| Definition | Jannaschia sp. CCS1 chromosome, complete genome. |
|---|---|
| Accession | NC_007802 |
| Length | 4,317,977 |
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The map label for this gene is murE
Identifier: 89055257
GI number: 89055257
Start: 2781362
End: 2782834
Strand: Reverse
Name: murE
Synonym: Jann_2766
Alternate gene names: 89055257
Gene position: 2782834-2781362 (Counterclockwise)
Preceding gene: 89055258
Following gene: 89055256
Centisome position: 64.45
GC content: 62.25
Gene sequence:
>1473_bases ATGGCGAAACGACTATCCGATCTTGGGCTGACACCGAAATCGGGCGGCGACGTGGTGGTCTCGGACCTGGCCTTCGATAG TCGTAAGGTCCAGGCGGGCACCCTGTTTGCGGCTTTGCCCGGCACGCGGGTGCATGGTGGCGACTTTATCCAATATGCGT TGCGTATGGGCGCGGGCGCCATCTTGACCGACCGCGCCGGTGCGGAGATTGCAGCGACAGATCTGGCCGCTACCGACGCG GCCCTCGTCGTCGTGGAGGATGCGGCGGACGCTCTGGCCCATGCCGCCGCGCTATTTTTTGGTGCGCAGCCCGAGACGAT GGTCGCTGTGACGGGAACGAATGGGAAGACGTCCGTCGCCAGTTTCACGCGTCAGATCTGGGAAGCGCTTGGCGTGCCCG CCGTGAACATCGGCACCACGGGCGTTGAGGGCGCATTTGAAGCACCCGGCATCCATACTACGCCGGAGCCCGTCACTCTG CACCGGGTTCTGGCAGAGATGGGGGCGGATGGCGTGACCCATGCGGCGATGGAAGCGTCATCCCACGGGCTGGACCAAAA GCGCATGGACGGCGTGCGGCTTGCCGCGGCGGCATTTACCAACCTGACCCAGGATCATCTGGACTATCACGGAACCATGG AGGCCTATTTTGAGGCCAAACTGCGCTTGTTCACCGGGCTTCTGCCCGATGGTGGCGTAGCTGTGGTGAACCTTGACGAC GATCACGGGCTTCGCGTTGCAGAGGCATGTTCCACCCGGGGGATCGAGGTGATCGGCGTTGCGCAATATGCCGAGGCCGC GCTGAAAATTACGGGTCGGCGCATTGATGAGACGGGCCAAGACGTCCTCTTCCGGTGGCAGGGAGACGCTTGCCAGGTGC GCCTGAACCTGATCGGCGCGTTCCAGGCGATGAATGTCCTCACAGCCGCCGGTCTGGTGATCGCGGGCGGCGAAGACCCA GAGGACGTTTTTGCAGTTCTCCACAAGATGGAGGGTGTACGGGGCCGGATGCAGTTGGCCGCGCGGCGCAGTCATGGGGC CCCCATCTATGTGGATTATTCGCATACTCCTGATAGTCTAGAAGTCGCACTCAAAGCATTGCGCCCCCACGTTCTGGGCC GCCTTGTCGTTGTTTTCGGTGCTGGAGGGGATCGTGATACGGCAAAAAGACCTCTCATGGGCAACGCAGCCACCCTGTGG AGTGATGTTGCATTTGTGACAGATGATAATCCACGCACCGAAGATCCCGCAGCCATCCGTGCGGCTGTTTTGGCCGGTTG TCCGGAGGCCACGGTCGTCGCGGATCGGGCGGAGGCAATCCTACGGGCTGTGGATATGTTGGAGCCCGGCGATGCGCTTC TCATAGCCGGAAAGGGCCATGAGACGGGCCAGCAAGTGGGCGATGTCATCTACCCGTTTGACGATGTCGAACAGGCGTCG GTCGCGGTTGCCGCCCTGGAGGGCGCGATATGA
Upstream 100 bases:
>100_bases GATCATCCGCCGCACCGCGCCGCTTCTGGGCCTACGTCCAGACGTTGAACATCCCCTCGGTTTGCAGCTATCCAACTCCT CTAACTAAGGGGTGGTGCAG
Downstream 100 bases:
>100_bases TTTTGTGGACTTCGGCAGACGCGGCATCGGCCACGGGCGGCACAAGTCAGGGCACCTGGACCGCGACGGGTGTGTCCATC GACACCCGCACGATTGAGCC
Product: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase
Products: NA
Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]
Number of amino acids: Translated: 490; Mature: 489
Protein sequence:
>490_residues MAKRLSDLGLTPKSGGDVVVSDLAFDSRKVQAGTLFAALPGTRVHGGDFIQYALRMGAGAILTDRAGAEIAATDLAATDA ALVVVEDAADALAHAAALFFGAQPETMVAVTGTNGKTSVASFTRQIWEALGVPAVNIGTTGVEGAFEAPGIHTTPEPVTL HRVLAEMGADGVTHAAMEASSHGLDQKRMDGVRLAAAAFTNLTQDHLDYHGTMEAYFEAKLRLFTGLLPDGGVAVVNLDD DHGLRVAEACSTRGIEVIGVAQYAEAALKITGRRIDETGQDVLFRWQGDACQVRLNLIGAFQAMNVLTAAGLVIAGGEDP EDVFAVLHKMEGVRGRMQLAARRSHGAPIYVDYSHTPDSLEVALKALRPHVLGRLVVVFGAGGDRDTAKRPLMGNAATLW SDVAFVTDDNPRTEDPAAIRAAVLAGCPEATVVADRAEAILRAVDMLEPGDALLIAGKGHETGQQVGDVIYPFDDVEQAS VAVAALEGAI
Sequences:
>Translated_490_residues MAKRLSDLGLTPKSGGDVVVSDLAFDSRKVQAGTLFAALPGTRVHGGDFIQYALRMGAGAILTDRAGAEIAATDLAATDA ALVVVEDAADALAHAAALFFGAQPETMVAVTGTNGKTSVASFTRQIWEALGVPAVNIGTTGVEGAFEAPGIHTTPEPVTL HRVLAEMGADGVTHAAMEASSHGLDQKRMDGVRLAAAAFTNLTQDHLDYHGTMEAYFEAKLRLFTGLLPDGGVAVVNLDD DHGLRVAEACSTRGIEVIGVAQYAEAALKITGRRIDETGQDVLFRWQGDACQVRLNLIGAFQAMNVLTAAGLVIAGGEDP EDVFAVLHKMEGVRGRMQLAARRSHGAPIYVDYSHTPDSLEVALKALRPHVLGRLVVVFGAGGDRDTAKRPLMGNAATLW SDVAFVTDDNPRTEDPAAIRAAVLAGCPEATVVADRAEAILRAVDMLEPGDALLIAGKGHETGQQVGDVIYPFDDVEQAS VAVAALEGAI >Mature_489_residues AKRLSDLGLTPKSGGDVVVSDLAFDSRKVQAGTLFAALPGTRVHGGDFIQYALRMGAGAILTDRAGAEIAATDLAATDAA LVVVEDAADALAHAAALFFGAQPETMVAVTGTNGKTSVASFTRQIWEALGVPAVNIGTTGVEGAFEAPGIHTTPEPVTLH RVLAEMGADGVTHAAMEASSHGLDQKRMDGVRLAAAAFTNLTQDHLDYHGTMEAYFEAKLRLFTGLLPDGGVAVVNLDDD HGLRVAEACSTRGIEVIGVAQYAEAALKITGRRIDETGQDVLFRWQGDACQVRLNLIGAFQAMNVLTAAGLVIAGGEDPE DVFAVLHKMEGVRGRMQLAARRSHGAPIYVDYSHTPDSLEVALKALRPHVLGRLVVVFGAGGDRDTAKRPLMGNAATLWS DVAFVTDDNPRTEDPAAIRAAVLAGCPEATVVADRAEAILRAVDMLEPGDALLIAGKGHETGQQVGDVIYPFDDVEQASV AVAALEGAI
Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]
COG id: COG0769
COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family. MurE subfamily [H]
Homologues:
Organism=Escherichia coli, GI1786273, Length=486, Percent_Identity=37.2427983539095, Blast_Score=214, Evalue=1e-56, Organism=Escherichia coli, GI1786274, Length=253, Percent_Identity=28.4584980237154, Blast_Score=70, Evalue=2e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005761 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.13 [H]
Molecular weight: Translated: 51167; Mature: 51036
Theoretical pI: Translated: 4.67; Mature: 4.67
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAKRLSDLGLTPKSGGDVVVSDLAFDSRKVQAGTLFAALPGTRVHGGDFIQYALRMGAGA CCCCCHHCCCCCCCCCCEEEEEECCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHCCCE ILTDRAGAEIAATDLAATDAALVVVEDAADALAHAAALFFGAQPETMVAVTGTNGKTSVA EEECCCCCEEEEHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH SFTRQIWEALGVPAVNIGTTGVEGAFEAPGIHTTPEPVTLHRVLAEMGADGVTHAAMEAS HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH SHGLDQKRMDGVRLAAAAFTNLTQDHLDYHGTMEAYFEAKLRLFTGLLPDGGVAVVNLDD HCCCCHHHHCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECC DHGLRVAEACSTRGIEVIGVAQYAEAALKITGRRIDETGQDVLFRWQGDACQVRLNLIGA CCCCCHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEHHHHH FQAMNVLTAAGLVIAGGEDPEDVFAVLHKMEGVRGRMQLAARRSHGAPIYVDYSHTPDSL HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCCCCHHH EVALKALRPHVLGRLVVVFGAGGDRDTAKRPLMGNAATLWSDVAFVTDDNPRTEDPAAIR HHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCHHHHHHCEEEEECCCCCCCCHHHHH AAVLAGCPEATVVADRAEAILRAVDMLEPGDALLIAGKGHETGQQVGDVIYPFDDVEQAS HHHHHCCCCHHEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCEECCCCCHHHHH VAVAALEGAI HHHHHHCCCC >Mature Secondary Structure AKRLSDLGLTPKSGGDVVVSDLAFDSRKVQAGTLFAALPGTRVHGGDFIQYALRMGAGA CCCCHHCCCCCCCCCCEEEEEECCCCCEEECCEEEEECCCCCCCCHHHHHHHHHHCCCE ILTDRAGAEIAATDLAATDAALVVVEDAADALAHAAALFFGAQPETMVAVTGTNGKTSVA EEECCCCCEEEEHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHH SFTRQIWEALGVPAVNIGTTGVEGAFEAPGIHTTPEPVTLHRVLAEMGADGVTHAAMEAS HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHH SHGLDQKRMDGVRLAAAAFTNLTQDHLDYHGTMEAYFEAKLRLFTGLLPDGGVAVVNLDD HCCCCHHHHCCHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECC DHGLRVAEACSTRGIEVIGVAQYAEAALKITGRRIDETGQDVLFRWQGDACQVRLNLIGA CCCCCHHHHHCCCCEEEEEHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEEHHHHH FQAMNVLTAAGLVIAGGEDPEDVFAVLHKMEGVRGRMQLAARRSHGAPIYVDYSHTPDSL HHHHHHHHHCCEEEECCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCCCCHHH EVALKALRPHVLGRLVVVFGAGGDRDTAKRPLMGNAATLWSDVAFVTDDNPRTEDPAAIR HHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCCCHHHHHHCEEEEECCCCCCCCHHHHH AAVLAGCPEATVVADRAEAILRAVDMLEPGDALLIAGKGHETGQQVGDVIYPFDDVEQAS HHHHHCCCCHHEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHCCEECCCCCHHHHH VAVAALEGAI HHHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11259647 [H]