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The map label for this gene is cysG [H]

Identifier: 89055538

GI number: 89055538

Start: 3076917

End: 3078320

Strand: Direct

Name: cysG [H]

Synonym: Jann_3047

Alternate gene names: 89055538

Gene position: 3076917-3078320 (Clockwise)

Preceding gene: 89055537

Following gene: 89055540

Centisome position: 71.26

GC content: 66.24

Gene sequence:

>1404_bases
ATGAAGAGTTTTCCGATGTTTTTCCGCACCAGCGGACGGCGTGTGGTGATTGTGGGCGGAGGTGAGCAGGCCGCCCAGAA
GGCGCGCTTGATCCTGAAGACGGACGCGCAGATCGTGCTGGCCGCGCCGGAGTTGGACCCGGAATTGGAGGGCATAGTCG
CATCAGGCCGTGCCATGCACCAAATGGGCCCAGTGACGGACACCACCTTCACCGGCGCGGCCATGGCGTTCATCGCCACC
GGCTGCCCCGGCTGGGACGCGAGCGTGCACGCGCTGGCGCAGGCCGCGCGGTGTCCGGTGAACGTCGTGGACCGCCCCGA
CCTGTGCGACATCACCACGCCGTCGATTGTGGACCGTGACCCGGTGGTCGTGGCGATCGGCACGGAAGGAACCGCCCCGG
TTCTGGGCCGCGAGATCAAGACCCGGGTCGAGCAGATGCTGCCGGTCAACATCGGCGGCTTGGCTGAGCTGGCAGGTCGC
CTTCGCCCCGCCGTCACCGCGCAGGTCCCTCGCGCCAAGCGTCGCGCGTTTTGGGCCTGGGTGTTCAAAAGCACGCCCCG
TACCACTTGGACGCGGGGTGCGGAACGGGACGGTGCGCGGATGATCAAGGAGGCCATCGCGCAGGGCGGCGCGCCTGACA
CGCAGACCAAGGGCTCCATCGCTTTGGTCGGTGCCGGACCCGGCGCGCGCGATCTGCTGACCCTGCGCGCGGTGGAGCGT
CTGCAGGAGGCCGATGTCATCTTCTACGACCGCCTCGTCGATCCGGACGTGCTGGAACTGGCGCGCCGCGATGCCGAGAG
GGTTTTCGTCGGCAAACACGTCGGCGCGCATGCCTGGCCGCAAGCGCAGATCAACGGGATGATCGTGGCGGAAGCCCTGA
AGGGGCGCCGTGTCGTGCGGCTGAAATCCGGCGATCCGGGCATCTTTGGACGCGCAGGCGAAGAGATTGAGGCCGCTGAG
ACGGCAGACATCCCCATCGAGGTTGTGCCCGGCATCACCGCCGCCTCTGCCGCAAGTGCTGCCATGGGCCAAAGCCTGAC
TACGCGCGGGCGAACTGACACACTGGTGCTGGCAACCGGCACCGGCAATCCCGACGCGCCGCTCCCCGATTGCGTCCGCT
TTGCAGGTCCCGGCACGACCACCGCAATCTATATGGGGGTCCGCCACGTGGACCGTATCTGCGCAGCCCTGCAGGCGCGG
GGTTTCCCCGCAAACGCGATGATAGATGTGTGCGTTGACGTGGAAAAGTGCACGCAGCGCCTGTTGTCTGAACACGTGGC
GACCCTGCCCATCCGCCTGAAAGCCGCGAAGATCGAGGGCTGCGCACTTCTACTGGTCAAATGGCCATTGGTTGAGCAAG
CAAACGTAGCTCCGGAACCAATCCTGATAGACGCAATGGGCTGA

Upstream 100 bases:

>100_bases
GGACTGCCGCGCTGGCTCTGGAAACCCTCGGCACCGAAGCGCCATTGGAGACCGCCCGCGCCCTTTGGCACACCCGCCCC
CCTTGGCAGGAGACCGCCGC

Downstream 100 bases:

>100_bases
CGGAGCGCTCGGTCGGGGTACTAGCCCTTACGACGAAACGTCTTGCGAGCGCTCATCAGCGCCGGCCCATCGAGTTGGCG
GAGCCGTGATCACGCGAGGT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MKSFPMFFRTSGRRVVIVGGGEQAAQKARLILKTDAQIVLAAPELDPELEGIVASGRAMHQMGPVTDTTFTGAAMAFIAT
GCPGWDASVHALAQAARCPVNVVDRPDLCDITTPSIVDRDPVVVAIGTEGTAPVLGREIKTRVEQMLPVNIGGLAELAGR
LRPAVTAQVPRAKRRAFWAWVFKSTPRTTWTRGAERDGARMIKEAIAQGGAPDTQTKGSIALVGAGPGARDLLTLRAVER
LQEADVIFYDRLVDPDVLELARRDAERVFVGKHVGAHAWPQAQINGMIVAEALKGRRVVRLKSGDPGIFGRAGEEIEAAE
TADIPIEVVPGITAASAASAAMGQSLTTRGRTDTLVLATGTGNPDAPLPDCVRFAGPGTTTAIYMGVRHVDRICAALQAR
GFPANAMIDVCVDVEKCTQRLLSEHVATLPIRLKAAKIEGCALLLVKWPLVEQANVAPEPILIDAMG

Sequences:

>Translated_467_residues
MKSFPMFFRTSGRRVVIVGGGEQAAQKARLILKTDAQIVLAAPELDPELEGIVASGRAMHQMGPVTDTTFTGAAMAFIAT
GCPGWDASVHALAQAARCPVNVVDRPDLCDITTPSIVDRDPVVVAIGTEGTAPVLGREIKTRVEQMLPVNIGGLAELAGR
LRPAVTAQVPRAKRRAFWAWVFKSTPRTTWTRGAERDGARMIKEAIAQGGAPDTQTKGSIALVGAGPGARDLLTLRAVER
LQEADVIFYDRLVDPDVLELARRDAERVFVGKHVGAHAWPQAQINGMIVAEALKGRRVVRLKSGDPGIFGRAGEEIEAAE
TADIPIEVVPGITAASAASAAMGQSLTTRGRTDTLVLATGTGNPDAPLPDCVRFAGPGTTTAIYMGVRHVDRICAALQAR
GFPANAMIDVCVDVEKCTQRLLSEHVATLPIRLKAAKIEGCALLLVKWPLVEQANVAPEPILIDAMG
>Mature_467_residues
MKSFPMFFRTSGRRVVIVGGGEQAAQKARLILKTDAQIVLAAPELDPELEGIVASGRAMHQMGPVTDTTFTGAAMAFIAT
GCPGWDASVHALAQAARCPVNVVDRPDLCDITTPSIVDRDPVVVAIGTEGTAPVLGREIKTRVEQMLPVNIGGLAELAGR
LRPAVTAQVPRAKRRAFWAWVFKSTPRTTWTRGAERDGARMIKEAIAQGGAPDTQTKGSIALVGAGPGARDLLTLRAVER
LQEADVIFYDRLVDPDVLELARRDAERVFVGKHVGAHAWPQAQINGMIVAEALKGRRVVRLKSGDPGIFGRAGEEIEAAE
TADIPIEVVPGITAASAASAAMGQSLTTRGRTDTLVLATGTGNPDAPLPDCVRFAGPGTTTAIYMGVRHVDRICAALQAR
GFPANAMIDVCVDVEKCTQRLLSEHVATLPIRLKAAKIEGCALLLVKWPLVEQANVAPEPILIDAMG

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=423, Percent_Identity=38.0614657210402, Blast_Score=269, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6322922, Length=186, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 49520; Mature: 49520

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSFPMFFRTSGRRVVIVGGGEQAAQKARLILKTDAQIVLAAPELDPELEGIVASGRAMH
CCCCCCCEECCCCEEEEECCCHHHHHHCEEEEEECCEEEEECCCCCCCHHHHHHCCCHHH
QMGPVTDTTFTGAAMAFIATGCPGWDASVHALAQAARCPVNVVDRPDLCDITTPSIVDRD
HCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCC
PVVVAIGTEGTAPVLGREIKTRVEQMLPVNIGGLAELAGRLRPAVTAQVPRAKRRAFWAW
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCHHHHHEEEEE
VFKSTPRTTWTRGAERDGARMIKEAIAQGGAPDTQTKGSIALVGAGPGARDLLTLRAVER
EECCCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
LQEADVIFYDRLVDPDVLELARRDAERVFVGKHVGAHAWPQAQINGMIVAEALKGRRVVR
HHHCCEEEECCCCCHHHHHHHHHCHHHEEEECCCCCCCCCCHHCCCEEEEEECCCCEEEE
LKSGDPGIFGRAGEEIEAAETADIPIEVVPGITAASAASAAMGQSLTTRGRTDTLVLATG
EECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCHHCCCCCCCEEEEEEC
TGNPDAPLPDCVRFAGPGTTTAIYMGVRHVDRICAALQARGFPANAMIDVCVDVEKCTQR
CCCCCCCCHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHH
LLSEHVATLPIRLKAAKIEGCALLLVKWPLVEQANVAPEPILIDAMG
HHHHHHHCCEEEEEEEEECCEEEEEEECCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure
MKSFPMFFRTSGRRVVIVGGGEQAAQKARLILKTDAQIVLAAPELDPELEGIVASGRAMH
CCCCCCCEECCCCEEEEECCCHHHHHHCEEEEEECCEEEEECCCCCCCHHHHHHCCCHHH
QMGPVTDTTFTGAAMAFIATGCPGWDASVHALAQAARCPVNVVDRPDLCDITTPSIVDRD
HCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCC
PVVVAIGTEGTAPVLGREIKTRVEQMLPVNIGGLAELAGRLRPAVTAQVPRAKRRAFWAW
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHCCCHHHHHEEEEE
VFKSTPRTTWTRGAERDGARMIKEAIAQGGAPDTQTKGSIALVGAGPGARDLLTLRAVER
EECCCCCCHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHH
LQEADVIFYDRLVDPDVLELARRDAERVFVGKHVGAHAWPQAQINGMIVAEALKGRRVVR
HHHCCEEEECCCCCHHHHHHHHHCHHHEEEECCCCCCCCCCHHCCCEEEEEECCCCEEEE
LKSGDPGIFGRAGEEIEAAETADIPIEVVPGITAASAASAAMGQSLTTRGRTDTLVLATG
EECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHCCHHCCCCCCCEEEEEEC
TGNPDAPLPDCVRFAGPGTTTAIYMGVRHVDRICAALQARGFPANAMIDVCVDVEKCTQR
CCCCCCCCHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHH
LLSEHVATLPIRLKAAKIEGCALLLVKWPLVEQANVAPEPILIDAMG
HHHHHHHCCEEEEEEEEECCEEEEEEECCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA