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The map label for this gene is hyuB [H]

Identifier: 89056303

GI number: 89056303

Start: 3899628

End: 3901334

Strand: Direct

Name: hyuB [H]

Synonym: Jann_3812

Alternate gene names: 89056303

Gene position: 3899628-3901334 (Clockwise)

Preceding gene: 89056302

Following gene: 89056304

Centisome position: 90.31

GC content: 64.5

Gene sequence:

>1707_bases
ATGAGTGCTTCAAACGACGCCGGGCCCGGCAATGTCGCCTACCAAGTCATGTGGAACCGCCTGATCTCCATCGTGGAGGA
ACAGGCGCAAGCGTTGGTGCGCACGGCATTCTCCACCTCCGTGCGCGAGGCCGGAGATCTGAGTGCCGGGGTCTACGACA
CCCATGGCCGCATGTTGGCTCAGGCCGTCACTGGCACACCGGGCCACGTTAACGCCATGGCCGATGCGGTGCCGCATTTC
ATCCGCCGCATCGGGCGGGACACGATGACTGAGGGCGACGTCTACATCACCAATGACCCATGGGAGGGCACGGGGCATTT
GCACGACATCACCATGGTCACGCCATCGTTCAAGGACGGCGCGCTGGTGGGGTTCTTCGCCTGCACCGCCCATGTGGTGG
ATATCGGCGGGCGCGGGTTCGGGGCGGATGGCCAATCCGTCTACGAGGAAGGCCTCTACCTGCCGATCATGCGGTTCGCC
GCGCGTGGAGAGGTCGATGAAACGCTGATCCGTATCGTGCGCGGCAATGTCCGCGAGCCGGATCAACTGGTCGGCGACAT
GTATGCGCTGGCAACCTGCAACGAGATCGGCCACCGCCGTCTGATTGACATGATGGCAGAGTTCACGCTTAGCGATCTGG
ATGGAATCGCGGAGTTCATCCTGTCCAACTCCCGCCGCGCGACGTTGGAGCGGATCAATGCCCTGCCCCGCAAGGCTGCG
GACGGAGAGATGACGGTGGACGGCTTCGACACACCAATCACCCTGAAAGCACGGGTCAGCATCGAAGAAGACAGGATCGT
CACCGATTTCACCGGCACATCCGGCATCGACAAGAAGGGCATCAACTGCCCGATGGTCTATACGAAAGCCTATGCCTGCT
ATGCGCTAAAGGTCGCGATTGCGCCCGAGATCCCCAACAACGCGGCCTCTCTCGCGCCGTTTGAGGTGACGGCCCCGGAA
GGCACCATCGTCAACGCCATGCATCCCGCGCCAGTGGCATTGCGCCATATCGTGGGGCATTTCGTGCCAGACGTCGTCTT
CGATGCGTTCGACAAGATCGTCCCTGGCCTGGTGCCTGCCGAAGGGGCCGGGTGTCTATGCAACTTCCAGATGTCGGTGC
GGCCAACCGCGCCCGGTGGCAGGCGCGCTGAGGTGCTGACATTCAATTCCGGCGGCTCCGGCGCGCGGCCCGAAGTGGAC
GGGTTGAACGCGACGGCCTTCCCCTCGGGCGTCATGACCATGCCGATTGAGGCCACAGAACACGCGGGCCCGGTGATCAT
CTGGCGCAAGGAACTGCGCCCGGGCTCCGGCGGGGCGGGCAGGACGCGCGGGGGCCTTGGTCAATACATGGACGTCAGCG
CCATGCCGGGCCACGAGTTCGACCTGCAGGCCATGTTCGACCGGGGCGGTCACCCTGCGCGCGGGCGGCGCGGGGGGCAG
GCCGGTGCACCAACAACAATTGCGCAGGACGACGGCACGGCAATGCGGGTCAAAGGCAAGCAATTCGTGGCAGAGGGGCG
GCGCGTCCAAATGGCGTTCCCCGGGGGCGCAGGCTACGGAAACGCCGCTGATCGTGACCCGGCTCTGGTCAAACGCGATC
TGGCGCGCGGCTACATCAGCGCGGAAGAGGCGTCGCGTGATTATGGGCTGTCGCCTAAGGACATTGCGGGCGTGGCGGCG
AGTGTCGCCAGAGGCGAAGACATCTGA

Upstream 100 bases:

>100_bases
ACAATCACCGAGGATGAAACGACGATCATCCTGCCCGCCAGCCGCCGCGCCTCTTGTCAGCCTGACGGCTGCATCGACCT
TGTGAAGAAGGATTGAGCCG

Downstream 100 bases:

>100_bases
GGACAGGAGAAACTCAATGACTAAAGTTGCACTGATAACTGCGGGCGGAAGCGGAATGGGCGCGGACAGCGCAAGCGCGC
TCGCGGCCGATGGCTACAAG

Product: 5-oxoprolinase

Products: NA

Alternate protein names: ORF3 [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MSASNDAGPGNVAYQVMWNRLISIVEEQAQALVRTAFSTSVREAGDLSAGVYDTHGRMLAQAVTGTPGHVNAMADAVPHF
IRRIGRDTMTEGDVYITNDPWEGTGHLHDITMVTPSFKDGALVGFFACTAHVVDIGGRGFGADGQSVYEEGLYLPIMRFA
ARGEVDETLIRIVRGNVREPDQLVGDMYALATCNEIGHRRLIDMMAEFTLSDLDGIAEFILSNSRRATLERINALPRKAA
DGEMTVDGFDTPITLKARVSIEEDRIVTDFTGTSGIDKKGINCPMVYTKAYACYALKVAIAPEIPNNAASLAPFEVTAPE
GTIVNAMHPAPVALRHIVGHFVPDVVFDAFDKIVPGLVPAEGAGCLCNFQMSVRPTAPGGRRAEVLTFNSGGSGARPEVD
GLNATAFPSGVMTMPIEATEHAGPVIIWRKELRPGSGGAGRTRGGLGQYMDVSAMPGHEFDLQAMFDRGGHPARGRRGGQ
AGAPTTIAQDDGTAMRVKGKQFVAEGRRVQMAFPGGAGYGNAADRDPALVKRDLARGYISAEEASRDYGLSPKDIAGVAA
SVARGEDI

Sequences:

>Translated_568_residues
MSASNDAGPGNVAYQVMWNRLISIVEEQAQALVRTAFSTSVREAGDLSAGVYDTHGRMLAQAVTGTPGHVNAMADAVPHF
IRRIGRDTMTEGDVYITNDPWEGTGHLHDITMVTPSFKDGALVGFFACTAHVVDIGGRGFGADGQSVYEEGLYLPIMRFA
ARGEVDETLIRIVRGNVREPDQLVGDMYALATCNEIGHRRLIDMMAEFTLSDLDGIAEFILSNSRRATLERINALPRKAA
DGEMTVDGFDTPITLKARVSIEEDRIVTDFTGTSGIDKKGINCPMVYTKAYACYALKVAIAPEIPNNAASLAPFEVTAPE
GTIVNAMHPAPVALRHIVGHFVPDVVFDAFDKIVPGLVPAEGAGCLCNFQMSVRPTAPGGRRAEVLTFNSGGSGARPEVD
GLNATAFPSGVMTMPIEATEHAGPVIIWRKELRPGSGGAGRTRGGLGQYMDVSAMPGHEFDLQAMFDRGGHPARGRRGGQ
AGAPTTIAQDDGTAMRVKGKQFVAEGRRVQMAFPGGAGYGNAADRDPALVKRDLARGYISAEEASRDYGLSPKDIAGVAA
SVARGEDI
>Mature_567_residues
SASNDAGPGNVAYQVMWNRLISIVEEQAQALVRTAFSTSVREAGDLSAGVYDTHGRMLAQAVTGTPGHVNAMADAVPHFI
RRIGRDTMTEGDVYITNDPWEGTGHLHDITMVTPSFKDGALVGFFACTAHVVDIGGRGFGADGQSVYEEGLYLPIMRFAA
RGEVDETLIRIVRGNVREPDQLVGDMYALATCNEIGHRRLIDMMAEFTLSDLDGIAEFILSNSRRATLERINALPRKAAD
GEMTVDGFDTPITLKARVSIEEDRIVTDFTGTSGIDKKGINCPMVYTKAYACYALKVAIAPEIPNNAASLAPFEVTAPEG
TIVNAMHPAPVALRHIVGHFVPDVVFDAFDKIVPGLVPAEGAGCLCNFQMSVRPTAPGGRRAEVLTFNSGGSGARPEVDG
LNATAFPSGVMTMPIEATEHAGPVIIWRKELRPGSGGAGRTRGGLGQYMDVSAMPGHEFDLQAMFDRGGHPARGRRGGQA
GAPTTIAQDDGTAMRVKGKQFVAEGRRVQMAFPGGAGYGNAADRDPALVKRDLARGYISAEEASRDYGLSPKDIAGVAAS
VARGEDI

Specific function: HyuA and hyuB convert D- and L-substituted hydantoins to corresponding N-carbamyl-amino acids [H]

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=543, Percent_Identity=27.0718232044199, Blast_Score=122, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI133901900, Length=530, Percent_Identity=27.3584905660377, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI133901902, Length=528, Percent_Identity=26.7045454545455, Blast_Score=132, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322634, Length=553, Percent_Identity=25.8589511754069, Blast_Score=131, Evalue=3e-31,
Organism=Drosophila melanogaster, GI45550492, Length=577, Percent_Identity=26.6897746967071, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: NA

Molecular weight: Translated: 60395; Mature: 60264

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASNDAGPGNVAYQVMWNRLISIVEEQAQALVRTAFSTSVREAGDLSAGVYDTHGRMLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHH
QAVTGTPGHVNAMADAVPHFIRRIGRDTMTEGDVYITNDPWEGTGHLHDITMVTPSFKDG
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCC
ALVGFFACTAHVVDIGGRGFGADGQSVYEEGLYLPIMRFAARGEVDETLIRIVRGNVREP
CEEHHHHHHHHHEECCCCCCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCH
DQLVGDMYALATCNEIGHRRLIDMMAEFTLSDLDGIAEFILSNSRRATLERINALPRKAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
DGEMTVDGFDTPITLKARVSIEEDRIVTDFTGTSGIDKKGINCPMVYTKAYACYALKVAI
CCCEEECCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCHHHHHEEEEEEEEEE
APEIPNNAASLAPFEVTAPEGTIVNAMHPAPVALRHIVGHFVPDVVFDAFDKIVPGLVPA
CCCCCCCCCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EGAGCLCNFQMSVRPTAPGGRRAEVLTFNSGGSGARPEVDGLNATAFPSGVMTMPIEATE
CCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECEECCC
HAGPVIIWRKELRPGSGGAGRTRGGLGQYMDVSAMPGHEFDLQAMFDRGGHPARGRRGGQ
CCCCEEEEHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHCCCCCCCCCCCCC
AGAPTTIAQDDGTAMRVKGKQFVAEGRRVQMAFPGGAGYGNAADRDPALVKRDLARGYIS
CCCCCEEECCCCCEEEECCHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
AEEASRDYGLSPKDIAGVAASVARGEDI
HHHCCCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SASNDAGPGNVAYQVMWNRLISIVEEQAQALVRTAFSTSVREAGDLSAGVYDTHGRMLA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHH
QAVTGTPGHVNAMADAVPHFIRRIGRDTMTEGDVYITNDPWEGTGHLHDITMVTPSFKDG
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCC
ALVGFFACTAHVVDIGGRGFGADGQSVYEEGLYLPIMRFAARGEVDETLIRIVRGNVREP
CEEHHHHHHHHHEECCCCCCCCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCH
DQLVGDMYALATCNEIGHRRLIDMMAEFTLSDLDGIAEFILSNSRRATLERINALPRKAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
DGEMTVDGFDTPITLKARVSIEEDRIVTDFTGTSGIDKKGINCPMVYTKAYACYALKVAI
CCCEEECCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCCCCHHHHHEEEEEEEEEE
APEIPNNAASLAPFEVTAPEGTIVNAMHPAPVALRHIVGHFVPDVVFDAFDKIVPGLVPA
CCCCCCCCCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EGAGCLCNFQMSVRPTAPGGRRAEVLTFNSGGSGARPEVDGLNATAFPSGVMTMPIEATE
CCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEECEECCC
HAGPVIIWRKELRPGSGGAGRTRGGLGQYMDVSAMPGHEFDLQAMFDRGGHPARGRRGGQ
CCCCEEEEHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCHHHHHHCCCCCCCCCCCCC
AGAPTTIAQDDGTAMRVKGKQFVAEGRRVQMAFPGGAGYGNAADRDPALVKRDLARGYIS
CCCCCEEECCCCCEEEECCHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCC
AEEASRDYGLSPKDIAGVAASVARGEDI
HHHCCCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1732229 [H]