Click here to switch to the map view.

The map label for this gene is murC [H]

Identifier: 89255606

GI number: 89255606

Start: 175402

End: 176757

Strand: Reverse

Name: murC [H]

Synonym: FTL_0172

Alternate gene names: 89255606

Gene position: 176757-175402 (Counterclockwise)

Preceding gene: 89255607

Following gene: 89255605

Centisome position: 9.32

GC content: 33.85

Gene sequence:

>1356_bases
TTGAACAAAAAAATATTATTTCTTGGAGTTGGCGGTATTGGAGTATCAGCTTTAGCTATTGCAGCTAAAAGGCTTGGTGC
ACATGTTGCTGGTTATGATAGTGTCGCAAATAAACTAACAGCAAAACTTGAAGCTTTAGGAATAGTAATATTTATTAGTC
CTAATGGTGTTGATGTTGCAAATTTTGATATTGTTGTATACTCAAGCGCTATACTTAGTAGTCATCCGCTGTTATCACAA
GCTCGAAGTCTAGGGATACAATGCTTACAAAGGGCAATGTTCCTAGCTGTTTTAATGAAAGACTTTAGTTATAGTCTTGC
GATTACTGGTACACATGGTAAAACAACTACCTCAAGTGTTTTGGCAACATTACTTTGTCAGCTAGATAAGTATAGTAGTT
TTATTGTTGGTGGAGTTGTTAAATATGCAGATTCGAATATACAGGTTAATGGTACTGATAAATTAGTTATCGAAGCTGAT
GAAAGTGATGCTTCATTTCTTTTTCTAAGCCCTCAGGTAGTGATAATTACTAATATTGATTTGGATCATATGGCAACTTA
TAACAATAGTTATCAAACCCTACTTGAGAACTTCACAGATTTTGTTAGTAAAGAAAGTGTAAAGAGTATTTATCTATGTG
TTGATGATCAAGGTTGTAGAGATTTATTAGCTAAATATAATCAATCAGACAAAAATGTTACATCCTATGGTTTTTCTATT
AATGCTGATGTGCAAATATATGATTATCATATTATTGATGAAATTACTCATTTTAAAATTAGATATAAGGGCGATGATTT
AAGTTTTAAGCTTCAGCTACCAGGTAGATATAATGTCCAAAACGCCACGGCGTGCATTATTACTTGTCTTGATTTGGGCT
TTAAATATGAGGATATTCGTAATGCACTAATTAAAGTTACTGGAGTAGCGAGGCGATTTGATCTCTACACTAAGGTAATC
TCAGGACATCAAGTAACGGTTATTGATGATTATGGTCATCATCCTGTTGAGGTCGCGAATAGTATAAGTGCAGTTAGAGA
TAGATATCCAAATAAAAAGATTATTCATGTTTTTCAGCCACATCGATATACACGTAACAGAGATTTGATAAAAGATTGGC
CAAAGGCTCTTTCACTGGCAGATCAACTAATTCTATTGCCTACATACTCAGCAGATGAGCAGATTATCAAGGGCGCTGAA
AGTCAAGATATTGTTAAAGGATTATCTGGATATCTACTTGCTGATGGTTTTGATCATGCAATATATTTTTTAGAAAAGCT
TGCTAATGAAAATACCGTTATATTGATTCAAGGTGCTGGAGACGTCACAAATTTGGTGGAGATATTGAGTGAATAG

Upstream 100 bases:

>100_bases
TATCGCTGTGTTTAAATATTGGCGTGGATTGTGATTAAGAATAAGGATTATGCTAAAATATTGTATACCAAATCATTATT
AGCATAGTTGCTAGGCTAGT

Downstream 100 bases:

>100_bases
TATAGAAAAAGCAACGCTTTATGTTGTTGCTACACCTATAGGCAATTTAGAGGATATAACTTATCGGGCATTAAACGTTC
TAAGTAATGTTGATATAATC

Product: UDP-N-acetylmuramate--alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNKKILFLGVGGIGVSALAIAAKRLGAHVAGYDSVANKLTAKLEALGIVIFISPNGVDVANFDIVVYSSAILSSHPLLSQ
ARSLGIQCLQRAMFLAVLMKDFSYSLAITGTHGKTTTSSVLATLLCQLDKYSSFIVGGVVKYADSNIQVNGTDKLVIEAD
ESDASFLFLSPQVVIITNIDLDHMATYNNSYQTLLENFTDFVSKESVKSIYLCVDDQGCRDLLAKYNQSDKNVTSYGFSI
NADVQIYDYHIIDEITHFKIRYKGDDLSFKLQLPGRYNVQNATACIITCLDLGFKYEDIRNALIKVTGVARRFDLYTKVI
SGHQVTVIDDYGHHPVEVANSISAVRDRYPNKKIIHVFQPHRYTRNRDLIKDWPKALSLADQLILLPTYSADEQIIKGAE
SQDIVKGLSGYLLADGFDHAIYFLEKLANENTVILIQGAGDVTNLVEILSE

Sequences:

>Translated_451_residues
MNKKILFLGVGGIGVSALAIAAKRLGAHVAGYDSVANKLTAKLEALGIVIFISPNGVDVANFDIVVYSSAILSSHPLLSQ
ARSLGIQCLQRAMFLAVLMKDFSYSLAITGTHGKTTTSSVLATLLCQLDKYSSFIVGGVVKYADSNIQVNGTDKLVIEAD
ESDASFLFLSPQVVIITNIDLDHMATYNNSYQTLLENFTDFVSKESVKSIYLCVDDQGCRDLLAKYNQSDKNVTSYGFSI
NADVQIYDYHIIDEITHFKIRYKGDDLSFKLQLPGRYNVQNATACIITCLDLGFKYEDIRNALIKVTGVARRFDLYTKVI
SGHQVTVIDDYGHHPVEVANSISAVRDRYPNKKIIHVFQPHRYTRNRDLIKDWPKALSLADQLILLPTYSADEQIIKGAE
SQDIVKGLSGYLLADGFDHAIYFLEKLANENTVILIQGAGDVTNLVEILSE
>Mature_451_residues
MNKKILFLGVGGIGVSALAIAAKRLGAHVAGYDSVANKLTAKLEALGIVIFISPNGVDVANFDIVVYSSAILSSHPLLSQ
ARSLGIQCLQRAMFLAVLMKDFSYSLAITGTHGKTTTSSVLATLLCQLDKYSSFIVGGVVKYADSNIQVNGTDKLVIEAD
ESDASFLFLSPQVVIITNIDLDHMATYNNSYQTLLENFTDFVSKESVKSIYLCVDDQGCRDLLAKYNQSDKNVTSYGFSI
NADVQIYDYHIIDEITHFKIRYKGDDLSFKLQLPGRYNVQNATACIITCLDLGFKYEDIRNALIKVTGVARRFDLYTKVI
SGHQVTVIDDYGHHPVEVANSISAVRDRYPNKKIIHVFQPHRYTRNRDLIKDWPKALSLADQLILLPTYSADEQIIKGAE
SQDIVKGLSGYLLADGFDHAIYFLEKLANENTVILIQGAGDVTNLVEILSE

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=439, Percent_Identity=35.7630979498861, Blast_Score=248, Evalue=7e-67,
Organism=Escherichia coli, GI1790680, Length=415, Percent_Identity=24.578313253012, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 49789; Mature: 49789

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKILFLGVGGIGVSALAIAAKRLGAHVAGYDSVANKLTAKLEALGIVIFISPNGVDVA
CCCEEEEEEECCHHHHHHHHHHHHHCCHHCCHHHHHHHHHHEEEEEEEEEEECCCCCCEE
NFDIVVYSSAILSSHPLLSQARSLGIQCLQRAMFLAVLMKDFSYSLAITGTHGKTTTSSV
EEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHH
LATLLCQLDKYSSFIVGGVVKYADSNIQVNGTDKLVIEADESDASFLFLSPQVVIITNID
HHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCEEEEEECCCCCEEEEECCCEEEEEECC
LDHMATYNNSYQTLLENFTDFVSKESVKSIYLCVDDQGCRDLLAKYNQSDKNVTSYGFSI
HHHHHHCCCHHHHHHHHHHHHHCHHCCCEEEEEECCCCHHHHHHHCCCCCCCEEEECEEE
NADVQIYDYHIIDEITHFKIRYKGDDLSFKLQLPGRYNVQNATACIITCLDLGFKYEDIR
ECCEEEEEEEEECCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHH
NALIKVTGVARRFDLYTKVISGHQVTVIDDYGHHPVEVANSISAVRDRYPNKKIIHVFQP
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECC
HRYTRNRDLIKDWPKALSLADQLILLPTYSADEQIIKGAESQDIVKGLSGYLLADGFDHA
CCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHCCCCHHHHHHHCCCEEEECCHHHH
IYFLEKLANENTVILIQGAGDVTNLVEILSE
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure
MNKKILFLGVGGIGVSALAIAAKRLGAHVAGYDSVANKLTAKLEALGIVIFISPNGVDVA
CCCEEEEEEECCHHHHHHHHHHHHHCCHHCCHHHHHHHHHHEEEEEEEEEEECCCCCCEE
NFDIVVYSSAILSSHPLLSQARSLGIQCLQRAMFLAVLMKDFSYSLAITGTHGKTTTSSV
EEEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHH
LATLLCQLDKYSSFIVGGVVKYADSNIQVNGTDKLVIEADESDASFLFLSPQVVIITNID
HHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCEEEEEECCCCCEEEEECCCEEEEEECC
LDHMATYNNSYQTLLENFTDFVSKESVKSIYLCVDDQGCRDLLAKYNQSDKNVTSYGFSI
HHHHHHCCCHHHHHHHHHHHHHCHHCCCEEEEEECCCCHHHHHHHCCCCCCCEEEECEEE
NADVQIYDYHIIDEITHFKIRYKGDDLSFKLQLPGRYNVQNATACIITCLDLGFKYEDIR
ECCEEEEEEEEECCCEEEEEEEECCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHH
NALIKVTGVARRFDLYTKVISGHQVTVIDDYGHHPVEVANSISAVRDRYPNKKIIHVFQP
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECC
HRYTRNRDLIKDWPKALSLADQLILLPTYSADEQIIKGAESQDIVKGLSGYLLADGFDHA
CCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHCCCCHHHHHHHCCCEEEECCHHHH
IYFLEKLANENTVILIQGAGDVTNLVEILSE
HHHHHHHCCCCEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA