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The map label for this gene is murC

Identifier: 89055250

GI number: 89055250

Start: 2772964

End: 2774388

Strand: Reverse

Name: murC

Synonym: Jann_2759

Alternate gene names: 89055250

Gene position: 2774388-2772964 (Counterclockwise)

Preceding gene: 89055251

Following gene: 89055249

Centisome position: 64.25

GC content: 64.07

Gene sequence:

>1425_bases
ATGAACGCCGCCGCCACCAAATTACCGACCCAACTGGGCTCCATCCACTTTGTGGGCATCGGCGGCATCGGCATGTCGGG
CATTGCCGAGGTGCTGTTGAACCACGGCTATGATGTGCAGGGATCGGATCTGAAGGCCTCCCCCATCACTGAACGACTGG
AGCGACTGGGCGCGCGCGTTTTCGTTGGGCAACAGGCCGAGAACTTGGAGGGCGCGGAGGTTGTGGTCATCTCGTCCGCG
ATCAAGCCGGGCAATCCGGAATATGACGCGGCGCGCCTGCGCGGCCTGCCCATCGTGCGCCGGGCCGAGATGCTGGCGGA
GCTGATGCGCCTGCGCTCCAACATCGCCGTCGGCGGCACCCACGGCAAAACGACGACAACGACCATGGTGGCGACCTTGC
TCGATCATGGCGGTGTCGATCCGACGGTGATCAACGGCGGGATCATCCACGCCTACGGGTCCAACGCGCGGGTGGGGCAG
GGCGACTGGATGGTGGTGGAGGCGGACGAGTCCGATGGCACCTTCAACCGCCTGCCCGCCACGATTGCCATCGTCACCAA
TATCGACCCCGAGCATATGGAGCATTGGGGCACGATTGAGAACCTGCGTCAGGGCTTCCTCGATTTCGTCTCCAACATCC
CGTTCTACGGCCTCGCCGTTTGCTGCACCGATCACCCGGAAGTGCAAACGCTGGTTGGCAAGATCACCGACCGCCGCGTC
GTGACCTTCGGGTTCAACGCCCAGGCCGACGTCCGCGCCGTCAACCTGCACTACAGGGCGGGGGTGGCCTGCTTTGATAT
CGCGCTCCAGTCTGAGGATATCCTGATTGAGGGCTGCACCCTGCCGATGCCCGGCGATCACAACGTCTCCAACGCCCTGG
CCGCCGTTGCCGTGGCGCGGCACCTTGGCATGAAAGCCGATGAGATCCGCGAAGCGCTGGATGGGTTCAAAGGCGTGAAC
CGTCGCTTCACCAAGGTGGGCGAGGTTGGCGGGATCACGGTGATCGACGATTACGGTCACCACCCCGTGGAAATCGCCGC
GGTCTTGAAGGCGGCCCGTCAGGCCTCCGACGGCCGCGTCATTGCGGTCCACCAGCCCCATCGCTACTCGCGCCTGCACA
GCTTGTTCGATGATTTCTGCGGCTGCTTCTCGGAAGCCGACGTTGTTGCCATCGCAGAGGTTTACGCTGCAGGCGAAGAC
CCGATTGAGGGCGCGTCCCGCGATGATCTGGTGGCTGGCATGATCCGCCACGGCCATCGCCACGCCCGCGCCATTCTGGA
TGAAGACGATCTGGAGCGTCTGGTCCGCGAACAGGCGCGTCCCGGCGATATGGTGGTCTGCCTCGGTGCCGGTACGATCT
CGGCCTGGGCCAATGGATTGCCCGCCCGTCTGTCTGACCTCGACAAAACGGCTGCCACGGGATGA

Upstream 100 bases:

>100_bases
GTCTATCGCCGCGCTTTCCGTGGCCGTGCCCGACGCAACGGAACGTCTCGTGGCGCTTGTCGAAACGCTTGCCGCCCCCA
CACCACAGGAAACCTGAGCC

Downstream 100 bases:

>100_bases
GCGGCGCGCGCACCATTAAAGGACATCCCCGATGACCGGTTTGGCCACTGCCCATGGCGTGATCTCCGCATTGCGTCGGG
CCTCTCGACAGCCGAGGGCG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNAAATKLPTQLGSIHFVGIGGIGMSGIAEVLLNHGYDVQGSDLKASPITERLERLGARVFVGQQAENLEGAEVVVISSA
IKPGNPEYDAARLRGLPIVRRAEMLAELMRLRSNIAVGGTHGKTTTTTMVATLLDHGGVDPTVINGGIIHAYGSNARVGQ
GDWMVVEADESDGTFNRLPATIAIVTNIDPEHMEHWGTIENLRQGFLDFVSNIPFYGLAVCCTDHPEVQTLVGKITDRRV
VTFGFNAQADVRAVNLHYRAGVACFDIALQSEDILIEGCTLPMPGDHNVSNALAAVAVARHLGMKADEIREALDGFKGVN
RRFTKVGEVGGITVIDDYGHHPVEIAAVLKAARQASDGRVIAVHQPHRYSRLHSLFDDFCGCFSEADVVAIAEVYAAGED
PIEGASRDDLVAGMIRHGHRHARAILDEDDLERLVREQARPGDMVVCLGAGTISAWANGLPARLSDLDKTAATG

Sequences:

>Translated_474_residues
MNAAATKLPTQLGSIHFVGIGGIGMSGIAEVLLNHGYDVQGSDLKASPITERLERLGARVFVGQQAENLEGAEVVVISSA
IKPGNPEYDAARLRGLPIVRRAEMLAELMRLRSNIAVGGTHGKTTTTTMVATLLDHGGVDPTVINGGIIHAYGSNARVGQ
GDWMVVEADESDGTFNRLPATIAIVTNIDPEHMEHWGTIENLRQGFLDFVSNIPFYGLAVCCTDHPEVQTLVGKITDRRV
VTFGFNAQADVRAVNLHYRAGVACFDIALQSEDILIEGCTLPMPGDHNVSNALAAVAVARHLGMKADEIREALDGFKGVN
RRFTKVGEVGGITVIDDYGHHPVEIAAVLKAARQASDGRVIAVHQPHRYSRLHSLFDDFCGCFSEADVVAIAEVYAAGED
PIEGASRDDLVAGMIRHGHRHARAILDEDDLERLVREQARPGDMVVCLGAGTISAWANGLPARLSDLDKTAATG
>Mature_474_residues
MNAAATKLPTQLGSIHFVGIGGIGMSGIAEVLLNHGYDVQGSDLKASPITERLERLGARVFVGQQAENLEGAEVVVISSA
IKPGNPEYDAARLRGLPIVRRAEMLAELMRLRSNIAVGGTHGKTTTTTMVATLLDHGGVDPTVINGGIIHAYGSNARVGQ
GDWMVVEADESDGTFNRLPATIAIVTNIDPEHMEHWGTIENLRQGFLDFVSNIPFYGLAVCCTDHPEVQTLVGKITDRRV
VTFGFNAQADVRAVNLHYRAGVACFDIALQSEDILIEGCTLPMPGDHNVSNALAAVAVARHLGMKADEIREALDGFKGVN
RRFTKVGEVGGITVIDDYGHHPVEIAAVLKAARQASDGRVIAVHQPHRYSRLHSLFDDFCGCFSEADVVAIAEVYAAGED
PIEGASRDDLVAGMIRHGHRHARAILDEDDLERLVREQARPGDMVVCLGAGTISAWANGLPARLSDLDKTAATG

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=457, Percent_Identity=43.1072210065646, Blast_Score=311, Evalue=7e-86,
Organism=Escherichia coli, GI1790680, Length=456, Percent_Identity=28.5087719298246, Blast_Score=162, Evalue=6e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_JANSC (Q28NN6)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510701.1
- ProteinModelPortal:   Q28NN6
- SMR:   Q28NN6
- STRING:   Q28NN6
- GeneID:   3935223
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2759
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- PhylomeDB:   Q28NN6
- ProtClustDB:   PRK00421
- BioCyc:   JSP290400:JANN_2759-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50720; Mature: 50720

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAAATKLPTQLGSIHFVGIGGIGMSGIAEVLLNHGYDVQGSDLKASPITERLERLGARV
CCCCHHHCHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEE
FVGQQAENLEGAEVVVISSAIKPGNPEYDAARLRGLPIVRRAEMLAELMRLRSNIAVGGT
EECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCEEECCC
HGKTTTTTMVATLLDHGGVDPTVINGGIIHAYGSNARVGQGDWMVVEADESDGTFNRLPA
CCCCHHHHHHHHHHHCCCCCCEEECCCEEEEECCCCEECCCCEEEEEECCCCCCHHHCCE
TIAIVTNIDPEHMEHWGTIENLRQGFLDFVSNIPFYGLAVCCTDHPEVQTLVGKITDRRV
EEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCEE
VTFGFNAQADVRAVNLHYRAGVACFDIALQSEDILIEGCTLPMPGDHNVSNALAAVAVAR
EEECCCCCCCEEEEEEEECCCCEEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
HLGMKADEIREALDGFKGVNRRFTKVGEVGGITVIDDYGHHPVEIAAVLKAARQASDGRV
HHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCE
IAVHQPHRYSRLHSLFDDFCGCFSEADVVAIAEVYAAGEDPIEGASRDDLVAGMIRHGHR
EEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHH
HARAILDEDDLERLVREQARPGDMVVCLGAGTISAWANGLPARLSDLDKTAATG
HHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MNAAATKLPTQLGSIHFVGIGGIGMSGIAEVLLNHGYDVQGSDLKASPITERLERLGARV
CCCCHHHCHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEE
FVGQQAENLEGAEVVVISSAIKPGNPEYDAARLRGLPIVRRAEMLAELMRLRSNIAVGGT
EECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHCCEEECCC
HGKTTTTTMVATLLDHGGVDPTVINGGIIHAYGSNARVGQGDWMVVEADESDGTFNRLPA
CCCCHHHHHHHHHHHCCCCCCEEECCCEEEEECCCCEECCCCEEEEEECCCCCCHHHCCE
TIAIVTNIDPEHMEHWGTIENLRQGFLDFVSNIPFYGLAVCCTDHPEVQTLVGKITDRRV
EEEEEECCCHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHCCCEE
VTFGFNAQADVRAVNLHYRAGVACFDIALQSEDILIEGCTLPMPGDHNVSNALAAVAVAR
EEECCCCCCCEEEEEEEECCCCEEEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
HLGMKADEIREALDGFKGVNRRFTKVGEVGGITVIDDYGHHPVEIAAVLKAARQASDGRV
HHCCCHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCE
IAVHQPHRYSRLHSLFDDFCGCFSEADVVAIAEVYAAGEDPIEGASRDDLVAGMIRHGHR
EEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCHH
HARAILDEDDLERLVREQARPGDMVVCLGAGTISAWANGLPARLSDLDKTAATG
HHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA