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The map label for this gene is kdc [H]

Identifier: 89255455

GI number: 89255455

Start: 4954

End: 6354

Strand: Reverse

Name: kdc [H]

Synonym: FTL_0006

Alternate gene names: 89255455

Gene position: 6354-4954 (Counterclockwise)

Preceding gene: 89255456

Following gene: 89255452

Centisome position: 0.34

GC content: 35.26

Gene sequence:

>1401_bases
ATGGGCTCAAAAGCTGAAAATCTTGTTGTTTTTCATCTAGTCGGTAGTCCAGGAGATGGCGCAGTAGGAAAGAAGAGACA
GGTTCATCATACATTAGGAGATGGAGTTTTTGGAAATTTCTTTGATCTATCAGCTTCAGCGGCTTGTGTTTCAGCTGTCA
TAACACCAGAAAATGCTCGTAGAGAAATGAATAGAGTCATAGCTGAAGCGTTCAAATATCGCAAACCTGCTTATATAAGC
GTATCTTTGGATAGTGGCAATCGCCCTGTAACCGATATCACACCTGATGATATAGACTGCAGCTATCTAAAAAGTGACTC
ACATCAGCTTGAATTAGCCACAAACCTAGTGCTAGAGCATTTAAGCAAGGCTAAAAAAGTTGTTGCTATCCCAGCCATAA
AATTAGATAGGTTTGGAGTAACTGAAAAAGCTATCAACCTTATAGAAAAGTTAAATATTCCTTTTAGTATTATGCCTCAT
GATAAAAGTGTCATATCCGAAACACATCCTAACTATGTAGGTTTTTATGCTGGCTTATTATCAGACACAAATACTGCTGA
AATAGTTGAGGGCGCAGATCTTATAATTAATTTAGGTGATGCGCTATGGTCAGACTTCAATACAGCTGGATTCACCAATA
ATTTAGATTTAAATAAAGTACTGAATTTAGGACCTCTATTTGTCGAAGATAACAAAACTTATCTAGCTGACGTTTACTTA
TCAGAACTACTTGATGCTTTATTAGAAAAAGTTGAAAGTATAAATTATCGTCCTAATTACTCTAGAATGAAGATACAAGA
CACTACTATAACGAAAGAAAAGTTAACTTTAAGAGCACTATATACTCAAGTTTTAAAATTTTTAGAAAATACAGATAGTC
TTGTTGTAGAAACCGGTTCCTCTTCACTTAATATGCCGAAGTTACCACTGCCTGAAGGAGTAAAATATTTCAATCAAACA
TTATGGGGATCAATCGGTTGGGCTACTCCTGCTGCACTTGGTGTGGCATTAGCTAATCCAGATTCTAGAACTATATTGAT
TACAGGTGAAGGGTCCCACCAATTAACACTTAATGAACTTGGTGTAATGGGTAGATATAAAATAAATCCTATTATCTTAT
GCATAAATAATGATGGTTACATGATTGAAAGAGCTTTGGAATTAGATCCTAACCCTAGCTATGATGATATTGCGCAACTT
AACTACACCAAACTTCCTGAAGCTTTTGGCTGTAATGATTGGTTAGCTATAAGAGTTAAAACAAGCGAAGAATTAGCCGA
AGCTCTTAAAAAAGCTAGAGAGCACCAAAGTGGCGTATATATAGAAGTCATTACAGGAAAATATGACTATGGTAATGCTT
TTGATTTCTTCAATAATCATTTAAAGGAAATGTATAGCTAA

Upstream 100 bases:

>100_bases
TAATGCTAGCTATGCTGCTGATGGTTACGTAAGAGTCAAAGGAGCTGCGATTCTTTCGACTACTTATGCAGTTGGTGAAC
TTAGTGCCCTAAATGGTGTA

Downstream 100 bases:

>100_bases
AATTGACTACTATTCCTCAACATATGCCTTTTCTAACACTTTTCTAAAAGAAATTCCTTGTATAAATATTGAAAGTAATA
CCGCTATATAAATTATCGAA

Product: indolepyruvate decarboxylase

Products: 2-(indol-3-yl)acetaldehyde; CO2

Alternate protein names: KDC [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGSKAENLVVFHLVGSPGDGAVGKKRQVHHTLGDGVFGNFFDLSASAACVSAVITPENARREMNRVIAEAFKYRKPAYIS
VSLDSGNRPVTDITPDDIDCSYLKSDSHQLELATNLVLEHLSKAKKVVAIPAIKLDRFGVTEKAINLIEKLNIPFSIMPH
DKSVISETHPNYVGFYAGLLSDTNTAEIVEGADLIINLGDALWSDFNTAGFTNNLDLNKVLNLGPLFVEDNKTYLADVYL
SELLDALLEKVESINYRPNYSRMKIQDTTITKEKLTLRALYTQVLKFLENTDSLVVETGSSSLNMPKLPLPEGVKYFNQT
LWGSIGWATPAALGVALANPDSRTILITGEGSHQLTLNELGVMGRYKINPIILCINNDGYMIERALELDPNPSYDDIAQL
NYTKLPEAFGCNDWLAIRVKTSEELAEALKKAREHQSGVYIEVITGKYDYGNAFDFFNNHLKEMYS

Sequences:

>Translated_466_residues
MGSKAENLVVFHLVGSPGDGAVGKKRQVHHTLGDGVFGNFFDLSASAACVSAVITPENARREMNRVIAEAFKYRKPAYIS
VSLDSGNRPVTDITPDDIDCSYLKSDSHQLELATNLVLEHLSKAKKVVAIPAIKLDRFGVTEKAINLIEKLNIPFSIMPH
DKSVISETHPNYVGFYAGLLSDTNTAEIVEGADLIINLGDALWSDFNTAGFTNNLDLNKVLNLGPLFVEDNKTYLADVYL
SELLDALLEKVESINYRPNYSRMKIQDTTITKEKLTLRALYTQVLKFLENTDSLVVETGSSSLNMPKLPLPEGVKYFNQT
LWGSIGWATPAALGVALANPDSRTILITGEGSHQLTLNELGVMGRYKINPIILCINNDGYMIERALELDPNPSYDDIAQL
NYTKLPEAFGCNDWLAIRVKTSEELAEALKKAREHQSGVYIEVITGKYDYGNAFDFFNNHLKEMYS
>Mature_465_residues
GSKAENLVVFHLVGSPGDGAVGKKRQVHHTLGDGVFGNFFDLSASAACVSAVITPENARREMNRVIAEAFKYRKPAYISV
SLDSGNRPVTDITPDDIDCSYLKSDSHQLELATNLVLEHLSKAKKVVAIPAIKLDRFGVTEKAINLIEKLNIPFSIMPHD
KSVISETHPNYVGFYAGLLSDTNTAEIVEGADLIINLGDALWSDFNTAGFTNNLDLNKVLNLGPLFVEDNKTYLADVYLS
ELLDALLEKVESINYRPNYSRMKIQDTTITKEKLTLRALYTQVLKFLENTDSLVVETGSSSLNMPKLPLPEGVKYFNQTL
WGSIGWATPAALGVALANPDSRTILITGEGSHQLTLNELGVMGRYKINPIILCINNDGYMIERALELDPNPSYDDIAQLN
YTKLPEAFGCNDWLAIRVKTSEELAEALKKAREHQSGVYIEVITGKYDYGNAFDFFNNHLKEMYS

Specific function: Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes [H]

COG id: COG3961

COG function: function code GHR; Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321524, Length=453, Percent_Identity=31.3465783664459, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323163, Length=457, Percent_Identity=31.5098468271335, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6323073, Length=435, Percent_Identity=31.7241379310345, Blast_Score=185, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320123, Length=446, Percent_Identity=27.5784753363229, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6320588, Length=508, Percent_Identity=27.755905511811, Blast_Score=143, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012110
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: 4.1.1.74

Molecular weight: Translated: 51594; Mature: 51463

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSKAENLVVFHLVGSPGDGAVGKKRQVHHTLGDGVFGNFFDLSASAACVSAVITPENAR
CCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCHHHCCCHHHHHEEEECCCHHH
REMNRVIAEAFKYRKPAYISVSLDSGNRPVTDITPDDIDCSYLKSDSHQLELATNLVLEH
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHH
LSKAKKVVAIPAIKLDRFGVTEKAINLIEKLNIPFSIMPHDKSVISETHPNYVGFYAGLL
HHHHCEEEEECCEEECCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCHHHHHHHHH
SDTNTAEIVEGADLIINLGDALWSDFNTAGFTNNLDLNKVLNLGPLFVEDNKTYLADVYL
CCCCCHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEHHHHH
SELLDALLEKVESINYRPNYSRMKIQDTTITKEKLTLRALYTQVLKFLENTDSLVVETGS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECC
SSLNMPKLPLPEGVKYFNQTLWGSIGWATPAALGVALANPDSRTILITGEGSHQLTLNEL
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHEEEEECCCCCEEEEEECCCCEEEHHHH
GVMGRYKINPIILCINNDGYMIERALELDPNPSYDDIAQLNYTKLPEAFGCNDWLAIRVK
CCCCEEECCEEEEEECCCCEEEEEEEECCCCCCHHHHHHCCHHCCCCCCCCCCEEEEEEE
TSEELAEALKKAREHQSGVYIEVITGKYDYGNAFDFFNNHLKEMYS
CHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
GSKAENLVVFHLVGSPGDGAVGKKRQVHHTLGDGVFGNFFDLSASAACVSAVITPENAR
CCCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCCCCCHHHCCCHHHHHEEEECCCHHH
REMNRVIAEAFKYRKPAYISVSLDSGNRPVTDITPDDIDCSYLKSDSHQLELATNLVLEH
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHH
LSKAKKVVAIPAIKLDRFGVTEKAINLIEKLNIPFSIMPHDKSVISETHPNYVGFYAGLL
HHHHCEEEEECCEEECCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHCCCCHHHHHHHHH
SDTNTAEIVEGADLIINLGDALWSDFNTAGFTNNLDLNKVLNLGPLFVEDNKTYLADVYL
CCCCCHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHCCCCEEEECCCEEEHHHHH
SELLDALLEKVESINYRPNYSRMKIQDTTITKEKLTLRALYTQVLKFLENTDSLVVETGS
HHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECC
SSLNMPKLPLPEGVKYFNQTLWGSIGWATPAALGVALANPDSRTILITGEGSHQLTLNEL
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHEEEEECCCCCEEEEEECCCCEEEHHHH
GVMGRYKINPIILCINNDGYMIERALELDPNPSYDDIAQLNYTKLPEAFGCNDWLAIRVK
CCCCEEECCEEEEEECCCCEEEEEEEECCCCCCHHHHHHCCHHCCCCCCCCCCEEEEEEE
TSEELAEALKKAREHQSGVYIEVITGKYDYGNAFDFFNNHLKEMYS
CHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-(indol-3-yl)pyruvate

Specific reaction: 3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA