Click here to switch to the map view.

The map label for this gene is yciC [H]

Identifier: 89054745

GI number: 89054745

Start: 2260616

End: 2261827

Strand: Reverse

Name: yciC [H]

Synonym: Jann_2254

Alternate gene names: 89054745

Gene position: 2261827-2260616 (Counterclockwise)

Preceding gene: 89054746

Following gene: 89054744

Centisome position: 52.38

GC content: 62.29

Gene sequence:

>1212_bases
ATGACCGATACCCGTCTACCCGTCACCGTTCTTTCCGGATTTCTAGGGGCCGGTAAGACCACGCTTCTCAACCGTGTTCT
CAACAACCGCGATGGGCGCCGCGTGGCCGTGATCGTCAACGATATGTCCGAGGTGAACATCGACGCTGATCTGGTTCGGG
CGGATACGGAGTTGAGCCGCACCGACGAGACGCTGGTTGAGATGTCGAACGGCTGCATCTGCTGCACGCTTCGCGATGAT
CTTCTGGCGGAGGTGCGCCGGCTCGCCGCTGAGGGGCGGTTCGACTACCTGCTGATCGAATCCACCGGCATATCCGAGCC
GCTGCCCGTCGCCACCACGTTCGATTTCCGCGATGAGGGTGGCGTCAGCCTGTCGGATGTGGCGCGGCTGGATACGATGG
TCACCGTAGTTGATGCGGTGAACCTGCTGAACGACTTCTCCTCCCACGATTTCCTGAAAGACCGGGGCGAGACCATGGGC
GAGGAGGACGACCGGACCCTTGTCCACCTGCTGACCGACCAGATAGAATTTGCGGATGTCGTGATCCTCAACAAGGTCAG
CGATGCAGGGCCAGAGAAGGTCGACGCCGCGCGCAAGATCATCCGCAGTCTGAATGCCGATACCCAGATCATTGAGGTCG
ACCAGTCCGATGTCGCCGCCACCGAAATCCTCAACACCGGGCTGTTCGATATCGACAAGGCCCAGGATCACCCGATGTGG
GCCAAGGAGCTTTACGGGTTCAAGGACCATGTGCCCGAAACGGAGGAATACGGTGTCGCGTCCTACGTCTACCGCGCCCG
CCTGCCCTTCATTCCTGACCGTGTTCTCGATGTCCTGAACGGCGATCTGCCTGGTGTGATCCGCGCCAAGGGGCATTTCT
GGATCTCCACGCGGCCCGAATGGGTGGCGGAATTTTCACTGGCCGGATCGCTGTCCAGCGTCAAACCGCTTGGCACATGG
TGGGCCTCCGTCCCGCAGGAGAAGTGGCCGGACCACGGCCGCGTCGAAGCCTATCTGCGGGACCATTGGCAGGAGCCGTG
GGGGGATCGGCGGCAGGAAATCGTGTTCATCGGCGCAGGCATCGACTGGCCTGCCCTGAAGGCCCGGCTGGACAGATGCC
TTGTGCCTGCCCTCGCGGCATCCGGGCCAGACACGCTCCCGGATTACCCCGACCCCTTCCCGATCTGGCGACGGGCGGAG
CAGGCAGCATGA

Upstream 100 bases:

>100_bases
ACAACGTCACCTCGGCTATCGGCGACGGATCGATGGCCGGAATTGGCTGTCACCAATCCCTTGTCTTCCCTGATTTCATC
CAACCCATCGAGGCCGCCGC

Downstream 100 bases:

>100_bases
CCTACGCCCGCAAGCCTGTGGCCGACGCCGGCATCGGCGTGGGCATTGCCGACGATCCGGCCTCCCTGTCGGTCCTGCAC
AAACCGGGATGTGCGGCGGC

Product: cobalamin synthesis protein, P47K

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTDTRLPVTVLSGFLGAGKTTLLNRVLNNRDGRRVAVIVNDMSEVNIDADLVRADTELSRTDETLVEMSNGCICCTLRDD
LLAEVRRLAAEGRFDYLLIESTGISEPLPVATTFDFRDEGGVSLSDVARLDTMVTVVDAVNLLNDFSSHDFLKDRGETMG
EEDDRTLVHLLTDQIEFADVVILNKVSDAGPEKVDAARKIIRSLNADTQIIEVDQSDVAATEILNTGLFDIDKAQDHPMW
AKELYGFKDHVPETEEYGVASYVYRARLPFIPDRVLDVLNGDLPGVIRAKGHFWISTRPEWVAEFSLAGSLSSVKPLGTW
WASVPQEKWPDHGRVEAYLRDHWQEPWGDRRQEIVFIGAGIDWPALKARLDRCLVPALAASGPDTLPDYPDPFPIWRRAE
QAA

Sequences:

>Translated_403_residues
MTDTRLPVTVLSGFLGAGKTTLLNRVLNNRDGRRVAVIVNDMSEVNIDADLVRADTELSRTDETLVEMSNGCICCTLRDD
LLAEVRRLAAEGRFDYLLIESTGISEPLPVATTFDFRDEGGVSLSDVARLDTMVTVVDAVNLLNDFSSHDFLKDRGETMG
EEDDRTLVHLLTDQIEFADVVILNKVSDAGPEKVDAARKIIRSLNADTQIIEVDQSDVAATEILNTGLFDIDKAQDHPMW
AKELYGFKDHVPETEEYGVASYVYRARLPFIPDRVLDVLNGDLPGVIRAKGHFWISTRPEWVAEFSLAGSLSSVKPLGTW
WASVPQEKWPDHGRVEAYLRDHWQEPWGDRRQEIVFIGAGIDWPALKARLDRCLVPALAASGPDTLPDYPDPFPIWRRAE
QAA
>Mature_402_residues
TDTRLPVTVLSGFLGAGKTTLLNRVLNNRDGRRVAVIVNDMSEVNIDADLVRADTELSRTDETLVEMSNGCICCTLRDDL
LAEVRRLAAEGRFDYLLIESTGISEPLPVATTFDFRDEGGVSLSDVARLDTMVTVVDAVNLLNDFSSHDFLKDRGETMGE
EDDRTLVHLLTDQIEFADVVILNKVSDAGPEKVDAARKIIRSLNADTQIIEVDQSDVAATEILNTGLFDIDKAQDHPMWA
KELYGFKDHVPETEEYGVASYVYRARLPFIPDRVLDVLNGDLPGVIRAKGHFWISTRPEWVAEFSLAGSLSSVKPLGTWW
ASVPQEKWPDHGRVEAYLRDHWQEPWGDRRQEIVFIGAGIDWPALKARLDRCLVPALAASGPDTLPDYPDPFPIWRRAEQ
AA

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=255, Percent_Identity=33.3333333333333, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI126722884, Length=255, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI148727351, Length=255, Percent_Identity=32.9411764705882, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI223941779, Length=216, Percent_Identity=35.1851851851852, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI146231952, Length=255, Percent_Identity=32.5490196078431, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI223941776, Length=217, Percent_Identity=34.5622119815668, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI119120938, Length=137, Percent_Identity=38.6861313868613, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082430, Length=376, Percent_Identity=25.531914893617, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1788499, Length=219, Percent_Identity=27.3972602739726, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324356, Length=235, Percent_Identity=28.0851063829787, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 44974; Mature: 44843

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTRLPVTVLSGFLGAGKTTLLNRVLNNRDGRRVAVIVNDMSEVNIDADLVRADTELSR
CCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCHHHHHCCCHHHH
TDETLVEMSNGCICCTLRDDLLAEVRRLAAEGRFDYLLIESTGISEPLPVATTFDFRDEG
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCC
GVSLSDVARLDTMVTVVDAVNLLNDFSSHDFLKDRGETMGEEDDRTLVHLLTDQIEFADV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHE
VILNKVSDAGPEKVDAARKIIRSLNADTQIIEVDQSDVAATEILNTGLFDIDKAQDHPMW
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCH
AKELYGFKDHVPETEEYGVASYVYRARLPFIPDRVLDVLNGDLPGVIRAKGHFWISTRPE
HHHHCCHHHCCCCCHHCCHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEECCEEEECCCCH
WVAEFSLAGSLSSVKPLGTWWASVPQEKWPDHGRVEAYLRDHWQEPWGDRRQEIVFIGAG
HHHHHHHHCCCCCCCHHHHHHHCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECC
IDWPALKARLDRCLVPALAASGPDTLPDYPDPFPIWRRAEQAA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TDTRLPVTVLSGFLGAGKTTLLNRVLNNRDGRRVAVIVNDMSEVNIDADLVRADTELSR
CCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEECHHHCCCCHHHHHCCCHHHH
TDETLVEMSNGCICCTLRDDLLAEVRRLAAEGRFDYLLIESTGISEPLPVATTFDFRDEG
HHHHHHHHCCCEEEEEECHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCC
GVSLSDVARLDTMVTVVDAVNLLNDFSSHDFLKDRGETMGEEDDRTLVHLLTDQIEFADV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHE
VILNKVSDAGPEKVDAARKIIRSLNADTQIIEVDQSDVAATEILNTGLFDIDKAQDHPMW
EEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCH
AKELYGFKDHVPETEEYGVASYVYRARLPFIPDRVLDVLNGDLPGVIRAKGHFWISTRPE
HHHHCCHHHCCCCCHHCCHHHHHHHHCCCCCHHHHHHHHCCCCCCEEEECCEEEECCCCH
WVAEFSLAGSLSSVKPLGTWWASVPQEKWPDHGRVEAYLRDHWQEPWGDRRQEIVFIGAG
HHHHHHHHCCCCCCCHHHHHHHCCCHHHCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECC
IDWPALKARLDRCLVPALAASGPDTLPDYPDPFPIWRRAEQAA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]