Click here to switch to the map view.

The map label for this gene is tmk

Identifier: 89053768

GI number: 89053768

Start: 1237590

End: 1238216

Strand: Reverse

Name: tmk

Synonym: Jann_1277

Alternate gene names: 89053768

Gene position: 1238216-1237590 (Counterclockwise)

Preceding gene: 89053769

Following gene: 89053767

Centisome position: 28.68

GC content: 67.78

Gene sequence:

>627_bases
ATGCCCCCCCTATTCATCAGCCTTGAGGGCATCGACGGCTCTGGCAAATCCACCCAGACCGCGCGCCTGGTCGATTGGCT
CCGCGTCCGGGGCCGCGATCCGCTACAGACACGGGAACCCGGCGGATCTGAGGGCGCTGAGGAGATCCGCCGCCTGCTCG
TGGAAGGTGACCCGGACCGGTGGAGCGCCGAGACGGAGATCTTGCTGTTCACCGCCGCCCGTCGCGATCATCTGGAGCGT
ACCATCCGCCCGGCCCTTGCATCCGGGCGTGACGTGGTGACCGACCGCTTCGCCGACAGCACCCGCGTGTATCAGGGGGC
CACGCGCGGCGCTTTGCGGGGTCTGGTCGACCGGATTCACGCCGAGGCGATTGAGGCGGAGCCGGACCTGACCCTGATCC
TCGACATGGACCCGGAACTGGCCCTGTCGCGCGGTCTGGCCCGCGACAGCGGAGAGGACAGGTTTGAGGATTTTGGTCTG
CCGTTCCAGCAAAAACTCCGCGCCGGGTTTCAGGCCCTGGCCCGGGAGTACCCCGACCGTTGCCATATCGTGGATGCCTC
CGCGGACCCCGACGCAATCGCCCACACCATCCAGACCATCGTCGGCCAGCGCCTAGCGGAGGCCTGA

Upstream 100 bases:

>100_bases
TGATCGAGCGCATCATATAGCGCGAAACGCCAACGCCTTGCCCCCAAAGGCAGGCCATGCCACATCTTTCAGCCAAGTGA
TCCAAGCCCGGAAGCCCTCC

Downstream 100 bases:

>100_bases
CATCAGCCGCATGCCCCCGATGGGCCAAGCAAATTGATATACCATTGATCTACCCTGCCCGCCGCTTGCGCCCCGTGCTA
CATCTGCCCCATGTCCGATG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MPPLFISLEGIDGSGKSTQTARLVDWLRVRGRDPLQTREPGGSEGAEEIRRLLVEGDPDRWSAETEILLFTAARRDHLER
TIRPALASGRDVVTDRFADSTRVYQGATRGALRGLVDRIHAEAIEAEPDLTLILDMDPELALSRGLARDSGEDRFEDFGL
PFQQKLRAGFQALAREYPDRCHIVDASADPDAIAHTIQTIVGQRLAEA

Sequences:

>Translated_208_residues
MPPLFISLEGIDGSGKSTQTARLVDWLRVRGRDPLQTREPGGSEGAEEIRRLLVEGDPDRWSAETEILLFTAARRDHLER
TIRPALASGRDVVTDRFADSTRVYQGATRGALRGLVDRIHAEAIEAEPDLTLILDMDPELALSRGLARDSGEDRFEDFGL
PFQQKLRAGFQALAREYPDRCHIVDASADPDAIAHTIQTIVGQRLAEA
>Mature_207_residues
PPLFISLEGIDGSGKSTQTARLVDWLRVRGRDPLQTREPGGSEGAEEIRRLLVEGDPDRWSAETEILLFTAARRDHLERT
IRPALASGRDVVTDRFADSTRVYQGATRGALRGLVDRIHAEAIEAEPDLTLILDMDPELALSRGLARDSGEDRFEDFGLP
FQQKLRAGFQALAREYPDRCHIVDASADPDAIAHTIQTIVGQRLAEA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=214, Percent_Identity=36.9158878504673, Blast_Score=107, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_JANSC (Q28SW8)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509219.1
- HSSP:   P65248
- ProteinModelPortal:   Q28SW8
- SMR:   Q28SW8
- STRING:   Q28SW8
- GeneID:   3933723
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1277
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q28SW8
- ProtClustDB:   CLSK933953
- BioCyc:   JSP290400:JANN_1277-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23025; Mature: 22894

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPLFISLEGIDGSGKSTQTARLVDWLRVRGRDPLQTREPGGSEGAEEIRRLLVEGDPDR
CCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
WSAETEILLFTAARRDHLERTIRPALASGRDVVTDRFADSTRVYQGATRGALRGLVDRIH
CCCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AEAIEAEPDLTLILDMDPELALSRGLARDSGEDRFEDFGLPFQQKLRAGFQALAREYPDR
HHHHCCCCCEEEEEECCHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCC
CHIVDASADPDAIAHTIQTIVGQRLAEA
EEEEECCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PPLFISLEGIDGSGKSTQTARLVDWLRVRGRDPLQTREPGGSEGAEEIRRLLVEGDPDR
CCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
WSAETEILLFTAARRDHLERTIRPALASGRDVVTDRFADSTRVYQGATRGALRGLVDRIH
CCCCCEEEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AEAIEAEPDLTLILDMDPELALSRGLARDSGEDRFEDFGLPFQQKLRAGFQALAREYPDR
HHHHCCCCCEEEEEECCHHHHHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCC
CHIVDASADPDAIAHTIQTIVGQRLAEA
EEEEECCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA