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The map label for this gene is icd [H]

Identifier: 89054863

GI number: 89054863

Start: 2377744

End: 2378958

Strand: Direct

Name: icd [H]

Synonym: Jann_2372

Alternate gene names: 89054863

Gene position: 2377744-2378958 (Clockwise)

Preceding gene: 89054862

Following gene: 89054864

Centisome position: 55.07

GC content: 58.85

Gene sequence:

>1215_bases
ATGACCAAAATCAAAGTAGACAACCCCATTGTCGAGATGGACGGCGACGAGATGACCCGCATCATCTGGCAGTTCATCAA
GGACAAGCTGATCCTGCCCTATCTCGACATTGACCTGCTCTACTACGATCTGGGCATTGAGGAGCGCGACCGCACCGAGG
ACCAGATCACAATCGACGCGGCCGAGAAAACGCTTGAAGTGGGCGTTGCCGTCAAATGTGCCACCATCACGCCCGATGAG
GCGCGGGTGGAGGAATTCGGCCTCAAGAAGATGTGGCGCTCGCCCAACGGGACGATCCGTAACATCCTCGGCGGGGTGAT
CTTTCGCCAGCCGATCATCTGCAAAAACGTCCCCCGCCTTGTGCCCGGCTGGACCCAGCCCATCGTCGTGGGTCGCCATG
CCTTTGGCGACCAGTATAAAGCCACCGACATGAAGTTCCCCGGCGCGGGCACGCTGACGATGAAATTCACCGGTGAAGAC
GGCACCGAGATCGAGCATGAGGTCTACAAGGCCGACGGCGCGGGCGTATTCATGTCGATGTATAATATCGACGCCTCCAT
CTATGACTTCGCGCGCGCGTCGTTCAACTATGGCCTGAACCTGGGCTGGCCCGTTTACCTCTCCACCAAAAATACCATTC
TGAAACAATACGATGGCCGCTTCCTTGAGATCTTCTCCGAAGTCTATGAGGCCGAGTTCAAGGAGGCGTTCGAGGAAAAG
AAGATCTGGTACGAACACCGCCTCATCGACGACATGGTCGCCTGTGCGATCAAGTGGAACGGCGGCTTTGTCTGGGCCTG
CAAGAATTACGACGGTGACGTACAGTCGGACGTTGTGGCGCAGGGCTTTGGCTCGCTCGGGATGATGGCCAGCCAGTTGA
TGACGCCCGACGGCAAGATCGTGGAATCGGAGGCCGCCCACGGCACCGTCACCCGTCACTACCGCAATCATCAGGAGGGG
AAGGCCACCTCCACCAACTCCATCGCCTCGATCTATGCCTGGACCGGCGGCCTGAAGCACCGCGCCAAGCTGGATGACAA
TGCGAAGCTGGCCGAATTCGCCGAAACGCTGGAGCGGGTGATCATCGAGACCGTGGAATCCGGGTTCATGACCAAGGACC
TCGCGCTTCTGGTGGGGCCGGATCAAAGCTGGCTGACGACCATGGGGTTCCTGGAGAAGATCGACGAGAACCTCAGCAAG
GCGCTGGCGGGCTAG

Upstream 100 bases:

>100_bases
CGCACCGCGACCCGCCGATGCGCGGCTTGTATCTTGCCTCCATCCCCACACTCGGTTCTAACCGGGTACACCCCAGACGC
GACCGAACAGGACCGCCCGT

Downstream 100 bases:

>100_bases
GGCAAGTCCGGCATTCCGCCAGTTGCGAACCCAACCGCGGTCGGTCTACTGGCCCTGTTCGGCGGGCGGCTTGCCCTCAT
GATCAGGAGCGGGCGCATGT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MTKIKVDNPIVEMDGDEMTRIIWQFIKDKLILPYLDIDLLYYDLGIEERDRTEDQITIDAAEKTLEVGVAVKCATITPDE
ARVEEFGLKKMWRSPNGTIRNILGGVIFRQPIICKNVPRLVPGWTQPIVVGRHAFGDQYKATDMKFPGAGTLTMKFTGED
GTEIEHEVYKADGAGVFMSMYNIDASIYDFARASFNYGLNLGWPVYLSTKNTILKQYDGRFLEIFSEVYEAEFKEAFEEK
KIWYEHRLIDDMVACAIKWNGGFVWACKNYDGDVQSDVVAQGFGSLGMMASQLMTPDGKIVESEAAHGTVTRHYRNHQEG
KATSTNSIASIYAWTGGLKHRAKLDDNAKLAEFAETLERVIIETVESGFMTKDLALLVGPDQSWLTTMGFLEKIDENLSK
ALAG

Sequences:

>Translated_404_residues
MTKIKVDNPIVEMDGDEMTRIIWQFIKDKLILPYLDIDLLYYDLGIEERDRTEDQITIDAAEKTLEVGVAVKCATITPDE
ARVEEFGLKKMWRSPNGTIRNILGGVIFRQPIICKNVPRLVPGWTQPIVVGRHAFGDQYKATDMKFPGAGTLTMKFTGED
GTEIEHEVYKADGAGVFMSMYNIDASIYDFARASFNYGLNLGWPVYLSTKNTILKQYDGRFLEIFSEVYEAEFKEAFEEK
KIWYEHRLIDDMVACAIKWNGGFVWACKNYDGDVQSDVVAQGFGSLGMMASQLMTPDGKIVESEAAHGTVTRHYRNHQEG
KATSTNSIASIYAWTGGLKHRAKLDDNAKLAEFAETLERVIIETVESGFMTKDLALLVGPDQSWLTTMGFLEKIDENLSK
ALAG
>Mature_403_residues
TKIKVDNPIVEMDGDEMTRIIWQFIKDKLILPYLDIDLLYYDLGIEERDRTEDQITIDAAEKTLEVGVAVKCATITPDEA
RVEEFGLKKMWRSPNGTIRNILGGVIFRQPIICKNVPRLVPGWTQPIVVGRHAFGDQYKATDMKFPGAGTLTMKFTGEDG
TEIEHEVYKADGAGVFMSMYNIDASIYDFARASFNYGLNLGWPVYLSTKNTILKQYDGRFLEIFSEVYEAEFKEAFEEKK
IWYEHRLIDDMVACAIKWNGGFVWACKNYDGDVQSDVVAQGFGSLGMMASQLMTPDGKIVESEAAHGTVTRHYRNHQEGK
ATSTNSIASIYAWTGGLKHRAKLDDNAKLAEFAETLERVIIETVESGFMTKDLALLVGPDQSWLTTMGFLEKIDENLSKA
LAG

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=64.7058823529412, Blast_Score=552, Evalue=1e-157,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=63.1707317073171, Blast_Score=536, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=62.6535626535627, Blast_Score=544, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17540874, Length=405, Percent_Identity=66.1728395061728, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6323203, Length=405, Percent_Identity=60.2469135802469, Blast_Score=509, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6320137, Length=407, Percent_Identity=60.1965601965602, Blast_Score=503, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=58.968058968059, Blast_Score=503, Evalue=1e-143,
Organism=Drosophila melanogaster, GI21356561, Length=407, Percent_Identity=62.1621621621622, Blast_Score=523, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221330987, Length=407, Percent_Identity=62.1621621621622, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI221330985, Length=407, Percent_Identity=62.1621621621622, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI28574947, Length=407, Percent_Identity=62.1621621621622, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24660849, Length=407, Percent_Identity=62.1621621621622, Blast_Score=523, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24660856, Length=407, Percent_Identity=62.1621621621622, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24660868, Length=407, Percent_Identity=62.1621621621622, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI24660860, Length=407, Percent_Identity=62.1621621621622, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI221330983, Length=407, Percent_Identity=62.1621621621622, Blast_Score=521, Evalue=1e-148,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45448; Mature: 45317

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIKVDNPIVEMDGDEMTRIIWQFIKDKLILPYLDIDLLYYDLGIEERDRTEDQITIDA
CCEEECCCCEEEECCHHHHHHHHHHHHCCEECCEECEEEEEEECCCCCCCCCCCEEEEEH
AEKTLEVGVAVKCATITPDEARVEEFGLKKMWRSPNGTIRNILGGVIFRQPIICKNVPRL
HHHHHEECEEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYKATDMKFPGAGTLTMKFTGEDGTEIEHEVYKADGAGVFMSM
CCCCCCCEEEECHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCEEEEEE
YNIDASIYDFARASFNYGLNLGWPVYLSTKNTILKQYDGRFLEIFSEVYEAEFKEAFEEK
ECCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
KIWYEHRLIDDMVACAIKWNGGFVWACKNYDGDVQSDVVAQGFGSLGMMASQLMTPDGKI
HHHHHHHHHHHHHEEEEEECCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VESEAAHGTVTRHYRNHQEGKATSTNSIASIYAWTGGLKHRAKLDDNAKLAEFAETLERV
EECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
IIETVESGFMTKDLALLVGPDQSWLTTMGFLEKIDENLSKALAG
HHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKIKVDNPIVEMDGDEMTRIIWQFIKDKLILPYLDIDLLYYDLGIEERDRTEDQITIDA
CEEECCCCEEEECCHHHHHHHHHHHHCCEECCEECEEEEEEECCCCCCCCCCCEEEEEH
AEKTLEVGVAVKCATITPDEARVEEFGLKKMWRSPNGTIRNILGGVIFRQPIICKNVPRL
HHHHHEECEEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIVVGRHAFGDQYKATDMKFPGAGTLTMKFTGEDGTEIEHEVYKADGAGVFMSM
CCCCCCCEEEECHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCEEEEEE
YNIDASIYDFARASFNYGLNLGWPVYLSTKNTILKQYDGRFLEIFSEVYEAEFKEAFEEK
ECCCHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
KIWYEHRLIDDMVACAIKWNGGFVWACKNYDGDVQSDVVAQGFGSLGMMASQLMTPDGKI
HHHHHHHHHHHHHEEEEEECCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCCE
VESEAAHGTVTRHYRNHQEGKATSTNSIASIYAWTGGLKHRAKLDDNAKLAEFAETLERV
EECCCCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHH
IIETVESGFMTKDLALLVGPDQSWLTTMGFLEKIDENLSKALAG
HHHHHHCCCCEECEEEEECCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]