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The map label for this gene is ahcY [H]

Identifier: 89054071

GI number: 89054071

Start: 1562343

End: 1563314

Strand: Direct

Name: ahcY [H]

Synonym: Jann_1580

Alternate gene names: 89054071

Gene position: 1562343-1563314 (Clockwise)

Preceding gene: 89054070

Following gene: 89054072

Centisome position: 36.18

GC content: 68.72

Gene sequence:

>972_bases
ATGAGCGCATCACTGGGCCAGACACCCGCCCTCGACCACGCGCTGGCGCGCGTGATGGATCAGGCGCCCCTCCGGGGCGT
TCCGGTGGCGCTGGCGCGCGGGATCGCTCCTCCGGCTGCCGCCGTCCTCGCGGCGCGGCTGCGCCACGCGGGCGCAGATG
TGCTGGACGGAGTAGGTGCAGGTCCGTGTTATGTATTGGGCGTGTTGGATGAGGATCTGACCGGCCATCGGGGGGCCACG
TCGCAGCTACCGGGGTTTGCGCAAGACGTGCCGGTTGTGGACCTGTCTCAGAGCCCCCTCATGCGGCTGGTGCACGACCA
TATCGGCATCGGGCAGGCCAGTGTCATGGCGCTTCTGGATATCACCAATCTACAGCTGGCGGGCCGTCATGTGGTGGTCT
GCGGATATGGTCCCACGGGTGCGGGTGTCGCGGCCCACGCAGCCGCCCTCGGCGCGCGGGTGACGGTGGTGGAACGGGAC
GCCCTGCGCGCCGCCAAGGCCTTGGGGCAAGGGCACAGCGTCGAGAGATTCGCGAGCGTGTTGCCCCGCGCGGAGGTCAT
TTTCGCAACAGGCGAGGGTCCCGATTTGGGGCAAGAGCAGACCCGCCATCTCGCGTCGGGCGTTATTCTGGCGGTGGCGG
GCATGCAGCACTCTACCGCTTTGGCGGACATCGCGCGGGGCCGGTCGCGCAGGTCCGTGCGCGCCCATGTAGAGGCCTTT
GACCTGCCCGACGCCACCGACCTGAAACTGATCGCGGGCGGACAGCCGCTGCATCTGGCGGGCGGGCAGGGCCTACCCCA
TGGCGTTCAGGATATCATGCTCGCGCTGCATGTTCTGGCTCTGGGGCAACTTCTGCGTGCGGGACCTGGCAGCGCGGGGT
CTGTCCCATTGGACCCCGCCCTGGAGGCCGGACTGGCAGCGTGTGTCGTGACGCACATGGGTGGTCAGTTGGAGGCCCAG
GCCGGTCGCTGA

Upstream 100 bases:

>100_bases
CCATTGCGGCGGCGAAACTGGCGTCCATGGGGATCACGCTGGAGGTCGCGCGGCCGGAGCAGGCCGACGATGTGACGGGT
CTGATCGGGAGGATTGCGTT

Downstream 100 bases:

>100_bases
CATGGGCGATTTGAGGCGGCGACGGCGCAGGTGATAGGTAAATGCTATGTGTCAATCATGATTTACAGTTGACCTGTCAG
TTAATTGTGACATTCTGTCC

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSASLGQTPALDHALARVMDQAPLRGVPVALARGIAPPAAAVLAARLRHAGADVLDGVGAGPCYVLGVLDEDLTGHRGAT
SQLPGFAQDVPVVDLSQSPLMRLVHDHIGIGQASVMALLDITNLQLAGRHVVVCGYGPTGAGVAAHAAALGARVTVVERD
ALRAAKALGQGHSVERFASVLPRAEVIFATGEGPDLGQEQTRHLASGVILAVAGMQHSTALADIARGRSRRSVRAHVEAF
DLPDATDLKLIAGGQPLHLAGGQGLPHGVQDIMLALHVLALGQLLRAGPGSAGSVPLDPALEAGLAACVVTHMGGQLEAQ
AGR

Sequences:

>Translated_323_residues
MSASLGQTPALDHALARVMDQAPLRGVPVALARGIAPPAAAVLAARLRHAGADVLDGVGAGPCYVLGVLDEDLTGHRGAT
SQLPGFAQDVPVVDLSQSPLMRLVHDHIGIGQASVMALLDITNLQLAGRHVVVCGYGPTGAGVAAHAAALGARVTVVERD
ALRAAKALGQGHSVERFASVLPRAEVIFATGEGPDLGQEQTRHLASGVILAVAGMQHSTALADIARGRSRRSVRAHVEAF
DLPDATDLKLIAGGQPLHLAGGQGLPHGVQDIMLALHVLALGQLLRAGPGSAGSVPLDPALEAGLAACVVTHMGGQLEAQ
AGR
>Mature_322_residues
SASLGQTPALDHALARVMDQAPLRGVPVALARGIAPPAAAVLAARLRHAGADVLDGVGAGPCYVLGVLDEDLTGHRGATS
QLPGFAQDVPVVDLSQSPLMRLVHDHIGIGQASVMALLDITNLQLAGRHVVVCGYGPTGAGVAAHAAALGARVTVVERDA
LRAAKALGQGHSVERFASVLPRAEVIFATGEGPDLGQEQTRHLASGVILAVAGMQHSTALADIARGRSRRSVRAHVEAFD
LPDATDLKLIAGGQPLHLAGGQGLPHGVQDIMLALHVLALGQLLRAGPGSAGSVPLDPALEAGLAACVVTHMGGQLEAQA
GR

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI298286489, Length=234, Percent_Identity=29.0598290598291, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI195539349, Length=234, Percent_Identity=29.0598290598291, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI195539337, Length=234, Percent_Identity=29.0598290598291, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI21361647, Length=234, Percent_Identity=29.0598290598291, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI24308043, Length=234, Percent_Identity=29.0598290598291, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17506425, Length=226, Percent_Identity=25.2212389380531, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24656245, Length=238, Percent_Identity=28.9915966386555, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 32736; Mature: 32605

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASLGQTPALDHALARVMDQAPLRGVPVALARGIAPPAAAVLAARLRHAGADVLDGVGA
CCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCC
GPCYVLGVLDEDLTGHRGATSQLPGFAQDVPVVDLSQSPLMRLVHDHIGIGQASVMALLD
CCEEEEEECCCCCCCCCCCCCCCCCCHHCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHH
ITNLQLAGRHVVVCGYGPTGAGVAAHAAALGARVTVVERDALRAAKALGQGHSVERFASV
HHCEEECCCEEEEEECCCCCCCHHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCHHHHHHH
LPRAEVIFATGEGPDLGQEQTRHLASGVILAVAGMQHSTALADIARGRSRRSVRAHVEAF
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCHHHHHHHHHHC
DLPDATDLKLIAGGQPLHLAGGQGLPHGVQDIMLALHVLALGQLLRAGPGSAGSVPLDPA
CCCCCCCEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
LEAGLAACVVTHMGGQLEAQAGR
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SASLGQTPALDHALARVMDQAPLRGVPVALARGIAPPAAAVLAARLRHAGADVLDGVGA
CCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCHHHCCCCC
GPCYVLGVLDEDLTGHRGATSQLPGFAQDVPVVDLSQSPLMRLVHDHIGIGQASVMALLD
CCEEEEEECCCCCCCCCCCCCCCCCCHHCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHH
ITNLQLAGRHVVVCGYGPTGAGVAAHAAALGARVTVVERDALRAAKALGQGHSVERFASV
HHCEEECCCEEEEEECCCCCCCHHHHHHHHCCEEEEEEHHHHHHHHHHCCCCCHHHHHHH
LPRAEVIFATGEGPDLGQEQTRHLASGVILAVAGMQHSTALADIARGRSRRSVRAHVEAF
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCHHHHHHHHHHC
DLPDATDLKLIAGGQPLHLAGGQGLPHGVQDIMLALHVLALGQLLRAGPGSAGSVPLDPA
CCCCCCCEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
LEAGLAACVVTHMGGQLEAQAGR
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11121031 [H]