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The map label for this gene is uvrB [H]

Identifier: 89056093

GI number: 89056093

Start: 3678087

End: 3680282

Strand: Direct

Name: uvrB [H]

Synonym: Jann_3602

Alternate gene names: 89056093

Gene position: 3678087-3680282 (Clockwise)

Preceding gene: 89056088

Following gene: 89056095

Centisome position: 85.18

GC content: 61.2

Gene sequence:

>2196_bases
ATGCACAACAATTCGCCCGAACAGATGCCTGACACGGGCCGCGCCGTGGACGCGCTGCGCGCACAATTGAAAATGGAGGG
TGGCAAAGCCTTTGTCCTCCAGACCGAGTTTGAACCGGCAGGCGATCAGCCCACCGCAATCGCAGAATTGTCCGAGGGGA
TTCGCGAGGGTGAACGGGACCAGGTGCTCCTTGGCGCAACGGGAACTGGTAAGACCTTCACCATGGCAAAGATGATTGAG
GAAACGCAGCGCCCCGCCATCATTCTTGCGCCCAACAAGACGTTGGCCGCGCAGCTTTATGCGGAGTTCAAGAACTTCTT
CCCGGAAAACGCCGTCGAATACTTCGTCAGCTACTACGACTATTATCAGCCCGAGGCCTATGTGGCGCGGTCCGACACCT
ACATCGAGAAAGAAAGCCAGATCAACGAACAGATCGACCGCATGCGCCACTCGGCCACGCGGGCCCTGTTGGAACGGGAC
GACGTTATCATCGTGGCATCCGTGTCGTGTATCTACGGCATCGGCAGCGTGGAAACCTACGGTGCGATGACCCAGGATCT
GCACGCAGGCCGGGAATATGACCAACGCAAGGTCATCGCCGATCTGGTGGCGCAGCAATATCGCCGCAACGACGCCGCCT
TTCAGCGGGGGTGTTTCCGCGTGCGCGGTGACAGTCTGGAAGTCTGGCCCGCCCACTTGGATGATCGCGCCTGGAAGCTG
TCGTTTTTTGGGGAAGAGCTGGAAAGCATCACCGAATTCGACCCCCTGACCGGTCAGAAGACGGACACGTTCGAGAAGAT
CCGCGTCTACGCGAATTCCCACTACGTCACGCCGCGCCCCACGATGCAGCAGGCCATGAAGGGCATTAAGTCTGAGCTGG
CGATGCGCCTGAAACAGATGATTGACGAGGGCAAGCTGCTGGAGGCCCAGCGGCTGGAACAACGCACCAACTTCGATCTG
GAGATGCTGGAAGCCACCGGCGTCTGCAACGGGATCGAGAACTACTCCCGCTATCTGACGGGCCGCGCGCCGGGTGAACC
GCCCCCCACCCTGTTCGAATACATCCCCGATAATGCGATTGTTTTCGCCGACGAAAGCCATGTTTCCGTGCCGCAGATCG
GCGGGATGTACCGCGGCGACTACCGGCGCAAATTCACGCTGGCAGAACACGGCTTCCGCCTGCCCTCCTGCATGGACAAC
CGCCCCCTGAAGTTTGAGGAATGGGACGCCATGCGGCCGCAATCCGTCTTCGTATCCGCCACACCCGCCGCGTGGGAGTT
GGAGCAGGCGGGCGGCGTTTTCACCGAACAGGTCATTCGCCCAACAGGCCTGATCGACCCGCAGATCGAGATCCGACCGG
TGGATATGCAGGTCGATGATCTGCTGGATGAGGTCCGCAAAGTGGCCGCCGATGGTTATCGCACGCTGGTCACGACGCTC
ACCAAGCGCATGGCCGAAGATCTGACGGAATACATGCACGAACAGGGCATCCGCGTGCGCTACATGCACTCGGATATCGA
CACACTGGAACGGATCGAAATCCTGCGCGACCTGCGGTTGGGCGCGTTTGACGTGCTGATCGGGATCAACCTGCTGCGCG
AGGGTCTCGACATTCCGGAATGCGGGTTGGTGGCCATTCTGGATGCCGACAAGGAAGGCTTTTTGCGGTCCGAGACGTCC
CTGATTCAGACCATTGGGCGGGCCGCGCGCAACGCCGACGGTCGCGTGATCATGTATGCGGACAAGATCACCGGCTCCAT
GGAGCGCGCCATGCGCGAGACCGAGCGGAGACGGGTCAAGCAGTTGGCGTATAACGAAGAACACGGCATCACGCCCGCAA
CGATCAAGAAGAATGTCGATGACATCCTGATGGGCGTCTACCAGGGTGACACCGACCAAAGCCGCGTCACGGCCAAGGTC
GACAAACCGCTTGTGGGCGCGAACCTTGCGGCGCATCTCGACGGCCTGCGCGACAAGATGCGCAAGGCGGCGGAGAACCT
GGAGTTTGAGGAAGCTGCGCGCCTGCGTGATGAGGTCAAGCGGTTGGAGACGGTGGAACTGGCCATCGCCGACGACCCGC
TGGCCCGCCAGTCAGCGGTGGAGGCGGCGGTGGAAGATGCGTCAAAGGCCAGCGGCCGGTCAACGGCAGGTCGGGGCGGT
CAACGGGGTGGGAACGTCAAGCGGCGGAAGCGGTAG

Upstream 100 bases:

>100_bases
GACAGCCTCCTGACACCATGCTGTCACCAGCTGACAAGACGCCCCCTTGCAGCTTCGGTCGACGGCTCCATTCTATGACG
TGACACTGGAGACGTAAGAG

Downstream 100 bases:

>100_bases
GTCGACATTTTGTGCGCTCACGCCCGCAGGGCCGCGTCTTCAAACCAAGGCGTGCCCTCAGTGAAGCCGCCGCGGATCAA
CAGCCCCGGTGCGGCCACTT

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 731; Mature: 731

Protein sequence:

>731_residues
MHNNSPEQMPDTGRAVDALRAQLKMEGGKAFVLQTEFEPAGDQPTAIAELSEGIREGERDQVLLGATGTGKTFTMAKMIE
ETQRPAIILAPNKTLAAQLYAEFKNFFPENAVEYFVSYYDYYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLERD
DVIIVASVSCIYGIGSVETYGAMTQDLHAGREYDQRKVIADLVAQQYRRNDAAFQRGCFRVRGDSLEVWPAHLDDRAWKL
SFFGEELESITEFDPLTGQKTDTFEKIRVYANSHYVTPRPTMQQAMKGIKSELAMRLKQMIDEGKLLEAQRLEQRTNFDL
EMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEYIPDNAIVFADESHVSVPQIGGMYRGDYRRKFTLAEHGFRLPSCMDN
RPLKFEEWDAMRPQSVFVSATPAAWELEQAGGVFTEQVIRPTGLIDPQIEIRPVDMQVDDLLDEVRKVAADGYRTLVTTL
TKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIPECGLVAILDADKEGFLRSETS
LIQTIGRAARNADGRVIMYADKITGSMERAMRETERRRVKQLAYNEEHGITPATIKKNVDDILMGVYQGDTDQSRVTAKV
DKPLVGANLAAHLDGLRDKMRKAAENLEFEEAARLRDEVKRLETVELAIADDPLARQSAVEAAVEDASKASGRSTAGRGG
QRGGNVKRRKR

Sequences:

>Translated_731_residues
MHNNSPEQMPDTGRAVDALRAQLKMEGGKAFVLQTEFEPAGDQPTAIAELSEGIREGERDQVLLGATGTGKTFTMAKMIE
ETQRPAIILAPNKTLAAQLYAEFKNFFPENAVEYFVSYYDYYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLERD
DVIIVASVSCIYGIGSVETYGAMTQDLHAGREYDQRKVIADLVAQQYRRNDAAFQRGCFRVRGDSLEVWPAHLDDRAWKL
SFFGEELESITEFDPLTGQKTDTFEKIRVYANSHYVTPRPTMQQAMKGIKSELAMRLKQMIDEGKLLEAQRLEQRTNFDL
EMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEYIPDNAIVFADESHVSVPQIGGMYRGDYRRKFTLAEHGFRLPSCMDN
RPLKFEEWDAMRPQSVFVSATPAAWELEQAGGVFTEQVIRPTGLIDPQIEIRPVDMQVDDLLDEVRKVAADGYRTLVTTL
TKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIPECGLVAILDADKEGFLRSETS
LIQTIGRAARNADGRVIMYADKITGSMERAMRETERRRVKQLAYNEEHGITPATIKKNVDDILMGVYQGDTDQSRVTAKV
DKPLVGANLAAHLDGLRDKMRKAAENLEFEEAARLRDEVKRLETVELAIADDPLARQSAVEAAVEDASKASGRSTAGRGG
QRGGNVKRRKR
>Mature_731_residues
MHNNSPEQMPDTGRAVDALRAQLKMEGGKAFVLQTEFEPAGDQPTAIAELSEGIREGERDQVLLGATGTGKTFTMAKMIE
ETQRPAIILAPNKTLAAQLYAEFKNFFPENAVEYFVSYYDYYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLERD
DVIIVASVSCIYGIGSVETYGAMTQDLHAGREYDQRKVIADLVAQQYRRNDAAFQRGCFRVRGDSLEVWPAHLDDRAWKL
SFFGEELESITEFDPLTGQKTDTFEKIRVYANSHYVTPRPTMQQAMKGIKSELAMRLKQMIDEGKLLEAQRLEQRTNFDL
EMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEYIPDNAIVFADESHVSVPQIGGMYRGDYRRKFTLAEHGFRLPSCMDN
RPLKFEEWDAMRPQSVFVSATPAAWELEQAGGVFTEQVIRPTGLIDPQIEIRPVDMQVDDLLDEVRKVAADGYRTLVTTL
TKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIPECGLVAILDADKEGFLRSETS
LIQTIGRAARNADGRVIMYADKITGSMERAMRETERRRVKQLAYNEEHGITPATIKKNVDDILMGVYQGDTDQSRVTAKV
DKPLVGANLAAHLDGLRDKMRKAAENLEFEEAARLRDEVKRLETVELAIADDPLARQSAVEAAVEDASKASGRSTAGRGG
QRGGNVKRRKR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=675, Percent_Identity=60, Blast_Score=794, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 82427; Mature: 82427

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNNSPEQMPDTGRAVDALRAQLKMEGGKAFVLQTEFEPAGDQPTAIAELSEGIREGERD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCC
QVLLGATGTGKTFTMAKMIEETQRPAIILAPNKTLAAQLYAEFKNFFPENAVEYFVSYYD
EEEEEECCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
YYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLERDDVIIVASVSCIYGIGSVETY
HCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHH
GAMTQDLHAGREYDQRKVIADLVAQQYRRNDAAFQRGCFRVRGDSLEVWPAHLDDRAWKL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCCEEECCCCCCCCCEEE
SFFGEELESITEFDPLTGQKTDTFEKIRVYANSHYVTPRPTMQQAMKGIKSELAMRLKQM
HHHHHHHHHHHHCCCCCCCCCCCHHHHEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHH
IDEGKLLEAQRLEQRTNFDLEMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEYIPDNAI
HCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEE
VFADESHVSVPQIGGMYRGDYRRKFTLAEHGFRLPSCMDNRPLKFEEWDAMRPQSVFVSA
EEECCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
TPAAWELEQAGGVFTEQVIRPTGLIDPQIEIRPVDMQVDDLLDEVRKVAADGYRTLVTTL
CCCCEEHHHHCCHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHH
TKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIPE
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
CGLVAILDADKEGFLRSETSLIQTIGRAARNADGRVIMYADKITGSMERAMRETERRRVK
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
QLAYNEEHGITPATIKKNVDDILMGVYQGDTDQSRVTAKVDKPLVGANLAAHLDGLRDKM
HHHCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHH
RKAAENLEFEEAARLRDEVKRLETVELAIADDPLARQSAVEAAVEDASKASGRSTAGRGG
HHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
QRGGNVKRRKR
CCCCCCCCCCC
>Mature Secondary Structure
MHNNSPEQMPDTGRAVDALRAQLKMEGGKAFVLQTEFEPAGDQPTAIAELSEGIREGERD
CCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCC
QVLLGATGTGKTFTMAKMIEETQRPAIILAPNKTLAAQLYAEFKNFFPENAVEYFVSYYD
EEEEEECCCCCHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
YYQPEAYVARSDTYIEKESQINEQIDRMRHSATRALLERDDVIIVASVSCIYGIGSVETY
HCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHCCCCHHHH
GAMTQDLHAGREYDQRKVIADLVAQQYRRNDAAFQRGCFRVRGDSLEVWPAHLDDRAWKL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHCCEEECCCCEEECCCCCCCCCEEE
SFFGEELESITEFDPLTGQKTDTFEKIRVYANSHYVTPRPTMQQAMKGIKSELAMRLKQM
HHHHHHHHHHHHCCCCCCCCCCCHHHHEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHH
IDEGKLLEAQRLEQRTNFDLEMLEATGVCNGIENYSRYLTGRAPGEPPPTLFEYIPDNAI
HCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEE
VFADESHVSVPQIGGMYRGDYRRKFTLAEHGFRLPSCMDNRPLKFEEWDAMRPQSVFVSA
EEECCCCCCCCCCCCCCCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
TPAAWELEQAGGVFTEQVIRPTGLIDPQIEIRPVDMQVDDLLDEVRKVAADGYRTLVTTL
CCCCEEHHHHCCHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCHHHHHHHHH
TKRMAEDLTEYMHEQGIRVRYMHSDIDTLERIEILRDLRLGAFDVLIGINLLREGLDIPE
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
CGLVAILDADKEGFLRSETSLIQTIGRAARNADGRVIMYADKITGSMERAMRETERRRVK
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
QLAYNEEHGITPATIKKNVDDILMGVYQGDTDQSRVTAKVDKPLVGANLAAHLDGLRDKM
HHHCCCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHH
RKAAENLEFEEAARLRDEVKRLETVELAIADDPLARQSAVEAAVEDASKASGRSTAGRGG
HHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCC
QRGGNVKRRKR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]