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The map label for this gene is hisN [H]

Identifier: 89053724

GI number: 89053724

Start: 1188886

End: 1189683

Strand: Direct

Name: hisN [H]

Synonym: Jann_1233

Alternate gene names: 89053724

Gene position: 1188886-1189683 (Clockwise)

Preceding gene: 89053723

Following gene: 89053725

Centisome position: 27.53

GC content: 65.66

Gene sequence:

>798_bases
ATGAAAGATGAGCAGGCATTGATTGAGACGGCCCATGCCATGGCCGATGCCGCGCGCGCGGCGATCCTGCCGCATTTCCG
GCAATCGGGGCTTGGCACGGTCTCCAAGGAAGCCGACCGCTACGATCCTGTAACGGTGGCCGACCGCGCGTCTGAGGCTG
CCATGCGCGCGGTTCTGGCAGAGCGTCGCCCGACAGATGCGATCCTGGGCGAAGAAGAGGGTGCGCAGCCCGGCACCAGC
GGGCTGACTTGGGTGCTCGACCCCATCGACGGCACACGTGGGTTTGTCTCGGGCACGCCGACCTGGGGCGTGTTGATCGC
ATTGTGCGATGCGGATGGCCCGATCTACGGGATCATCGACCAACCCTATATCGGTGAACGGTTTGAGGGCGGCTTTGGCC
GCGCGCAGATGAACGGGCCGCTGGGACCGCGTCCCCTTCGTGCCACGGCCTCCGCCAGCCTGGCCGAGACGACCTTGTTC
ACGACCTTTCCGGAAGTGGGCAGCGCGGCCGAGCGGCGCGGGTTTGAGGCAGTCCGCGACCGGGTGCAGCTGGTCCGATA
TGGATGTGATTGTTACGCTTATGCGCTTCTGGCGGCGGGCCAGATTGATCTGGTGATCGAGGCCGGTCTGCAAAGCTATG
ACATCGCGGCCCCTGTGGCTTTGGTGCAGGCGGCCGGCGGTGTGATCACGAATTGGGAGGGCGGGCCGGTCCATGACGGG
GGACGCGCGATCGCCGCCGCCTCGCCCGCGCTACATGCCGAGGCGATGGCCTTGGTGAAAGGTACAGTAGATGACTGA

Upstream 100 bases:

>100_bases
CGTGCTGTCGGATGCCGCCGCCTGACCCCTGACGCCGGAACCTTGACGTCTGCACGCGCAACATGTCACCCCCGGATCTT
GTTTGGATATGGGGGCCACC

Downstream 100 bases:

>100_bases
TCTGGTCCTGCGCAACGTCGCCCATTGCCTGACGATGGATGACGCGGGGACCGAGCCGCGCGACGTCGATATCCTGTTGC
GGGATGGGCAGATTTCTGAA

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MKDEQALIETAHAMADAARAAILPHFRQSGLGTVSKEADRYDPVTVADRASEAAMRAVLAERRPTDAILGEEEGAQPGTS
GLTWVLDPIDGTRGFVSGTPTWGVLIALCDADGPIYGIIDQPYIGERFEGGFGRAQMNGPLGPRPLRATASASLAETTLF
TTFPEVGSAAERRGFEAVRDRVQLVRYGCDCYAYALLAAGQIDLVIEAGLQSYDIAAPVALVQAAGGVITNWEGGPVHDG
GRAIAAASPALHAEAMALVKGTVDD

Sequences:

>Translated_265_residues
MKDEQALIETAHAMADAARAAILPHFRQSGLGTVSKEADRYDPVTVADRASEAAMRAVLAERRPTDAILGEEEGAQPGTS
GLTWVLDPIDGTRGFVSGTPTWGVLIALCDADGPIYGIIDQPYIGERFEGGFGRAQMNGPLGPRPLRATASASLAETTLF
TTFPEVGSAAERRGFEAVRDRVQLVRYGCDCYAYALLAAGQIDLVIEAGLQSYDIAAPVALVQAAGGVITNWEGGPVHDG
GRAIAAASPALHAEAMALVKGTVDD
>Mature_265_residues
MKDEQALIETAHAMADAARAAILPHFRQSGLGTVSKEADRYDPVTVADRASEAAMRAVLAERRPTDAILGEEEGAQPGTS
GLTWVLDPIDGTRGFVSGTPTWGVLIALCDADGPIYGIIDQPYIGERFEGGFGRAQMNGPLGPRPLRATASASLAETTLF
TTFPEVGSAAERRGFEAVRDRVQLVRYGCDCYAYALLAAGQIDLVIEAGLQSYDIAAPVALVQAAGGVITNWEGGPVHDG
GRAIAAASPALHAEAMALVKGTVDD

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine (Probable) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI7657236, Length=251, Percent_Identity=27.4900398406374, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI5031789, Length=230, Percent_Identity=26.9565217391304, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI221625487, Length=230, Percent_Identity=26.9565217391304, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788882, Length=230, Percent_Identity=29.5652173913043, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193202572, Length=263, Percent_Identity=26.615969581749, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193202570, Length=263, Percent_Identity=26.615969581749, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320493, Length=251, Percent_Identity=23.9043824701195, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357957, Length=242, Percent_Identity=28.5123966942149, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24664918, Length=266, Percent_Identity=24.812030075188, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664922, Length=233, Percent_Identity=27.4678111587983, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI21357303, Length=221, Percent_Identity=27.1493212669683, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357329, Length=226, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24664926, Length=201, Percent_Identity=25.3731343283582, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27707; Mature: 27707

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: PS00629 IMP_1 ; PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDEQALIETAHAMADAARAAILPHFRQSGLGTVSKEADRYDPVTVADRASEAAMRAVLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHHH
ERRPTDAILGEEEGAQPGTSGLTWVLDPIDGTRGFVSGTPTWGVLIALCDADGPIYGIID
HCCCCHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCEEEECC
QPYIGERFEGGFGRAQMNGPLGPRPLRATASASLAETTLFTTFPEVGSAAERRGFEAVRD
CCCCCCCCCCCCCEEECCCCCCCCCCCHHHCCHHHHHHHHHCCHHHCCHHHHCCHHHHHH
RVQLVRYGCDCYAYALLAAGQIDLVIEAGLQSYDIAAPVALVQAAGGVITNWEGGPVHDG
HHHHHHHCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCC
GRAIAAASPALHAEAMALVKGTVDD
CCEEEECCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKDEQALIETAHAMADAARAAILPHFRQSGLGTVSKEADRYDPVTVADRASEAAMRAVLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEHHHHHHHHHHHHHHH
ERRPTDAILGEEEGAQPGTSGLTWVLDPIDGTRGFVSGTPTWGVLIALCDADGPIYGIID
HCCCCHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCCCEEEECC
QPYIGERFEGGFGRAQMNGPLGPRPLRATASASLAETTLFTTFPEVGSAAERRGFEAVRD
CCCCCCCCCCCCCEEECCCCCCCCCCCHHHCCHHHHHHHHHCCHHHCCHHHHCCHHHHHH
RVQLVRYGCDCYAYALLAAGQIDLVIEAGLQSYDIAAPVALVQAAGGVITNWEGGPVHDG
HHHHHHHCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCC
GRAIAAASPALHAEAMALVKGTVDD
CCEEEECCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]