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The map label for this gene is 89056255

Identifier: 89056255

GI number: 89056255

Start: 3845502

End: 3847196

Strand: Direct

Name: 89056255

Synonym: Jann_3764

Alternate gene names: NA

Gene position: 3845502-3847196 (Clockwise)

Preceding gene: 89056254

Following gene: 89056256

Centisome position: 89.06

GC content: 64.78

Gene sequence:

>1695_bases
ATGAGCGAGGATATCGATCCGATCACGTTGGCGGTTCTTGCGGGGCGGATGGAGCAAATTGCCGATGAGATGGACGCGAC
CCTGTTTCGCGCCGCCTTCAACCCCATCATCGCCGAGGCCCATGATGCCAGCCACGGCCTCTATCACGCGACCAGTGGCG
ATACGCTGGTGCAAGGCAAGTCGGGCCTGCCGATCTTCGTCGGTGTTATGTCTTTCGCGGTCAAGGCTGTCATCGACAAG
GCGGCAGAGGCGGGCGATCTGGCCGATGGCGACATCTATATCTTCAACGATGCGCATATGGGCGGCACACACCTGTCGGA
CATGCGCCTTGTCCGGCCGTATTTCCGCGATGGGGCGTTGTTCTGCTACCTCGCCTCGGTCGGGCACTGGCACGATGTGG
GCGGCGCGGTGCCCGGCAACTATAACCCGTCGGCCACCGATGTGTTTCAGGAAGCCTTCGTGCTGCCACCGGTCAAGCTG
GCGCGTGGGGGCGAGATCCAGCAGGACATCATCGACATCCTTTTGCGCAACACCCGGCTGCCGCAATCGGCGATGGGCGA
TCTGAACGGGCAACTTGGGGCGCTTGATCTGGGCGTGAAGCGCCTTGATGAATTGCTGGATGAATATGGGCCGAAGACGG
TCCATGCGGGCCTTGATGCGCTCCAGGATCGGGCCGAGGTCTTGATGCGCGCGGAATTGTCGGACCTGCCGGACGGGCGT
TGGGAGGCCGAAGATTTCCTCGACAATGACGGGATTACCGACACCGCCCTGCCGATCCGCGTGGCGCTGGAGATCACCGG
CGACACGATGGTGCTCGACTTTGAGGGCACCGCACCCGTCACTGCGGGGCCAGTGAACATCGCCCTGCCCACGGCGGTGG
CCACGGCCTATGTCGCGATCAAACACATCTTTCCCGACCTGCCCGCCAATGCAGGTGTGATGCGGCCCATCGAGGTGCGC
GTGCCGGACGGCTCGCTGTTGTCGGCAGAGTTCCCGGCCCCGGTGGGCGGCTATACCGAAACCATCCTGCGCATGATCGA
CGTGATGTTTTCCGCCGCCTCCCAAGCCGCGCCCGACCGGGTCGTGGCCAACGCCTATGGCACGATCAACGCGCTGTCCA
TCGCCGGCAAGCGCGCGAATGGCGCGCCGTGGGTGATGTTCAGCTTCTACGGCGGCGGGCATGGCGGCAGCGTTGAGAGC
GACGGGTTGAACCATGGCAATGCGCCGATCTCCACCGCGACGATCCCACCGATGGAGATCCTTGAGGCGGCCTATCCCGT
GATGTTCCGGCAATGGGCACTGCGGCCCGACAGTGCCGGTGCCGGGGCCCATCGCGGCGGGCTTGGGGCCGTCTATGAAA
TTGAAGTGCTGGAGGAGAAGGCCGAGGCGTTCCTGTTCGGGGAACGCGGGCGGTTTGCGCCGCAAGGTGTGACCGGCGGC
GCGCCGGGTGCGATGAACGTCTTCACTTACGAGCAGGACGACGGCTGGAAGACCCCACCGCTGGCCTCCAAGATGCTCGG
GATGCGATTGCGGAAGGGGCAGGCCGTGCGCCTTGAGACCCCCGGTGGTGGTGGGTATGGCGATCCTGCGGACCGTTCGC
CCGAAGCCGTGGCGCGCGATGTGGCGCTTGGCTACCTGAGTGCTGAGGCGGCGACCGAAAGCTACGGGTCGGCCTGGCAG
GAGTGCGCATCATGA

Upstream 100 bases:

>100_bases
CTCCGTTTTCCGGGATCCGGTTCATTGATCGGTTTGAGGTCGCAGATGGTCTGCTGATCCGGCAGGACGTGTGGAACGAT
CTGGCGGAGGCGCGCGGGAC

Downstream 100 bases:

>100_bases
GCCGCATGATCGGCGTCGATGTTGGCGGCACATTCACCGATGTCTTCGTACTTGATGAGGACAGCGGCGTGGCCGAGGTC
GCCAAGGTGCCGACGACGCG

Product: 5-oxoprolinase

Products: ADP; phosphate; N-carbamoylsarcosine

Alternate protein names: NA

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MSEDIDPITLAVLAGRMEQIADEMDATLFRAAFNPIIAEAHDASHGLYHATSGDTLVQGKSGLPIFVGVMSFAVKAVIDK
AAEAGDLADGDIYIFNDAHMGGTHLSDMRLVRPYFRDGALFCYLASVGHWHDVGGAVPGNYNPSATDVFQEAFVLPPVKL
ARGGEIQQDIIDILLRNTRLPQSAMGDLNGQLGALDLGVKRLDELLDEYGPKTVHAGLDALQDRAEVLMRAELSDLPDGR
WEAEDFLDNDGITDTALPIRVALEITGDTMVLDFEGTAPVTAGPVNIALPTAVATAYVAIKHIFPDLPANAGVMRPIEVR
VPDGSLLSAEFPAPVGGYTETILRMIDVMFSAASQAAPDRVVANAYGTINALSIAGKRANGAPWVMFSFYGGGHGGSVES
DGLNHGNAPISTATIPPMEILEAAYPVMFRQWALRPDSAGAGAHRGGLGAVYEIEVLEEKAEAFLFGERGRFAPQGVTGG
APGAMNVFTYEQDDGWKTPPLASKMLGMRLRKGQAVRLETPGGGGYGDPADRSPEAVARDVALGYLSAEAATESYGSAWQ
ECAS

Sequences:

>Translated_564_residues
MSEDIDPITLAVLAGRMEQIADEMDATLFRAAFNPIIAEAHDASHGLYHATSGDTLVQGKSGLPIFVGVMSFAVKAVIDK
AAEAGDLADGDIYIFNDAHMGGTHLSDMRLVRPYFRDGALFCYLASVGHWHDVGGAVPGNYNPSATDVFQEAFVLPPVKL
ARGGEIQQDIIDILLRNTRLPQSAMGDLNGQLGALDLGVKRLDELLDEYGPKTVHAGLDALQDRAEVLMRAELSDLPDGR
WEAEDFLDNDGITDTALPIRVALEITGDTMVLDFEGTAPVTAGPVNIALPTAVATAYVAIKHIFPDLPANAGVMRPIEVR
VPDGSLLSAEFPAPVGGYTETILRMIDVMFSAASQAAPDRVVANAYGTINALSIAGKRANGAPWVMFSFYGGGHGGSVES
DGLNHGNAPISTATIPPMEILEAAYPVMFRQWALRPDSAGAGAHRGGLGAVYEIEVLEEKAEAFLFGERGRFAPQGVTGG
APGAMNVFTYEQDDGWKTPPLASKMLGMRLRKGQAVRLETPGGGGYGDPADRSPEAVARDVALGYLSAEAATESYGSAWQ
ECAS
>Mature_563_residues
SEDIDPITLAVLAGRMEQIADEMDATLFRAAFNPIIAEAHDASHGLYHATSGDTLVQGKSGLPIFVGVMSFAVKAVIDKA
AEAGDLADGDIYIFNDAHMGGTHLSDMRLVRPYFRDGALFCYLASVGHWHDVGGAVPGNYNPSATDVFQEAFVLPPVKLA
RGGEIQQDIIDILLRNTRLPQSAMGDLNGQLGALDLGVKRLDELLDEYGPKTVHAGLDALQDRAEVLMRAELSDLPDGRW
EAEDFLDNDGITDTALPIRVALEITGDTMVLDFEGTAPVTAGPVNIALPTAVATAYVAIKHIFPDLPANAGVMRPIEVRV
PDGSLLSAEFPAPVGGYTETILRMIDVMFSAASQAAPDRVVANAYGTINALSIAGKRANGAPWVMFSFYGGGHGGSVESD
GLNHGNAPISTATIPPMEILEAAYPVMFRQWALRPDSAGAGAHRGGLGAVYEIEVLEEKAEAFLFGERGRFAPQGVTGGA
PGAMNVFTYEQDDGWKTPPLASKMLGMRLRKGQAVRLETPGGGGYGDPADRSPEAVARDVALGYLSAEAATESYGSAWQE
CAS

Specific function: Unknown

COG id: COG0146

COG function: function code EQ; N-methylhydantoinase B/acetone carboxylase, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the oxoprolinase family [H]

Homologues:

Organism=Homo sapiens, GI48314820, Length=554, Percent_Identity=31.4079422382672, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI133901900, Length=555, Percent_Identity=31.3513513513514, Blast_Score=221, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI133901902, Length=517, Percent_Identity=31.1411992263056, Blast_Score=195, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6322634, Length=560, Percent_Identity=27.1428571428571, Blast_Score=177, Evalue=3e-45,
Organism=Drosophila melanogaster, GI45550492, Length=576, Percent_Identity=27.6041666666667, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003692 [H]

Pfam domain/function: PF02538 Hydantoinase_B [H]

EC number: 3.5.2.14

Molecular weight: Translated: 59685; Mature: 59554

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDIDPITLAVLAGRMEQIADEMDATLFRAAFNPIIAEAHDASHGLYHATSGDTLVQGK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECC
SGLPIFVGVMSFAVKAVIDKAAEAGDLADGDIYIFNDAHMGGTHLSDMRLVRPYFRDGAL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCE
FCYLASVGHWHDVGGAVPGNYNPSATDVFQEAFVLPPVKLARGGEIQQDIIDILLRNTRL
EEEEHHCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCC
PQSAMGDLNGQLGALDLGVKRLDELLDEYGPKTVHAGLDALQDRAEVLMRAELSDLPDGR
CHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
WEAEDFLDNDGITDTALPIRVALEITGDTMVLDFEGTAPVTAGPVNIALPTAVATAYVAI
CCHHHHCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHH
KHIFPDLPANAGVMRPIEVRVPDGSLLSAEFPAPVGGYTETILRMIDVMFSAASQAAPDR
HHHCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
VVANAYGTINALSIAGKRANGAPWVMFSFYGGGHGGSVESDGLNHGNAPISTATIPPMEI
EEHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LEAAYPVMFRQWALRPDSAGAGAHRGGLGAVYEIEVLEEKAEAFLFGERGRFAPQGVTGG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHEEEECCCCCCCCCCCCCC
APGAMNVFTYEQDDGWKTPPLASKMLGMRLRKGQAVRLETPGGGGYGDPADRSPEAVARD
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHH
VALGYLSAEAATESYGSAWQECAS
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEDIDPITLAVLAGRMEQIADEMDATLFRAAFNPIIAEAHDASHGLYHATSGDTLVQGK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEECC
SGLPIFVGVMSFAVKAVIDKAAEAGDLADGDIYIFNDAHMGGTHLSDMRLVRPYFRDGAL
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCE
FCYLASVGHWHDVGGAVPGNYNPSATDVFQEAFVLPPVKLARGGEIQQDIIDILLRNTRL
EEEEHHCCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHCCCC
PQSAMGDLNGQLGALDLGVKRLDELLDEYGPKTVHAGLDALQDRAEVLMRAELSDLPDGR
CHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
WEAEDFLDNDGITDTALPIRVALEITGDTMVLDFEGTAPVTAGPVNIALPTAVATAYVAI
CCHHHHCCCCCCCCCCCEEEEEEEECCCEEEEEECCCCCCCCCCCEEEHHHHHHHHHHHH
KHIFPDLPANAGVMRPIEVRVPDGSLLSAEFPAPVGGYTETILRMIDVMFSAASQAAPDR
HHHCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
VVANAYGTINALSIAGKRANGAPWVMFSFYGGGHGGSVESDGLNHGNAPISTATIPPMEI
EEHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LEAAYPVMFRQWALRPDSAGAGAHRGGLGAVYEIEVLEEKAEAFLFGERGRFAPQGVTGG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHEEEECCCCCCCCCCCCCC
APGAMNVFTYEQDDGWKTPPLASKMLGMRLRKGQAVRLETPGGGGYGDPADRSPEAVARD
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHH
VALGYLSAEAATESYGSAWQECAS
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; N-methylimidazolidine-2,4-dione; H2O

Specific reaction: ATP + N-methylimidazolidine-2,4-dione + 2 H2O = ADP + phosphate + N-carbamoylsarcosine

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]