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The map label for this gene is hisB

Identifier: 89055279

GI number: 89055279

Start: 2806606

End: 2807193

Strand: Direct

Name: hisB

Synonym: Jann_2788

Alternate gene names: 89055279

Gene position: 2806606-2807193 (Clockwise)

Preceding gene: 89055275

Following gene: 89055280

Centisome position: 65.0

GC content: 63.1

Gene sequence:

>588_bases
ATGCGCACCGCCCAGATCACCCGCAAGACCGCCGAGACCGACATCTCTGTCGAGATCAATCTTGACGGCACCGGCACCTA
CGACAATCTGACCGGCGTGGGCTTCTTCGATCATATGCTGGACCAACTGGCGCGCCACGCATTGATGGACATGACGGTCC
GTTGCGCCGGCGATCTGCACATCGACGACCACCATTCCGTCGAGGATGTGGGCATTGCGTTGGGCCAGGCCCTGACGCAA
GCGATGGGCGACAAGCGGGGCATCCGCCGCTATGGCGAATGTGTTCTGCCGATGGATGACGCACGCGTTGCCTGCGCGCT
GGACCTGTCCGGGCGGCCGTTTCTCGTATGGGACGTTGAGATGCCGACCGCGAAGATCGGCACCTTCGACACAGAACTGG
TTCGGGAGTTCTTCCAGGCGTTTGCAACCCATGGCGGGATCACATTGCACCTGACGCAAGCGGCGGGCGTGAACAGCCAC
CACATCGCCGAGGCCGCTTTCAAGGCGACAGCCCGCGCCCTGCGAGATGCGTTGGAGGTTGACCCACGCACGGCCGACGC
CATCCCATCGACCAAGGGCAGCCTGTAA

Upstream 100 bases:

>100_bases
ATAAACCACGGCGGAAACGGTCAAAGTGCACCGGCTCTACTCCGCCCTTCCCTGCCCTTGATCTGCCCCCTATAAGCGCA
GCCGAGCCAGGAGAGACCCG

Downstream 100 bases:

>100_bases
ACGCGCCCTCCAGAGCACATCTTTGTTTAAGGAACGCACGCGATGACGACCGTTCTGATCGACTATGACGCGGGCAATCT
GCACTCCGCCGAGAAGGCGT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRTAQITRKTAETDISVEINLDGTGTYDNLTGVGFFDHMLDQLARHALMDMTVRCAGDLHIDDHHSVEDVGIALGQALTQ
AMGDKRGIRRYGECVLPMDDARVACALDLSGRPFLVWDVEMPTAKIGTFDTELVREFFQAFATHGGITLHLTQAAGVNSH
HIAEAAFKATARALRDALEVDPRTADAIPSTKGSL

Sequences:

>Translated_195_residues
MRTAQITRKTAETDISVEINLDGTGTYDNLTGVGFFDHMLDQLARHALMDMTVRCAGDLHIDDHHSVEDVGIALGQALTQ
AMGDKRGIRRYGECVLPMDDARVACALDLSGRPFLVWDVEMPTAKIGTFDTELVREFFQAFATHGGITLHLTQAAGVNSH
HIAEAAFKATARALRDALEVDPRTADAIPSTKGSL
>Mature_195_residues
MRTAQITRKTAETDISVEINLDGTGTYDNLTGVGFFDHMLDQLARHALMDMTVRCAGDLHIDDHHSVEDVGIALGQALTQ
AMGDKRGIRRYGECVLPMDDARVACALDLSGRPFLVWDVEMPTAKIGTFDTELVREFFQAFATHGGITLHLTQAAGVNSH
HIAEAAFKATARALRDALEVDPRTADAIPSTKGSL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=49.4845360824742, Blast_Score=185, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=38.5321100917431, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_JANSC (Q28NK7)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510730.1
- ProteinModelPortal:   Q28NK7
- SMR:   Q28NK7
- STRING:   Q28NK7
- GeneID:   3935253
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2788
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q28NK7
- ProtClustDB:   PRK00951
- BioCyc:   JSP290400:JANN_2788-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21177; Mature: 21177

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAQITRKTAETDISVEINLDGTGTYDNLTGVGFFDHMLDQLARHALMDMTVRCAGDLH
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
IDDHHSVEDVGIALGQALTQAMGDKRGIRRYGECVLPMDDARVACALDLSGRPFLVWDVE
ECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCEECCCCCCCEEEEEECCCCEEEEEECC
MPTAKIGTFDTELVREFFQAFATHGGITLHLTQAAGVNSHHIAEAAFKATARALRDALEV
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
DPRTADAIPSTKGSL
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTAQITRKTAETDISVEINLDGTGTYDNLTGVGFFDHMLDQLARHALMDMTVRCAGDLH
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEE
IDDHHSVEDVGIALGQALTQAMGDKRGIRRYGECVLPMDDARVACALDLSGRPFLVWDVE
ECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCEECCCCCCCEEEEEECCCCEEEEEECC
MPTAKIGTFDTELVREFFQAFATHGGITLHLTQAAGVNSHHIAEAAFKATARALRDALEV
CCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
DPRTADAIPSTKGSL
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA