| Definition | Jannaschia sp. CCS1 chromosome, complete genome. |
|---|---|
| Accession | NC_007802 |
| Length | 4,317,977 |
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The map label for this gene is lepA
Identifier: 89055922
GI number: 89055922
Start: 3477854
End: 3479653
Strand: Direct
Name: lepA
Synonym: Jann_3431
Alternate gene names: 89055922
Gene position: 3477854-3479653 (Clockwise)
Preceding gene: 89055917
Following gene: 89055923
Centisome position: 80.54
GC content: 62.11
Gene sequence:
>1800_bases ATGACCGACCTCAATCGCATCCGCAACTTCTCCATCGTCGCCCACATCGACCACGGGAAATCCACGCTGGCGGATCGTTT GATCCAGCTGACCGGCACCGTGGCCGCGCGCGATATGCAGGCGCAGCTCCTAGATCAGATGGATATCGAGCGGGAGCGCG GAATTACCATCAAGGCCAACACCGTCCGCATCGAATACCCGGCGAAGGACGGCCACACCTATATCCTCAACCTCATCGAC ACGCCCGGCCACGTCGATTTCGCCTATGAGGTCAGCCGCTCCATGCAGGCGGTCGAGGGCTCCCTGCTGGTCGTCGATGC CTCCCAGGGGGTGGAGGCGCAAACGCTCGCCAACGTCTATCAGGCCATCGACGCGGATCATGAGATTGTGCCGGTCCTCA ACAAGGTCGACCTGCCCGCCGCAGAGCCCGACCGGGTGCGCGAGCAGATCGAAGACGTCATCGGCATCGACGCCTCGGAA GCCGTTGAAATCTCCGCCAAAACCGGCATCGGCATCCCCGATGTGCTGGAGGCCATCGTCACCCGCCTGCCTGCCCCCAA GGGCGACCGCGACGCGCCGCTGAAGGCCATGCTGGTGGACAGCTATTATGACAGCTATCTGGGCGTCGTTGTCCTGATCC GCGTCATCGACGGGGTCATCAAGAAGGGCGACAAGATCAAGATGATGCGCACCGGCGGGCAGTATCCCGTTGACAGGCTT GGGGTGTTCACGCCCAAGATGAAAGATATCGGAGAGCTTGGTCCGGGCGAAATGGGGTTCCTGACCGCCTCCATCAAACA GGTGCGTGACACGCGGGTGGGCGACACGATCACCCATGACAAACACGGCGCCGAGCAGCCGCTTGCGGGCTTCAAACCCT CCCAGCCCGTGGTCTTCTGCGGCCTCTTCCCCGTGGACACCAACCAGTTTGAGGACCTACGCGACGCCATCGAAAAGCTC GCCCTCAACGACGCGAGTTTCTCCCACGAGATGGAGACATCTGCCGCCCTCGGCTTCGGCTTCCGCTGCGGGTTCCTGGG CCTGCTGCACCTCGAAGTGATCCGCGACCGGTTGGAGCGCGAATACGATATCGACCTGATCACCACCGCGCCCTCGGTCA TCTACCACGTCCACATGCGCGACGAGACCATGGTGGACCTGCACAACCCCGCCGACATGCCCGACCCCGCCGCGATTGAC CGCATCGAGGAGCCGCGCATCAAGGCCACGATCCTGGTCCCCGACGACTACCTCGGCGATGTCCTGAAACTCTGCCAGGA CCGGCGCGGCATCCAGATCGACCTCACCTACGCCGGCACCCGCGCGATGGTCGTCTACGACCTGCCCCTGAACGAGGTGG TCTTCGACTTCTACGATAGGCTGAAAAGTGTGACCAAAGGGTATGCGTCCTTCGATTATCAGATGATCGGCTACCGCGAG GATGCGCTGGTCAAGATGCAGGTGCTGGTGAATGACGAGCCGGTCGACGCCCTCTCGATCATGGTCCACCGTGACAGGGC CGAGACCCGGGGCCGCGCGATGGTCGAAAAACTCAAGGACCTCATCCCCCGCCACATGTTCAAGATCCCGATCCAGGCGG CGATTGGCGGGCGTGTAATTGCGCGTGAAACGCTATCCGCCATGCGCAAGGACGTGACGGCGAAGTGCTATGGCGGCGAC GCGTCCCGGAAGCGGAAGCTGCTGGACAAGCAGAAGGCCGGTAAGAAGAAAATGCGGCAGTTCGGGAAAGTCGAAATTCC CCAATCCGCCTTCATTTCCGCTCTCAAGATGGACGGCTAG
Upstream 100 bases:
>100_bases GCCGCCGGACGCAATGCGCCCGGACCGGGCCTCACCCCCCTTCCCCCGCCTCCACCAACACGCTACATCCCGCTGAACTC AACGCTTCAAGGCCGCGCCC
Downstream 100 bases:
>100_bases ACGCAACAGACGTTTGTCGCGCAACCGGGAATTTCGAACGGTGGGCGACAGCGGTTTTTGCTTGCAAAAACTAGCGGGCC CACACAGTAGTTGTTGGGCG
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA
Number of amino acids: Translated: 599; Mature: 598
Protein sequence:
>599_residues MTDLNRIRNFSIVAHIDHGKSTLADRLIQLTGTVAARDMQAQLLDQMDIERERGITIKANTVRIEYPAKDGHTYILNLID TPGHVDFAYEVSRSMQAVEGSLLVVDASQGVEAQTLANVYQAIDADHEIVPVLNKVDLPAAEPDRVREQIEDVIGIDASE AVEISAKTGIGIPDVLEAIVTRLPAPKGDRDAPLKAMLVDSYYDSYLGVVVLIRVIDGVIKKGDKIKMMRTGGQYPVDRL GVFTPKMKDIGELGPGEMGFLTASIKQVRDTRVGDTITHDKHGAEQPLAGFKPSQPVVFCGLFPVDTNQFEDLRDAIEKL ALNDASFSHEMETSAALGFGFRCGFLGLLHLEVIRDRLEREYDIDLITTAPSVIYHVHMRDETMVDLHNPADMPDPAAID RIEEPRIKATILVPDDYLGDVLKLCQDRRGIQIDLTYAGTRAMVVYDLPLNEVVFDFYDRLKSVTKGYASFDYQMIGYRE DALVKMQVLVNDEPVDALSIMVHRDRAETRGRAMVEKLKDLIPRHMFKIPIQAAIGGRVIARETLSAMRKDVTAKCYGGD ASRKRKLLDKQKAGKKKMRQFGKVEIPQSAFISALKMDG
Sequences:
>Translated_599_residues MTDLNRIRNFSIVAHIDHGKSTLADRLIQLTGTVAARDMQAQLLDQMDIERERGITIKANTVRIEYPAKDGHTYILNLID TPGHVDFAYEVSRSMQAVEGSLLVVDASQGVEAQTLANVYQAIDADHEIVPVLNKVDLPAAEPDRVREQIEDVIGIDASE AVEISAKTGIGIPDVLEAIVTRLPAPKGDRDAPLKAMLVDSYYDSYLGVVVLIRVIDGVIKKGDKIKMMRTGGQYPVDRL GVFTPKMKDIGELGPGEMGFLTASIKQVRDTRVGDTITHDKHGAEQPLAGFKPSQPVVFCGLFPVDTNQFEDLRDAIEKL ALNDASFSHEMETSAALGFGFRCGFLGLLHLEVIRDRLEREYDIDLITTAPSVIYHVHMRDETMVDLHNPADMPDPAAID RIEEPRIKATILVPDDYLGDVLKLCQDRRGIQIDLTYAGTRAMVVYDLPLNEVVFDFYDRLKSVTKGYASFDYQMIGYRE DALVKMQVLVNDEPVDALSIMVHRDRAETRGRAMVEKLKDLIPRHMFKIPIQAAIGGRVIARETLSAMRKDVTAKCYGGD ASRKRKLLDKQKAGKKKMRQFGKVEIPQSAFISALKMDG >Mature_598_residues TDLNRIRNFSIVAHIDHGKSTLADRLIQLTGTVAARDMQAQLLDQMDIERERGITIKANTVRIEYPAKDGHTYILNLIDT PGHVDFAYEVSRSMQAVEGSLLVVDASQGVEAQTLANVYQAIDADHEIVPVLNKVDLPAAEPDRVREQIEDVIGIDASEA VEISAKTGIGIPDVLEAIVTRLPAPKGDRDAPLKAMLVDSYYDSYLGVVVLIRVIDGVIKKGDKIKMMRTGGQYPVDRLG VFTPKMKDIGELGPGEMGFLTASIKQVRDTRVGDTITHDKHGAEQPLAGFKPSQPVVFCGLFPVDTNQFEDLRDAIEKLA LNDASFSHEMETSAALGFGFRCGFLGLLHLEVIRDRLEREYDIDLITTAPSVIYHVHMRDETMVDLHNPADMPDPAAIDR IEEPRIKATILVPDDYLGDVLKLCQDRRGIQIDLTYAGTRAMVVYDLPLNEVVFDFYDRLKSVTKGYASFDYQMIGYRED ALVKMQVLVNDEPVDALSIMVHRDRAETRGRAMVEKLKDLIPRHMFKIPIQAAIGGRVIARETLSAMRKDVTAKCYGGDA SRKRKLLDKQKAGKKKMRQFGKVEIPQSAFISALKMDG
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily
Homologues:
Organism=Homo sapiens, GI157426893, Length=602, Percent_Identity=48.5049833887043, Blast_Score=610, Evalue=1e-174, Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=43.1818181818182, Blast_Score=109, Evalue=9e-24, Organism=Homo sapiens, GI4503483, Length=143, Percent_Identity=41.2587412587413, Blast_Score=107, Evalue=3e-23, Organism=Homo sapiens, GI18390331, Length=160, Percent_Identity=35.625, Blast_Score=102, Evalue=1e-21, Organism=Homo sapiens, GI25306283, Length=150, Percent_Identity=40.6666666666667, Blast_Score=98, Evalue=3e-20, Organism=Homo sapiens, GI19923640, Length=150, Percent_Identity=40.6666666666667, Blast_Score=97, Evalue=4e-20, Organism=Homo sapiens, GI25306287, Length=150, Percent_Identity=40.6666666666667, Blast_Score=97, Evalue=4e-20, Organism=Homo sapiens, GI310132016, Length=109, Percent_Identity=40.3669724770642, Blast_Score=89, Evalue=9e-18, Organism=Homo sapiens, GI310110807, Length=109, Percent_Identity=40.3669724770642, Blast_Score=89, Evalue=9e-18, Organism=Homo sapiens, GI310123363, Length=109, Percent_Identity=40.3669724770642, Blast_Score=89, Evalue=9e-18, Organism=Homo sapiens, GI217272892, Length=139, Percent_Identity=32.3741007194245, Blast_Score=87, Evalue=6e-17, Organism=Homo sapiens, GI217272894, Length=139, Percent_Identity=32.3741007194245, Blast_Score=86, Evalue=7e-17, Organism=Homo sapiens, GI53729339, Length=252, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=1e-15, Organism=Homo sapiens, GI53729337, Length=252, Percent_Identity=28.5714285714286, Blast_Score=82, Evalue=1e-15, Organism=Escherichia coli, GI1788922, Length=592, Percent_Identity=56.7567567567568, Blast_Score=694, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=509, Percent_Identity=29.2730844793713, Blast_Score=164, Evalue=2e-41, Organism=Escherichia coli, GI1790835, Length=166, Percent_Identity=31.3253012048193, Blast_Score=91, Evalue=3e-19, Organism=Escherichia coli, GI1789738, Length=161, Percent_Identity=37.2670807453416, Blast_Score=91, Evalue=3e-19, Organism=Escherichia coli, GI1789559, Length=222, Percent_Identity=29.2792792792793, Blast_Score=77, Evalue=3e-15, Organism=Escherichia coli, GI1789737, Length=243, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=3e-11, Organism=Escherichia coli, GI1790412, Length=243, Percent_Identity=29.6296296296296, Blast_Score=64, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17557151, Length=612, Percent_Identity=40.6862745098039, Blast_Score=480, Evalue=1e-136, Organism=Caenorhabditis elegans, GI17556745, Length=465, Percent_Identity=27.0967741935484, Blast_Score=120, Evalue=2e-27, Organism=Caenorhabditis elegans, GI17533571, Length=162, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17506493, Length=156, Percent_Identity=35.2564102564103, Blast_Score=94, Evalue=2e-19, Organism=Caenorhabditis elegans, GI71988811, Length=133, Percent_Identity=36.0902255639098, Blast_Score=91, Evalue=2e-18, Organism=Caenorhabditis elegans, GI71988819, Length=133, Percent_Identity=36.0902255639098, Blast_Score=91, Evalue=2e-18, Organism=Caenorhabditis elegans, GI17552882, Length=133, Percent_Identity=35.3383458646617, Blast_Score=87, Evalue=3e-17, Organism=Caenorhabditis elegans, GI71994658, Length=221, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=1e-12, Organism=Caenorhabditis elegans, GI17556456, Length=246, Percent_Identity=28.8617886178862, Blast_Score=67, Evalue=2e-11, Organism=Caenorhabditis elegans, GI32566303, Length=245, Percent_Identity=26.1224489795918, Blast_Score=65, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6323320, Length=602, Percent_Identity=44.1860465116279, Blast_Score=521, Evalue=1e-148, Organism=Saccharomyces cerevisiae, GI6323098, Length=192, Percent_Identity=36.4583333333333, Blast_Score=114, Evalue=7e-26, Organism=Saccharomyces cerevisiae, GI6324707, Length=149, Percent_Identity=41.6107382550336, Blast_Score=113, Evalue=1e-25, Organism=Saccharomyces cerevisiae, GI6320593, Length=149, Percent_Identity=41.6107382550336, Blast_Score=113, Evalue=1e-25, Organism=Saccharomyces cerevisiae, GI6322359, Length=137, Percent_Identity=37.2262773722628, Blast_Score=95, Evalue=3e-20, Organism=Saccharomyces cerevisiae, GI6324166, Length=175, Percent_Identity=33.1428571428571, Blast_Score=79, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6324761, Length=247, Percent_Identity=30.3643724696356, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI78706572, Length=602, Percent_Identity=44.6843853820598, Blast_Score=543, Evalue=1e-154, Organism=Drosophila melanogaster, GI24582462, Length=162, Percent_Identity=37.037037037037, Blast_Score=104, Evalue=2e-22, Organism=Drosophila melanogaster, GI24585709, Length=147, Percent_Identity=36.734693877551, Blast_Score=99, Evalue=1e-20, Organism=Drosophila melanogaster, GI24585711, Length=147, Percent_Identity=36.734693877551, Blast_Score=99, Evalue=1e-20, Organism=Drosophila melanogaster, GI24585713, Length=147, Percent_Identity=36.734693877551, Blast_Score=99, Evalue=1e-20, Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=42.0289855072464, Blast_Score=96, Evalue=9e-20, Organism=Drosophila melanogaster, GI21357743, Length=133, Percent_Identity=35.3383458646617, Blast_Score=87, Evalue=4e-17, Organism=Drosophila melanogaster, GI221458488, Length=154, Percent_Identity=37.6623376623377, Blast_Score=82, Evalue=1e-15, Organism=Drosophila melanogaster, GI281363316, Length=237, Percent_Identity=29.957805907173, Blast_Score=69, Evalue=1e-11, Organism=Drosophila melanogaster, GI17864358, Length=237, Percent_Identity=29.957805907173, Blast_Score=69, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): LEPA_JANSC (Q28LR4)
Other databases:
- EMBL: CP000264 - RefSeq: YP_511373.1 - ProteinModelPortal: Q28LR4 - SMR: Q28LR4 - STRING: Q28LR4 - GeneID: 3935905 - GenomeReviews: CP000264_GR - KEGG: jan:Jann_3431 - eggNOG: COG0481 - HOGENOM: HBG286375 - OMA: YDSYRGV - PhylomeDB: Q28LR4 - ProtClustDB: PRK05433 - BioCyc: JSP290400:JANN_3431-MONOMER - GO: GO:0006412 - HAMAP: MF_00071 - InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR004161 - InterPro: IPR009000 - Gene3D: G3DSA:3.30.70.240 - PRINTS: PR00315 - SMART: SM00838 - TIGRFAMs: TIGR01393 - TIGRFAMs: TIGR00231
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C; SSF54980 EFG_III_V; SSF50447 Translat_factor
EC number: NA
Molecular weight: Translated: 66647; Mature: 66515
Theoretical pI: Translated: 5.67; Mature: 5.67
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 3.7 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 3.5 %Met (Mature Protein) 4.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTDLNRIRNFSIVAHIDHGKSTLADRLIQLTGTVAARDMQAQLLDQMDIERERGITIKAN CCCHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEE TVRIEYPAKDGHTYILNLIDTPGHVDFAYEVSRSMQAVEGSLLVVDASQGVEAQTLANVY EEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH QAIDADHEIVPVLNKVDLPAAEPDRVREQIEDVIGIDASEAVEISAKTGIGIPDVLEAIV HHHCCCCCEEHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHEEEECCCCCCCHHHHHHHH TRLPAPKGDRDAPLKAMLVDSYYDSYLGVVVLIRVIDGVIKKGDKIKMMRTGGQYPVDRL HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH GVFTPKMKDIGELGPGEMGFLTASIKQVRDTRVGDTITHDKHGAEQPLAGFKPSQPVVFC CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE GLFPVDTNQFEDLRDAIEKLALNDASFSHEMETSAALGFGFRCGFLGLLHLEVIRDRLER EEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC EYDIDLITTAPSVIYHVHMRDETMVDLHNPADMPDPAAIDRIEEPRIKATILVPDDYLGD CCCCEEEECCCCEEEEEEECCCEEEEECCCCCCCCCHHHHCCCCCCEEEEEECCCHHHHH VLKLCQDRRGIQIDLTYAGTRAMVVYDLPLNEVVFDFYDRLKSVTKGYASFDYQMIGYRE HHHHHHCCCCCEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC DALVKMQVLVNDEPVDALSIMVHRDRAETRGRAMVEKLKDLIPRHMFKIPIQAAIGGRVI CCEEEEEEEECCCCCCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHH ARETLSAMRKDVTAKCYGGDASRKRKLLDKQKAGKKKMRQFGKVEIPQSAFISALKMDG HHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC >Mature Secondary Structure TDLNRIRNFSIVAHIDHGKSTLADRLIQLTGTVAARDMQAQLLDQMDIERERGITIKAN CCHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCEEEEEE TVRIEYPAKDGHTYILNLIDTPGHVDFAYEVSRSMQAVEGSLLVVDASQGVEAQTLANVY EEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH QAIDADHEIVPVLNKVDLPAAEPDRVREQIEDVIGIDASEAVEISAKTGIGIPDVLEAIV HHHCCCCCEEHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHEEEECCCCCCCHHHHHHHH TRLPAPKGDRDAPLKAMLVDSYYDSYLGVVVLIRVIDGVIKKGDKIKMMRTGGQYPVDRL HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHH GVFTPKMKDIGELGPGEMGFLTASIKQVRDTRVGDTITHDKHGAEQPLAGFKPSQPVVFC CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE GLFPVDTNQFEDLRDAIEKLALNDASFSHEMETSAALGFGFRCGFLGLLHLEVIRDRLER EEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC EYDIDLITTAPSVIYHVHMRDETMVDLHNPADMPDPAAIDRIEEPRIKATILVPDDYLGD CCCCEEEECCCCEEEEEEECCCEEEEECCCCCCCCCHHHHCCCCCCEEEEEECCCHHHHH VLKLCQDRRGIQIDLTYAGTRAMVVYDLPLNEVVFDFYDRLKSVTKGYASFDYQMIGYRE HHHHHHCCCCCEEEEEECCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC DALVKMQVLVNDEPVDALSIMVHRDRAETRGRAMVEKLKDLIPRHMFKIPIQAAIGGRVI CCEEEEEEEECCCCCCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHH ARETLSAMRKDVTAKCYGGDASRKRKLLDKQKAGKKKMRQFGKVEIPQSAFISALKMDG HHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA