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The map label for this gene is cytR [H]

Identifier: 89053950

GI number: 89053950

Start: 1428122

End: 1429144

Strand: Reverse

Name: cytR [H]

Synonym: Jann_1459

Alternate gene names: 89053950

Gene position: 1429144-1428122 (Counterclockwise)

Preceding gene: 89053961

Following gene: 89053946

Centisome position: 33.1

GC content: 64.81

Gene sequence:

>1023_bases
ATGGCGCAGAAAAGCGCAACGATCCAGGATGTGGCGACAGTTGCCAAGGTCTCCACCGCGACGGTCAGCCGGGCGTTGTC
GAATCCGGGGCTCTTGTCGGACACCACGCGTGAGGCGGTGTTGGAGGCGGTGCGGATAACGGGATACCGCGTCAACCAGG
CGGCCCGCAACCTGCGCATGCAGCGGGCGGGGGCTGTTCTGATCCTCGTGCCAAACCTTGGCAAACCCTTTTATTCCGAG
ATCTTGCAGGGCATTTCCGATGGCTTTGCGGGCAGCGACTATGCGGTCCTGATTGCCGATACCGAAAGTCGCCCACTGCA
CAAGGCTGAGCTTGCGGGCAACTTCATCAGCGGACGCATCGACGGGGTCGTGTCGCTGGATGGCGGGCTCAGCCCGGCCG
CGCTGGATGCCTGCAAGGCCGCCGGTGTGGACGGGCGCATCGTCTTTGCCTGCGAATGGGTGGAGGGATACACCTTCCCC
TCGATCCAATCCGATAATGCCGAGGGCGCGCGCCTGGCGATCCGGCATCTGACCGAGCTGGGGCATCGCAAGATCGCCCA
TATCACCGGGCCGCAAGGCAACGTCCTGACGGGGGTGCGGCGGCGCGGGATGATGGAGGAACGCACCCGTCTGGGCCTTC
CGGCGCGGGAAGACTGGATCATTCGCGGCGATTTCTCTCTCCAATCGGGACATGAGGCGGCCGCGAAGATCCTGTTCATG
GACGACCGCCCCACGGCCGTCTTTTGTGCTGCGGATATGGTGGCCTTCGGACTGATGGCGGGATTGCAGGCGGGCGGTGT
TCGGGTGCCCGATGACATCTCGGTCGTGGGCTTCGATGATATTGATATGTCCGAATTTTACGTGCCCGCGCTGACGACCA
TTCGGCAGGATCGGGTGCGTCTGGGCCGGACCGCCGCCGCGCGTCTGTTGGAGCGGATCAGCGCGCCGCAAGCGCCCCTG
CCGCCGGAAGATCTGTTGTCGGTGGACCTGGTCGTGCGCGCGTCTACCGCGCCACCGCGCTAG

Upstream 100 bases:

>100_bases
GCCCTTAGAATTTTCTTCTTTGTCGGCTCTGAAATCGATTACATACTCGAACCAGCGACGGATTCGAGTCAAGACGTAAT
TCAACTTTCGCGGGGGCCCC

Downstream 100 bases:

>100_bases
GGCGGTGCGCCTGCGATCCATTGCTCCAGATCAAGACACACACCGCTCATCGGGCGGGCGGCATCGGACAACATCCAGAC
GGCCTGCGCCGCGCATTCCA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MAQKSATIQDVATVAKVSTATVSRALSNPGLLSDTTREAVLEAVRITGYRVNQAARNLRMQRAGAVLILVPNLGKPFYSE
ILQGISDGFAGSDYAVLIADTESRPLHKAELAGNFISGRIDGVVSLDGGLSPAALDACKAAGVDGRIVFACEWVEGYTFP
SIQSDNAEGARLAIRHLTELGHRKIAHITGPQGNVLTGVRRRGMMEERTRLGLPAREDWIIRGDFSLQSGHEAAAKILFM
DDRPTAVFCAADMVAFGLMAGLQAGGVRVPDDISVVGFDDIDMSEFYVPALTTIRQDRVRLGRTAAARLLERISAPQAPL
PPEDLLSVDLVVRASTAPPR

Sequences:

>Translated_340_residues
MAQKSATIQDVATVAKVSTATVSRALSNPGLLSDTTREAVLEAVRITGYRVNQAARNLRMQRAGAVLILVPNLGKPFYSE
ILQGISDGFAGSDYAVLIADTESRPLHKAELAGNFISGRIDGVVSLDGGLSPAALDACKAAGVDGRIVFACEWVEGYTFP
SIQSDNAEGARLAIRHLTELGHRKIAHITGPQGNVLTGVRRRGMMEERTRLGLPAREDWIIRGDFSLQSGHEAAAKILFM
DDRPTAVFCAADMVAFGLMAGLQAGGVRVPDDISVVGFDDIDMSEFYVPALTTIRQDRVRLGRTAAARLLERISAPQAPL
PPEDLLSVDLVVRASTAPPR
>Mature_339_residues
AQKSATIQDVATVAKVSTATVSRALSNPGLLSDTTREAVLEAVRITGYRVNQAARNLRMQRAGAVLILVPNLGKPFYSEI
LQGISDGFAGSDYAVLIADTESRPLHKAELAGNFISGRIDGVVSLDGGLSPAALDACKAAGVDGRIVFACEWVEGYTFPS
IQSDNAEGARLAIRHLTELGHRKIAHITGPQGNVLTGVRRRGMMEERTRLGLPAREDWIIRGDFSLQSGHEAAAKILFMD
DRPTAVFCAADMVAFGLMAGLQAGGVRVPDDISVVGFDDIDMSEFYVPALTTIRQDRVRLGRTAAARLLERISAPQAPLP
PEDLLSVDLVVRASTAPPR

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=335, Percent_Identity=35.8208955223881, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1787948, Length=310, Percent_Identity=31.2903225806452, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790194, Length=311, Percent_Identity=29.2604501607717, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786540, Length=338, Percent_Identity=32.2485207100592, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1788474, Length=289, Percent_Identity=30.7958477508651, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789202, Length=335, Percent_Identity=29.5522388059701, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI48994940, Length=313, Percent_Identity=28.1150159744409, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789068, Length=291, Percent_Identity=28.5223367697594, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1787906, Length=321, Percent_Identity=27.4143302180685, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787580, Length=321, Percent_Identity=24.2990654205607, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789456, Length=320, Percent_Identity=27.5, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1790689, Length=329, Percent_Identity=26.1398176291793, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36357; Mature: 36226

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQKSATIQDVATVAKVSTATVSRALSNPGLLSDTTREAVLEAVRITGYRVNQAARNLRM
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHH
QRAGAVLILVPNLGKPFYSEILQGISDGFAGSDYAVLIADTESRPLHKAELAGNFISGRI
HHCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCCCHHCCCC
DGVVSLDGGLSPAALDACKAAGVDGRIVFACEWVEGYTFPSIQSDNAEGARLAIRHLTEL
CEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
GHRKIAHITGPQGNVLTGVRRRGMMEERTRLGLPAREDWIIRGDFSLQSGHEAAAKILFM
CCCEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEEEE
DDRPTAVFCAADMVAFGLMAGLQAGGVRVPDDISVVGFDDIDMSEFYVPALTTIRQDRVR
CCCCCEEEHHHHHHHHHHHHHHCCCCEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
LGRTAAARLLERISAPQAPLPPEDLLSVDLVVRASTAPPR
HHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEEECCCCCC
>Mature Secondary Structure 
AQKSATIQDVATVAKVSTATVSRALSNPGLLSDTTREAVLEAVRITGYRVNQAARNLRM
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEHHHHHHHHHH
QRAGAVLILVPNLGKPFYSEILQGISDGFAGSDYAVLIADTESRPLHKAELAGNFISGRI
HHCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHCCCHHCCCC
DGVVSLDGGLSPAALDACKAAGVDGRIVFACEWVEGYTFPSIQSDNAEGARLAIRHLTEL
CEEEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
GHRKIAHITGPQGNVLTGVRRRGMMEERTRLGLPAREDWIIRGDFSLQSGHEAAAKILFM
CCCEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEEEEE
DDRPTAVFCAADMVAFGLMAGLQAGGVRVPDDISVVGFDDIDMSEFYVPALTTIRQDRVR
CCCCCEEEHHHHHHHHHHHHHHCCCCEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHH
LGRTAAARLLERISAPQAPLPPEDLLSVDLVVRASTAPPR
HHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]