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The map label for this gene is alkK [H]

Identifier: 89055470

GI number: 89055470

Start: 2997860

End: 2999491

Strand: Direct

Name: alkK [H]

Synonym: Jann_2979

Alternate gene names: 89055470

Gene position: 2997860-2999491 (Clockwise)

Preceding gene: 89055468

Following gene: 89055471

Centisome position: 69.43

GC content: 62.25

Gene sequence:

>1632_bases
ATGGGGTGGATGAAGGATGAGACGGGGCTCGACAAAACACCGGCCAATTTCGTGCCACTCACTCCGCTCAGCCATCTTGC
GCGCGCAGCCCGTGTCTTCCCAAACCGCGAAGCCGTGATCGACGGCGCGCATCGCAAGACCTATGCCGAATACCATGCCC
GCGTCTCGCAACTGGCCTCGGCGCTTGCCCGGCGCGGGATTGCGCCCGGCGATGTCGTGGCGACCGTCCTGCCCAACACC
TACCCCCATGCGGAGGCGCATTTCGGCGTCCCTGCCGCCGGAGCGGTCCTGAACGCCATCAATATCCGGTTGGATGTCAG
CACAATCGCCTATATCCTAGACCATGGAGAGGCAAAGCTGGTGCTGGTCGACACGCAGTTCCTGCCCGTTGTCATGGATG
CCGTCGAGGCGATGGATGGCACGCCCCCGATCCTCATCGAATGTCCGTCTGCCGTTGCCGGATACCCAGCCACCGGCGAT
CACACGATCTACGAAGACCTTCTGCGGGAGGGCGATACAGACGCGCCCTGGCACATGCCCGACGATGAATGGGAAAGTAT
CTCGCTCAACTACACGTCGGGCACCACAGGTCGGCCCAAGGGTGTCGTCTACCACCACCGGGGCGCGTATCTGATCACCA
TGGGCACGCCGATTTCCTGGCGCATGACACTTTACCCCAAGTACCTGACCATCGTGCCGATGTTCCACTGCAATAACTGG
TGTCACACCTGGATGATGCCCGCCGTGGGCGGCACGCTGGTCTGCTGTCGCGATATCACGGCCTCCGCGATCTACGATGC
CATCGCCGATGAAGGCGTGACCCATATGGGCGGGGCGCCGATCGTGTTGAACATGCTGGTGAACGCCAAAGACAGCGACC
GCCGCGATTTTGATCACACGGTGGAGGTTTTCACAGCTGGCGCGCCACCCGCAGCCGCGACGCTGGCGGCGATTGAGACG
ATGGGCTTTCACGTCACCCAAGTCTACGGCCTGACGGAAAGCTACGGCCATGCCACCGAATGCGTCTGGCAGGACAGCGA
CTGGTCCGCACTGGATGCGGCGGCGCGGGCTGGCATCAAGGCGCGTCAGGGGGTCGCTTTGCCAAACATGGACCACATCA
CCGTCATGGACCCCGACACGATGGAACAGATCCCCATGGACGGCGCGGTCACCGGCGAAATCATGATGCGCGGCAATTCC
ACCATGAAGGGCTATTACAAGAATCCCGACGCCACGGCGGAGGCGTTTGCGGGCGGCTATTTTCACACCGGCGATATCGC
CGTGCAGCACCCTGACAGCTACATCCAGATCGCGGACCGCGCCAAGGATATCATCATCTCGGGCGGCGAGAATATCTCAT
CGGTAGAGGTTGAGGGCGTGTTGATGCACCACCCCGCCGTGCTGCTCTGCGCCGTTGTCGCCAAGCCCGACGATAAATGG
GGTGAGATCCCCTGCGCCTTCGTGGAGCTGAAAGAGGGGGCGGAGGCCACCGAGGCCGAAATCATCGCCTTCGCCCGCGC
GCGCCTTGCGGGTTTCAAGACCCCCAAGCGCGTGGTGTTCGCGGAACTGCCCAAAACCTCCACCGGCAAGATCCAGAAGT
TTGAGCTGCGAAAACGGGCGCGAGAAAGTTGA

Upstream 100 bases:

>100_bases
CCCCATAGGCACGAAACCCCTGCCCCTTCCCTTTTTGCGCAACCTCCGGCAAGACTTTCGCCAGTTTTCAAGCGACCGCA
ACCTGGGGAGGAATTGGGAC

Downstream 100 bases:

>100_bases
CCCCCCGAAATTTGACCGCATGTCCGAACCGCTGACAAATCGGCTGAGGCCGAGTACAGTTCCGTATTCAACTATTCGGA
GATTTCCATGCAGTCCTTTG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Medium-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MGWMKDETGLDKTPANFVPLTPLSHLARAARVFPNREAVIDGAHRKTYAEYHARVSQLASALARRGIAPGDVVATVLPNT
YPHAEAHFGVPAAGAVLNAINIRLDVSTIAYILDHGEAKLVLVDTQFLPVVMDAVEAMDGTPPILIECPSAVAGYPATGD
HTIYEDLLREGDTDAPWHMPDDEWESISLNYTSGTTGRPKGVVYHHRGAYLITMGTPISWRMTLYPKYLTIVPMFHCNNW
CHTWMMPAVGGTLVCCRDITASAIYDAIADEGVTHMGGAPIVLNMLVNAKDSDRRDFDHTVEVFTAGAPPAAATLAAIET
MGFHVTQVYGLTESYGHATECVWQDSDWSALDAAARAGIKARQGVALPNMDHITVMDPDTMEQIPMDGAVTGEIMMRGNS
TMKGYYKNPDATAEAFAGGYFHTGDIAVQHPDSYIQIADRAKDIIISGGENISSVEVEGVLMHHPAVLLCAVVAKPDDKW
GEIPCAFVELKEGAEATEAEIIAFARARLAGFKTPKRVVFAELPKTSTGKIQKFELRKRARES

Sequences:

>Translated_543_residues
MGWMKDETGLDKTPANFVPLTPLSHLARAARVFPNREAVIDGAHRKTYAEYHARVSQLASALARRGIAPGDVVATVLPNT
YPHAEAHFGVPAAGAVLNAINIRLDVSTIAYILDHGEAKLVLVDTQFLPVVMDAVEAMDGTPPILIECPSAVAGYPATGD
HTIYEDLLREGDTDAPWHMPDDEWESISLNYTSGTTGRPKGVVYHHRGAYLITMGTPISWRMTLYPKYLTIVPMFHCNNW
CHTWMMPAVGGTLVCCRDITASAIYDAIADEGVTHMGGAPIVLNMLVNAKDSDRRDFDHTVEVFTAGAPPAAATLAAIET
MGFHVTQVYGLTESYGHATECVWQDSDWSALDAAARAGIKARQGVALPNMDHITVMDPDTMEQIPMDGAVTGEIMMRGNS
TMKGYYKNPDATAEAFAGGYFHTGDIAVQHPDSYIQIADRAKDIIISGGENISSVEVEGVLMHHPAVLLCAVVAKPDDKW
GEIPCAFVELKEGAEATEAEIIAFARARLAGFKTPKRVVFAELPKTSTGKIQKFELRKRARES
>Mature_542_residues
GWMKDETGLDKTPANFVPLTPLSHLARAARVFPNREAVIDGAHRKTYAEYHARVSQLASALARRGIAPGDVVATVLPNTY
PHAEAHFGVPAAGAVLNAINIRLDVSTIAYILDHGEAKLVLVDTQFLPVVMDAVEAMDGTPPILIECPSAVAGYPATGDH
TIYEDLLREGDTDAPWHMPDDEWESISLNYTSGTTGRPKGVVYHHRGAYLITMGTPISWRMTLYPKYLTIVPMFHCNNWC
HTWMMPAVGGTLVCCRDITASAIYDAIADEGVTHMGGAPIVLNMLVNAKDSDRRDFDHTVEVFTAGAPPAAATLAAIETM
GFHVTQVYGLTESYGHATECVWQDSDWSALDAAARAGIKARQGVALPNMDHITVMDPDTMEQIPMDGAVTGEIMMRGNST
MKGYYKNPDATAEAFAGGYFHTGDIAVQHPDSYIQIADRAKDIIISGGENISSVEVEGVLMHHPAVLLCAVVAKPDDKWG
EIPCAFVELKEGAEATEAEIIAFARARLAGFKTPKRVVFAELPKTSTGKIQKFELRKRARES

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=564, Percent_Identity=28.3687943262411, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI187761345, Length=548, Percent_Identity=25, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI187761343, Length=548, Percent_Identity=25, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI157311624, Length=521, Percent_Identity=25.7197696737044, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI157311622, Length=521, Percent_Identity=25.7197696737044, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI58082049, Length=521, Percent_Identity=26.1036468330134, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI122937307, Length=496, Percent_Identity=26.6129032258064, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI38505220, Length=494, Percent_Identity=27.5303643724696, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI42544132, Length=520, Percent_Identity=24.8076923076923, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI115511026, Length=504, Percent_Identity=25.1984126984127, Blast_Score=94, Evalue=5e-19,
Organism=Homo sapiens, GI28416953, Length=529, Percent_Identity=22.6843100189036, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI40807357, Length=552, Percent_Identity=24.8188405797101, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI13375727, Length=539, Percent_Identity=23.747680890538, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI38524616, Length=458, Percent_Identity=24.6724890829694, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI40807491, Length=486, Percent_Identity=23.4567901234568, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI57165410, Length=324, Percent_Identity=25, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI57165412, Length=324, Percent_Identity=24.3827160493827, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=523, Percent_Identity=28.6806883365201, Blast_Score=162, Evalue=6e-41,
Organism=Escherichia coli, GI1788107, Length=546, Percent_Identity=26.3736263736264, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1786810, Length=523, Percent_Identity=27.5334608030593, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI221142682, Length=503, Percent_Identity=27.6341948310139, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790505, Length=575, Percent_Identity=23.6521739130435, Blast_Score=86, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=557, Percent_Identity=29.0843806104129, Blast_Score=185, Evalue=7e-47,
Organism=Caenorhabditis elegans, GI71994694, Length=557, Percent_Identity=29.0843806104129, Blast_Score=184, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI71994690, Length=557, Percent_Identity=29.0843806104129, Blast_Score=184, Evalue=9e-47,
Organism=Caenorhabditis elegans, GI17559526, Length=522, Percent_Identity=27.9693486590038, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17560308, Length=554, Percent_Identity=26.5342960288809, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32563687, Length=518, Percent_Identity=27.027027027027, Blast_Score=135, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17538037, Length=543, Percent_Identity=26.3351749539595, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17558820, Length=512, Percent_Identity=25.390625, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=513, Percent_Identity=23.5867446393762, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17557194, Length=533, Percent_Identity=24.202626641651, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17560140, Length=501, Percent_Identity=22.9540918163673, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71985884, Length=358, Percent_Identity=26.8156424581006, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI71996755, Length=532, Percent_Identity=24.0601503759398, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71982997, Length=553, Percent_Identity=25.8589511754069, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=548, Percent_Identity=26.6423357664234, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17551278, Length=550, Percent_Identity=23.0909090909091, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115534440, Length=547, Percent_Identity=22.6691042047532, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17556552, Length=416, Percent_Identity=25.9615384615385, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319699, Length=350, Percent_Identity=27.4285714285714, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6319264, Length=569, Percent_Identity=25.4833040421793, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323182, Length=571, Percent_Identity=24.8686514886165, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24581924, Length=552, Percent_Identity=26.268115942029, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21355181, Length=539, Percent_Identity=26.7161410018553, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI18859661, Length=499, Percent_Identity=26.25250501002, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI21356947, Length=555, Percent_Identity=22.5225225225225, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24648260, Length=517, Percent_Identity=24.1779497098646, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24656500, Length=510, Percent_Identity=23.7254901960784, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24666501, Length=321, Percent_Identity=25.2336448598131, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24666497, Length=321, Percent_Identity=25.2336448598131, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281366413, Length=321, Percent_Identity=25.2336448598131, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281365686, Length=477, Percent_Identity=20.7547169811321, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24667959, Length=147, Percent_Identity=34.0136054421769, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI62472339, Length=147, Percent_Identity=34.0136054421769, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24667955, Length=147, Percent_Identity=34.0136054421769, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20130357, Length=155, Percent_Identity=28.3870967741935, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 58930; Mature: 58798

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGWMKDETGLDKTPANFVPLTPLSHLARAARVFPNREAVIDGAHRKTYAEYHARVSQLAS
CCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHEECCHHHHHHHHHHHHHHHHHH
ALARRGIAPGDVVATVLPNTYPHAEAHFGVPAAGAVLNAINIRLDVSTIAYILDHGEAKL
HHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHEEEEEEEEEHHHHHHHHCCCCEEE
VLVDTQFLPVVMDAVEAMDGTPPILIECPSAVAGYPATGDHTIYEDLLREGDTDAPWHMP
EEEECCHHHHHHHHHHHHCCCCCEEEECCCHHCCCCCCCCHHHHHHHHHCCCCCCCCCCC
DDEWESISLNYTSGTTGRPKGVVYHHRGAYLITMGTPISWRMTLYPKYLTIVPMFHCNNW
CCCCCEEEEEECCCCCCCCCCEEEEECCEEEEEECCCCEEEEEECCCEEEEEEEHHCCCH
CHTWMMPAVGGTLVCCRDITASAIYDAIADEGVTHMGGAPIVLNMLVNAKDSDRRDFDHT
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCE
VEVFTAGAPPAAATLAAIETMGFHVTQVYGLTESYGHATECVWQDSDWSALDAAARAGIK
EEEEECCCCCHHHHHHHHHHCCCEEEEEEECHHCCCCCEEEEEECCCCHHHHHHHHCCCC
ARQGVALPNMDHITVMDPDTMEQIPMDGAVTGEIMMRGNSTMKGYYKNPDATAEAFAGGY
HHCCCCCCCCCEEEEECCCHHHHCCCCCCEEEEEEEECCCCCCCEECCCCCHHHHHCCCE
FHTGDIAVQHPDSYIQIADRAKDIIISGGENISSVEVEGVLMHHPAVLLCAVVAKPDDKW
EECCCEEEECCCHHHHHHCCCCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCC
GEIPCAFVELKEGAEATEAEIIAFARARLAGFKTPKRVVFAELPKTSTGKIQKFELRKRA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
RES
CCC
>Mature Secondary Structure 
GWMKDETGLDKTPANFVPLTPLSHLARAARVFPNREAVIDGAHRKTYAEYHARVSQLAS
CCCCCCCCCCCCCCCEECCCHHHHHHHHHHHCCCCHHEECCHHHHHHHHHHHHHHHHHH
ALARRGIAPGDVVATVLPNTYPHAEAHFGVPAAGAVLNAINIRLDVSTIAYILDHGEAKL
HHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHEEEEEEEEEHHHHHHHHCCCCEEE
VLVDTQFLPVVMDAVEAMDGTPPILIECPSAVAGYPATGDHTIYEDLLREGDTDAPWHMP
EEEECCHHHHHHHHHHHHCCCCCEEEECCCHHCCCCCCCCHHHHHHHHHCCCCCCCCCCC
DDEWESISLNYTSGTTGRPKGVVYHHRGAYLITMGTPISWRMTLYPKYLTIVPMFHCNNW
CCCCCEEEEEECCCCCCCCCCEEEEECCEEEEEECCCCEEEEEECCCEEEEEEEHHCCCH
CHTWMMPAVGGTLVCCRDITASAIYDAIADEGVTHMGGAPIVLNMLVNAKDSDRRDFDHT
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCE
VEVFTAGAPPAAATLAAIETMGFHVTQVYGLTESYGHATECVWQDSDWSALDAAARAGIK
EEEEECCCCCHHHHHHHHHHCCCEEEEEEECHHCCCCCEEEEEECCCCHHHHHHHHCCCC
ARQGVALPNMDHITVMDPDTMEQIPMDGAVTGEIMMRGNSTMKGYYKNPDATAEAFAGGY
HHCCCCCCCCCEEEEECCCHHHHCCCCCCEEEEEEEECCCCCCCEECCCCCHHHHHCCCE
FHTGDIAVQHPDSYIQIADRAKDIIISGGENISSVEVEGVLMHHPAVLLCAVVAKPDDKW
EECCCEEEECCCHHHHHHCCCCEEEEECCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCC
GEIPCAFVELKEGAEATEAEIIAFARARLAGFKTPKRVVFAELPKTSTGKIQKFELRKRA
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
RES
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1453953 [H]