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The map label for this gene is lpxA [H]

Identifier: 89054941

GI number: 89054941

Start: 2442767

End: 2443573

Strand: Reverse

Name: lpxA [H]

Synonym: Jann_2450

Alternate gene names: 89054941

Gene position: 2443573-2442767 (Counterclockwise)

Preceding gene: 89054942

Following gene: 89054940

Centisome position: 56.59

GC content: 64.19

Gene sequence:

>807_bases
ATGGCGATCCACGCCTCCGCCCAGATCCACCCCTCCGCCGTGATCGAGGAGGGGGCCGTGATCGGCGCGAACTGCCAGAT
CGGCCCGTTCTGCCTTGTCGGGCCGGAGGTCACGCTTGGCGAGGGTGTGGTGATGAAATCCCACGCTATCATCACCGGCT
GGACCGATATCGGCGATGAATGTGAGCTGTATCCCTTCACCAATATCGGCGACATCCCCCAGGACAAGAAGTTCGGCGGC
GAACGCACGCGCCTGATCGTGGGCAAACGCAACCGCATCCGCGAAGGCGTCACGATGAACACCGGGACGGAGGGCGGCGG
TGGTCTGACAACGGTCGGCGATGACGGTCTGTTTCTGGCCAATTCCCATGTGGCCCATGATTGTCAGGTCGGTGACCGGG
TCATCATGGTCAATTCCAGCGCGCTTGCGGGCCATTGCATTGTGGGCGACGATGTAATCATCGGCGGGCTCTCGGGCGTG
CATCAATTCGTCCGTCTGGGGCGCGGCGCGATCATCGGGGCGGTCACGATGGTGACCAATGACGTCATCCCCTACGGCCT
TGTGCAGGCCCCGCGCGGGCGGCTCGACGGGCTGAACCTTGTGGGTCTCAAGCGCCGGGGCGTCGCCAAATCGGACATCA
CGGCATTGCGTGCGGCGCTTCAGGCGCTCAAACAGGGCGAGGGGGCCAGCTTTCAGGACCGCGCGCGCCGTCTGGGCGAA
AGCGATGACATCGACAGCGATTATGTGCGCGAGATCGTGGCCTTCGTTCTGGGCGACAGCGACCGCTCCTACCTGACGCC
GGAGTAG

Upstream 100 bases:

>100_bases
GTTCGATGGTCGTGCGGAGGTCGATGGAGAGCTGGCCTGCGAATGCTCCTTCACCGCGATGATGGACCTTCCGACGTCCC
CCCCCGGGGAGGCTGGGTGA

Downstream 100 bases:

>100_bases
ATCCATGCGCGCGATCCTTGCAGGCACAGGCGCGTTGCCGGGGCTGCTGTTGCAGGCCGATGAGGCGCGGGTTGTGGGAT
TCAAAGGGGTGCCCGTGGGC

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MAIHASAQIHPSAVIEEGAVIGANCQIGPFCLVGPEVTLGEGVVMKSHAIITGWTDIGDECELYPFTNIGDIPQDKKFGG
ERTRLIVGKRNRIREGVTMNTGTEGGGGLTTVGDDGLFLANSHVAHDCQVGDRVIMVNSSALAGHCIVGDDVIIGGLSGV
HQFVRLGRGAIIGAVTMVTNDVIPYGLVQAPRGRLDGLNLVGLKRRGVAKSDITALRAALQALKQGEGASFQDRARRLGE
SDDIDSDYVREIVAFVLGDSDRSYLTPE

Sequences:

>Translated_268_residues
MAIHASAQIHPSAVIEEGAVIGANCQIGPFCLVGPEVTLGEGVVMKSHAIITGWTDIGDECELYPFTNIGDIPQDKKFGG
ERTRLIVGKRNRIREGVTMNTGTEGGGGLTTVGDDGLFLANSHVAHDCQVGDRVIMVNSSALAGHCIVGDDVIIGGLSGV
HQFVRLGRGAIIGAVTMVTNDVIPYGLVQAPRGRLDGLNLVGLKRRGVAKSDITALRAALQALKQGEGASFQDRARRLGE
SDDIDSDYVREIVAFVLGDSDRSYLTPE
>Mature_267_residues
AIHASAQIHPSAVIEEGAVIGANCQIGPFCLVGPEVTLGEGVVMKSHAIITGWTDIGDECELYPFTNIGDIPQDKKFGGE
RTRLIVGKRNRIREGVTMNTGTEGGGGLTTVGDDGLFLANSHVAHDCQVGDRVIMVNSSALAGHCIVGDDVIIGGLSGVH
QFVRLGRGAIIGAVTMVTNDVIPYGLVQAPRGRLDGLNLVGLKRRGVAKSDITALRAALQALKQGEGASFQDRARRLGES
DDIDSDYVREIVAFVLGDSDRSYLTPE

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=223, Percent_Identity=50.2242152466368, Blast_Score=232, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28274; Mature: 28142

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIHASAQIHPSAVIEEGAVIGANCQIGPFCLVGPEVTLGEGVVMKSHAIITGWTDIGDE
CEECCCCCCCHHHHHCCCCEEECCCCCCCEEEECCCEECCCCEEEECCEEEEECCCCCCC
CELYPFTNIGDIPQDKKFGGERTRLIVGKRNRIREGVTMNTGTEGGGGLTTVGDDGLFLA
CEEEECCCCCCCCCCCCCCCCEEEEEEECCHHHHCCCEECCCCCCCCCEEEECCCCEEEE
NSHVAHDCQVGDRVIMVNSSALAGHCIVGDDVIIGGLSGVHQFVRLGRGAIIGAVTMVTN
CCCCCCCCCCCCEEEEEECCCCCCEEEECCCEEECCHHHHHHHHHHCCCHHEEHHHHHHC
DVIPYGLVQAPRGRLDGLNLVGLKRRGVAKSDITALRAALQALKQGEGASFQDRARRLGE
CCCCCCCEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
SDDIDSDYVREIVAFVLGDSDRSYLTPE
CCCCCHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AIHASAQIHPSAVIEEGAVIGANCQIGPFCLVGPEVTLGEGVVMKSHAIITGWTDIGDE
EECCCCCCCHHHHHCCCCEEECCCCCCCEEEECCCEECCCCEEEECCEEEEECCCCCCC
CELYPFTNIGDIPQDKKFGGERTRLIVGKRNRIREGVTMNTGTEGGGGLTTVGDDGLFLA
CEEEECCCCCCCCCCCCCCCCEEEEEEECCHHHHCCCEECCCCCCCCCEEEECCCCEEEE
NSHVAHDCQVGDRVIMVNSSALAGHCIVGDDVIIGGLSGVHQFVRLGRGAIIGAVTMVTN
CCCCCCCCCCCCEEEEEECCCCCCEEEECCCEEECCHHHHHHHHHHCCCHHEEHHHHHHC
DVIPYGLVQAPRGRLDGLNLVGLKRRGVAKSDITALRAALQALKQGEGASFQDRARRLGE
CCCCCCCEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCC
SDDIDSDYVREIVAFVLGDSDRSYLTPE
CCCCCHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA