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The map label for this gene is ahcY [H]

Identifier: 89054070

GI number: 89054070

Start: 1561048

End: 1562346

Strand: Direct

Name: ahcY [H]

Synonym: Jann_1579

Alternate gene names: 89054070

Gene position: 1561048-1562346 (Clockwise)

Preceding gene: 89054069

Following gene: 89054071

Centisome position: 36.15

GC content: 65.9

Gene sequence:

>1299_bases
ATGAACAGTTTTGGCGACAACGGACCGGATCATCAGGCCTTGGTCGATGACGGCCACGCAAGGATTGCCTGGGTCAAGGA
TTTCTCCCCGGTCATGAATGGCCTTGTATCCCGTGCCTTTGCCGATGGGTCGCTGAAGGGCAAACGCATTGCGGTCGTCG
TGCATCTGGAGGCAAAGACGGCCTATCTGGCCTCCCTTCTGGCCGATGCGGGGGCGGAGGTGATCGCGGCAGGCTCCAAC
CCCCACACCACTCACGGCGCAGTTGTTGCGGCGCTGCGGGACAAGGGCATCCGCGTGGTCTCGGACGCGGGTGGCACCCA
TGCGACGTGGGAGGCAGAGCTGCGCGCTGCTGCCGATCTGGAGCCGGAATATATCATTGATGACGGCGCGGAACTGACCC
TGCGGGTCGGCGCCCACCGCCCGGACGTGTTCAAACACCTCAAGGGCGTGTCGGAAGAGACGACGACCGGCACCGCGCGG
CTGCACGCGTTGGCGGCGGCGGGCAAACTGCCGTTCCCGGCGCTGACGGCCAATGACGCGCGCTGCAAGCATCTGTTCGA
CAACCGCTATGGCACGGGCCAGACCACGTTGCAGGCGGTCCTGCGCCTGACGGGGATGCAGATGGCGGGCGCGCAGGTTG
TGGTTGTCGGCTACGGCTTCGTGGGCCGGGGAATTGCGGACTACGCCGCGCGGATGCACGCACAGGTCCGCGTGATCGAG
ACAGATCCTGTGCGCGCGTTGGAGGTGCATATGGATGGCCACCGGGTGGGCAAGGCCGCCGCCATGTTGCCTGGCGCGCA
GGTGGTGATCACCGCCACGGGCGGGATGCGGGCCATCGGCGCGCCGGAATTTGCGCATCTGGATGATGGCGTCGTGCTGG
CCAATGCAGGTCATCACGACCTTGAGATAGATGTGGCCGCCCTTGCGGAGATCGCCAGAGGGACCGCGGCGAGGAGGGCC
TCGGATGAGGCCGAGGAGCGGGCTGAGGGCCAGCCCGACATCACGACGTATCAGCTCGCAGAGCGGGCGGTTCATGTGCT
GTCCAATGGCGCGCTGGTGAACATCGCCGGCGGCTCCGGACATCCGGTGGAGATCATGGACCTGACCTTTGCGGTGCAAG
GTCTGGGGGCGCATTATCTGGTGAACACGCGGATGGAGCCAGGCGTCCATGTGCTGCCCCGCGCCGTGGACGATTCCATT
GCGGCGGCGAAACTGGCGTCCATGGGGATCACGCTGGAGGTCGCGCGGCCGGAGCAGGCCGACGATGTGACGGGTCTGAT
CGGGAGGATTGCGTTATGA

Upstream 100 bases:

>100_bases
CGCTGCTCCATCGCAGCAAACTGGGCAAGGCAGGGTAGGGCGCATGCTTTGCGATCCGGGCTGAGGCTCGCTATCCCTTG
GCGGATAGGGAGGGCCACGG

Downstream 100 bases:

>100_bases
GCGCATCACTGGGCCAGACACCCGCCCTCGACCACGCGCTGGCGCGCGTGATGGATCAGGCGCCCCTCCGGGGCGTTCCG
GTGGCGCTGGCGCGCGGGAT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNSFGDNGPDHQALVDDGHARIAWVKDFSPVMNGLVSRAFADGSLKGKRIAVVVHLEAKTAYLASLLADAGAEVIAAGSN
PHTTHGAVVAALRDKGIRVVSDAGGTHATWEAELRAAADLEPEYIIDDGAELTLRVGAHRPDVFKHLKGVSEETTTGTAR
LHALAAAGKLPFPALTANDARCKHLFDNRYGTGQTTLQAVLRLTGMQMAGAQVVVVGYGFVGRGIADYAARMHAQVRVIE
TDPVRALEVHMDGHRVGKAAAMLPGAQVVITATGGMRAIGAPEFAHLDDGVVLANAGHHDLEIDVAALAEIARGTAARRA
SDEAEERAEGQPDITTYQLAERAVHVLSNGALVNIAGGSGHPVEIMDLTFAVQGLGAHYLVNTRMEPGVHVLPRAVDDSI
AAAKLASMGITLEVARPEQADDVTGLIGRIAL

Sequences:

>Translated_432_residues
MNSFGDNGPDHQALVDDGHARIAWVKDFSPVMNGLVSRAFADGSLKGKRIAVVVHLEAKTAYLASLLADAGAEVIAAGSN
PHTTHGAVVAALRDKGIRVVSDAGGTHATWEAELRAAADLEPEYIIDDGAELTLRVGAHRPDVFKHLKGVSEETTTGTAR
LHALAAAGKLPFPALTANDARCKHLFDNRYGTGQTTLQAVLRLTGMQMAGAQVVVVGYGFVGRGIADYAARMHAQVRVIE
TDPVRALEVHMDGHRVGKAAAMLPGAQVVITATGGMRAIGAPEFAHLDDGVVLANAGHHDLEIDVAALAEIARGTAARRA
SDEAEERAEGQPDITTYQLAERAVHVLSNGALVNIAGGSGHPVEIMDLTFAVQGLGAHYLVNTRMEPGVHVLPRAVDDSI
AAAKLASMGITLEVARPEQADDVTGLIGRIAL
>Mature_432_residues
MNSFGDNGPDHQALVDDGHARIAWVKDFSPVMNGLVSRAFADGSLKGKRIAVVVHLEAKTAYLASLLADAGAEVIAAGSN
PHTTHGAVVAALRDKGIRVVSDAGGTHATWEAELRAAADLEPEYIIDDGAELTLRVGAHRPDVFKHLKGVSEETTTGTAR
LHALAAAGKLPFPALTANDARCKHLFDNRYGTGQTTLQAVLRLTGMQMAGAQVVVVGYGFVGRGIADYAARMHAQVRVIE
TDPVRALEVHMDGHRVGKAAAMLPGAQVVITATGGMRAIGAPEFAHLDDGVVLANAGHHDLEIDVAALAEIARGTAARRA
SDEAEERAEGQPDITTYQLAERAVHVLSNGALVNIAGGSGHPVEIMDLTFAVQGLGAHYLVNTRMEPGVHVLPRAVDDSI
AAAKLASMGITLEVARPEQADDVTGLIGRIAL

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI195539349, Length=397, Percent_Identity=32.4937027707809, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI298286489, Length=397, Percent_Identity=32.4937027707809, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI195539337, Length=397, Percent_Identity=32.4937027707809, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI24308043, Length=397, Percent_Identity=32.4937027707809, Blast_Score=198, Evalue=7e-51,
Organism=Homo sapiens, GI9951915, Length=397, Percent_Identity=32.2418136020151, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI239937451, Length=397, Percent_Identity=32.2418136020151, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI21361647, Length=386, Percent_Identity=32.1243523316062, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17506425, Length=417, Percent_Identity=32.3741007194245, Blast_Score=193, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320882, Length=406, Percent_Identity=33.4975369458128, Blast_Score=192, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24656245, Length=397, Percent_Identity=33.2493702770781, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24642172, Length=383, Percent_Identity=32.1148825065274, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI45553387, Length=396, Percent_Identity=32.3232323232323, Blast_Score=168, Evalue=6e-42,
Organism=Drosophila melanogaster, GI45553385, Length=396, Percent_Identity=32.3232323232323, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 45189; Mature: 45189

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSFGDNGPDHQALVDDGHARIAWVKDFSPVMNGLVSRAFADGSLKGKRIAVVVHLEAKT
CCCCCCCCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHH
AYLASLLADAGAEVIAAGSNPHTTHGAVVAALRDKGIRVVSDAGGTHATWEAELRAAADL
HHHHHHHHHCCCEEEEECCCCCCCCHHEEEEECCCCEEEEECCCCCCEEEHHHHHHHCCC
EPEYIIDDGAELTLRVGAHRPDVFKHLKGVSEETTTGTARLHALAAAGKLPFPALTANDA
CCCEEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH
RCKHLFDNRYGTGQTTLQAVLRLTGMQMAGAQVVVVGYGFVGRGIADYAARMHAQVRVIE
HHHHHHCCCCCCCHHHHHHHHHHHCCEECCCEEEEEECCCCCCCHHHHHHHHEEEEEEEE
TDPVRALEVHMDGHRVGKAAAMLPGAQVVITATGGMRAIGAPEFAHLDDGVVLANAGHHD
CCCCEEEEEEECCCHHCCHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCEEEECCCCCC
LEIDVAALAEIARGTAARRASDEAEERAEGQPDITTYQLAERAVHVLSNGALVNIAGGSG
EEEEHHHHHHHHHCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
HPVEIMDLTFAVQGLGAHYLVNTRMEPGVHVLPRAVDDSIAAAKLASMGITLEVARPEQA
CCEEEEEEEEHHHCCCEEEEEECCCCCCCEECCCHHCCHHHHHHHHHCCEEEEECCCCCC
DDVTGLIGRIAL
CHHHHHHHHHCC
>Mature Secondary Structure
MNSFGDNGPDHQALVDDGHARIAWVKDFSPVMNGLVSRAFADGSLKGKRIAVVVHLEAKT
CCCCCCCCCCCCCEECCCCEEEEEECHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCHH
AYLASLLADAGAEVIAAGSNPHTTHGAVVAALRDKGIRVVSDAGGTHATWEAELRAAADL
HHHHHHHHHCCCEEEEECCCCCCCCHHEEEEECCCCEEEEECCCCCCEEEHHHHHHHCCC
EPEYIIDDGAELTLRVGAHRPDVFKHLKGVSEETTTGTARLHALAAAGKLPFPALTANDA
CCCEEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCH
RCKHLFDNRYGTGQTTLQAVLRLTGMQMAGAQVVVVGYGFVGRGIADYAARMHAQVRVIE
HHHHHHCCCCCCCHHHHHHHHHHHCCEECCCEEEEEECCCCCCCHHHHHHHHEEEEEEEE
TDPVRALEVHMDGHRVGKAAAMLPGAQVVITATGGMRAIGAPEFAHLDDGVVLANAGHHD
CCCCEEEEEEECCCHHCCHHHHCCCCEEEEEECCCEEECCCCCCCCCCCCEEEECCCCCC
LEIDVAALAEIARGTAARRASDEAEERAEGQPDITTYQLAERAVHVLSNGALVNIAGGSG
EEEEHHHHHHHHHCHHHHHCCCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCC
HPVEIMDLTFAVQGLGAHYLVNTRMEPGVHVLPRAVDDSIAAAKLASMGITLEVARPEQA
CCEEEEEEEEHHHCCCEEEEEECCCCCCCEECCCHHCCHHHHHHHHHCCEEEEECCCCCC
DDVTGLIGRIAL
CHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9440516; 10360571 [H]