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The map label for this gene is csd [H]

Identifier: 89054846

GI number: 89054846

Start: 2360983

End: 2362206

Strand: Reverse

Name: csd [H]

Synonym: Jann_2355

Alternate gene names: 89054846

Gene position: 2362206-2360983 (Counterclockwise)

Preceding gene: 89054847

Following gene: 89054841

Centisome position: 54.71

GC content: 61.19

Gene sequence:

>1224_bases
ATGAGCTATGACGTACAGGCGATCCGAGCCGATTTCCCAATCCTGTCGCGTGAGGTGAACGGCAAGCCGCTCGTCTACCT
CGACAATGGGGCATCGGCCCAGAAGCCGCAGGTGGTGATCGATGCGATCACCCAGGCCTATTCCCAGGAATATGCCAATG
TGCACAGGGGGTTGCATTACCTCAGCACACTGGCGACCGAAAAGTATGAGGGCACGCGCGGCACCATCGCGCGGTTTCTC
GGCGCGAAGAATGAGGACGAGATTGTCTTTACGTCCGGCACCACGGAGGCGATCAATCTGGTGGCATATGCCTGGGCCAT
GCCCCGGATGGAGGCGGGTGATGAGATCATCCTGACCATTGCCGAGCATCACGCCAACATCGTCCCCTGGCATTTCCTGC
GGGAACGTCAGGGCGTGAAACTGGTCTGGGTCGATGTGGATGCCAACGGCGATCTGGACCCGCAAGCGGTGATTGACGCC
ATGGGGCCGAAGACCAAACTGGTCGCCATGGCGCATATGTCAAACGTGCTTGGGACGGTGTTCGACGTGAAAGCGGTGGT
CAAGGCGGCCCATGCGCGCGGAATTGCGGTGCTGGTCGATGGCTCGCAATCCGCCGTCCACATGCCGGTAGATGTGGACG
CTTTGGGCGCGGATTTTTACGCAATTACCGGGCATAAGCTATACGGGCCAAGCGGGTCTGGCGCGATGCACATCAAGTCA
GAGCGGATGGCCGAGATGCGTCCGTTCATGGGCGGCGGCGACATGATCCGGGAGGTGCACCGCGATGAGATCACCTGGAA
CGACCCGCCGATGAAGTTTGAGGCCGGAACGCCCGGCATCGTTCAGCAGATCGGTCTGGGCGTGGCGCTGGACTATATGA
TGGGGGTCGGCATGGACGCGATTGCGGCCCATGAGGCGGATCTGGCGACCTATGCGGCTGAGCAGTTGACGGGCTTGAAC
TGGCTGAACGTGCAGGGGCAATCGGTCACGAAGGGGGCGATTTTCAGCTTCACCATGTCCGGCGCCGCCCATGCCCACGA
TATCTCGACGGTACTGGACAAAAAGGGCGTGGCCGTCCGCGCGGGCCACCATTGTGCGCAGCCGCTGATGGAGCATATGG
GCGTCAACGCCACGGCGCGGGCGTCGTTCGGGATGTATAACACGCGGGCGGAGGTCGATGTTTTGATCGAGGCGTTGGAG
CTGTGTCACGATTTGCTCGCCTGA

Upstream 100 bases:

>100_bases
GTGTTCGTCATGACGCTGGTCAGCTTCGTCAGCATCATCTTCCTTATCAGCCTTGTCCTGACGGTCCTGGGCTTCACCTT
CGAGCCGGGCGGTTTTTCCA

Downstream 100 bases:

>100_bases
AGACCGGATGGCGCGAGGCGTTTGGGTCAGGATTGAGTTGTATTTGCCAAGATGAAGGGGGGAGCGGGTGCTGCGATTGG
CGAGTGCCGTGAACTGGTGT

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSYDVQAIRADFPILSREVNGKPLVYLDNGASAQKPQVVIDAITQAYSQEYANVHRGLHYLSTLATEKYEGTRGTIARFL
GAKNEDEIVFTSGTTEAINLVAYAWAMPRMEAGDEIILTIAEHHANIVPWHFLRERQGVKLVWVDVDANGDLDPQAVIDA
MGPKTKLVAMAHMSNVLGTVFDVKAVVKAAHARGIAVLVDGSQSAVHMPVDVDALGADFYAITGHKLYGPSGSGAMHIKS
ERMAEMRPFMGGGDMIREVHRDEITWNDPPMKFEAGTPGIVQQIGLGVALDYMMGVGMDAIAAHEADLATYAAEQLTGLN
WLNVQGQSVTKGAIFSFTMSGAAHAHDISTVLDKKGVAVRAGHHCAQPLMEHMGVNATARASFGMYNTRAEVDVLIEALE
LCHDLLA

Sequences:

>Translated_407_residues
MSYDVQAIRADFPILSREVNGKPLVYLDNGASAQKPQVVIDAITQAYSQEYANVHRGLHYLSTLATEKYEGTRGTIARFL
GAKNEDEIVFTSGTTEAINLVAYAWAMPRMEAGDEIILTIAEHHANIVPWHFLRERQGVKLVWVDVDANGDLDPQAVIDA
MGPKTKLVAMAHMSNVLGTVFDVKAVVKAAHARGIAVLVDGSQSAVHMPVDVDALGADFYAITGHKLYGPSGSGAMHIKS
ERMAEMRPFMGGGDMIREVHRDEITWNDPPMKFEAGTPGIVQQIGLGVALDYMMGVGMDAIAAHEADLATYAAEQLTGLN
WLNVQGQSVTKGAIFSFTMSGAAHAHDISTVLDKKGVAVRAGHHCAQPLMEHMGVNATARASFGMYNTRAEVDVLIEALE
LCHDLLA
>Mature_406_residues
SYDVQAIRADFPILSREVNGKPLVYLDNGASAQKPQVVIDAITQAYSQEYANVHRGLHYLSTLATEKYEGTRGTIARFLG
AKNEDEIVFTSGTTEAINLVAYAWAMPRMEAGDEIILTIAEHHANIVPWHFLRERQGVKLVWVDVDANGDLDPQAVIDAM
GPKTKLVAMAHMSNVLGTVFDVKAVVKAAHARGIAVLVDGSQSAVHMPVDVDALGADFYAITGHKLYGPSGSGAMHIKSE
RMAEMRPFMGGGDMIREVHRDEITWNDPPMKFEAGTPGIVQQIGLGVALDYMMGVGMDAIAAHEADLATYAAEQLTGLNW
LNVQGQSVTKGAIFSFTMSGAAHAHDISTVLDKKGVAVRAGHHCAQPLMEHMGVNATARASFGMYNTRAEVDVLIEALEL
CHDLLA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=236, Percent_Identity=27.5423728813559, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI156713448, Length=422, Percent_Identity=26.0663507109005, Blast_Score=89, Evalue=6e-18,
Organism=Escherichia coli, GI1787970, Length=407, Percent_Identity=47.9115479115479, Blast_Score=373, Evalue=1e-104,
Organism=Escherichia coli, GI1789175, Length=407, Percent_Identity=40.2948402948403, Blast_Score=311, Evalue=4e-86,
Organism=Escherichia coli, GI48994898, Length=396, Percent_Identity=28.2828282828283, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25143064, Length=233, Percent_Identity=28.3261802575107, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI193211090, Length=377, Percent_Identity=24.1379310344828, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=393, Percent_Identity=23.6641221374046, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI20129463, Length=256, Percent_Identity=29.296875, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 43949; Mature: 43818

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDVQAIRADFPILSREVNGKPLVYLDNGASAQKPQVVIDAITQAYSQEYANVHRGLHY
CCCCHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LSTLATEKYEGTRGTIARFLGAKNEDEIVFTSGTTEAINLVAYAWAMPRMEAGDEIILTI
HHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEE
AEHHANIVPWHFLRERQGVKLVWVDVDANGDLDPQAVIDAMGPKTKLVAMAHMSNVLGTV
EHHCCCCCCHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
FDVKAVVKAAHARGIAVLVDGSQSAVHMPVDVDALGADFYAITGHKLYGPSGSGAMHIKS
HHHHHHHHHHHCCCEEEEEECCCCEEECCCCHHHCCCCEEEEECCEEECCCCCCEEEECH
ERMAEMRPFMGGGDMIREVHRDEITWNDPPMKFEAGTPGIVQQIGLGVALDYMMGVGMDA
HHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHH
IAAHEADLATYAAEQLTGLNWLNVQGQSVTKGAIFSFTMSGAAHAHDISTVLDKKGVAVR
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEE
AGHHCAQPLMEHMGVNATARASFGMYNTRAEVDVLIEALELCHDLLA
CCHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SYDVQAIRADFPILSREVNGKPLVYLDNGASAQKPQVVIDAITQAYSQEYANVHRGLHY
CCCHHHHHCCCCEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LSTLATEKYEGTRGTIARFLGAKNEDEIVFTSGTTEAINLVAYAWAMPRMEAGDEIILTI
HHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEEE
AEHHANIVPWHFLRERQGVKLVWVDVDANGDLDPQAVIDAMGPKTKLVAMAHMSNVLGTV
EHHCCCCCCHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHH
FDVKAVVKAAHARGIAVLVDGSQSAVHMPVDVDALGADFYAITGHKLYGPSGSGAMHIKS
HHHHHHHHHHHCCCEEEEEECCCCEEECCCCHHHCCCCEEEEECCEEECCCCCCEEEECH
ERMAEMRPFMGGGDMIREVHRDEITWNDPPMKFEAGTPGIVQQIGLGVALDYMMGVGMDA
HHHHHHCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHH
IAAHEADLATYAAEQLTGLNWLNVQGQSVTKGAIFSFTMSGAAHAHDISTVLDKKGVAVR
HHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEE
AGHHCAQPLMEHMGVNATARASFGMYNTRAEVDVLIEALELCHDLLA
CCHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]