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The map label for this gene is clpP

Identifier: 89055299

GI number: 89055299

Start: 2822710

End: 2823336

Strand: Reverse

Name: clpP

Synonym: Jann_2808

Alternate gene names: 89055299

Gene position: 2823336-2822710 (Counterclockwise)

Preceding gene: 89055301

Following gene: 89055298

Centisome position: 65.39

GC content: 57.42

Gene sequence:

>627_bases
ATGCATGATCCCGTGGAATACTTCCAAAACAACCTGGTCCCGATGGTGGTTGAACAAACCAGCCGTGGCGAGCGGGCCTA
TGACATTTTTTCGCGCCTCCTGAAGGAGCGGATCGTTTTCGTGAACGGACCCGTCCATTCCGGGATGAGCCACCTGATTG
TCGCGCAATTGCTGCACCTGGAGGCGGAGAACCCGTCGAAGGAAATCTCCATGTATATCAACTCGCCAGGCGGCGAAGTT
ACAGCGGGCATGTCGATCTACGACACGATGCAATATATCAAACCGAAAGTATCGACGCTGGTCTGCGGCATGGCCGCCTC
AATGGGGTCTGTGATCGCGGTTGGCGGTGAGAAGGGCATGCGCTTGGCGCTTCCCAACGCAGAATTCCTGGTTCACCAGC
CATCAGGTGGTGCGCGGGGCACCGCATCTGACATCTTGATCTCTGCGCGGTCGATCGAGGCGACGCGGGAGCGACTTTAT
CAACTATATGTTAAGCATACTGGGCAAGACTACGAGACGGTTCAGCGCGCGCTGGACCGGGATACGTGGATGACCCCCGA
AGTGGCGCTGGAATGGGGCCACGTTGATGAGATTGTGACAACCCGCGGCGCAGACGACGCGGAATAA

Upstream 100 bases:

>100_bases
GATTGGTCAAGCCGCGCGAATTCGACGGAAGGTGCCCTTGCAGCCCCCCATGGCCAGACATAGTCTCAGTCAGAACGATA
CATCTGATGAGGCAGGCACG

Downstream 100 bases:

>100_bases
CATTTGAAAGCAGGGCGCAGGGCCAGATTTGGCCCTGTTGCACGATGGGGTCAGCGCTTGGCCCGCGTCGGAATTTGCGA
TTGTGACCGGGGCAGGCCTG

Product: ATP-dependent Clp protease proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MHDPVEYFQNNLVPMVVEQTSRGERAYDIFSRLLKERIVFVNGPVHSGMSHLIVAQLLHLEAENPSKEISMYINSPGGEV
TAGMSIYDTMQYIKPKVSTLVCGMAASMGSVIAVGGEKGMRLALPNAEFLVHQPSGGARGTASDILISARSIEATRERLY
QLYVKHTGQDYETVQRALDRDTWMTPEVALEWGHVDEIVTTRGADDAE

Sequences:

>Translated_208_residues
MHDPVEYFQNNLVPMVVEQTSRGERAYDIFSRLLKERIVFVNGPVHSGMSHLIVAQLLHLEAENPSKEISMYINSPGGEV
TAGMSIYDTMQYIKPKVSTLVCGMAASMGSVIAVGGEKGMRLALPNAEFLVHQPSGGARGTASDILISARSIEATRERLY
QLYVKHTGQDYETVQRALDRDTWMTPEVALEWGHVDEIVTTRGADDAE
>Mature_208_residues
MHDPVEYFQNNLVPMVVEQTSRGERAYDIFSRLLKERIVFVNGPVHSGMSHLIVAQLLHLEAENPSKEISMYINSPGGEV
TAGMSIYDTMQYIKPKVSTLVCGMAASMGSVIAVGGEKGMRLALPNAEFLVHQPSGGARGTASDILISARSIEATRERLY
QLYVKHTGQDYETVQRALDRDTWMTPEVALEWGHVDEIVTTRGADDAE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=188, Percent_Identity=53.7234042553192, Blast_Score=216, Evalue=8e-57,
Organism=Escherichia coli, GI1786641, Length=191, Percent_Identity=56.5445026178011, Blast_Score=230, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17538017, Length=192, Percent_Identity=52.0833333333333, Blast_Score=211, Evalue=3e-55,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=55.026455026455, Blast_Score=218, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_JANSC (Q28NI7)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510750.1
- HSSP:   P0A6G7
- ProteinModelPortal:   Q28NI7
- SMR:   Q28NI7
- STRING:   Q28NI7
- MEROPS:   S14.001
- GeneID:   3935274
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2808
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- BioCyc:   JSP290400:JANN_2808-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22982; Mature: 22982

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 107-107 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDPVEYFQNNLVPMVVEQTSRGERAYDIFSRLLKERIVFVNGPVHSGMSHLIVAQLLHL
CCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHH
EAENPSKEISMYINSPGGEVTAGMSIYDTMQYIKPKVSTLVCGMAASMGSVIAVGGEKGM
CCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
RLALPNAEFLVHQPSGGARGTASDILISARSIEATRERLYQLYVKHTGQDYETVQRALDR
EEECCCCEEEEECCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
DTWMTPEVALEWGHVDEIVTTRGADDAE
CCCCCHHHEEECCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MHDPVEYFQNNLVPMVVEQTSRGERAYDIFSRLLKERIVFVNGPVHSGMSHLIVAQLLHL
CCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHH
EAENPSKEISMYINSPGGEVTAGMSIYDTMQYIKPKVSTLVCGMAASMGSVIAVGGEKGM
CCCCCCCEEEEEEECCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCC
RLALPNAEFLVHQPSGGARGTASDILISARSIEATRERLYQLYVKHTGQDYETVQRALDR
EEECCCCEEEEECCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
DTWMTPEVALEWGHVDEIVTTRGADDAE
CCCCCHHHEEECCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA