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The map label for this gene is dtd

Identifier: 89055166

GI number: 89055166

Start: 2685808

End: 2686251

Strand: Direct

Name: dtd

Synonym: Jann_2675

Alternate gene names: 89055166

Gene position: 2685808-2686251 (Clockwise)

Preceding gene: 89055165

Following gene: 89055167

Centisome position: 62.2

GC content: 63.29

Gene sequence:

>444_bases
ATGAGAGCCCTGATCCAACGCGTCCACAATGCGCGGGTCGAGGTGGAGGGAGCCATTGTGGGCCAGACAGGGCCGGGCCT
TCTGATCCTGCTGTGCGCCATGGCAGGCGACACGGAGGCCGAGGCTGAAAAGCTCATCACCAAGATCACCAAGTTGCGCA
TCTTCAAGGATGAGGCGGGCAAGATGAACCGCTCGCTTCTGGACATTGGGGGCGGTGCGCTGGTGGTCAGTCAGTTTACG
CTGTCCGCCGACACGTCGCGCGGGAACAGGCCCGGTTTTTCGGCTGCGGCCCCGCCACAGGAGGGCGAGGCCCTCTACCT
ACACGCGGTCGACCTGCTGCGCGGCCACGGGGTCGCCACGCAAACGGGCCAGTTCGGCGCGGATATGGATGTGCATCTGG
TCAATGATGGCCCTGTTACCATTTGGATGGACACATCCGCATAG

Upstream 100 bases:

>100_bases
CTTGGCGTGCGTGCATCTGCCGTGACCGTCACCCGCGCGGGCGCAAATCCGCCGCGCCGGGATGAGCTGTCTTGAAAACA
CTCCACCAGCGGAGGCGGGC

Downstream 100 bases:

>100_bases
CGCCTCAATTTTAGGCAAACCTCCTTCAAGACCATGAAAATATGGTAAGAATGACTGGCCCTTTCACTCAGAGACTCATC
TGTTAGGGTCATGCGCTTGG

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MRALIQRVHNARVEVEGAIVGQTGPGLLILLCAMAGDTEAEAEKLITKITKLRIFKDEAGKMNRSLLDIGGGALVVSQFT
LSADTSRGNRPGFSAAAPPQEGEALYLHAVDLLRGHGVATQTGQFGADMDVHLVNDGPVTIWMDTSA

Sequences:

>Translated_147_residues
MRALIQRVHNARVEVEGAIVGQTGPGLLILLCAMAGDTEAEAEKLITKITKLRIFKDEAGKMNRSLLDIGGGALVVSQFT
LSADTSRGNRPGFSAAAPPQEGEALYLHAVDLLRGHGVATQTGQFGADMDVHLVNDGPVTIWMDTSA
>Mature_147_residues
MRALIQRVHNARVEVEGAIVGQTGPGLLILLCAMAGDTEAEAEKLITKITKLRIFKDEAGKMNRSLLDIGGGALVVSQFT
LSADTSRGNRPGFSAAAPPQEGEALYLHAVDLLRGHGVATQTGQFGADMDVHLVNDGPVTIWMDTSA

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=150, Percent_Identity=40, Blast_Score=105, Evalue=2e-23,
Organism=Escherichia coli, GI1790320, Length=143, Percent_Identity=53.1468531468531, Blast_Score=149, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI115533292, Length=149, Percent_Identity=36.241610738255, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=35.1351351351351, Blast_Score=92, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281361569, Length=147, Percent_Identity=42.1768707482993, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_JANSC (Q28NX0)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510617.1
- HSSP:   O66742
- ProteinModelPortal:   Q28NX0
- SMR:   Q28NX0
- STRING:   Q28NX0
- GeneID:   3935139
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2675
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q28NX0
- ProtClustDB:   PRK05273
- BioCyc:   JSP290400:JANN_2675-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15523; Mature: 15523

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALIQRVHNARVEVEGAIVGQTGPGLLILLCAMAGDTEAEAEKLITKITKLRIFKDEAG
CHHHHHHHHCCEEEEEEEEEECCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHEEECCCCC
KMNRSLLDIGGGALVVSQFTLSADTSRGNRPGFSAAAPPQEGEALYLHAVDLLRGHGVAT
CCCCCEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHCCCCCC
QTGQFGADMDVHLVNDGPVTIWMDTSA
CCCCCCCCEEEEEECCCCEEEEEECCC
>Mature Secondary Structure
MRALIQRVHNARVEVEGAIVGQTGPGLLILLCAMAGDTEAEAEKLITKITKLRIFKDEAG
CHHHHHHHHCCEEEEEEEEEECCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHEEECCCCC
KMNRSLLDIGGGALVVSQFTLSADTSRGNRPGFSAAAPPQEGEALYLHAVDLLRGHGVAT
CCCCCEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHCCCCCC
QTGQFGADMDVHLVNDGPVTIWMDTSA
CCCCCCCCEEEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA