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The map label for this gene is hemB [H]

Identifier: 89054815

GI number: 89054815

Start: 2329626

End: 2330624

Strand: Direct

Name: hemB [H]

Synonym: Jann_2324

Alternate gene names: 89054815

Gene position: 2329626-2330624 (Clockwise)

Preceding gene: 89054810

Following gene: 89054816

Centisome position: 53.95

GC content: 64.66

Gene sequence:

>999_bases
ATGACCGTCACCCAAGCCCCCTACCCGCTGACCCGGTTCCGCCGCACCCGTGCCAGCGCGCCCCTGCGCAATCTGGTGCG
CGAAAGCAGCCTGTCGGTCCATGATCTGATCTGGCCGGTCTTTGTCTGTGCCGGCACAGGCGAGCGGCAGGCCGTGGCCT
CCATGCCCGGAGTGGAGCGGCTGTCCGTCGATCTGATGGTGGCGGCGGCGCGAGAGGCGGCCAGCATTGGCATCCCGGCG
ATCTGCATCTTTCCCTACACCGACCCGTCCCTGAAGACGGAGCTGTGTGAAGAAGCGTGGAACCCCGACAACCTGTCGAA
CCGCGCCATCAGGGCGATCCGGGACGCGGGCATCGAGATCGCGATCATGACCGATATCGCGCTGGACCCTTATAATATCA
ATGGCCATGACGGCATCGTGCGGGACGGCATCATCGTGAATGATGAATCGGTGGAGGCACTGGTGAAGATGGGTCTGGCC
CAGGCCGAGGCGGGGGCGGATATTCTGGGCCCGTCGGACATGATGGACGGGCGTATCGGGGCGATCCGGGCCGCGTTGGA
ACACAACGGGCATACCAACGTCACGATCATGTCCTATGCGGCCAAGTTCGCCAGCGCCTTCTATGGCCCGTTCCGCGATG
CGGTGGGCGCATCGGGCGCGCTGAAAGGCGACAAGAAGACCTACCAGATCGACCCGCTGAACGCGCGCGAGGCGTTGCGC
TGCGTCGAGAGGGATCTGCGCGAGGGCGCGGATATGGTGATGGTGAAGCCCGGCCTGCCCTATCTGGACATGTGCCGACA
GGTCAAAGACCGCTTCGGCGCGCCGACCTACGCCTATCAGGTCAGCGGCGAATACGCGATGATCGAGGCCGCAAGCGCCA
ATGGCTGGATCGACGGCGACAAGGTCATGCTGGAGAGCCTGATGGCGTTCCGGCGGGCGGGATGTGACGGGGTGCTGAGC
TATTTTGCGCCGCGCGTGGCGAAGATCCTGAACGGCTGA

Upstream 100 bases:

>100_bases
CGCGGTATTTGCGGGACGCCAGCCCCTGTCTGGATGCTTGCAAGGCCTCCGTTGCCGTGGCACCCCTGTCGCGCATGCCT
GACACCTGAAAGAGGCCGAC

Downstream 100 bases:

>100_bases
GGCCCACAGATCGGGTTATTTTCGGCGAAAAGTCGCAGGTCTTGTGGTTTGACAGATGACAGGCCCTGCATTTCGGCGTA
TTCTTGCCGCCAAGGATCGG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTVTQAPYPLTRFRRTRASAPLRNLVRESSLSVHDLIWPVFVCAGTGERQAVASMPGVERLSVDLMVAAAREAASIGIPA
ICIFPYTDPSLKTELCEEAWNPDNLSNRAIRAIRDAGIEIAIMTDIALDPYNINGHDGIVRDGIIVNDESVEALVKMGLA
QAEAGADILGPSDMMDGRIGAIRAALEHNGHTNVTIMSYAAKFASAFYGPFRDAVGASGALKGDKKTYQIDPLNAREALR
CVERDLREGADMVMVKPGLPYLDMCRQVKDRFGAPTYAYQVSGEYAMIEAASANGWIDGDKVMLESLMAFRRAGCDGVLS
YFAPRVAKILNG

Sequences:

>Translated_332_residues
MTVTQAPYPLTRFRRTRASAPLRNLVRESSLSVHDLIWPVFVCAGTGERQAVASMPGVERLSVDLMVAAAREAASIGIPA
ICIFPYTDPSLKTELCEEAWNPDNLSNRAIRAIRDAGIEIAIMTDIALDPYNINGHDGIVRDGIIVNDESVEALVKMGLA
QAEAGADILGPSDMMDGRIGAIRAALEHNGHTNVTIMSYAAKFASAFYGPFRDAVGASGALKGDKKTYQIDPLNAREALR
CVERDLREGADMVMVKPGLPYLDMCRQVKDRFGAPTYAYQVSGEYAMIEAASANGWIDGDKVMLESLMAFRRAGCDGVLS
YFAPRVAKILNG
>Mature_331_residues
TVTQAPYPLTRFRRTRASAPLRNLVRESSLSVHDLIWPVFVCAGTGERQAVASMPGVERLSVDLMVAAAREAASIGIPAI
CIFPYTDPSLKTELCEEAWNPDNLSNRAIRAIRDAGIEIAIMTDIALDPYNINGHDGIVRDGIIVNDESVEALVKMGLAQ
AEAGADILGPSDMMDGRIGAIRAALEHNGHTNVTIMSYAAKFASAFYGPFRDAVGASGALKGDKKTYQIDPLNAREALRC
VERDLREGADMVMVKPGLPYLDMCRQVKDRFGAPTYAYQVSGEYAMIEAASANGWIDGDKVMLESLMAFRRAGCDGVLSY
FAPRVAKILNG

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=40.5228758169935, Blast_Score=220, Evalue=2e-57,
Organism=Escherichia coli, GI87081728, Length=323, Percent_Identity=42.7244582043344, Blast_Score=236, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6321398, Length=319, Percent_Identity=35.423197492163, Blast_Score=172, Evalue=5e-44,
Organism=Drosophila melanogaster, GI21358291, Length=314, Percent_Identity=36.9426751592357, Blast_Score=219, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35950; Mature: 35818

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTQAPYPLTRFRRTRASAPLRNLVRESSLSVHDLIWPVFVCAGTGERQAVASMPGVER
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHCCCHHH
LSVDLMVAAAREAASIGIPAICIFPYTDPSLKTELCEEAWNPDNLSNRAIRAIRDAGIEI
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEE
AIMTDIALDPYNINGHDGIVRDGIIVNDESVEALVKMGLAQAEAGADILGPSDMMDGRIG
EEEEEEEECCCCCCCCCCEEECCEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHH
AIRAALEHNGHTNVTIMSYAAKFASAFYGPFRDAVGASGALKGDKKTYQIDPLNAREALR
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHH
CVERDLREGADMVMVKPGLPYLDMCRQVKDRFGAPTYAYQVSGEYAMIEAASANGWIDGD
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCHH
KVMLESLMAFRRAGCDGVLSYFAPRVAKILNG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVTQAPYPLTRFRRTRASAPLRNLVRESSLSVHDLIWPVFVCAGTGERQAVASMPGVER
CCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHCCCHHH
LSVDLMVAAAREAASIGIPAICIFPYTDPSLKTELCEEAWNPDNLSNRAIRAIRDAGIEI
HHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEE
AIMTDIALDPYNINGHDGIVRDGIIVNDESVEALVKMGLAQAEAGADILGPSDMMDGRIG
EEEEEEEECCCCCCCCCCEEECCEEECCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCHHH
AIRAALEHNGHTNVTIMSYAAKFASAFYGPFRDAVGASGALKGDKKTYQIDPLNAREALR
HHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHH
CVERDLREGADMVMVKPGLPYLDMCRQVKDRFGAPTYAYQVSGEYAMIEAASANGWIDGD
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCEEEEEECCCCCCCCHH
KVMLESLMAFRRAGCDGVLSYFAPRVAKILNG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7784513 [H]