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The map label for this gene is purM [H]

Identifier: 89255806

GI number: 89255806

Start: 364624

End: 365667

Strand: Direct

Name: purM [H]

Synonym: FTL_0395

Alternate gene names: 89255806

Gene position: 364624-365667 (Clockwise)

Preceding gene: 89255805

Following gene: 89255807

Centisome position: 19.23

GC content: 37.36

Gene sequence:

>1044_bases
ATGGCAGGCTTAAAATATGAAGATGCTGGCGTAAATATCGAAGCTGGTAATCAAGCTGTAGAAAGAATGAAGCAGCATGT
CAAAAAAACTTTTACCCAAGATGTTTTGACAGGTTTGGGTAGCTTTGGTTCTTTATACTCACTAAAAAATATTATAAATA
ATTATGATGATCCTGTCTTAGTACAGTCGATTGATGGTGTTGGTACAAAGACAAAAGTCGCGGTAATGTGTGGTAAGTTT
GAAAACCTTGGTTATGATCTTTTCTCAGCTGCGACAAATGATATTGTTGTAATGGGTGCCAAGCCAATTACGTTTCTAGA
TTATGTCGCGCATGATAAGCTTGATCCTGCAATTATGGAAGAGCTCGTCAAAGGGATGTCAAAAGCTTGTGCTGAGTGTG
GGGTTTCGCTGGTAGGTGGCGAGACTGCGGAAATGCCTGGAGTATATCAAGCTGGTGAGATTGACATGGTTGGAGTTATC
ACTGGTATCGTTGGTAGAAAAAGAATTATCAATGGTGAGAATATCAAAGAGGGTGATATTGTCTTTGGGCTTAGTTCATC
AGGATTACATACAAATGGCTACTCTTTTGCACGTAAACTATTTTTTGATGTAGCAGGCAACAAACATACTGATACTTATC
CAGAGTTAGAGGGTAAAACTATCGGTGATGTGCTACTTGAACCACATATCAACTATACTAATATCATCCATGATTTCTTA
GATAATGGTGTTGATATCAAAGGTATGGCACATATCACAGGTGGCGGGTTTATCGAGAATATTCCACGCGTATTACCACA
AGGTTTAGGTGCCCAAATTGACAAAGATAGTTTTGCAACTCCAGCTATTTTTAAGCTAATGCAGAGAATCGGCGATATAA
GCGAGTTTGAAATGTATCGCTCATTTAATATGGGTATTGGTATGACGATAATTGCTAGCCAAGATCAATTTGACAAGATG
CAAGAATTAGCTAAAAAACATACTAATACAAAACTATATCAAATTGGTAAAATCACAAATTCAGGAAAGGTAGAAATTAT
CTAA

Upstream 100 bases:

>100_bases
TTTTAGAAGTATAGGATCTCTTGACAGGAACAATTAAGTAATAAGATTCTGGATCAAGTCCGGAATGACAAATATTTTTA
ATTGATTAAAAGGAAATAAA

Downstream 100 bases:

>100_bases
TGTTTGATAAACAAATCATTGCTAATAATATAAAAAATGTTCTAAAATCAACAAATCTTGATATCAAGAATAAATATATA
GGTAAAGTAAGAGATATGTA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MAGLKYEDAGVNIEAGNQAVERMKQHVKKTFTQDVLTGLGSFGSLYSLKNIINNYDDPVLVQSIDGVGTKTKVAVMCGKF
ENLGYDLFSAATNDIVVMGAKPITFLDYVAHDKLDPAIMEELVKGMSKACAECGVSLVGGETAEMPGVYQAGEIDMVGVI
TGIVGRKRIINGENIKEGDIVFGLSSSGLHTNGYSFARKLFFDVAGNKHTDTYPELEGKTIGDVLLEPHINYTNIIHDFL
DNGVDIKGMAHITGGGFIENIPRVLPQGLGAQIDKDSFATPAIFKLMQRIGDISEFEMYRSFNMGIGMTIIASQDQFDKM
QELAKKHTNTKLYQIGKITNSGKVEII

Sequences:

>Translated_347_residues
MAGLKYEDAGVNIEAGNQAVERMKQHVKKTFTQDVLTGLGSFGSLYSLKNIINNYDDPVLVQSIDGVGTKTKVAVMCGKF
ENLGYDLFSAATNDIVVMGAKPITFLDYVAHDKLDPAIMEELVKGMSKACAECGVSLVGGETAEMPGVYQAGEIDMVGVI
TGIVGRKRIINGENIKEGDIVFGLSSSGLHTNGYSFARKLFFDVAGNKHTDTYPELEGKTIGDVLLEPHINYTNIIHDFL
DNGVDIKGMAHITGGGFIENIPRVLPQGLGAQIDKDSFATPAIFKLMQRIGDISEFEMYRSFNMGIGMTIIASQDQFDKM
QELAKKHTNTKLYQIGKITNSGKVEII
>Mature_346_residues
AGLKYEDAGVNIEAGNQAVERMKQHVKKTFTQDVLTGLGSFGSLYSLKNIINNYDDPVLVQSIDGVGTKTKVAVMCGKFE
NLGYDLFSAATNDIVVMGAKPITFLDYVAHDKLDPAIMEELVKGMSKACAECGVSLVGGETAEMPGVYQAGEIDMVGVIT
GIVGRKRIINGENIKEGDIVFGLSSSGLHTNGYSFARKLFFDVAGNKHTDTYPELEGKTIGDVLLEPHINYTNIIHDFLD
NGVDIKGMAHITGGGFIENIPRVLPQGLGAQIDKDSFATPAIFKLMQRIGDISEFEMYRSFNMGIGMTIIASQDQFDKMQ
ELAKKHTNTKLYQIGKITNSGKVEII

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=339, Percent_Identity=40.117994100295, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI209869995, Length=339, Percent_Identity=40.117994100295, Blast_Score=260, Evalue=1e-69,
Organism=Homo sapiens, GI209869993, Length=339, Percent_Identity=40.117994100295, Blast_Score=260, Evalue=1e-69,
Organism=Escherichia coli, GI1788845, Length=338, Percent_Identity=42.8994082840237, Blast_Score=271, Evalue=7e-74,
Organism=Caenorhabditis elegans, GI17567511, Length=350, Percent_Identity=40.5714285714286, Blast_Score=230, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6321203, Length=315, Percent_Identity=37.7777777777778, Blast_Score=219, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24582400, Length=318, Percent_Identity=37.4213836477987, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 37722; Mature: 37591

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLKYEDAGVNIEAGNQAVERMKQHVKKTFTQDVLTGLGSFGSLYSLKNIINNYDDPVL
CCCCEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEE
VQSIDGVGTKTKVAVMCGKFENLGYDLFSAATNDIVVMGAKPITFLDYVAHDKLDPAIME
EEECCCCCCCEEEEEEECCHHHCCHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCHHHHH
ELVKGMSKACAECGVSLVGGETAEMPGVYQAGEIDMVGVITGIVGRKRIINGENIKEGDI
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEEHHHHHHHHHCCCEEECCCCCCCCCE
VFGLSSSGLHTNGYSFARKLFFDVAGNKHTDTYPELEGKTIGDVLLEPHINYTNIIHDFL
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHH
DNGVDIKGMAHITGGGFIENIPRVLPQGLGAQIDKDSFATPAIFKLMQRIGDISEFEMYR
HCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
SFNMGIGMTIIASQDQFDKMQELAKKHTNTKLYQIGKITNSGKVEII
HHCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEC
>Mature Secondary Structure 
AGLKYEDAGVNIEAGNQAVERMKQHVKKTFTQDVLTGLGSFGSLYSLKNIINNYDDPVL
CCCEECCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEE
VQSIDGVGTKTKVAVMCGKFENLGYDLFSAATNDIVVMGAKPITFLDYVAHDKLDPAIME
EEECCCCCCCEEEEEEECCHHHCCHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCHHHHH
ELVKGMSKACAECGVSLVGGETAEMPGVYQAGEIDMVGVITGIVGRKRIINGENIKEGDI
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEEHHHHHHHHHCCCEEECCCCCCCCCE
VFGLSSSGLHTNGYSFARKLFFDVAGNKHTDTYPELEGKTIGDVLLEPHINYTNIIHDFL
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHH
DNGVDIKGMAHITGGGFIENIPRVLPQGLGAQIDKDSFATPAIFKLMQRIGDISEFEMYR
HCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHH
SFNMGIGMTIIASQDQFDKMQELAKKHTNTKLYQIGKITNSGKVEII
HHCCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEEEEECCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA