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The map label for this gene is gmk

Identifier: 89054931

GI number: 89054931

Start: 2432132

End: 2432788

Strand: Reverse

Name: gmk

Synonym: Jann_2440

Alternate gene names: 89054931

Gene position: 2432788-2432132 (Counterclockwise)

Preceding gene: 89054932

Following gene: 89054930

Centisome position: 56.34

GC content: 60.88

Gene sequence:

>657_bases
ATGACGATGTCTGATTTGAGACGGCGTGGCCTTCTGATTATCCTGTCCTCACCATCGGGTGCGGGCAAATCGACCCTCGC
GCGGCGCTTGATGGCCTGGGACGAGACGCTGAGTTTCTCCGTCTCGGCCACGACGCGCCAAGCCCGGCCCGGCGAGGAAG
ACGGAGTTCACTACCGCTTCTTGCCGGAGGCGGAGTTCAAATCCCTCGTTTCGAGCGGCCAGATGCTGGAGCACGCCCAT
GTCTTCGGCAACTTCTACGGCTCCCCCATGGCACCGGTGTCCCAGGCGATCGAGGCCGGGCATGATGTGTTGTTCGACAT
CGACTGGCAGGGCGCCCAACAGATCCGCAATTCTGACCTGGGCAAGCACACGCTGTCGATCTTCATCCTGCCCCCCTCGA
TCCCCGAGCTGAAACGGCGGTTGGAAAGCCGCGCCCAGGACAGCGACGATGTGATCGAGAAGCGGATGCGCAAAAGCTGG
GATGAGATCAGCCGCTGGGACGCCTATGATTACGTCTTGGTTAACGATGATCTGTCCGTCACCGAAGAGCGCCTGAAAAC
CATCATCACCGCGGAGCGGTTGCGCCGGGAACAGCAGCCCGCCCTGCAAACCCATGTGCGGGCGCTGCAAACGGAATTTG
AGGATTTGGAGCAATGA

Upstream 100 bases:

>100_bases
ACACGCTCTGCGCCAAATCGTCCGACACCGCGCTGACGGCCATTGGCCTTGACCTGAAACTGACCATAGATCAGATGCGC
GAGCAGGTGCAAAATGTGGA

Downstream 100 bases:

>100_bases
TTTATGCACTCGACGGCGTCGCGCCCGACATCGAAGACGACACATGGGTCGCGCCCGATGCCAATGTCATCGGCCATGTG
GTGCTGGAGACGGGCGCGAG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MTMSDLRRRGLLIILSSPSGAGKSTLARRLMAWDETLSFSVSATTRQARPGEEDGVHYRFLPEAEFKSLVSSGQMLEHAH
VFGNFYGSPMAPVSQAIEAGHDVLFDIDWQGAQQIRNSDLGKHTLSIFILPPSIPELKRRLESRAQDSDDVIEKRMRKSW
DEISRWDAYDYVLVNDDLSVTEERLKTIITAERLRREQQPALQTHVRALQTEFEDLEQ

Sequences:

>Translated_218_residues
MTMSDLRRRGLLIILSSPSGAGKSTLARRLMAWDETLSFSVSATTRQARPGEEDGVHYRFLPEAEFKSLVSSGQMLEHAH
VFGNFYGSPMAPVSQAIEAGHDVLFDIDWQGAQQIRNSDLGKHTLSIFILPPSIPELKRRLESRAQDSDDVIEKRMRKSW
DEISRWDAYDYVLVNDDLSVTEERLKTIITAERLRREQQPALQTHVRALQTEFEDLEQ
>Mature_217_residues
TMSDLRRRGLLIILSSPSGAGKSTLARRLMAWDETLSFSVSATTRQARPGEEDGVHYRFLPEAEFKSLVSSGQMLEHAHV
FGNFYGSPMAPVSQAIEAGHDVLFDIDWQGAQQIRNSDLGKHTLSIFILPPSIPELKRRLESRAQDSDDVIEKRMRKSWD
EISRWDAYDYVLVNDDLSVTEERLKTIITAERLRREQQPALQTHVRALQTEFEDLEQ

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=185, Percent_Identity=35.1351351351351, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4504221, Length=185, Percent_Identity=35.1351351351351, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI226874831, Length=185, Percent_Identity=35.1351351351351, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI21361598, Length=206, Percent_Identity=26.2135922330097, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI52630447, Length=206, Percent_Identity=27.1844660194175, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=29.8913043478261, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI14780902, Length=183, Percent_Identity=26.2295081967213, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790080, Length=195, Percent_Identity=51.7948717948718, Blast_Score=187, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI193203132, Length=171, Percent_Identity=36.8421052631579, Blast_Score=114, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=171, Percent_Identity=36.8421052631579, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=28.1767955801105, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=40.5405405405405, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI21356141, Length=198, Percent_Identity=33.8383838383838, Blast_Score=123, Evalue=8e-29,
Organism=Drosophila melanogaster, GI116007136, Length=197, Percent_Identity=26.3959390862944, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85724806, Length=189, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554481, Length=197, Percent_Identity=26.3959390862944, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640542, Length=189, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554489, Length=189, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161077626, Length=189, Percent_Identity=25.9259259259259, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI221330164, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330166, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221330162, Length=198, Percent_Identity=29.2929292929293, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_JANSC (Q28PK5)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510382.1
- ProteinModelPortal:   Q28PK5
- STRING:   Q28PK5
- GeneID:   3934897
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2440
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q28PK5
- ProtClustDB:   PRK00300
- BioCyc:   JSP290400:JANN_2440-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24900; Mature: 24769

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMSDLRRRGLLIILSSPSGAGKSTLARRLMAWDETLSFSVSATTRQARPGEEDGVHYRF
CCHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEE
LPEAEFKSLVSSGQMLEHAHVFGNFYGSPMAPVSQAIEAGHDVLFDIDWQGAQQIRNSDL
CCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCCC
GKHTLSIFILPPSIPELKRRLESRAQDSDDVIEKRMRKSWDEISRWDAYDYVLVNDDLSV
CCEEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
TEERLKTIITAERLRREQQPALQTHVRALQTEFEDLEQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TMSDLRRRGLLIILSSPSGAGKSTLARRLMAWDETLSFSVSATTRQARPGEEDGVHYRF
CHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEEEEE
LPEAEFKSLVSSGQMLEHAHVFGNFYGSPMAPVSQAIEAGHDVLFDIDWQGAQQIRNSDL
CCCHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHCCC
GKHTLSIFILPPSIPELKRRLESRAQDSDDVIEKRMRKSWDEISRWDAYDYVLVNDDLSV
CCEEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
TEERLKTIITAERLRREQQPALQTHVRALQTEFEDLEQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA