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The map label for this gene is ndk

Identifier: 89054313

GI number: 89054313

Start: 1811860

End: 1812282

Strand: Direct

Name: ndk

Synonym: Jann_1822

Alternate gene names: 89054313

Gene position: 1811860-1812282 (Clockwise)

Preceding gene: 89054310

Following gene: 89054317

Centisome position: 41.96

GC content: 61.7

Gene sequence:

>423_bases
ATGGCCATCCAGCGCACCTTCTCGATCATCAAACCCGACGCCACCAAACGCAACCTGACCGGCCAGATTGCCGCCAAGTT
TGAAGAGGCCGGCCTGCGGATTGTCGCGTCCAAGCGCATCCAGCTGACCCTGGCCCAGGCGCAGGCCTTCTACGGCGTCC
ACTCCGAGCGTCCATTCTTCGGTGAGTTGTGCGAGTTCATGATCTCCGAGCCCATCGTCGTGCAGGTTCTGGAAGGTGAA
GACGCCATCGTCAAGAACCGCGAAGTCATGGGGGCAACCAACCCCGCCGACGCAGCCCCCGGTACGATCCGCAAGGAATT
CGCGCTGTCGATTGGCGAGAATTCCGTTCACGGCTCCGACGCGCCCGAGACGGCTGCCGAAGAGATCGCGTTCTTTTTCT
CGGGCCTTGAGCTGGTTGGCTGA

Upstream 100 bases:

>100_bases
GTGACCCCCGTAAACCATGCAATTGCGTGAGCCCTTTCCAAACCTGCGCGCCCATGTTAGCCCGCCGCCAAATCTTAACC
TCGTTAACCGGAGCAGCCCA

Downstream 100 bases:

>100_bases
GGCCTAGACGGCCACCGCCGTGTGATGAATTCGGGCCGTGCTGTTGCGCGGCCCTTTTTCGTAGATCGTGGGGATTGTTT
CGCGCTCCGCAAAATCACGG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MAIQRTFSIIKPDATKRNLTGQIAAKFEEAGLRIVASKRIQLTLAQAQAFYGVHSERPFFGELCEFMISEPIVVQVLEGE
DAIVKNREVMGATNPADAAPGTIRKEFALSIGENSVHGSDAPETAAEEIAFFFSGLELVG

Sequences:

>Translated_140_residues
MAIQRTFSIIKPDATKRNLTGQIAAKFEEAGLRIVASKRIQLTLAQAQAFYGVHSERPFFGELCEFMISEPIVVQVLEGE
DAIVKNREVMGATNPADAAPGTIRKEFALSIGENSVHGSDAPETAAEEIAFFFSGLELVG
>Mature_139_residues
AIQRTFSIIKPDATKRNLTGQIAAKFEEAGLRIVASKRIQLTLAQAQAFYGVHSERPFFGELCEFMISEPIVVQVLEGED
AIVKNREVMGATNPADAAPGTIRKEFALSIGENSVHGSDAPETAAEEIAFFFSGLELVG

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=138, Percent_Identity=44.2028985507246, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=41.6058394160584, Blast_Score=121, Evalue=1e-28,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=41.6058394160584, Blast_Score=121, Evalue=1e-28,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=41.6058394160584, Blast_Score=121, Evalue=1e-28,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=41.6058394160584, Blast_Score=121, Evalue=1e-28,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=41.6058394160584, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=42.6470588235294, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=42.6470588235294, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=36.7647058823529, Blast_Score=101, Evalue=2e-22,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=36.7647058823529, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=33.0827067669173, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=33.0827067669173, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI30023828, Length=140, Percent_Identity=32.8571428571429, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=31.1594202898551, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=56.390977443609, Blast_Score=160, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=43.7037037037037, Blast_Score=123, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=41.1764705882353, Blast_Score=122, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=44.1176470588235, Blast_Score=126, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_JANSC (Q28RC3)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509764.1
- ProteinModelPortal:   Q28RC3
- SMR:   Q28RC3
- STRING:   Q28RC3
- GeneID:   3934271
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1822
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   FHFAGRE
- PhylomeDB:   Q28RC3
- BioCyc:   JSP290400:JANN_1822-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15142; Mature: 15011

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIQRTFSIIKPDATKRNLTGQIAAKFEEAGLRIVASKRIQLTLAQAQAFYGVHSERPFF
CCCCCCHHEECCCCCCCCCCHHHHHHHHHCCEEEEECCCEEEEHHHHHHHHCCCCCCCHH
GELCEFMISEPIVVQVLEGEDAIVKNREVMGATNPADAAPGTIRKEFALSIGENSVHGSD
HHHHHHHHCCCEEEEEECCCCCEECCCEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
APETAAEEIAFFFSGLELVG
CCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AIQRTFSIIKPDATKRNLTGQIAAKFEEAGLRIVASKRIQLTLAQAQAFYGVHSERPFF
CCCCCHHEECCCCCCCCCCHHHHHHHHHCCEEEEECCCEEEEHHHHHHHHCCCCCCCHH
GELCEFMISEPIVVQVLEGEDAIVKNREVMGATNPADAAPGTIRKEFALSIGENSVHGSD
HHHHHHHHCCCEEEEEECCCCCEECCCEECCCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
APETAAEEIAFFFSGLELVG
CCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA