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The map label for this gene is trxA [H]

Identifier: 89056558

GI number: 89056558

Start: 4176112

End: 4176432

Strand: Direct

Name: trxA [H]

Synonym: Jann_4067

Alternate gene names: 89056558

Gene position: 4176112-4176432 (Clockwise)

Preceding gene: 89056557

Following gene: 89056559

Centisome position: 96.71

GC content: 59.19

Gene sequence:

>321_bases
ATGGCTACCACCGCCGTCACCGACGCCACGTTTGATACCGAAGTGAAGCAATCCGACATCCCCGTTGTCGTCGATTTCTG
GGCCGAATGGTGCGGGCCCTGCAAGCAGATCGGCCCGGCTCTGGAAGAGCTGTCCGAGGAGTATGAGGGCCGCGTGAAAA
TCGTGAAACTCAACGTCGACGAAAACGCCAATGCACCGATGCAACTGGGCGTGCGCGGCATTCCGGCGCTGTTCATGTTC
AAGGACGGCGAAGTCGTGTCCAACAAGGTTGGCGCGGCCCCGAAAGCGGCATTGCAAAAGTGGATTGACGAGGCCGTTTG
A

Upstream 100 bases:

>100_bases
TCGTGTCTCAGGCGCTGAGACGCGCAACCAGTGCTTGACGCGCAGAGGCCCTGTCCATACGTTCAGCCCCCGACATAACC
CCGCCAGGAGGGCCCCGACC

Downstream 100 bases:

>100_bases
GGCGCGATCCCTGCAAAATTCCGGAAAGGCGTCCCCGCACGATTGGCCGGGGGCGCTTTTTTTGTGCCGGTATGCCAATC
GTTTCAACTGCGACCGTTTG

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MATTAVTDATFDTEVKQSDIPVVVDFWAEWCGPCKQIGPALEELSEEYEGRVKIVKLNVDENANAPMQLGVRGIPALFMF
KDGEVVSNKVGAAPKAALQKWIDEAV

Sequences:

>Translated_106_residues
MATTAVTDATFDTEVKQSDIPVVVDFWAEWCGPCKQIGPALEELSEEYEGRVKIVKLNVDENANAPMQLGVRGIPALFMF
KDGEVVSNKVGAAPKAALQKWIDEAV
>Mature_105_residues
ATTAVTDATFDTEVKQSDIPVVVDFWAEWCGPCKQIGPALEELSEEYEGRVKIVKLNVDENANAPMQLGVRGIPALFMFK
DGEVVSNKVGAAPKAALQKWIDEAV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=96, Percent_Identity=34.375, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=50, Blast_Score=120, Evalue=1e-29,
Organism=Escherichia coli, GI1788936, Length=100, Percent_Identity=41, Blast_Score=97, Evalue=3e-22,
Organism=Escherichia coli, GI87081747, Length=102, Percent_Identity=29.4117647058824, Blast_Score=65, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=40.625, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=35.8974358974359, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=99, Percent_Identity=42.4242424242424, Blast_Score=80, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6321648, Length=99, Percent_Identity=38.3838383838384, Blast_Score=75, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=104, Percent_Identity=37.5, Blast_Score=71, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=40, Blast_Score=89, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24639826, Length=74, Percent_Identity=44.5945945945946, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664269, Length=71, Percent_Identity=40.8450704225352, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=35.4166666666667, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17648013, Length=80, Percent_Identity=40, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=80, Percent_Identity=40, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=34.4086021505376, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921434, Length=75, Percent_Identity=37.3333333333333, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11538; Mature: 11407

Theoretical pI: Translated: 4.20; Mature: 4.20

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTAVTDATFDTEVKQSDIPVVVDFWAEWCGPCKQIGPALEELSEEYEGRVKIVKLNVD
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECC
ENANAPMQLGVRGIPALFMFKDGEVVSNKVGAAPKAALQKWIDEAV
CCCCCCCEECCCCCCEEEEEECCCHHHHCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ATTAVTDATFDTEVKQSDIPVVVDFWAEWCGPCKQIGPALEELSEEYEGRVKIVKLNVD
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEEECC
ENANAPMQLGVRGIPALFMFKDGEVVSNKVGAAPKAALQKWIDEAV
CCCCCCCEECCCCCCEEEEEECCCHHHHCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2137818; 3280308 [H]