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The map label for this gene is clcA [H]

Identifier: 89255539

GI number: 89255539

Start: 96799

End: 97863

Strand: Reverse

Name: clcA [H]

Synonym: FTL_0101

Alternate gene names: 89255539

Gene position: 97863-96799 (Counterclockwise)

Preceding gene: 89255540

Following gene: 89255538

Centisome position: 5.16

GC content: 36.24

Gene sequence:

>1065_bases
ATGCCCGTGAAATTTATAAGTGGACTTTTTTCGTTAGGCTCAGGTTTAAGTTTAGGTAAAGAGGGACCATCAATTCATAT
GGCTGCTGCATTAGCGCAGTTTTTTGTTGATAAATTTAAACTTACTACAAAATATGCTAATGCGGTTATCTCTGCTGGGG
CTGGAGCTGGACTAGCAGCTGCTTTTAATACCCCACTTTCTGGGATTATCTTTGTTATTGAAGAGATGAATAGAAAGTTT
AGATTTAGTGTTTCGGCAATAAAGTGTGTGCTAGTAGCATGTATCATGAGTACAGTTATCTCTAGAGCTATTATGGGTAA
TCCTCCAGCAATACGCGTAGAAACTTTCAGCTCAGTACCACAAAATACTCTTTGGTTATTTATGGTATTAGGGATTATAT
TTGGTTATTTTGGTTTACTATTTAACAAATCCTTAATCAAAGTGGCAAACTTTTTCTCAGAAGGATCCAAGAAGAGGTAT
TGGACTTTAGTTATAATTGTTTGCATAATTTTTGGTATTGGTGTTGTTCTATCTCCAAATGCTGTTGGCGGTGGCTATAT
TGTCATAGCAAATACTCTTGATTATAACTTATCAATCAAGATGCTTTTAGTGCTTTTTGTACTTCGTTTTGCTGGAGTTA
TTTTCTCATATGGCACCGGCGTTACTGGTGGGATATTCGCACCAATGATTGCGCTTGGTACTGTTTTTGGACTAGCTTAT
GGTTTATCAGTGGAGCAACTCTTCCCTCAGTATAATATTGAACCTGGAGTTTTTGCAGTTGCTGGAATGAGTGCACTATT
TACAGCAACTGTAGGTGCACCATTAACGGGTATTGTACTAGTAATGGAGATGACTTGGAATTTCCATCTTTTACTTCCTT
TGATGATAACTTGCTTTAGTGCATCTATGCTGACCTATATTCATCATCAAAAACCAATATATGATACCCTATTAAGACGT
ACTATTTCTAACGAAAGAAAACAACAAGCAAAGGAAAAAAATGAGCGCAATCAAAAGCCAACTCCAAATACTTCAGGACA
AACTATCTCAAAAGAAGAAATATAA

Upstream 100 bases:

>100_bases
CGATTTTTATTGTTAAAAAATTTGCGAAAGAGGCTGGTGTAGCGGTATCCAAGAGGTTGAGGGTGCTTTAAAAGGCTGCC
GCAAAATACGTAAAAGAGTT

Downstream 100 bases:

>100_bases
TCACGCAATTTCTCTAATGCACTGGGACTTAGAAACACAAGCCCCTAAAAACTCAATCAACACAACATCTGAAGTTATTG
GGTTTTTCAGTGAAAAAATC

Product: voltage-gated ClC-type chloride channel clcA

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MPVKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAAAFNTPLSGIIFVIEEMNRKF
RFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQNTLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRY
WTLVIIVCIIFGIGVVLSPNAVGGGYIVIANTLDYNLSIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAY
GLSVEQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFSASMLTYIHHQKPIYDTLLRR
TISNERKQQAKEKNERNQKPTPNTSGQTISKEEI

Sequences:

>Translated_354_residues
MPVKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAAAFNTPLSGIIFVIEEMNRKF
RFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQNTLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRY
WTLVIIVCIIFGIGVVLSPNAVGGGYIVIANTLDYNLSIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAY
GLSVEQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFSASMLTYIHHQKPIYDTLLRR
TISNERKQQAKEKNERNQKPTPNTSGQTISKEEI
>Mature_353_residues
PVKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAAAFNTPLSGIIFVIEEMNRKFR
FSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQNTLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRYW
TLVIIVCIIFGIGVVLSPNAVGGGYIVIANTLDYNLSIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAYG
LSVEQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFSASMLTYIHHQKPIYDTLLRRT
ISNERKQQAKEKNERNQKPTPNTSGQTISKEEI

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI55770840, Length=378, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI55770838, Length=378, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI189217923, Length=375, Percent_Identity=23.4666666666667, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI189217921, Length=375, Percent_Identity=23.4666666666667, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4557473, Length=375, Percent_Identity=23.4666666666667, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI153252026, Length=371, Percent_Identity=22.911051212938, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1786350, Length=349, Percent_Identity=41.2607449856734, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87081943, Length=313, Percent_Identity=26.517571884984, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532615, Length=348, Percent_Identity=24.4252873563218, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322500, Length=340, Percent_Identity=27.3529411764706, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24665008, Length=374, Percent_Identity=24.5989304812834, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 38420; Mature: 38289

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAA
CCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AFNTPLSGIIFVIEEMNRKFRFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVP
HHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCC
QNTLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRYWTLVIIVCIIFGIGVVLSPN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCC
AVGGGYIVIANTLDYNLSIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAY
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GLSVEQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFS
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
ASMLTYIHHQKPIYDTLLRRTISNERKQQAKEKNERNQKPTPNTSGQTISKEEI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PVKFISGLFSLGSGLSLGKEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAA
CHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AFNTPLSGIIFVIEEMNRKFRFSVSAIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVP
HHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCC
QNTLWLFMVLGIIFGYFGLLFNKSLIKVANFFSEGSKKRYWTLVIIVCIIFGIGVVLSPN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEECCC
AVGGGYIVIANTLDYNLSIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAY
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GLSVEQLFPQYNIEPGVFAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFS
CCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
ASMLTYIHHQKPIYDTLLRRTISNERKQQAKEKNERNQKPTPNTSGQTISKEEI
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA