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The map label for this gene is kdsA [H]

Identifier: 89056149

GI number: 89056149

Start: 3732099

End: 3732932

Strand: Direct

Name: kdsA [H]

Synonym: Jann_3658

Alternate gene names: 89056149

Gene position: 3732099-3732932 (Clockwise)

Preceding gene: 89056148

Following gene: 89056150

Centisome position: 86.43

GC content: 62.71

Gene sequence:

>834_bases
ATGAAAACGGTTGAGATTGGAGGGCTGAGCGTCTCCAACACGGCCCCGCTTCTGGTAATCGCGGGGCCCTGCCAGCTGGA
AAGTCTGGATCACGCGCGCATGATCGCGGGGCACATGTCCCAGGTCTGCGCGCAGGTCGGCGCGCAATTTGTCTTCAAAG
GCAGTTATGACAAAGCCAACCGCACCTCTCTTGACGGCAAGCGCGGCCTTGGGATGACAGCGGGGCTGGAGATCCTGGCC
ACGATCCGAGACGAGTTGGGCTGCCCGGTGCTCACCGATGTCCACACGCCCGAGCAATGTGATCCAGTGGCCGGTGCGGT
CGATATCTTGCAAATTCCCGCCTTCCTGTGCCGCCAGACCGATCTGCTATTGGCCGCAGGCAAAACCGGGGCCGCGATCA
ATGTGAAGAAGGGGCAATTCCTGGCCCCATGGGATATGGCGAATGTGGCGCAGAAGGTCGCAAGCACGGGCAACGAGCGG
TTGATGCTGACGGAGCGCGGCGTGTCATTCGGCTACAACGCGCTGGTTGCTGACATGCGGTCACTGCCGGAGATGGCGAA
GACCGGTTACCCGGTGATCATGGATGCGACCCACGCCGTGGCACAACCCGGCGGGCTTGGCGGATCATCGGGAGGACAGC
GGGAATTCGCGCCGGTGCTGGCCCGTTCCGCCGTGGCGCTGGGAATTGGCGGTGTATTCCTGGAAACCCACGAAGACCCG
GACACCGCGCCGTCAGACGGACCCAACATGATCCGCCTGGACGATATGGAAGGGGTCCTCGGCACGCTTATGGCGCTGGA
CAAAGTGGCCAAGGCCAACCCGGTGCAGCTATGA

Upstream 100 bases:

>100_bases
GGCATCTACCTTCTGGTATCGATGACCGCCTCGATCTTGCGGGAACAGGTAAGCTCCTGATCCGCACCACCTCGGGGCCA
TGGCCCCGAGGAGCATCTGC

Downstream 100 bases:

>100_bases
TCAGAACGCTCCTCGCCATGCTCCTCGCCGCAATGCTCTGCGGGCCGGTCATTGCACAAACGGAGGGCAGCCAGCCCGAT
GGCACCATTGCCGTGGAAAG

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MKTVEIGGLSVSNTAPLLVIAGPCQLESLDHARMIAGHMSQVCAQVGAQFVFKGSYDKANRTSLDGKRGLGMTAGLEILA
TIRDELGCPVLTDVHTPEQCDPVAGAVDILQIPAFLCRQTDLLLAAGKTGAAINVKKGQFLAPWDMANVAQKVASTGNER
LMLTERGVSFGYNALVADMRSLPEMAKTGYPVIMDATHAVAQPGGLGGSSGGQREFAPVLARSAVALGIGGVFLETHEDP
DTAPSDGPNMIRLDDMEGVLGTLMALDKVAKANPVQL

Sequences:

>Translated_277_residues
MKTVEIGGLSVSNTAPLLVIAGPCQLESLDHARMIAGHMSQVCAQVGAQFVFKGSYDKANRTSLDGKRGLGMTAGLEILA
TIRDELGCPVLTDVHTPEQCDPVAGAVDILQIPAFLCRQTDLLLAAGKTGAAINVKKGQFLAPWDMANVAQKVASTGNER
LMLTERGVSFGYNALVADMRSLPEMAKTGYPVIMDATHAVAQPGGLGGSSGGQREFAPVLARSAVALGIGGVFLETHEDP
DTAPSDGPNMIRLDDMEGVLGTLMALDKVAKANPVQL
>Mature_277_residues
MKTVEIGGLSVSNTAPLLVIAGPCQLESLDHARMIAGHMSQVCAQVGAQFVFKGSYDKANRTSLDGKRGLGMTAGLEILA
TIRDELGCPVLTDVHTPEQCDPVAGAVDILQIPAFLCRQTDLLLAAGKTGAAINVKKGQFLAPWDMANVAQKVASTGNER
LMLTERGVSFGYNALVADMRSLPEMAKTGYPVIMDATHAVAQPGGLGGSSGGQREFAPVLARSAVALGIGGVFLETHEDP
DTAPSDGPNMIRLDDMEGVLGTLMALDKVAKANPVQL

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=272, Percent_Identity=43.3823529411765, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 28896; Mature: 28896

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVEIGGLSVSNTAPLLVIAGPCQLESLDHARMIAGHMSQVCAQVGAQFVFKGSYDKAN
CCEEEECCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
RTSLDGKRGLGMTAGLEILATIRDELGCPVLTDVHTPEQCDPVAGAVDILQIPAFLCRQT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCC
DLLLAAGKTGAAINVKKGQFLAPWDMANVAQKVASTGNERLMLTERGVSFGYNALVADMR
CEEEEECCCCCEEEECCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
SLPEMAKTGYPVIMDATHAVAQPGGLGGSSGGQREFAPVLARSAVALGIGGVFLETHEDP
HHHHHHHCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCC
DTAPSDGPNMIRLDDMEGVLGTLMALDKVAKANPVQL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTVEIGGLSVSNTAPLLVIAGPCQLESLDHARMIAGHMSQVCAQVGAQFVFKGSYDKAN
CCEEEECCEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
RTSLDGKRGLGMTAGLEILATIRDELGCPVLTDVHTPEQCDPVAGAVDILQIPAFLCRQT
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCC
DLLLAAGKTGAAINVKKGQFLAPWDMANVAQKVASTGNERLMLTERGVSFGYNALVADMR
CEEEEECCCCCEEEECCCCEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHH
SLPEMAKTGYPVIMDATHAVAQPGGLGGSSGGQREFAPVLARSAVALGIGGVFLETHEDP
HHHHHHHCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCC
DTAPSDGPNMIRLDDMEGVLGTLMALDKVAKANPVQL
CCCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA