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The map label for this gene is yieO [C]

Identifier: 89055709

GI number: 89055709

Start: 3262788

End: 3263996

Strand: Direct

Name: yieO [C]

Synonym: Jann_3218

Alternate gene names: 89055709

Gene position: 3262788-3263996 (Clockwise)

Preceding gene: 89055708

Following gene: 89055710

Centisome position: 75.56

GC content: 55.33

Gene sequence:

>1209_bases
ATGGCTGAGCAACACCTCTCGCAATTGGAGCCGAAAGCAACAGACATCCGCAGGATAACCGGAGGGCTGGCCGTGCCCCG
TGCCGTGATTATCGGACCTATCGCGGCGTACATCGCCTTTGTGATGGAGTTCACCCTCGTCCCGCTGTTGTTGCCTGCCA
TACAGTCGCAGTTCGGCTTGTCGGTCGGGGATCTTGCCTGGGTGTTCAACTCTTACGGTGCGGCGGTCGCCATTGGCGTG
CTGTTTTGCGGATACTTCGGCGACACCCTCAACATCAGGCGGGTGTTTGGATTAGGGGTCGCCCTGTTTGCGACGGGGGC
GCTGGTATCAGCAATAGCGCAGAACTATGAAACCCTTGTTGCCGGGCGACTTTTGCAAGGTTTTGGGAGCGGTGTTTTCT
CCCCACTTGTGCCGATATATTTGACGCGCGCCTCCCCAGACACGCCGGGACGCGCATTGATATTATGGGGAAGTATAGCA
GGCTACATCGCTGCTTTCGCCCCCCTTCTATACGGCAATCTCCTTGGGGATCACAGCTGGAGATTAGCATTCGTCTTCAT
CGCGATCATCGCCGCGTGCGCATGGGTTTTGCTGACCAGATCACAGCTATCGCAAGACCCGGAACCTGCCACATCATGCA
AGCGGGACTACCGCGAAATCTTACGTAGCCGAGACCTTCTGATCACTTTTGCATACGTGTTCTGCACGTACGGCAGCATT
ACCTATTACATATTTCGCCTGCCGATTTGGCTGTCCGAGAATGAGATCGGTGCCTCCAGCATAGGCCTTTTCTTATCAGT
GGCGTGGCTCACCTTTTCCTTTATCAGCACCCTGCTGAGGAACCTGGTCGATCGCCATCATATTCTAGGGATCATGCTTG
CGGCCCCGCTCCTTATCGCCGTCGCGGTGCTACTTTTGTTCAATCATCAAAGCTTCCTGCTCGTCGCGCTGTCGTCAATT
CTGATCGGTGCAGGACTGGCGTGCAGCAATGCGCCGTCGACACAGTTGATCCTGAGATTTGCACCAGAGGGAATGACCGC
GGTTTCGGCAAGCCTGGACATCACGTTTGCACGGATAGGTGGAATCGCAACAATATCCATTCTGGCATGGATGGAGGGAG
GGTACGCTGATCTTACGATATGCGTCTTGTGCCTATTGGCACTGGTCTGTGCGCAAAGTGTAAGCCGCAGCCGCATCGGG
ACAGGTTAA

Upstream 100 bases:

>100_bases
TCAAAAACACGACCAGCAGCCCAAGGCGCGGCCGGTGCCCCCAAGACAACGGTTGCCGCTTCACTCGCGCAAGCCGCTCT
TGATGTGGGGGTACGAGTCA

Downstream 100 bases:

>100_bases
TCTCTCACAGGTGGCGGTTTAACGCGCCGATGGGAAGCAAAGCACACGCGCCTTCGACCGGTGGCGCGTCGTGTTTTGTT
AACCACTCGTTAACTACTGG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MAEQHLSQLEPKATDIRRITGGLAVPRAVIIGPIAAYIAFVMEFTLVPLLLPAIQSQFGLSVGDLAWVFNSYGAAVAIGV
LFCGYFGDTLNIRRVFGLGVALFATGALVSAIAQNYETLVAGRLLQGFGSGVFSPLVPIYLTRASPDTPGRALILWGSIA
GYIAAFAPLLYGNLLGDHSWRLAFVFIAIIAACAWVLLTRSQLSQDPEPATSCKRDYREILRSRDLLITFAYVFCTYGSI
TYYIFRLPIWLSENEIGASSIGLFLSVAWLTFSFISTLLRNLVDRHHILGIMLAAPLLIAVAVLLLFNHQSFLLVALSSI
LIGAGLACSNAPSTQLILRFAPEGMTAVSASLDITFARIGGIATISILAWMEGGYADLTICVLCLLALVCAQSVSRSRIG
TG

Sequences:

>Translated_402_residues
MAEQHLSQLEPKATDIRRITGGLAVPRAVIIGPIAAYIAFVMEFTLVPLLLPAIQSQFGLSVGDLAWVFNSYGAAVAIGV
LFCGYFGDTLNIRRVFGLGVALFATGALVSAIAQNYETLVAGRLLQGFGSGVFSPLVPIYLTRASPDTPGRALILWGSIA
GYIAAFAPLLYGNLLGDHSWRLAFVFIAIIAACAWVLLTRSQLSQDPEPATSCKRDYREILRSRDLLITFAYVFCTYGSI
TYYIFRLPIWLSENEIGASSIGLFLSVAWLTFSFISTLLRNLVDRHHILGIMLAAPLLIAVAVLLLFNHQSFLLVALSSI
LIGAGLACSNAPSTQLILRFAPEGMTAVSASLDITFARIGGIATISILAWMEGGYADLTICVLCLLALVCAQSVSRSRIG
TG
>Mature_401_residues
AEQHLSQLEPKATDIRRITGGLAVPRAVIIGPIAAYIAFVMEFTLVPLLLPAIQSQFGLSVGDLAWVFNSYGAAVAIGVL
FCGYFGDTLNIRRVFGLGVALFATGALVSAIAQNYETLVAGRLLQGFGSGVFSPLVPIYLTRASPDTPGRALILWGSIAG
YIAAFAPLLYGNLLGDHSWRLAFVFIAIIAACAWVLLTRSQLSQDPEPATSCKRDYREILRSRDLLITFAYVFCTYGSIT
YYIFRLPIWLSENEIGASSIGLFLSVAWLTFSFISTLLRNLVDRHHILGIMLAAPLLIAVAVLLLFNHQSFLLVALSSIL
IGAGLACSNAPSTQLILRFAPEGMTAVSASLDITFARIGGIATISILAWMEGGYADLTICVLCLLALVCAQSVSRSRIGT
G

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43148; Mature: 43017

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEQHLSQLEPKATDIRRITGGLAVPRAVIIGPIAAYIAFVMEFTLVPLLLPAIQSQFGL
CCHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SVGDLAWVFNSYGAAVAIGVLFCGYFGDTLNIRRVFGLGVALFATGALVSAIAQNYETLV
CHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGRLLQGFGSGVFSPLVPIYLTRASPDTPGRALILWGSIAGYIAAFAPLLYGNLLGDHSW
HHHHHHHHCCCHHHHHHHHEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCH
RLAFVFIAIIAACAWVLLTRSQLSQDPEPATSCKRDYREILRSRDLLITFAYVFCTYGSI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHH
TYYIFRLPIWLSENEIGASSIGLFLSVAWLTFSFISTLLRNLVDRHHILGIMLAAPLLIA
HHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVLLLFNHQSFLLVALSSILIGAGLACSNAPSTQLILRFAPEGMTAVSASLDITFARIG
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEHHHHEEHHHHHC
GIATISILAWMEGGYADLTICVLCLLALVCAQSVSRSRIGTG
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEQHLSQLEPKATDIRRITGGLAVPRAVIIGPIAAYIAFVMEFTLVPLLLPAIQSQFGL
CHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SVGDLAWVFNSYGAAVAIGVLFCGYFGDTLNIRRVFGLGVALFATGALVSAIAQNYETLV
CHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGRLLQGFGSGVFSPLVPIYLTRASPDTPGRALILWGSIAGYIAAFAPLLYGNLLGDHSW
HHHHHHHHCCCHHHHHHHHEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCH
RLAFVFIAIIAACAWVLLTRSQLSQDPEPATSCKRDYREILRSRDLLITFAYVFCTYGSI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHH
TYYIFRLPIWLSENEIGASSIGLFLSVAWLTFSFISTLLRNLVDRHHILGIMLAAPLLIA
HHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAVLLLFNHQSFLLVALSSILIGAGLACSNAPSTQLILRFAPEGMTAVSASLDITFARIG
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEHHHHEEHHHHHC
GIATISILAWMEGGYADLTICVLCLLALVCAQSVSRSRIGTG
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]