BacMap

Definition	Jannaschia sp. CCS1 chromosome, complete genome.
Accession	NC_007802
Length	4,317,977

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The map label for this gene is ccmA

Identifier: 89055138

GI number: 89055138

Start: 2661960

End: 2662595

Strand: Direct

Name: ccmA

Synonym: Jann_2647

Alternate gene names: 89055138

Gene position: 2661960-2662595 (Clockwise)

Preceding gene: 89055134

Following gene: 89055139

Centisome position: 61.65

GC content: 67.3

Gene sequence:

>636_bases
ATGGTCCTGACCGTCACTGATCTCGCCTGCGCCCGTGGGCCCGCGCAAGTCCTTTCGGGCGTTTCATTTTCCGTGTCGGC
GGGTGAGGCGCTGATCCTGCGCGGCCCAAATGGCGCGGGCAAGACGACACTCCTGCGGACGTTGGCGGGGCTGACCCCGC
CTCTCGCCGGGACGATATCCCACGCCGAGGACGCCATCGCCTACGCCGCCCATGCCGATGGGCTGAAAGCGCAACTCACC
GTGGCTGAGAACCTCACCTTCTGGGCGACGATCTTCGGCACCCTGGATATTGCCCCCGCCATCGCGGCCTTTGCCCTCGC
CCCCCTCGCCGACCGCCCCGCCGGGGAGCTTTCTGCCGGACAAAAACGCCGCCTGTCTCTGGCGCGGCTTCTGGTGACGG
GCCGTCCCATCTGGGCGCTGGATGAACCGACCGTGTCGCTCGACACCGAAAACACCGCGCGATTTGCCGCGGCTGTTGAG
GCACATCTGCGCGCAGGCGGCGCCGCGATCATCGCCACTCATATCGACCTGGGCCTGCCCAATGCGCGCAGTCTCGACAT
CACGCCCTTCATCGCCAAGGGGTTGCCCGCGTCCGATCCGTTCGCCGACGATCCATTTCTTGGGGCGGCCCTGTGA

Upstream 100 bases:

>100_bases
TCAGGCCGCTCCTCCGCAAGATGCGTCCTCGCGGCCTTGCCGATGCAGCAGATGTTGCGCCCCCTTCCCCCCCTCTGGCA
AACCCGTTACCGATTTGACC

Downstream 100 bases:

>100_bases
TCGGCTTGCTGAAACGGGACCTCGCGCTTGCCCTGCGCGCGGGGGGCGGGTTCGGGCTGAGCCTCGCCTTCTTCCTGATC
TTCACCGCGCTGGTGCCCTT

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MVLTVTDLACARGPAQVLSGVSFSVSAGEALILRGPNGAGKTTLLRTLAGLTPPLAGTISHAEDAIAYAAHADGLKAQLT
VAENLTFWATIFGTLDIAPAIAAFALAPLADRPAGELSAGQKRRLSLARLLVTGRPIWALDEPTVSLDTENTARFAAAVE
AHLRAGGAAIIATHIDLGLPNARSLDITPFIAKGLPASDPFADDPFLGAAL

Sequences:

>Translated_211_residues
MVLTVTDLACARGPAQVLSGVSFSVSAGEALILRGPNGAGKTTLLRTLAGLTPPLAGTISHAEDAIAYAAHADGLKAQLT
VAENLTFWATIFGTLDIAPAIAAFALAPLADRPAGELSAGQKRRLSLARLLVTGRPIWALDEPTVSLDTENTARFAAAVE
AHLRAGGAAIIATHIDLGLPNARSLDITPFIAKGLPASDPFADDPFLGAAL
>Mature_211_residues
MVLTVTDLACARGPAQVLSGVSFSVSAGEALILRGPNGAGKTTLLRTLAGLTPPLAGTISHAEDAIAYAAHADGLKAQLT
VAENLTFWATIFGTLDIAPAIAAFALAPLADRPAGELSAGQKRRLSLARLLVTGRPIWALDEPTVSLDTENTARFAAAVE
AHLRAGGAAIIATHIDLGLPNARSLDITPFIAKGLPASDPFADDPFLGAAL

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI27436953, Length=173, Percent_Identity=30.635838150289, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI27881501, Length=176, Percent_Identity=28.4090909090909, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI30795238, Length=176, Percent_Identity=28.4090909090909, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI6005701, Length=169, Percent_Identity=33.1360946745562, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI46592964, Length=179, Percent_Identity=30.7262569832402, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI46592971, Length=179, Percent_Identity=30.7262569832402, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI46592978, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI46592915, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592898, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI27477115, Length=158, Percent_Identity=30.379746835443, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592956, Length=179, Percent_Identity=30.7262569832402, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI105990541, Length=171, Percent_Identity=30.9941520467836, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI27262624, Length=153, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27262626, Length=153, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI153792144, Length=167, Percent_Identity=29.3413173652695, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI4505771, Length=188, Percent_Identity=29.2553191489362, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI9961252, Length=188, Percent_Identity=29.2553191489362, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082064, Length=198, Percent_Identity=36.3636363636364, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1788761, Length=170, Percent_Identity=32.3529411764706, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI2367384, Length=184, Percent_Identity=32.6086956521739, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI87081782, Length=210, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790739, Length=216, Percent_Identity=28.7037037037037, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786698, Length=193, Percent_Identity=31.6062176165803, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788165, Length=189, Percent_Identity=30.1587301587302, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1787089, Length=199, Percent_Identity=28.1407035175879, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790467, Length=191, Percent_Identity=28.7958115183246, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI87081709, Length=152, Percent_Identity=28.2894736842105, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1789593, Length=191, Percent_Identity=29.8429319371728, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787772, Length=172, Percent_Identity=33.1395348837209, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787029, Length=208, Percent_Identity=27.8846153846154, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1786253, Length=146, Percent_Identity=35.6164383561644, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI87082267, Length=179, Percent_Identity=27.9329608938547, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1790190, Length=183, Percent_Identity=28.9617486338798, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI48994943, Length=170, Percent_Identity=29.4117647058824, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1787370, Length=183, Percent_Identity=28.9617486338798, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI87081834, Length=215, Percent_Identity=29.3023255813954, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786563, Length=160, Percent_Identity=30, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1787792, Length=199, Percent_Identity=28.1407035175879, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1789873, Length=193, Percent_Identity=30.5699481865285, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788644, Length=225, Percent_Identity=27.1111111111111, Blast_Score=60, Evalue=8e-11,
Organism=Escherichia coli, GI1786345, Length=210, Percent_Identity=29.5238095238095, Blast_Score=60, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI115533608, Length=193, Percent_Identity=31.0880829015544, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565586, Length=153, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221500365, Length=171, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI116007184, Length=171, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19920532, Length=179, Percent_Identity=30.1675977653631, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24580930, Length=179, Percent_Identity=30.1675977653631, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI85816269, Length=190, Percent_Identity=32.1052631578947, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24580553, Length=190, Percent_Identity=32.1052631578947, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI85724864, Length=190, Percent_Identity=32.1052631578947, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24580555, Length=190, Percent_Identity=32.1052631578947, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24666836, Length=168, Percent_Identity=32.1428571428571, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076682, Length=199, Percent_Identity=31.1557788944724, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076684, Length=199, Percent_Identity=31.1557788944724, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581617, Length=199, Percent_Identity=31.1557788944724, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24581615, Length=199, Percent_Identity=31.1557788944724, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA_JANSC (Q28NZ8)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510589.1
- ProteinModelPortal:   Q28NZ8
- SMR:   Q28NZ8
- STRING:   Q28NZ8
- GeneID:   3935111
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2647
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   SARRGED
- PhylomeDB:   Q28NZ8
- ProtClustDB:   PRK13539
- BioCyc:   JSP290400:JANN_2647-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 21548; Mature: 21548

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLTVTDLACARGPAQVLSGVSFSVSAGEALILRGPNGAGKTTLLRTLAGLTPPLAGTIS
CEEEEEHHHHCCCHHHHHCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHH
HAEDAIAYAAHADGLKAQLTVAENLTFWATIFGTLDIAPAIAAFALAPLADRPAGELSAG
HHHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
QKRRLSLARLLVTGRPIWALDEPTVSLDTENTARFAAAVEAHLRAGGAAIIATHIDLGLP
HHHHHHHHHHHHCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCC
NARSLDITPFIAKGLPASDPFADDPFLGAAL
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVLTVTDLACARGPAQVLSGVSFSVSAGEALILRGPNGAGKTTLLRTLAGLTPPLAGTIS
CEEEEEHHHHCCCHHHHHCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHH
HAEDAIAYAAHADGLKAQLTVAENLTFWATIFGTLDIAPAIAAFALAPLADRPAGELSAG
HHHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
QKRRLSLARLLVTGRPIWALDEPTVSLDTENTARFAAAVEAHLRAGGAAIIATHIDLGLP
HHHHHHHHHHHHCCCCEEEECCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCC
NARSLDITPFIAKGLPASDPFADDPFLGAAL
CCCCCCCCHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA