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The map label for this gene is rnd [H]

Identifier: 89054329

GI number: 89054329

Start: 1823833

End: 1824993

Strand: Direct

Name: rnd [H]

Synonym: Jann_1838

Alternate gene names: 89054329

Gene position: 1823833-1824993 (Clockwise)

Preceding gene: 89054328

Following gene: 89054331

Centisome position: 42.24

GC content: 60.55

Gene sequence:

>1161_bases
GTGCCGCACACAATCACCACCACCGATGAGCTGGCCGCCTATTGCGCCCGCGCCGCAACCCAACCTTATGTCACGGTCGA
CACGGAATTCCTGCGCGAACGCACCTATTTTGCGCAGCTCTGCCTGGTGCAGGTGGCCATGCCCGGCACCGATGACACGG
ACGCGGTCCTGATCGATCCCCTGGCCGAAGGGCTTTCGCTGGAACCGCTTTACGAGCTGTTCCGAAACGTTAATGTCGTT
AAGGTTTTTCACGCCGCGCGCCAGGATCTGGAAATTTTCTTCGTTGAAGGCGGCCTCGTGCCCACGCCCTTGTTCGATAC
GCAAGTGGCCGCGATGGTCTGTGGTTTCGGGGATCAGGTCGGGTACGAGACGCTGGTGCGCCGGATTGCGAAGGCCAATC
TGGACAAATCCTCTCGCTTTACCGACTGGTCGCGCAGGCCGTTGTCGGATGCGCAAAAGGTCTACGCGCTGGCCGATGTG
ACCTATTTGCGCGAGATCTACGAGTATCTCTCGGCGGAGTTGGCGCGGACCGATCGCACCCATTGGCTGGAAGAGGAATT
GGCTCAACTAACCAATGCCGACGCCTATGTTGTTGATCCTGAGAATGCGTGGAAGCGTTTGAAGTTGCGATCCAATTCAG
GGCGTGTCGTGGCGATTGCACAGCAGCTTGCGGCCTTCCGCGAAACCTATGCCCAGGAAAAGAACGTGCCCCGCAACCGG
GTGCTGAAAGACGATGCACTGTTGGAGTTGGCCGGAACCAAGCCCAAGACCGTGGCCGATCTTGGCAAGTCGCGTCTTTT
GTTGCGCGATGCCCGCAAAGGCGCGATTGCCGAGGGGCTTGTGGCCGCTGTCGCGCGCGGCATGTCGGTGCCCAACAGCG
AAATCCCCAAGGTGCAAGCGGGCCGCGACCGGTCCAACCTGAACCCGGCCCTGGCCGATCTGTTGCGGGTTCTGTTGAAG
GCCAAGGCCGAAAACGCCGGTGTTGCGACGAAGTTGATCGCGTCCTCCAGCGATCTTGACGACATCGCGTCGGGGTTCAC
GGATGGGGTCTGGGCCTCAGGCTGGCGCAGTGAAGTCTTCGGCGCGGATGCGCTTCGGCTTTTGAACGGAGAGGTCGCCC
TTGCGGCCAAGGGCCAGAAAGTCAAGATCGTCGAGGTTTAG

Upstream 100 bases:

>100_bases
CTCAGCTAACCGGCTCAATTCTCCGCAGCGTCTTCCCTTCCGCCTCCGGGTCCTCTACACCCGCAAACAACCTATTTTTC
TGACGAAGACGCTCCCTCCC

Downstream 100 bases:

>100_bases
GCGGCGCGTGATTTCAATCGCTTAGCGGCGCGTGACCGTGCGGCGGTTGGATTGCGAGATCACGGTGATCGTGCGGATGC
CCGCCAGTTCGGCCACCGAC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MPHTITTTDELAAYCARAATQPYVTVDTEFLRERTYFAQLCLVQVAMPGTDDTDAVLIDPLAEGLSLEPLYELFRNVNVV
KVFHAARQDLEIFFVEGGLVPTPLFDTQVAAMVCGFGDQVGYETLVRRIAKANLDKSSRFTDWSRRPLSDAQKVYALADV
TYLREIYEYLSAELARTDRTHWLEEELAQLTNADAYVVDPENAWKRLKLRSNSGRVVAIAQQLAAFRETYAQEKNVPRNR
VLKDDALLELAGTKPKTVADLGKSRLLLRDARKGAIAEGLVAAVARGMSVPNSEIPKVQAGRDRSNLNPALADLLRVLLK
AKAENAGVATKLIASSSDLDDIASGFTDGVWASGWRSEVFGADALRLLNGEVALAAKGQKVKIVEV

Sequences:

>Translated_386_residues
MPHTITTTDELAAYCARAATQPYVTVDTEFLRERTYFAQLCLVQVAMPGTDDTDAVLIDPLAEGLSLEPLYELFRNVNVV
KVFHAARQDLEIFFVEGGLVPTPLFDTQVAAMVCGFGDQVGYETLVRRIAKANLDKSSRFTDWSRRPLSDAQKVYALADV
TYLREIYEYLSAELARTDRTHWLEEELAQLTNADAYVVDPENAWKRLKLRSNSGRVVAIAQQLAAFRETYAQEKNVPRNR
VLKDDALLELAGTKPKTVADLGKSRLLLRDARKGAIAEGLVAAVARGMSVPNSEIPKVQAGRDRSNLNPALADLLRVLLK
AKAENAGVATKLIASSSDLDDIASGFTDGVWASGWRSEVFGADALRLLNGEVALAAKGQKVKIVEV
>Mature_385_residues
PHTITTTDELAAYCARAATQPYVTVDTEFLRERTYFAQLCLVQVAMPGTDDTDAVLIDPLAEGLSLEPLYELFRNVNVVK
VFHAARQDLEIFFVEGGLVPTPLFDTQVAAMVCGFGDQVGYETLVRRIAKANLDKSSRFTDWSRRPLSDAQKVYALADVT
YLREIYEYLSAELARTDRTHWLEEELAQLTNADAYVVDPENAWKRLKLRSNSGRVVAIAQQLAAFRETYAQEKNVPRNRV
LKDDALLELAGTKPKTVADLGKSRLLLRDARKGAIAEGLVAAVARGMSVPNSEIPKVQAGRDRSNLNPALADLLRVLLKA
KAENAGVATKLIASSSDLDDIASGFTDGVWASGWRSEVFGADALRLLNGEVALAAKGQKVKIVEV

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI50301240, Length=322, Percent_Identity=23.6024844720497, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4505917, Length=322, Percent_Identity=23.6024844720497, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1788105, Length=391, Percent_Identity=31.4578005115089, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17531757, Length=262, Percent_Identity=28.2442748091603, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324574, Length=180, Percent_Identity=30.5555555555556, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42399; Mature: 42268

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHTITTTDELAAYCARAATQPYVTVDTEFLRERTYFAQLCLVQVAMPGTDDTDAVLIDP
CCCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECH
LAEGLSLEPLYELFRNVNVVKVFHAARQDLEIFFVEGGLVPTPLFDTQVAAMVCGFGDQV
HHCCCCCCHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCC
GYETLVRRIAKANLDKSSRFTDWSRRPLSDAQKVYALADVTYLREIYEYLSAELARTDRT
CHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HWLEEELAQLTNADAYVVDPENAWKRLKLRSNSGRVVAIAQQLAAFRETYAQEKNVPRNR
HHHHHHHHHHCCCCEEEECCHHHHHHEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCHHH
VLKDDALLELAGTKPKTVADLGKSRLLLRDARKGAIAEGLVAAVARGMSVPNSEIPKVQA
CCCCCHHHEECCCCCHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCC
GRDRSNLNPALADLLRVLLKAKAENAGVATKLIASSSDLDDIASGFTDGVWASGWRSEVF
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHC
GADALRLLNGEVALAAKGQKVKIVEV
CHHHHHHHCCCEEEEECCCEEEEEEC
>Mature Secondary Structure 
PHTITTTDELAAYCARAATQPYVTVDTEFLRERTYFAQLCLVQVAMPGTDDTDAVLIDP
CCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECH
LAEGLSLEPLYELFRNVNVVKVFHAARQDLEIFFVEGGLVPTPLFDTQVAAMVCGFGDQV
HHCCCCCCHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCC
GYETLVRRIAKANLDKSSRFTDWSRRPLSDAQKVYALADVTYLREIYEYLSAELARTDRT
CHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HWLEEELAQLTNADAYVVDPENAWKRLKLRSNSGRVVAIAQQLAAFRETYAQEKNVPRNR
HHHHHHHHHHCCCCEEEECCHHHHHHEEEECCCCCEEHHHHHHHHHHHHHHHHCCCCHHH
VLKDDALLELAGTKPKTVADLGKSRLLLRDARKGAIAEGLVAAVARGMSVPNSEIPKVQA
CCCCCHHHEECCCCCHHHHHHCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCC
GRDRSNLNPALADLLRVLLKAKAENAGVATKLIASSSDLDDIASGFTDGVWASGWRSEVF
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHC
GADALRLLNGEVALAAKGQKVKIVEV
CHHHHHHHCCCEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]