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The map label for this gene is fadJ [H]

Identifier: 89055468

GI number: 89055468

Start: 2994814

End: 2997015

Strand: Direct

Name: fadJ [H]

Synonym: Jann_2977

Alternate gene names: 89055468

Gene position: 2994814-2997015 (Clockwise)

Preceding gene: 89055467

Following gene: 89055470

Centisome position: 69.36

GC content: 62.81

Gene sequence:

>2202_bases
ATGACCGATTTCACCATGCAGACCGACGCCGATGGCGTTGCTGTCATCACCTGGGACGTGCCCGGAAAATCCATGAATGT
GCTGAACCGGGATGCCTTTGATGTCGTCGAAGAGTTGGTCGATGCAGCGCTGGCCGATGAGACGGTCAAGGGCATCGTGA
TCACCTCCGGCAAGTCGTCCTTTGCGGGGGGTATGGACCTCAATGTGCTGGCCTCGATCCGCGCGGAAAGCGGCGACAAC
CCGGCGGAGGGCCTGTTCAACTTCACGATGAACGGCCACCGCATCCTGCGCAAGATTGAGCGCGCGGGGATGGAGCCCAA
GACCAACAAGGGTGGCAAGCCCATCGCCTGCGCCATTCCGGGCACCTGTGCGGGCATCGGCACGGAGATCGCGCTCGCCT
GCCACCGCCGTTTCATGGCGGACAATCCCAAGGCGAAGATGGGCCTGCCGGAGATCCTCGTGGGCCTTTTCCCCGGCGCG
GGCGGCACCACCCGCTATTCGCGCATGGTCGGAGCCATGGCCGCAGCGCCTGTGCTGCTGGAGGGCCGGATGCTGGACCC
GAAGAAGGCCAAGTCCGCTCAATTGGTGGATGAGGTCGTTCCGGCGGACGAGCTGCTGTCTGCTGCCAAGGACTGGGTCT
TGAACGCGGCCCCCGCAGACATCGTGAAGCCGTGGGACGCCAAAGGCTACAAGATGCCCGGCGGCGCGCCCTACCATCCT
GCGGGGTTCATGACCTTTGTGGGCGCGAACGCAATGATCCACGGCAAGACCAAAGGCGTCTATCCGGCCGCCAAGGCGCT
TTTGTCGTCGATCTATGAGGGCGCGTTGGTGGATTTCGACACGGCGCTCAAGATCGAGGCGCGGTATTTCACTCAAATCC
TGATGAACCCCTCGTCATCCGCGATGATCCGGTCGCTGTTCATCAACAAGCAAGCGTTGGAGAAGGGCGCGAACCGTCCT
TCCGTTCCCGATCAGACGGTCAAGAAGGTCGGCATCATCGGCGCAGGCATGATGGGCGCGGGCATTGCCTATGTCTCGGC
CTTGGCTGGCATTGAAGTCGTGCTGATCGACGCCGCGCAAGACTCTGCGGATCGCGGCAAAGCCTACTCGGAAGGGCTTC
TCGACAAAGGCATGAAACGCGGCAAGGTGACGGAGGAGAAGAAGGCCAAGGTCCTGGGCCAGATCACCGCCACCACGGAT
TATGATGCGCTGAATGGCTGCGACCTGATTGTGGAGGCCGTGTTTGAAGACCCCAAGGTCAAGGCAGAGGTGACCGCAAA
GGCCGAAGCCGCGATGAATGCAGACGGGATCTTTGCCACCAACACCTCCACCCTGCCCATTACGATGCTGGCCAAGGCAT
CGTCGCGCGCGGAGCAATTCATCGGCATCCACTTCTTCTCTCCGGTCGACAAAATGGCGCTGGTGGAGATCATCAAGGGC
AAACAAACCGGGGATGTGGCCGTGGCCAAAGCGCTCGATTTCGTGCGCCAGATCCGCAAGACGCCCATCGTCGTGAACGA
CGAGCGGTTCTTCTACGCCAACCGCTGCATCCTGCCCTACGTCAATGAGGGCGTGCGGATGTTGCAGGAAGGCGTGGCCC
CTGCCCTGATCGAGAACGCCGCCAAACTGGTCGGCATGCCGCTGGGTCCGCTGCAATTGACCGACGAGACATCCATTGAC
CTCGGCGCCAAAATCGCCCGCGCCACCAAGGCCGCCGACCCGGACTATGACGACACCACCGATGAGCTGATCTTCTGGAT
GGAAGAGGAAGGGCGCCTGGGTCGCAAGGCCAATGCGGGCTTCTACAGCTATGATGAGAAGGGCAAGCGGCAGGGCCTCT
GGGACGGTCTGGGCGCGCGCTACGCTCAGGCCGATGATCAGCCCGAGTTGACCGACGTGCAGCACCGCCTCCTGTTCGCG
CAGGTGTTGGAGGCCGTCCGCGCACTGGAGGCTGGCGTTCTGATGGACATCCGCGAAGGCGACGTCGGTGCGATCCTGGG
ATGGGGCTTTGCGCCCTGGTCCGGTGGTCCGTTCTCCTGGCTCGACATCCTGGGCACGCCCTATGCGGCGGAACGCTGCG
ACCAACTGGAGGCCGAGTTTGGCCCCCGCTTCGCCTGCCCGCCCCTGCTGCGTGAGATGGCCGACAAGGGGCAAAGCTTC
TACGGCCGCTTCGGCGAGGGTGTGGACAGCAAAGCAGCCTGA

Upstream 100 bases:

>100_bases
ACGTCACGAATTCCCTGGCCAATGATCGGTTTGCCGAAGGCGCGTTTGCGCCCACGACCCGGCTGCCGACGTTGCGCCAA
ATAAACAAGAGGATGCAAGA

Downstream 100 bases:

>100_bases
CAAAAAAAGCCGCCGTCGGGATCATCCGGCGGCGGCCTTTCTACGGCAATAAGACCTAGAAGCGGTACGCCGCCCCGATC
CCGAAGGACGTCACCGACAG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 733; Mature: 732

Protein sequence:

>733_residues
MTDFTMQTDADGVAVITWDVPGKSMNVLNRDAFDVVEELVDAALADETVKGIVITSGKSSFAGGMDLNVLASIRAESGDN
PAEGLFNFTMNGHRILRKIERAGMEPKTNKGGKPIACAIPGTCAGIGTEIALACHRRFMADNPKAKMGLPEILVGLFPGA
GGTTRYSRMVGAMAAAPVLLEGRMLDPKKAKSAQLVDEVVPADELLSAAKDWVLNAAPADIVKPWDAKGYKMPGGAPYHP
AGFMTFVGANAMIHGKTKGVYPAAKALLSSIYEGALVDFDTALKIEARYFTQILMNPSSSAMIRSLFINKQALEKGANRP
SVPDQTVKKVGIIGAGMMGAGIAYVSALAGIEVVLIDAAQDSADRGKAYSEGLLDKGMKRGKVTEEKKAKVLGQITATTD
YDALNGCDLIVEAVFEDPKVKAEVTAKAEAAMNADGIFATNTSTLPITMLAKASSRAEQFIGIHFFSPVDKMALVEIIKG
KQTGDVAVAKALDFVRQIRKTPIVVNDERFFYANRCILPYVNEGVRMLQEGVAPALIENAAKLVGMPLGPLQLTDETSID
LGAKIARATKAADPDYDDTTDELIFWMEEEGRLGRKANAGFYSYDEKGKRQGLWDGLGARYAQADDQPELTDVQHRLLFA
QVLEAVRALEAGVLMDIREGDVGAILGWGFAPWSGGPFSWLDILGTPYAAERCDQLEAEFGPRFACPPLLREMADKGQSF
YGRFGEGVDSKAA

Sequences:

>Translated_733_residues
MTDFTMQTDADGVAVITWDVPGKSMNVLNRDAFDVVEELVDAALADETVKGIVITSGKSSFAGGMDLNVLASIRAESGDN
PAEGLFNFTMNGHRILRKIERAGMEPKTNKGGKPIACAIPGTCAGIGTEIALACHRRFMADNPKAKMGLPEILVGLFPGA
GGTTRYSRMVGAMAAAPVLLEGRMLDPKKAKSAQLVDEVVPADELLSAAKDWVLNAAPADIVKPWDAKGYKMPGGAPYHP
AGFMTFVGANAMIHGKTKGVYPAAKALLSSIYEGALVDFDTALKIEARYFTQILMNPSSSAMIRSLFINKQALEKGANRP
SVPDQTVKKVGIIGAGMMGAGIAYVSALAGIEVVLIDAAQDSADRGKAYSEGLLDKGMKRGKVTEEKKAKVLGQITATTD
YDALNGCDLIVEAVFEDPKVKAEVTAKAEAAMNADGIFATNTSTLPITMLAKASSRAEQFIGIHFFSPVDKMALVEIIKG
KQTGDVAVAKALDFVRQIRKTPIVVNDERFFYANRCILPYVNEGVRMLQEGVAPALIENAAKLVGMPLGPLQLTDETSID
LGAKIARATKAADPDYDDTTDELIFWMEEEGRLGRKANAGFYSYDEKGKRQGLWDGLGARYAQADDQPELTDVQHRLLFA
QVLEAVRALEAGVLMDIREGDVGAILGWGFAPWSGGPFSWLDILGTPYAAERCDQLEAEFGPRFACPPLLREMADKGQSF
YGRFGEGVDSKAA
>Mature_732_residues
TDFTMQTDADGVAVITWDVPGKSMNVLNRDAFDVVEELVDAALADETVKGIVITSGKSSFAGGMDLNVLASIRAESGDNP
AEGLFNFTMNGHRILRKIERAGMEPKTNKGGKPIACAIPGTCAGIGTEIALACHRRFMADNPKAKMGLPEILVGLFPGAG
GTTRYSRMVGAMAAAPVLLEGRMLDPKKAKSAQLVDEVVPADELLSAAKDWVLNAAPADIVKPWDAKGYKMPGGAPYHPA
GFMTFVGANAMIHGKTKGVYPAAKALLSSIYEGALVDFDTALKIEARYFTQILMNPSSSAMIRSLFINKQALEKGANRPS
VPDQTVKKVGIIGAGMMGAGIAYVSALAGIEVVLIDAAQDSADRGKAYSEGLLDKGMKRGKVTEEKKAKVLGQITATTDY
DALNGCDLIVEAVFEDPKVKAEVTAKAEAAMNADGIFATNTSTLPITMLAKASSRAEQFIGIHFFSPVDKMALVEIIKGK
QTGDVAVAKALDFVRQIRKTPIVVNDERFFYANRCILPYVNEGVRMLQEGVAPALIENAAKLVGMPLGPLQLTDETSIDL
GAKIARATKAADPDYDDTTDELIFWMEEEGRLGRKANAGFYSYDEKGKRQGLWDGLGARYAQADDQPELTDVQHRLLFAQ
VLEAVRALEAGVLMDIREGDVGAILGWGFAPWSGGPFSWLDILGTPYAAERCDQLEAEFGPRFACPPLLREMADKGQSFY
GRFGEGVDSKAA

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=735, Percent_Identity=33.0612244897959, Blast_Score=360, Evalue=4e-99,
Organism=Homo sapiens, GI68989263, Length=751, Percent_Identity=25.2996005326232, Blast_Score=225, Evalue=1e-58,
Organism=Homo sapiens, GI261878539, Length=627, Percent_Identity=25.518341307815, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=36.2068965517241, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=34.2019543973941, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI194097323, Length=199, Percent_Identity=27.6381909547739, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1788682, Length=728, Percent_Identity=35.1648351648352, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI1790281, Length=727, Percent_Identity=32.4621733149931, Blast_Score=312, Evalue=5e-86,
Organism=Escherichia coli, GI1787661, Length=302, Percent_Identity=31.4569536423841, Blast_Score=136, Evalue=6e-33,
Organism=Escherichia coli, GI1787659, Length=191, Percent_Identity=32.4607329842932, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=736, Percent_Identity=31.6576086956522, Blast_Score=329, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI17508953, Length=736, Percent_Identity=32.0652173913043, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI17508951, Length=736, Percent_Identity=32.0652173913043, Blast_Score=316, Evalue=2e-86,
Organism=Caenorhabditis elegans, GI25144276, Length=610, Percent_Identity=32.9508196721311, Blast_Score=274, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI71985923, Length=378, Percent_Identity=31.4814814814815, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71985930, Length=366, Percent_Identity=30.8743169398907, Blast_Score=171, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=34.0277777777778, Blast_Score=143, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=30.6620209059233, Blast_Score=136, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=29.4117647058824, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25145438, Length=201, Percent_Identity=30.8457711442786, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17554946, Length=201, Percent_Identity=28.8557213930348, Blast_Score=76, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=194, Percent_Identity=27.8350515463918, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24583077, Length=742, Percent_Identity=32.7493261455526, Blast_Score=310, Evalue=3e-84,
Organism=Drosophila melanogaster, GI24583079, Length=742, Percent_Identity=32.7493261455526, Blast_Score=310, Evalue=3e-84,
Organism=Drosophila melanogaster, GI19921000, Length=742, Percent_Identity=32.7493261455526, Blast_Score=310, Evalue=3e-84,
Organism=Drosophila melanogaster, GI20129971, Length=202, Percent_Identity=32.1782178217822, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24653477, Length=202, Percent_Identity=32.1782178217822, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 78487; Mature: 78356

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFTMQTDADGVAVITWDVPGKSMNVLNRDAFDVVEELVDAALADETVKGIVITSGKSS
CCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
FAGGMDLNVLASIRAESGDNPAEGLFNFTMNGHRILRKIERAGMEPKTNKGGKPIACAIP
CCCCCCHHHHEEEHHCCCCCHHHHHEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEECC
GTCAGIGTEIALACHRRFMADNPKAKMGLPEILVGLFPGAGGTTRYSRMVGAMAAAPVLL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHC
EGRMLDPKKAKSAQLVDEVVPADELLSAAKDWVLNAAPADIVKPWDAKGYKMPGGAPYHP
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHEECCCCHHHCCCCCCCCEECCCCCCCCC
AGFMTFVGANAMIHGKTKGVYPAAKALLSSIYEGALVDFDTALKIEARYFTQILMNPSSS
CCHHHEECCCEEEECCCCCCCHHHHHHHHHHHCCCEECCCCCEEEHHHHHHHHHCCCCHH
AMIRSLFINKQALEKGANRPSVPDQTVKKVGIIGAGMMGAGIAYVSALAGIEVVLIDAAQ
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCC
DSADRGKAYSEGLLDKGMKRGKVTEEKKAKVLGQITATTDYDALNGCDLIVEAVFEDPKV
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHCCCCC
KAEVTAKAEAAMNADGIFATNTSTLPITMLAKASSRAEQFIGIHFFSPVDKMALVEIIKG
EEEEEEHHHHHCCCCCEEEECCCCCEEEEEHHHHHHHHHEEEEEECCCHHHHHHHHHHCC
KQTGDVAVAKALDFVRQIRKTPIVVNDERFFYANRCILPYVNEGVRMLQEGVAPALIENA
CCCCHHHHHHHHHHHHHHHCCCEEECCCCEEEECCEECHHHHHHHHHHHHCCCHHHHHHH
AKLVGMPLGPLQLTDETSIDLGAKIARATKAADPDYDDTTDELIFWMEEEGRLGRKANAG
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
FYSYDEKGKRQGLWDGLGARYAQADDQPELTDVQHRLLFAQVLEAVRALEAGVLMDIREG
CCCCCCCCCCCCCHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
DVGAILGWGFAPWSGGPFSWLDILGTPYAAERCDQLEAEFGPRFACPPLLREMADKGQSF
CCCEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHH
YGRFGEGVDSKAA
HHHHCCCCCCCCC
>Mature Secondary Structure 
TDFTMQTDADGVAVITWDVPGKSMNVLNRDAFDVVEELVDAALADETVKGIVITSGKSS
CCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
FAGGMDLNVLASIRAESGDNPAEGLFNFTMNGHRILRKIERAGMEPKTNKGGKPIACAIP
CCCCCCHHHHEEEHHCCCCCHHHHHEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEECC
GTCAGIGTEIALACHRRFMADNPKAKMGLPEILVGLFPGAGGTTRYSRMVGAMAAAPVLL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHC
EGRMLDPKKAKSAQLVDEVVPADELLSAAKDWVLNAAPADIVKPWDAKGYKMPGGAPYHP
CCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHEECCCCHHHCCCCCCCCEECCCCCCCCC
AGFMTFVGANAMIHGKTKGVYPAAKALLSSIYEGALVDFDTALKIEARYFTQILMNPSSS
CCHHHEECCCEEEECCCCCCCHHHHHHHHHHHCCCEECCCCCEEEHHHHHHHHHCCCCHH
AMIRSLFINKQALEKGANRPSVPDQTVKKVGIIGAGMMGAGIAYVSALAGIEVVLIDAAQ
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCC
DSADRGKAYSEGLLDKGMKRGKVTEEKKAKVLGQITATTDYDALNGCDLIVEAVFEDPKV
CCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHCCCCC
KAEVTAKAEAAMNADGIFATNTSTLPITMLAKASSRAEQFIGIHFFSPVDKMALVEIIKG
EEEEEEHHHHHCCCCCEEEECCCCCEEEEEHHHHHHHHHEEEEEECCCHHHHHHHHHHCC
KQTGDVAVAKALDFVRQIRKTPIVVNDERFFYANRCILPYVNEGVRMLQEGVAPALIENA
CCCCHHHHHHHHHHHHHHHCCCEEECCCCEEEECCEECHHHHHHHHHHHHCCCHHHHHHH
AKLVGMPLGPLQLTDETSIDLGAKIARATKAADPDYDDTTDELIFWMEEEGRLGRKANAG
HHHHCCCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCC
FYSYDEKGKRQGLWDGLGARYAQADDQPELTDVQHRLLFAQVLEAVRALEAGVLMDIREG
CCCCCCCCCCCCCHHHHCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCC
DVGAILGWGFAPWSGGPFSWLDILGTPYAAERCDQLEAEFGPRFACPPLLREMADKGQSF
CCCEEEECCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCHHH
YGRFGEGVDSKAA
HHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA