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The map label for this gene is kefC [H]

Identifier: 89055839

GI number: 89055839

Start: 3401331

End: 3403211

Strand: Direct

Name: kefC [H]

Synonym: Jann_3348

Alternate gene names: 89055839

Gene position: 3401331-3403211 (Clockwise)

Preceding gene: 89055837

Following gene: 89055842

Centisome position: 78.77

GC content: 62.31

Gene sequence:

>1881_bases
ATGACTGACTTCCTCCTCCTTTCCTTCATCTTCCTGATCGCGGGCGTGATTGCGGTGCCGATTGCCAGCCGTCTGGGATT
GGGGTCGGTGCTGGGATACCTGATCGCGGGGATCGTGATATCGCCGGTGCTGCGCGTTCTGGGGGTCGACGTGATCTCCA
TCCAACATTTCGCGGAATTCGGCGTGGTGATGATGCTGTTTCTGGTGGGGTTGGAGCTGCAACCCAAAGCACTGTGGGAA
ATGCGCGCGCGGTTGATCGGGCTTGGCGGCGGGCAGGTCGTGCTGACGATACTTGCGGTCCTGGGCGTGGCGATTGCGCT
GGGGCAAAGCTGGCAAATCGGGCTGGCCGTGGGTTTCATTTTCGCGCTGTCATCGACGGCGATCGTGCTGCAAACCCTTG
GCGAAAAAGGCCTTCTGAGGTCCGACGGTGGGCAGGGCAGCTTTTCGGTCCTGCTGACCCAAGACATTGCGGTGATCCCG
ATGCTGGCAATCTTGCCGCTTCTGGCCATGGCGCCGGATATGGCGCCGGACTTGGCTGACATGGGGGCGGATGCCAGCCA
TGGGGCGGCAGGTCACGACAGTGCTGACGCGTCGCACGGCGCGCAGGAGCATGCCGGTGACGGCCACGGTGACGCGATGA
GCCTCGTCTCCGGCCTGAATGGATGGCAAACCGCGCTGGTGACACTCGGCGCGGTGGGCTTTGTGGTTGTCGGTGGATCG
CTCCTGACGGGGCCGCTGTTCCGCTTCATCGCCGCGGCCAACCTGCGCGAATTGTTCACGGCCACCGCGCTGATGATGGT
GATCGGCATCGCACTTCTGATGTCGCTTGTGGGCCTCTCCCCTGCCCTTGGAACGTTCCTTGCGGGCGTCGTTCTGGCAA
ATTCCGCCTACCGGCACGAGTTGGAATCGGACATTGACCCCTTTCGCGGCCTCCTTCTGGGCCTCTTTTTCATGACCGTG
GGCGCGGGCGTGAACTTCACGCTTCTGGGGGAGAACCTCGGCACGGTTCTGGGTTTGACGCTTGGCTTGATGGTTCTGAA
AGCGGTGGTCCTCATCGCGCTCGCCTATGTGTTCCGGATCAAGGGCGCGGACAAATGGTTGATGGCGCTGAGCCTGGCGC
AGGCCGGTGAGTTCGGCTTCGTCCTGTTGTCCTTCACGGTGGCTAACAACGTCTTGCCTGCCGCCCTGTCAGATCTGCTT
TTGCTGGTCGTGGCCCTGTCGATGTTGCTGACGCCCGCGCTTTTCATCCTGTATGACCGGGTCATCGCACCCCGCTATGC
TGCAGGCGAGGCACGGGAGGCGGATGCCATGCCCGACGAGGCGAAGATCATCATCGCAGGCGCAGGCCGGGTGGGTGGGC
TGATCGACCGGGTTCTGCGCGGGGCGGGTCACGAGACGACGGTGATTGACTATAACTCGCGCCGCCTGGATATCATGGCG
AAATTCGGGGTGAAGAACTACTTCGGCGACGCCACGCGCCCCGACCTTCTGGCCGCCGCCGGTCTCGCCGAAGCCAGCGT
GCTGATCGTCGCGATAGACGACCGCGACAGCATCACCCAGATCGTGGATTACGCCCACAAGACATATCCCAACCTGCACG
TCATTGCCCGGGCGACAGACCGCGATCACGTCTATGACCTGTGGTTCCACGGCTGCCGGGACATCATCCGGGAGACCTAC
GACAGCACCCTGCGCATGGGTCGCTCGGCGTTTGAGGCATTGGGTATTGAGGCCGAGACCGCCCAGGAGATGGTTGATGC
GTTCAACGCCCATGACCGTGAGATCATGTTGGCCATTGCATCGGTCCACAAGGTGGGCGTGGCCCCCCATGAGAACCCCG
GATTATGTAGCGAAAGTGGCAGAGCTGCGCGACGATTTTGA

Upstream 100 bases:

>100_bases
AATTTTGGACATAATCGTAGCGCGCGGGCCCCGACACAAGGCAATTGACGAAGATGTGAGCCTGGCGTCAATTGAACCCC
GGACCTACGGAGCGCGCGCC

Downstream 100 bases:

>100_bases
CCGCGCCGTGCGCGCGGATATGGATGCGATCCGCGAAGGCCGCCCCCGGCCCGAGCCGGAGGTGGGTTAAGTAAGTAAGC
GTGCCGGAGGTGGGTTGAGT

Product: sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 626; Mature: 625

Protein sequence:

>626_residues
MTDFLLLSFIFLIAGVIAVPIASRLGLGSVLGYLIAGIVISPVLRVLGVDVISIQHFAEFGVVMMLFLVGLELQPKALWE
MRARLIGLGGGQVVLTILAVLGVAIALGQSWQIGLAVGFIFALSSTAIVLQTLGEKGLLRSDGGQGSFSVLLTQDIAVIP
MLAILPLLAMAPDMAPDLADMGADASHGAAGHDSADASHGAQEHAGDGHGDAMSLVSGLNGWQTALVTLGAVGFVVVGGS
LLTGPLFRFIAAANLRELFTATALMMVIGIALLMSLVGLSPALGTFLAGVVLANSAYRHELESDIDPFRGLLLGLFFMTV
GAGVNFTLLGENLGTVLGLTLGLMVLKAVVLIALAYVFRIKGADKWLMALSLAQAGEFGFVLLSFTVANNVLPAALSDLL
LLVVALSMLLTPALFILYDRVIAPRYAAGEAREADAMPDEAKIIIAGAGRVGGLIDRVLRGAGHETTVIDYNSRRLDIMA
KFGVKNYFGDATRPDLLAAAGLAEASVLIVAIDDRDSITQIVDYAHKTYPNLHVIARATDRDHVYDLWFHGCRDIIRETY
DSTLRMGRSAFEALGIEAETAQEMVDAFNAHDREIMLAIASVHKVGVAPHENPGLCSESGRAARRF

Sequences:

>Translated_626_residues
MTDFLLLSFIFLIAGVIAVPIASRLGLGSVLGYLIAGIVISPVLRVLGVDVISIQHFAEFGVVMMLFLVGLELQPKALWE
MRARLIGLGGGQVVLTILAVLGVAIALGQSWQIGLAVGFIFALSSTAIVLQTLGEKGLLRSDGGQGSFSVLLTQDIAVIP
MLAILPLLAMAPDMAPDLADMGADASHGAAGHDSADASHGAQEHAGDGHGDAMSLVSGLNGWQTALVTLGAVGFVVVGGS
LLTGPLFRFIAAANLRELFTATALMMVIGIALLMSLVGLSPALGTFLAGVVLANSAYRHELESDIDPFRGLLLGLFFMTV
GAGVNFTLLGENLGTVLGLTLGLMVLKAVVLIALAYVFRIKGADKWLMALSLAQAGEFGFVLLSFTVANNVLPAALSDLL
LLVVALSMLLTPALFILYDRVIAPRYAAGEAREADAMPDEAKIIIAGAGRVGGLIDRVLRGAGHETTVIDYNSRRLDIMA
KFGVKNYFGDATRPDLLAAAGLAEASVLIVAIDDRDSITQIVDYAHKTYPNLHVIARATDRDHVYDLWFHGCRDIIRETY
DSTLRMGRSAFEALGIEAETAQEMVDAFNAHDREIMLAIASVHKVGVAPHENPGLCSESGRAARRF
>Mature_625_residues
TDFLLLSFIFLIAGVIAVPIASRLGLGSVLGYLIAGIVISPVLRVLGVDVISIQHFAEFGVVMMLFLVGLELQPKALWEM
RARLIGLGGGQVVLTILAVLGVAIALGQSWQIGLAVGFIFALSSTAIVLQTLGEKGLLRSDGGQGSFSVLLTQDIAVIPM
LAILPLLAMAPDMAPDLADMGADASHGAAGHDSADASHGAQEHAGDGHGDAMSLVSGLNGWQTALVTLGAVGFVVVGGSL
LTGPLFRFIAAANLRELFTATALMMVIGIALLMSLVGLSPALGTFLAGVVLANSAYRHELESDIDPFRGLLLGLFFMTVG
AGVNFTLLGENLGTVLGLTLGLMVLKAVVLIALAYVFRIKGADKWLMALSLAQAGEFGFVLLSFTVANNVLPAALSDLLL
LVVALSMLLTPALFILYDRVIAPRYAAGEAREADAMPDEAKIIIAGAGRVGGLIDRVLRGAGHETTVIDYNSRRLDIMAK
FGVKNYFGDATRPDLLAAAGLAEASVLIVAIDDRDSITQIVDYAHKTYPNLHVIARATDRDHVYDLWFHGCRDIIRETYD
STLRMGRSAFEALGIEAETAQEMVDAFNAHDREIMLAIASVHKVGVAPHENPGLCSESGRAARRF

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=402, Percent_Identity=25.1243781094527, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786232, Length=602, Percent_Identity=41.0299003322259, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789749, Length=606, Percent_Identity=38.7788778877888, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1786685, Length=562, Percent_Identity=28.1138790035587, Blast_Score=148, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 66044; Mature: 65913

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFLLLSFIFLIAGVIAVPIASRLGLGSVLGYLIAGIVISPVLRVLGVDVISIQHFAEF
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GVVMMLFLVGLELQPKALWEMRARLIGLGGGQVVLTILAVLGVAIALGQSWQIGLAVGFI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FALSSTAIVLQTLGEKGLLRSDGGQGSFSVLLTQDIAVIPMLAILPLLAMAPDMAPDLAD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCHHH
MGADASHGAAGHDSADASHGAQEHAGDGHGDAMSLVSGLNGWQTALVTLGAVGFVVVGGS
CCCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCH
LLTGPLFRFIAAANLRELFTATALMMVIGIALLMSLVGLSPALGTFLAGVVLANSAYRHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LESDIDPFRGLLLGLFFMTVGAGVNFTLLGENLGTVLGLTLGLMVLKAVVLIALAYVFRI
HHHCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGADKWLMALSLAQAGEFGFVLLSFTVANNVLPAALSDLLLLVVALSMLLTPALFILYDR
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIAPRYAAGEAREADAMPDEAKIIIAGAGRVGGLIDRVLRGAGHETTVIDYNSRRLDIMA
HHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEECCCCEEEHHH
KFGVKNYFGDATRPDLLAAAGLAEASVLIVAIDDRDSITQIVDYAHKTYPNLHVIARATD
HHCHHHHCCCCCCCHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECC
RDHVYDLWFHGCRDIIRETYDSTLRMGRSAFEALGIEAETAQEMVDAFNAHDREIMLAIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHH
SVHKVGVAPHENPGLCSESGRAARRF
HHHHHCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
TDFLLLSFIFLIAGVIAVPIASRLGLGSVLGYLIAGIVISPVLRVLGVDVISIQHFAEF
CHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
GVVMMLFLVGLELQPKALWEMRARLIGLGGGQVVLTILAVLGVAIALGQSWQIGLAVGFI
HHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FALSSTAIVLQTLGEKGLLRSDGGQGSFSVLLTQDIAVIPMLAILPLLAMAPDMAPDLAD
HHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCCCHHH
MGADASHGAAGHDSADASHGAQEHAGDGHGDAMSLVSGLNGWQTALVTLGAVGFVVVGGS
CCCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCH
LLTGPLFRFIAAANLRELFTATALMMVIGIALLMSLVGLSPALGTFLAGVVLANSAYRHE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
LESDIDPFRGLLLGLFFMTVGAGVNFTLLGENLGTVLGLTLGLMVLKAVVLIALAYVFRI
HHHCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KGADKWLMALSLAQAGEFGFVLLSFTVANNVLPAALSDLLLLVVALSMLLTPALFILYDR
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIAPRYAAGEAREADAMPDEAKIIIAGAGRVGGLIDRVLRGAGHETTVIDYNSRRLDIMA
HHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCEEEECCCCEEEHHH
KFGVKNYFGDATRPDLLAAAGLAEASVLIVAIDDRDSITQIVDYAHKTYPNLHVIARATD
HHCHHHHCCCCCCCHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECC
RDHVYDLWFHGCRDIIRETYDSTLRMGRSAFEALGIEAETAQEMVDAFNAHDREIMLAIA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHH
SVHKVGVAPHENPGLCSESGRAARRF
HHHHHCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA