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The map label for this gene is lpxD [H]

Identifier: 89054637

GI number: 89054637

Start: 2154005

End: 2155102

Strand: Direct

Name: lpxD [H]

Synonym: Jann_2146

Alternate gene names: 89054637

Gene position: 2154005-2155102 (Clockwise)

Preceding gene: 89054636

Following gene: 89054638

Centisome position: 49.88

GC content: 65.66

Gene sequence:

>1098_bases
ATGGCTGAGTTCAGCGTAAGAGACATTGCAGCGGCGCTTGGGGCGGAGGTCCTGGGCGCCGCTGATCTTTTTGTCAGCGG
TGTGGCGGAGCCCGCGGCGGCGGGGTCGGAGCATCTAGCGCTGGCGATGCGGCCTGAATATGCCGACGGACTGGCGGCCG
GGAACGCCCGGGTCGCGGTGATCGGCGCGGGTATGGATTGGCAGGCGCTGGGGCTGGACGCCGCAATCATCGCGCCGCGC
CCCCGCTACGCCATGGCGGGTGTGACGGCGGCGATGGATCCGGGGCCGGATATTGCGCCCGGCGTGCATCCGATGGCCGT
GGTGGACGCAACGGCAGAGATCGGAGAGGGGGCCGCGATTGGGCCTTTCGTCGTGATCGGCAAGGACGTGCGGATCGGCG
CACGGGTGCGGATCGCGTCCCACGTCTCGATCCAGACCGGCGCGGTGATCGGCGAGGATGCGCTGCTCCATGAAGGCGTG
CGTATCTGCCACCGTGTCCAGATTGGCGACCGCTTCATTGCCCAACCCGGCGCTGTTCTGGGCGGCGACGGTTTCAGCTT
CGTGACGCCCCAGAAATCTCAGGTCGAGGCCGCGCGCGAAAGCCTGGGCACCGCAAAAGATGCCGCGACGGATCAATCCT
GGGTGCGCATCCATTCGCTTGGAAGCCTTATCATCGGCGACGATGTTGAGGTTGGGGCCAACGCCGCCATTGACCGCGGC
ACGATTGCCCATTCGCGGATCGGCGACGGCACCAAGGTCGATAACCTCGTCCATATCGGTCACAATTGCGTCATCGGGCG
GGACTGTCTGATCTGCGGGCAAACGGGCTTTGCCGGGTCCGTCCAGATGGGCGACCGCGTCGTTCTGGGCGGCAAATGCG
GGGTCAGCGACAATATCACCATCGGGTCCGATGTGGTGGCGGCGGGCGCATCGAAGCTGTTCACCAATGTCCCCTCTGGC
CGCATGGTCATGGGGCACCCGGCAGTGAAGATGGACACCCATGTGGAGATGTATAAGGCGCTGCGTCGTTTGCCCCGCAC
CGCGCGCGCCGTTGCGGAATTGCAGAAAGCCGTTTCCAACCCCGACAAGACGCCCTAG

Upstream 100 bases:

>100_bases
TGGGCGGAACGCGGAACTGCGCCAGGCGATCCAGAACCTTGGGGTGGAGATCAGGGGCGTGAACAGCTAATCGTATCCTC
GCATCCACGCGGGGAATGAC

Downstream 100 bases:

>100_bases
ATGAAGCCTGAGAAACAGGAAAAGCCCATGGCCGAGCGCGTCGACACCACCGTCCAGGACAAGATCATCGCCATCATCGC
CGAACAGGCGGTGTTGGAGC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MAEFSVRDIAAALGAEVLGAADLFVSGVAEPAAAGSEHLALAMRPEYADGLAAGNARVAVIGAGMDWQALGLDAAIIAPR
PRYAMAGVTAAMDPGPDIAPGVHPMAVVDATAEIGEGAAIGPFVVIGKDVRIGARVRIASHVSIQTGAVIGEDALLHEGV
RICHRVQIGDRFIAQPGAVLGGDGFSFVTPQKSQVEAARESLGTAKDAATDQSWVRIHSLGSLIIGDDVEVGANAAIDRG
TIAHSRIGDGTKVDNLVHIGHNCVIGRDCLICGQTGFAGSVQMGDRVVLGGKCGVSDNITIGSDVVAAGASKLFTNVPSG
RMVMGHPAVKMDTHVEMYKALRRLPRTARAVAELQKAVSNPDKTP

Sequences:

>Translated_365_residues
MAEFSVRDIAAALGAEVLGAADLFVSGVAEPAAAGSEHLALAMRPEYADGLAAGNARVAVIGAGMDWQALGLDAAIIAPR
PRYAMAGVTAAMDPGPDIAPGVHPMAVVDATAEIGEGAAIGPFVVIGKDVRIGARVRIASHVSIQTGAVIGEDALLHEGV
RICHRVQIGDRFIAQPGAVLGGDGFSFVTPQKSQVEAARESLGTAKDAATDQSWVRIHSLGSLIIGDDVEVGANAAIDRG
TIAHSRIGDGTKVDNLVHIGHNCVIGRDCLICGQTGFAGSVQMGDRVVLGGKCGVSDNITIGSDVVAAGASKLFTNVPSG
RMVMGHPAVKMDTHVEMYKALRRLPRTARAVAELQKAVSNPDKTP
>Mature_364_residues
AEFSVRDIAAALGAEVLGAADLFVSGVAEPAAAGSEHLALAMRPEYADGLAAGNARVAVIGAGMDWQALGLDAAIIAPRP
RYAMAGVTAAMDPGPDIAPGVHPMAVVDATAEIGEGAAIGPFVVIGKDVRIGARVRIASHVSIQTGAVIGEDALLHEGVR
ICHRVQIGDRFIAQPGAVLGGDGFSFVTPQKSQVEAARESLGTAKDAATDQSWVRIHSLGSLIIGDDVEVGANAAIDRGT
IAHSRIGDGTKVDNLVHIGHNCVIGRDCLICGQTGFAGSVQMGDRVVLGGKCGVSDNITIGSDVVAAGASKLFTNVPSGR
MVMGHPAVKMDTHVEMYKALRRLPRTARAVAELQKAVSNPDKTP

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=310, Percent_Identity=31.2903225806452, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786378, Length=267, Percent_Identity=26.2172284644195, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37419; Mature: 37288

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00101 HEXAPEP_TRANSFERASES ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEFSVRDIAAALGAEVLGAADLFVSGVAEPAAAGSEHLALAMRPEYADGLAAGNARVAV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEE
IGAGMDWQALGLDAAIIAPRPRYAMAGVTAAMDPGPDIAPGVHPMAVVDATAEIGEGAAI
EECCCCCHHHCCCEEEECCCCCHHHHCEEECCCCCCCCCCCCCCEEEEECHHHHCCCCCC
GPFVVIGKDVRIGARVRIASHVSIQTGAVIGEDALLHEGVRICHRVQIGDRFIAQPGAVL
CCEEEECCCEEECEEEEEEEEEEEECCCEECCHHHHHHHHHHHHHHHHCCEECCCCCCEE
GGDGFSFVTPQKSQVEAARESLGTAKDAATDQSWVRIHSLGSLIIGDDVEVGANAAIDRG
CCCCCEEECCCHHHHHHHHHHHCCHHHCCCCCHHEEEEECCCEEECCCCCCCCCCCCCCC
TIAHSRIGDGTKVDNLVHIGHNCVIGRDCLICGQTGFAGSVQMGDRVVLGGKCGVSDNIT
CCCCCCCCCCCCCCCEEEECCCEEECCCEEEECCCCCCCEEECCCEEEECCCCCCCCCCE
IGSDVVAAGASKLFTNVPSGRMVMGHPAVKMDTHVEMYKALRRLPRTARAVAELQKAVSN
ECCHHHHHCHHHHHHCCCCCCEEECCCCEEECHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PDKTP
CCCCC
>Mature Secondary Structure 
AEFSVRDIAAALGAEVLGAADLFVSGVAEPAAAGSEHLALAMRPEYADGLAAGNARVAV
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEE
IGAGMDWQALGLDAAIIAPRPRYAMAGVTAAMDPGPDIAPGVHPMAVVDATAEIGEGAAI
EECCCCCHHHCCCEEEECCCCCHHHHCEEECCCCCCCCCCCCCCEEEEECHHHHCCCCCC
GPFVVIGKDVRIGARVRIASHVSIQTGAVIGEDALLHEGVRICHRVQIGDRFIAQPGAVL
CCEEEECCCEEECEEEEEEEEEEEECCCEECCHHHHHHHHHHHHHHHHCCEECCCCCCEE
GGDGFSFVTPQKSQVEAARESLGTAKDAATDQSWVRIHSLGSLIIGDDVEVGANAAIDRG
CCCCCEEECCCHHHHHHHHHHHCCHHHCCCCCHHEEEEECCCEEECCCCCCCCCCCCCCC
TIAHSRIGDGTKVDNLVHIGHNCVIGRDCLICGQTGFAGSVQMGDRVVLGGKCGVSDNIT
CCCCCCCCCCCCCCCEEEECCCEEECCCEEEECCCCCCCEEECCCEEEECCCCCCCCCCE
IGSDVVAAGASKLFTNVPSGRMVMGHPAVKMDTHVEMYKALRRLPRTARAVAELQKAVSN
ECCHHHHHCHHHHHHCCCCCCEEECCCCEEECHHHHHHHHHHHCCHHHHHHHHHHHHHCC
PDKTP
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA