIIDYETQQLGLSLTKE
ATQLLALKTEGNLIATKQILKLLSRQDSRVFDENTIRPFLHEHANFDVFDLSEAILSQHKSKALKILNSILNENDKPPLV
LWALKRELRILSQLKNTQITYHQKIFKDNNIWSAKQKFYISLANKLSPKKISAGLEKCLDTDLCIKGARKGNIQLKLNEI
VFDIF

Sequences:

>Translated_325_residues
MELSYFELLQKNDLTAYKLFIITGDEPLQKHNTIEKITNQFKTKNFEISYHDLSEQNIDVLYNEVDSLSLFSIDKFIQFN
FDKPPQKKLQQTLVDKLINDDDNVYLLVFSGMKKQNTSAKWFQSLEHKAIHIRIFQPNLDNAINIIDYETQQLGLSLTKE
ATQLLALKTEGNLIATKQILKLLSRQDSRVFDENTIRPFLHEHANFDVFDLSEAILSQHKSKALKILNSILNENDKPPLV
LWALKRELRILSQLKNTQITYHQKIFKDNNIWSAKQKFYISLANKLSPKKISAGLEKCLDTDLCIKGARKGNIQLKLNEI
VFDIF
>Mature_325_residues
MELSYFELLQKNDLTAYKLFIITGDEPLQKHNTIEKITNQFKTKNFEISYHDLSEQNIDVLYNEVDSLSLFSIDKFIQFN
FDKPPQKKLQQTLVDKLINDDDNVYLLVFSGMKKQNTSAKWFQSLEHKAIHIRIFQPNLDNAINIIDYETQQLGLSLTKE
ATQLLALKTEGNLIATKQILKLLSRQDSRVFDENTIRPFLHEHANFDVFDLSEAILSQHKSKALKILNSILNENDKPPLV
LWALKRELRILSQLKNTQITYHQKIFKDNNIWSAKQKFYISLANKLSPKKISAGLEKCLDTDLCIKGARKGNIQLKLNEI
VFDIF

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=275, Percent_Identity=25.0909090909091, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 37774; Mature: 37774

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSYFELLQKNDLTAYKLFIITGDEPLQKHNTIEKITNQFKTKNFEISYHDLSEQNIDV
CCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
LYNEVDSLSLFSIDKFIQFNFDKPPQKKLQQTLVDKLINDDDNVYLLVFSGMKKQNTSAK
HHHHHCCEEHEEHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
WFQSLEHKAIHIRIFQPNLDNAINIIDYETQQLGLSLTKEATQLLALKTEGNLIATKQIL
HHHHHCCCEEEEEEECCCCCCCEEEEEECHHHHCCHHHHHHHHEEEEECCCCEEHHHHHH
KLLSRQDSRVFDENTIRPFLHEHANFDVFDLSEAILSQHKSKALKILNSILNENDKPPLV
HHHCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LWALKRELRILSQLKNTQITYHQKIFKDNNIWSAKQKFYISLANKLSPKKISAGLEKCLD
EHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECHHHHHHEEHHHCCCHHHHHHHHHHHCC
TDLCIKGARKGNIQLKLNEIVFDIF
CHHHHCCCCCCCEEEEEEHEEEECC
>Mature Secondary Structure
MELSYFELLQKNDLTAYKLFIITGDEPLQKHNTIEKITNQFKTKNFEISYHDLSEQNIDV
CCCHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHH
LYNEVDSLSLFSIDKFIQFNFDKPPQKKLQQTLVDKLINDDDNVYLLVFSGMKKQNTSAK
HHHHHCCEEHEEHHHHEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHH
WFQSLEHKAIHIRIFQPNLDNAINIIDYETQQLGLSLTKEATQLLALKTEGNLIATKQIL
HHHHHCCCEEEEEEECCCCCCCEEEEEECHHHHCCHHHHHHHHEEEEECCCCEEHHHHHH
KLLSRQDSRVFDENTIRPFLHEHANFDVFDLSEAILSQHKSKALKILNSILNENDKPPLV
HHHCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LWALKRELRILSQLKNTQITYHQKIFKDNNIWSAKQKFYISLANKLSPKKISAGLEKCLD
EHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEECHHHHHHEEHHHCCCHHHHHHHHHHHCC
TDLCIKGARKGNIQLKLNEIVFDIF
CHHHHCCCCCCCEEEEEEHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]