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The map label for this gene is ubiA

Identifier: 89255776

GI number: 89255776

Start: 332404

End: 333258

Strand: Reverse

Name: ubiA

Synonym: FTL_0355

Alternate gene names: 89255776

Gene position: 333258-332404 (Counterclockwise)

Preceding gene: 89255777

Following gene: 89255775

Centisome position: 17.58

GC content: 28.65

Gene sequence:

>855_bases
ATGAATAAACAACAACTAAAAGCATATTTCATGCTAATGCGACTACATCGCCCTATTCCGATATTACTAATCTTGTGGCC
AACACTTACAGCATTAGTCTTAGCAAGTCATGGACTACCAGATATTAGCTATCTAGTTATTTTCACTATCGGTGTAGTAG
TAATGCGTACTGTAGGTTGTATTATCAATGATATTGCTGATGTCGATTTTGACAAACATGTAGCTCGCACAAATACTCGA
CCTTTAACAAGTGGACAATTAAGTATTAAAAATGCTATTTGGCTTTGTATTTCTCTTACATTAGTTGCATTTATATGTGT
ATTATTTTTGAACTTATACACGATTTTATTATCATTTGTAGCACTATTCTTAGCAATACTATATCCGTTTTGTAAACGAT
TTTTTGCGATACCTCAACTAATACTCGGATTAGCATTTAATTTTGGTATTTTTATGGCTTTTTCTGCAATACAAAACCAA
ATACCAGTCGAAGCGTGGATATTTTATATAGCTACGATATGCTGGACAATAGCTTATGATACTATCTATGCACTAGCTGA
TCGAGAATTTGATTTAGAGATTGGTATAAAGTCATCTGCTGTTTTATTTGGTAATAAAGTATTTAGATATATCTTATTAT
TTAATTTCTTATCTTTACTTCTTTTAATAATCCTTGGTATTTATTGTGATTTTAATAGTTTTTTTTATTTAGGTGTTGTT
ATTTGTAGTTTATTTTTCGTTAGAAATTATTTTTTATATAAAAAATTAGGCATCACTAACTGTATAAATGCTTTTTCTGC
TAATCATTGGATTGGCTTAATAATTTTTATTATAGCAGTGATACAATATATATAA

Upstream 100 bases:

>100_bases
AAATATTCTCTCGTAGCTCAATATTTGAATATAAAGATAACTCAGAACTTAAATTTTTGATTACGGAATATTTCCTAGTT
TTACCCGAGCAATACTGACT

Downstream 100 bases:

>100_bases
TCAAGGAATTTTTATGATAAAAGTTTTCTATGATGGTAAATGTGGTCTTTGCACTAAAGAAATAAACCACTACAAAAAGA
TAGCTCCAAAGAATATTTTT

Product: 4-hydroxybenzoate polyprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGCIINDIADVDFDKHVARTNTR
PLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFVALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQ
IPVEAWIFYIATICWTIAYDTIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYI

Sequences:

>Translated_284_residues
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGCIINDIADVDFDKHVARTNTR
PLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFVALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQ
IPVEAWIFYIATICWTIAYDTIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYI
>Mature_284_residues
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGCIINDIADVDFDKHVARTNTR
PLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFVALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQ
IPVEAWIFYIATICWTIAYDTIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYI

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family

Homologues:

Organism=Homo sapiens, GI260656052, Length=278, Percent_Identity=34.8920863309352, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1790473, Length=283, Percent_Identity=41.3427561837456, Blast_Score=210, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17553718, Length=276, Percent_Identity=34.4202898550725, Blast_Score=170, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI32565247, Length=280, Percent_Identity=32.8571428571429, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17553720, Length=188, Percent_Identity=37.7659574468085, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI32565245, Length=144, Percent_Identity=39.5833333333333, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI32565243, Length=143, Percent_Identity=39.1608391608392, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6324370, Length=291, Percent_Identity=30.2405498281787, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21355567, Length=275, Percent_Identity=37.8181818181818, Blast_Score=185, Evalue=4e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIA_FRATF (A7NA50)

Other databases:

- EMBL:   CP000803
- RefSeq:   YP_001427809.1
- STRING:   A7NA50
- GeneID:   5524532
- GenomeReviews:   CP000803_GR
- KEGG:   fta:FTA_0376
- eggNOG:   COG0382
- HOGENOM:   HBG324383
- OMA:   YHYTLIR
- ProtClustDB:   PRK12847
- BioCyc:   FTUL458234:FTA_0376-MONOMER
- HAMAP:   MF_01635
- InterPro:   IPR006370
- InterPro:   IPR000537
- TIGRFAMs:   TIGR01474

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.- [C]

Molecular weight: Translated: 32460; Mature: 32460

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe055cf0)-; HASH(0xfea6018)-; HASH(0x1049810c)-; HASH(0x104513d0)-; HASH(0xff87c4c)-; HASH(0x100ee244)-; HASH(0xf946014)-; HASH(0x10479e10)-; HASH(0x104981e4)-;

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGC
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IINDIADVDFDKHVARTNTRPLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFV
HHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQIPVEAWIFYIATICWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
HHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
>Mature Secondary Structure
MNKQQLKAYFMLMRLHRPIPILLILWPTLTALVLASHGLPDISYLVIFTIGVVVMRTVGC
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
IINDIADVDFDKHVARTNTRPLTSGQLSIKNAIWLCISLTLVAFICVLFLNLYTILLSFV
HHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFLAILYPFCKRFFAIPQLILGLAFNFGIFMAFSAIQNQIPVEAWIFYIATICWTIAYD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TIYALADREFDLEIGIKSSAVLFGNKVFRYILLFNFLSLLLLIILGIYCDFNSFFYLGVV
HHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
ICSLFFVRNYFLYKKLGITNCINAFSANHWIGLIIFIIAVIQYI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA