Click here to switch to the map view.

The map label for this gene is pyrD [H]

Identifier: 89055454

GI number: 89055454

Start: 2983118

End: 2984164

Strand: Direct

Name: pyrD [H]

Synonym: Jann_2963

Alternate gene names: 89055454

Gene position: 2983118-2984164 (Clockwise)

Preceding gene: 89055453

Following gene: 89055455

Centisome position: 69.09

GC content: 64.18

Gene sequence:

>1047_bases
ATGCTGGAAAAACTGGCCCTGCCCCTTCTACGTCGCCTTGATCCGGAGCGCGCCCATGGGCTTGCGCTGAAGGGGGTGAA
GGCAGGGTTCGGGCCGCTGGAAGGACCCTACACCTCCCCCCGTCTGGCCACGCGGATCGCCGGGATGGACCTGCCCAATC
CCATCGGGCTGGCGGCAGGATTTGACAAGAACGCAGAGATTGCAGGCCCCTTGCAACGGGTGGGCTTCGGGTTTCTGGAG
GTCGGTGCCGCCACCCCAAAGCCGCAGCCCGGCAACCCCAAACCGCGCCTGTTTCGCCTGACCGAGGACCAAGCCGCGAT
CAATCGCTTTGGCTTCAACAATGACGGAATGGACGCCATCGCCGCGCGCCTGAATGGCCTGCCGCGCGAGGTTCCGATCG
GCCTCAACCTGGGCGCCAACAAGGACAGCGCAGACCGCGTCGCCGACTTCGCTCGGGTCTTCCAGACCTGCGCGCCGCAT
ATCGACTTCGCCACAATCAACGTCTCCTCCCCCAACACCGAGAAATTGCGCGATCTGCAAGGCAAAGCGGCACTTCGCCA
GATTATCGCGCAGGTGGATGCCGCCCGCACCGATGCGCGAGTGGCGTTGTTTCTGAAGATCGCGCCCGACCTGACGATGG
ACGAGCTGGCCGATATCGCCGAGGTCGCTTTGGACAGCCCGCTTCAGGGCCTCATCGCCACCAACACAACGCTGGATCGC
ACCGGCCTCAAAAGCCGCCATGGGCAGGAAAAGGGCGGCCTCTCCGGCCAGCCAGTGTTTGAAAAATCGACCCGCACGCT
GGCCCGTCTCTACCAACTGACCGAGGGCAAACTGCCGCTCATCGGCGTCGGCGGCGTCGCCTCGGCCGAGCAGGCCTATA
CCAAGATCCGCGCGGGCGCGACCGCTGTTCAACTCTATACCGGGCTTGTCTATGGCGGGTTATCGATGGTGACCAAGATG
GTCAAAGGGGTTGATGCGCGCCTCCAGCGTGACGGCTTCGCCAGCGTGTCCGACGCCACGGGCACAGGAGTGTCCGAATG
GACATGA

Upstream 100 bases:

>100_bases
TTCCCTCACCTATATGGCCCTCTGCGTCGTGCGGACGTGATCTGGCACGCGCCCCTTCCGGTCAAGGACGGTGCCCACGT
CTTCCCCGAGGGCATGTGAG

Downstream 100 bases:

>100_bases
TCCCGCCGCTGACCCTTTGGCACAATCCGCGTTGTTCCAAATCCCGTGCCGCACTTGCGCTCCTGGAAGATGCCGGCCAT
GCGCCCGATATCCGCCTCTA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MLEKLALPLLRRLDPERAHGLALKGVKAGFGPLEGPYTSPRLATRIAGMDLPNPIGLAAGFDKNAEIAGPLQRVGFGFLE
VGAATPKPQPGNPKPRLFRLTEDQAAINRFGFNNDGMDAIAARLNGLPREVPIGLNLGANKDSADRVADFARVFQTCAPH
IDFATINVSSPNTEKLRDLQGKAALRQIIAQVDAARTDARVALFLKIAPDLTMDELADIAEVALDSPLQGLIATNTTLDR
TGLKSRHGQEKGGLSGQPVFEKSTRTLARLYQLTEGKLPLIGVGGVASAEQAYTKIRAGATAVQLYTGLVYGGLSMVTKM
VKGVDARLQRDGFASVSDATGTGVSEWT

Sequences:

>Translated_348_residues
MLEKLALPLLRRLDPERAHGLALKGVKAGFGPLEGPYTSPRLATRIAGMDLPNPIGLAAGFDKNAEIAGPLQRVGFGFLE
VGAATPKPQPGNPKPRLFRLTEDQAAINRFGFNNDGMDAIAARLNGLPREVPIGLNLGANKDSADRVADFARVFQTCAPH
IDFATINVSSPNTEKLRDLQGKAALRQIIAQVDAARTDARVALFLKIAPDLTMDELADIAEVALDSPLQGLIATNTTLDR
TGLKSRHGQEKGGLSGQPVFEKSTRTLARLYQLTEGKLPLIGVGGVASAEQAYTKIRAGATAVQLYTGLVYGGLSMVTKM
VKGVDARLQRDGFASVSDATGTGVSEWT
>Mature_348_residues
MLEKLALPLLRRLDPERAHGLALKGVKAGFGPLEGPYTSPRLATRIAGMDLPNPIGLAAGFDKNAEIAGPLQRVGFGFLE
VGAATPKPQPGNPKPRLFRLTEDQAAINRFGFNNDGMDAIAARLNGLPREVPIGLNLGANKDSADRVADFARVFQTCAPH
IDFATINVSSPNTEKLRDLQGKAALRQIIAQVDAARTDARVALFLKIAPDLTMDELADIAEVALDSPLQGLIATNTTLDR
TGLKSRHGQEKGGLSGQPVFEKSTRTLARLYQLTEGKLPLIGVGGVASAEQAYTKIRAGATAVQLYTGLVYGGLSMVTKM
VKGVDARLQRDGFASVSDATGTGVSEWT

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=342, Percent_Identity=46.1988304093567, Blast_Score=291, Evalue=4e-79,
Organism=Escherichia coli, GI1787177, Length=327, Percent_Identity=38.2262996941896, Blast_Score=215, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17509475, Length=365, Percent_Identity=41.3698630136986, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI281361352, Length=353, Percent_Identity=44.4759206798867, Blast_Score=292, Evalue=2e-79,
Organism=Drosophila melanogaster, GI17137316, Length=353, Percent_Identity=44.4759206798867, Blast_Score=292, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36919; Mature: 36919

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKLALPLLRRLDPERAHGLALKGVKAGFGPLEGPYTSPRLATRIAGMDLPNPIGLAAG
CCHHHHHHHHHHCCHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECC
FDKNAEIAGPLQRVGFGFLEVGAATPKPQPGNPKPRLFRLTEDQAAINRFGFNNDGMDAI
CCCCCCCCCHHHHHCCCHHEECCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCHHHH
AARLNGLPREVPIGLNLGANKDSADRVADFARVFQTCAPHIDFATINVSSPNTEKLRDLQ
HHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
GKAALRQIIAQVDAARTDARVALFLKIAPDLTMDELADIAEVALDSPLQGLIATNTTLDR
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHEECCCCCCC
TGLKSRHGQEKGGLSGQPVFEKSTRTLARLYQLTEGKLPLIGVGGVASAEQAYTKIRAGA
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCH
TAVQLYTGLVYGGLSMVTKMVKGVDARLQRDGFASVSDATGTGVSEWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLEKLALPLLRRLDPERAHGLALKGVKAGFGPLEGPYTSPRLATRIAGMDLPNPIGLAAG
CCHHHHHHHHHHCCHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEECC
FDKNAEIAGPLQRVGFGFLEVGAATPKPQPGNPKPRLFRLTEDQAAINRFGFNNDGMDAI
CCCCCCCCCHHHHHCCCHHEECCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCHHHH
AARLNGLPREVPIGLNLGANKDSADRVADFARVFQTCAPHIDFATINVSSPNTEKLRDLQ
HHHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHH
GKAALRQIIAQVDAARTDARVALFLKIAPDLTMDELADIAEVALDSPLQGLIATNTTLDR
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHEECCCCCCC
TGLKSRHGQEKGGLSGQPVFEKSTRTLARLYQLTEGKLPLIGVGGVASAEQAYTKIRAGA
CCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHCCH
TAVQLYTGLVYGGLSMVTKMVKGVDARLQRDGFASVSDATGTGVSEWT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA