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The map label for this gene is lldD [H]

Identifier: 89055269

GI number: 89055269

Start: 2794615

End: 2795769

Strand: Direct

Name: lldD [H]

Synonym: Jann_2778

Alternate gene names: 89055269

Gene position: 2794615-2795769 (Clockwise)

Preceding gene: 89055266

Following gene: 89055270

Centisome position: 64.72

GC content: 66.41

Gene sequence:

>1155_bases
ATGGATTTGCACAGCCGATACCCCGCGTTGGCGGATCTTCGCGCGCGCGCAAGGCGGCGAATTCCGCATTTTGTGTGGGA
ATACCTGGACTCTGCAACCGGTCTGGAGGCTGGGGCAGCTCGCAATCGCGCCGCGTTGGAGGCCGTGTTGTTCCGACCGG
CCGCACTGTTGGGCGAGGTATCGCCGGATCTTGGATGTACGTTTCTGGGGCGCGACTATCCGGTCCCGTTCGGGATCGCA
CCACTGGGCATGTCTGGGCTCATCTGGCCCGGAGCGGAGCGATTTCTGGCCCGCCATAGCGCGCAGACTGGCATCCCCTA
TGGCTTGTCGACGGTCGCGACCGTGCTGCCAGAGACGTTGGCAGCGGATATCGGCGATCAGGGATGGTTTCAGATGTATC
CGCCGAAATCACCGGAGGTGCGCGACGATATGCTGGCCCGCGCCAGGGCAGCGGGCTTTCATACCTTGGTTTTGACGGTG
GATGTGCCCGCCGCCTCTCGCAGAGAGCGGCAAACGCGGGGCGGATTGGTGCAGCCCCCACGCCTGACGCCGCGCCTATT
GGCGCAGGTCGCGACATGTCCCACCTGGGCGCGGGGGATCGCGGACACCGGGATGCCAAGGATGCGGTTGATGGACAGCT
ATGCCGAAGATCTGGCCGTCAATCTGACAGGCGGCCCCCTGCCCTCGACCGCCCATGTCGGCTACCTGCTGCGCGCCGCA
CCCGATTGGGAATACGTCGCCGCATTGAGGGACCGGTGGGAGAGTGCGTTCGTCCTGAAAGGCGTGTGCGAGCCGGACGT
CGCCGCACGGGCGCAGCAGGAGGGTGTGGATGCCATCTGGGTCTCAACCCATGCGGGGCGGCAGTTTGACGGCGCTCCGG
GTGCCGCGGCGATGTTGCCGGGGATCCGGGCCGCGACGGACCTGCCCATTGTGTTCGACAGCGGTGTGGAAGGCGGGCTG
GATGTGCTGCGCGCGTTGGCGCTGGGGGCGGATTTCGTCATGATGGGCCGCGCCTGGCACTACGCTCTGGGTGCTTTGGG
AGCTGAGGGGCCGGCCCACTGGCACGACGTTCTGGTGCGCGACATGGCCAGCAACATGGCCCAGATCGGGGCGCGCACGC
TTGCCGATCTGCCCGGTCGGCTGGTTCGGGATTAA

Upstream 100 bases:

>100_bases
GCCCGACGCGCCGCATTTGCGTGGGCCAAGATGAAGGAAACATGCATATTTTTACAGGAATTCGATTGAGTTGCCGCCAG
TTGCGCGATTGGGTGGGCCC

Downstream 100 bases:

>100_bases
CCAATTTCCTTAACGCGGGGTTAACATCGGCCCCGCATGTTCCTATATCGTTCTCATGACAGAAGCCCAGGCCATCGCAA
TTCTCTGCGCCATGTTGGGG

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MDLHSRYPALADLRARARRRIPHFVWEYLDSATGLEAGAARNRAALEAVLFRPAALLGEVSPDLGCTFLGRDYPVPFGIA
PLGMSGLIWPGAERFLARHSAQTGIPYGLSTVATVLPETLAADIGDQGWFQMYPPKSPEVRDDMLARARAAGFHTLVLTV
DVPAASRRERQTRGGLVQPPRLTPRLLAQVATCPTWARGIADTGMPRMRLMDSYAEDLAVNLTGGPLPSTAHVGYLLRAA
PDWEYVAALRDRWESAFVLKGVCEPDVAARAQQEGVDAIWVSTHAGRQFDGAPGAAAMLPGIRAATDLPIVFDSGVEGGL
DVLRALALGADFVMMGRAWHYALGALGAEGPAHWHDVLVRDMASNMAQIGARTLADLPGRLVRD

Sequences:

>Translated_384_residues
MDLHSRYPALADLRARARRRIPHFVWEYLDSATGLEAGAARNRAALEAVLFRPAALLGEVSPDLGCTFLGRDYPVPFGIA
PLGMSGLIWPGAERFLARHSAQTGIPYGLSTVATVLPETLAADIGDQGWFQMYPPKSPEVRDDMLARARAAGFHTLVLTV
DVPAASRRERQTRGGLVQPPRLTPRLLAQVATCPTWARGIADTGMPRMRLMDSYAEDLAVNLTGGPLPSTAHVGYLLRAA
PDWEYVAALRDRWESAFVLKGVCEPDVAARAQQEGVDAIWVSTHAGRQFDGAPGAAAMLPGIRAATDLPIVFDSGVEGGL
DVLRALALGADFVMMGRAWHYALGALGAEGPAHWHDVLVRDMASNMAQIGARTLADLPGRLVRD
>Mature_384_residues
MDLHSRYPALADLRARARRRIPHFVWEYLDSATGLEAGAARNRAALEAVLFRPAALLGEVSPDLGCTFLGRDYPVPFGIA
PLGMSGLIWPGAERFLARHSAQTGIPYGLSTVATVLPETLAADIGDQGWFQMYPPKSPEVRDDMLARARAAGFHTLVLTV
DVPAASRRERQTRGGLVQPPRLTPRLLAQVATCPTWARGIADTGMPRMRLMDSYAEDLAVNLTGGPLPSTAHVGYLLRAA
PDWEYVAALRDRWESAFVLKGVCEPDVAARAQQEGVDAIWVSTHAGRQFDGAPGAAAMLPGIRAATDLPIVFDSGVEGGL
DVLRALALGADFVMMGRAWHYALGALGAEGPAHWHDVLVRDMASNMAQIGARTLADLPGRLVRD

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=378, Percent_Identity=25.9259259259259, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI7705393, Length=378, Percent_Identity=25.9259259259259, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI11068137, Length=382, Percent_Identity=26.1780104712042, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=33.9522546419098, Blast_Score=184, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI193208036, Length=380, Percent_Identity=25.7894736842105, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32566217, Length=288, Percent_Identity=26.3888888888889, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323587, Length=381, Percent_Identity=24.9343832020997, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI78707188, Length=377, Percent_Identity=28.9124668435013, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281363140, Length=377, Percent_Identity=28.9124668435013, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI78707190, Length=377, Percent_Identity=28.9124668435013, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 41324; Mature: 41324

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLHSRYPALADLRARARRRIPHFVWEYLDSATGLEAGAARNRAALEAVLFRPAALLGEV
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
SPDLGCTFLGRDYPVPFGIAPLGMSGLIWPGAERFLARHSAQTGIPYGLSTVATVLPETL
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AADIGDQGWFQMYPPKSPEVRDDMLARARAAGFHTLVLTVDVPAASRRERQTRGGLVQPP
HHHCCCCCCEEECCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHCCCCCCCC
RLTPRLLAQVATCPTWARGIADTGMPRMRLMDSYAEDLAVNLTGGPLPSTAHVGYLLRAA
CCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCC
PDWEYVAALRDRWESAFVLKGVCEPDVAARAQQEGVDAIWVSTHAGRQFDGAPGAAAMLP
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHCC
GIRAATDLPIVFDSGVEGGLDVLRALALGADFVMMGRAWHYALGALGAEGPAHWHDVLVR
CCHHHCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DMASNMAQIGARTLADLPGRLVRD
HHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MDLHSRYPALADLRARARRRIPHFVWEYLDSATGLEAGAARNRAALEAVLFRPAALLGEV
CCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCC
SPDLGCTFLGRDYPVPFGIAPLGMSGLIWPGAERFLARHSAQTGIPYGLSTVATVLPETL
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AADIGDQGWFQMYPPKSPEVRDDMLARARAAGFHTLVLTVDVPAASRRERQTRGGLVQPP
HHHCCCCCCEEECCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCHHHHHHHCCCCCCCC
RLTPRLLAQVATCPTWARGIADTGMPRMRLMDSYAEDLAVNLTGGPLPSTAHVGYLLRAA
CCCHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHCC
PDWEYVAALRDRWESAFVLKGVCEPDVAARAQQEGVDAIWVSTHAGRQFDGAPGAAAMLP
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHCC
GIRAATDLPIVFDSGVEGGLDVLRALALGADFVMMGRAWHYALGALGAEGPAHWHDVLVR
CCHHHCCCCEEECCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
DMASNMAQIGARTLADLPGRLVRD
HHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA