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The map label for this gene is pdhR [H]

Identifier: 89054157

GI number: 89054157

Start: 1650514

End: 1651281

Strand: Reverse

Name: pdhR [H]

Synonym: Jann_1666

Alternate gene names: 89054157

Gene position: 1651281-1650514 (Counterclockwise)

Preceding gene: 89054158

Following gene: 89054154

Centisome position: 38.24

GC content: 61.33

Gene sequence:

>768_bases
ATGCCATTCCAACGTATTGAGGCCGAGAAGCTCTCCCGCTCTGTCGTCAAACAAATCGAGCAGTTGATCCTGCGTGGCAT
CCTGCGCCCCGGCGAACGCCTGCCATCGGAGCGGGAGTTGAGCGAGCGGCTCAGCGTGTCGCGCCCCAGCTTGCGGGAGG
CCGTAGCCGAGTTGCAGGACAAGGGGTTGCTGGCGACGCGCGCGGGCGCGGGCATCTATGTGGCCGACGTATTGGGATCG
GCGTTTTCGCCTGCGCTGATTGACCTTCTGGCCGCCCATGAGGAGGCGGTGTTCGACTATATTTCCTTCCGGCAGGATCT
GGAGGGGATCGCGGCAGAGCGCGCGGCCATCCACGGCTCGGACACCGATCTGAAAGTGATCGACACGATCATGCAGAAGA
TGGAAGTGGCCCATCGCAAGAGAAACCCCGCCGACGAGGCCGAGCTGGATGCGGAGTTCCATCTGGCGATCATCGAGGCC
AGCCACAACGTGATCCTGCTGCACATGATGCGCGCCAGTTTCAACCTGCTGCGCCAGGGCGTGTTCTTCAACCGCCAGCA
GATGTTCAAGAACCGGACCACCCGTGACATGCTTCTGGATCAGCACCGCGCGATCAATGTCGGCATTCAGGAGCGGGATG
CGGAGGCCGCAAAGACCGCCGTGATTGAGCATCTGGATTATGTGAAGGAAGAGATGATGGCGCTGAAGACCTCGGAGAAG
AACGAGGAGATCGCGCGGTTGCGCTATGCCCATGAGCGCGAGCGGTAA

Upstream 100 bases:

>100_bases
TTAGCGGCCCGCCTCAATCGGCGGGCCGTTTTGCGGTGTTTCTCTGGACAGCGGGTCGCCACTGGTCATATCCTTTGACC
AATTCGCGCGGAGTTTTCAG

Downstream 100 bases:

>100_bases
CGCCAGGCAGGTCCGGCAACCGCGCCTCCGGCGGGGGCTAAACGCGCCTTCGGCGCGGGTATGGCCCTGCGGGCCATTAG
TCGACGGCTCCGCCGCCGAA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MPFQRIEAEKLSRSVVKQIEQLILRGILRPGERLPSERELSERLSVSRPSLREAVAELQDKGLLATRAGAGIYVADVLGS
AFSPALIDLLAAHEEAVFDYISFRQDLEGIAAERAAIHGSDTDLKVIDTIMQKMEVAHRKRNPADEAELDAEFHLAIIEA
SHNVILLHMMRASFNLLRQGVFFNRQQMFKNRTTRDMLLDQHRAINVGIQERDAEAAKTAVIEHLDYVKEEMMALKTSEK
NEEIARLRYAHERER

Sequences:

>Translated_255_residues
MPFQRIEAEKLSRSVVKQIEQLILRGILRPGERLPSERELSERLSVSRPSLREAVAELQDKGLLATRAGAGIYVADVLGS
AFSPALIDLLAAHEEAVFDYISFRQDLEGIAAERAAIHGSDTDLKVIDTIMQKMEVAHRKRNPADEAELDAEFHLAIIEA
SHNVILLHMMRASFNLLRQGVFFNRQQMFKNRTTRDMLLDQHRAINVGIQERDAEAAKTAVIEHLDYVKEEMMALKTSEK
NEEIARLRYAHERER
>Mature_254_residues
PFQRIEAEKLSRSVVKQIEQLILRGILRPGERLPSERELSERLSVSRPSLREAVAELQDKGLLATRAGAGIYVADVLGSA
FSPALIDLLAAHEEAVFDYISFRQDLEGIAAERAAIHGSDTDLKVIDTIMQKMEVAHRKRNPADEAELDAEFHLAIIEAS
HNVILLHMMRASFNLLRQGVFFNRQQMFKNRTTRDMLLDQHRAINVGIQERDAEAAKTAVIEHLDYVKEEMMALKTSEKN
EEIARLRYAHERER

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=37.3390557939914, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790780, Length=227, Percent_Identity=33.4801762114537, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1790032, Length=228, Percent_Identity=34.2105263157895, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789353, Length=229, Percent_Identity=31.0043668122271, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI87082208, Length=245, Percent_Identity=24.8979591836735, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789621, Length=238, Percent_Identity=29.8319327731092, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48994961, Length=229, Percent_Identity=30.1310043668122, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787821, Length=229, Percent_Identity=26.2008733624454, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 29037; Mature: 28905

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFQRIEAEKLSRSVVKQIEQLILRGILRPGERLPSERELSERLSVSRPSLREAVAELQD
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCCCHHHHHHHHHHH
KGLLATRAGAGIYVADVLGSAFSPALIDLLAAHEEAVFDYISFRQDLEGIAAERAAIHGS
CCCEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DTDLKVIDTIMQKMEVAHRKRNPADEAELDAEFHLAIIEASHNVILLHMMRASFNLLRQG
CCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHH
VFFNRQQMFKNRTTRDMLLDQHRAINVGIQERDAEAAKTAVIEHLDYVKEEMMALKTSEK
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NEEIARLRYAHERER
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
PFQRIEAEKLSRSVVKQIEQLILRGILRPGERLPSERELSERLSVSRPSLREAVAELQD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCCCHHHHHHHHHHH
KGLLATRAGAGIYVADVLGSAFSPALIDLLAAHEEAVFDYISFRQDLEGIAAERAAIHGS
CCCEEECCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DTDLKVIDTIMQKMEVAHRKRNPADEAELDAEFHLAIIEASHNVILLHMMRASFNLLRQG
CCHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHH
VFFNRQQMFKNRTTRDMLLDQHRAINVGIQERDAEAAKTAVIEHLDYVKEEMMALKTSEK
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NEEIARLRYAHERER
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]