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The map label for this gene is hom [H]

Identifier: 89055489

GI number: 89055489

Start: 3017375

End: 3018661

Strand: Direct

Name: hom [H]

Synonym: Jann_2998

Alternate gene names: 89055489

Gene position: 3017375-3018661 (Clockwise)

Preceding gene: 89055488

Following gene: 89055490

Centisome position: 69.88

GC content: 64.34

Gene sequence:

>1287_bases
ATGACCGACACACTCAGACTTGGCATTGCGGGGCTTGGCACCGTGGGCATTGGTGTCGTAAAGATCGTCCAGCGGCAGGC
TGATTTGCTGAGCGCGCGGACGGGCAAGGAGATCACAATCTCGGCCATCTCCGCCCGCTCCCGCGACAAGGATCGCGGCG
TGAACCTGTCGTCTTATGCGTGGGAGGATGACCCGGTGGCGTTGGCCAAACGCGACGACGTGGACGTGTTTCTGGAATTG
ATGGGTGGCGAAGACGGCCCGGCCAAAGCTTCCACCGAAGCTGCGCTGGCGGCAGGCAAGGACGTGGTGTCCGCCAACAA
GGCGCTGCTGGCCCACCACGGGCAGGCATTGGCGGAACTGGCCGAAGCGAAAGGCGTGGCCCTGCGCTACGAGGCCGCCG
TTGCGGGCGGTATCCCGGTGATCAAGTCGCTGACCGAGGGGCTGGCTGGCAACCGCATCACCCGCGTCATGGGGGTGATG
AACGGGACGTGCAACTACATCCTGACCCGCATGGATGAGGCCGGGCTGTCCTATCAGGAAGCTTTCGATGAGGCCGACGG
GTTGGGGTATCTGGAGGCCGACCCAAATCTGGACGTGGGCGGCATTGATGCGGGCCACAAGCTGGCGCTGCTGGCGTCCA
TCGCGTTCGGCACCAAGGTTGCGTTCGGCGATCTGCGGTTGGAGGGGATTGGCGCGGTTTCCATTGATGATATCCGCCGC
GCGGGGGATTTGGGCTACAAGATCAAGCTTTTAGGCGTGGCACAGATGACAGGGCGAGGGTTGGAGCAGCGCATGACACC
CTGCCTTGTGCCCGCGACCTCTCCGCTGGGGCAGTTGGTCGGTGGGACCAACATGGTGGTGATCGAGGGCGACGCGGTAG
AACAAATCGTGTTGCGCGGCCCCGGCGCGGGGGAAGGGCCCACGGCCTCCGCCGTCGTTGGTGATATCTGCGACATCGCG
CGCGGCCTGCGCCTGCCGGTCTTTGGTCAGCCTGCAGGCGGCCTGACCACCGCACCACCCGCGAATTCGGAAAGCCCGGC
GCGTTTTTACCTGCGGATGGAGTTGGTCGACAAACCCGGCGCGTTGGCAAAGGTCGCAACGGCATTGGGGGAGAATGGTA
TCTCCATCGACCGGATGCGCCAGTATGACCACGACGGCACCAATGCGCCGGTGCTGATCATCACCCACAAAAGTGCGCGG
CCTGATCTGGACGCCGCCATTGCCGCACTTCCTGCGACCGGCGTGATGGCTGGGACCCCCGTGGCGCTGCGGATTGAGGA
TGTGTGA

Upstream 100 bases:

>100_bases
GCCATGGCCCTTTAGTACACTTACCGCCGCGCGTGCGTTGCAGCGATGGGGCGGGTCGGCTACACCCGGCGCGATCAGAC
ACATGCGCCCGGAGGCCTCC

Downstream 100 bases:

>100_bases
CGCGGCCCATGGTTGACCGCATCCTCGGGCCGCTTCTGATCCTGGATCATGTGGCCGATGGTCAGATGCATGTTGCGGCG
GTGTTCGTGGCCCCTCTGGG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTDTLRLGIAGLGTVGIGVVKIVQRQADLLSARTGKEITISAISARSRDKDRGVNLSSYAWEDDPVALAKRDDVDVFLEL
MGGEDGPAKASTEAALAAGKDVVSANKALLAHHGQALAELAEAKGVALRYEAAVAGGIPVIKSLTEGLAGNRITRVMGVM
NGTCNYILTRMDEAGLSYQEAFDEADGLGYLEADPNLDVGGIDAGHKLALLASIAFGTKVAFGDLRLEGIGAVSIDDIRR
AGDLGYKIKLLGVAQMTGRGLEQRMTPCLVPATSPLGQLVGGTNMVVIEGDAVEQIVLRGPGAGEGPTASAVVGDICDIA
RGLRLPVFGQPAGGLTTAPPANSESPARFYLRMELVDKPGALAKVATALGENGISIDRMRQYDHDGTNAPVLIITHKSAR
PDLDAAIAALPATGVMAGTPVALRIEDV

Sequences:

>Translated_428_residues
MTDTLRLGIAGLGTVGIGVVKIVQRQADLLSARTGKEITISAISARSRDKDRGVNLSSYAWEDDPVALAKRDDVDVFLEL
MGGEDGPAKASTEAALAAGKDVVSANKALLAHHGQALAELAEAKGVALRYEAAVAGGIPVIKSLTEGLAGNRITRVMGVM
NGTCNYILTRMDEAGLSYQEAFDEADGLGYLEADPNLDVGGIDAGHKLALLASIAFGTKVAFGDLRLEGIGAVSIDDIRR
AGDLGYKIKLLGVAQMTGRGLEQRMTPCLVPATSPLGQLVGGTNMVVIEGDAVEQIVLRGPGAGEGPTASAVVGDICDIA
RGLRLPVFGQPAGGLTTAPPANSESPARFYLRMELVDKPGALAKVATALGENGISIDRMRQYDHDGTNAPVLIITHKSAR
PDLDAAIAALPATGVMAGTPVALRIEDV
>Mature_427_residues
TDTLRLGIAGLGTVGIGVVKIVQRQADLLSARTGKEITISAISARSRDKDRGVNLSSYAWEDDPVALAKRDDVDVFLELM
GGEDGPAKASTEAALAAGKDVVSANKALLAHHGQALAELAEAKGVALRYEAAVAGGIPVIKSLTEGLAGNRITRVMGVMN
GTCNYILTRMDEAGLSYQEAFDEADGLGYLEADPNLDVGGIDAGHKLALLASIAFGTKVAFGDLRLEGIGAVSIDDIRRA
GDLGYKIKLLGVAQMTGRGLEQRMTPCLVPATSPLGQLVGGTNMVVIEGDAVEQIVLRGPGAGEGPTASAVVGDICDIAR
GLRLPVFGQPAGGLTTAPPANSESPARFYLRMELVDKPGALAKVATALGENGISIDRMRQYDHDGTNAPVLIITHKSARP
DLDAAIAALPATGVMAGTPVALRIEDV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=236, Percent_Identity=27.9661016949153, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790376, Length=361, Percent_Identity=25.7617728531856, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44233; Mature: 44102

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTLRLGIAGLGTVGIGVVKIVQRQADLLSARTGKEITISAISARSRDKDRGVNLSSYA
CCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCCCCCCCCC
WEDDPVALAKRDDVDVFLELMGGEDGPAKASTEAALAAGKDVVSANKALLAHHGQALAEL
CCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHCCHHHHHHCCHHHHHH
AEAKGVALRYEAAVAGGIPVIKSLTEGLAGNRITRVMGVMNGTCNYILTRMDEAGLSYQE
HHHCCEEEEEEHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHEEHHHHCCCCHHH
AFDEADGLGYLEADPNLDVGGIDAGHKLALLASIAFGTKVAFGDLRLEGIGAVSIDDIRR
HHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCEEEECCCEEEHHHHHH
AGDLGYKIKLLGVAQMTGRGLEQRMTPCLVPATSPLGQLVGGTNMVVIEGDAVEQIVLRG
HCCCCEEEEEEEEHHHHCCCHHHHCCCEEEECCCHHHHHHCCCEEEEEECCCEEEHEEEC
PGAGEGPTASAVVGDICDIARGLRLPVFGQPAGGLTTAPPANSESPARFYLRMELVDKPG
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCC
ALAKVATALGENGISIDRMRQYDHDGTNAPVLIITHKSARPDLDAAIAALPATGVMAGTP
HHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCC
VALRIEDV
EEEEEECC
>Mature Secondary Structure 
TDTLRLGIAGLGTVGIGVVKIVQRQADLLSARTGKEITISAISARSRDKDRGVNLSSYA
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCCCCCCCCC
WEDDPVALAKRDDVDVFLELMGGEDGPAKASTEAALAAGKDVVSANKALLAHHGQALAEL
CCCCCEEEEECCCHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHCCHHHHHHCCHHHHHH
AEAKGVALRYEAAVAGGIPVIKSLTEGLAGNRITRVMGVMNGTCNYILTRMDEAGLSYQE
HHHCCEEEEEEHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHEEHHHHCCCCHHH
AFDEADGLGYLEADPNLDVGGIDAGHKLALLASIAFGTKVAFGDLRLEGIGAVSIDDIRR
HHHHCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHCCEEEECCEEEECCCEEEHHHHHH
AGDLGYKIKLLGVAQMTGRGLEQRMTPCLVPATSPLGQLVGGTNMVVIEGDAVEQIVLRG
HCCCCEEEEEEEEHHHHCCCHHHHCCCEEEECCCHHHHHHCCCEEEEEECCCEEEHEEEC
PGAGEGPTASAVVGDICDIARGLRLPVFGQPAGGLTTAPPANSESPARFYLRMELVDKPG
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCC
ALAKVATALGENGISIDRMRQYDHDGTNAPVLIITHKSARPDLDAAIAALPATGVMAGTP
HHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCC
VALRIEDV
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]