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The map label for this gene is coxS [H]

Identifier: 89053428

GI number: 89053428

Start: 893299

End: 894759

Strand: Reverse

Name: coxS [H]

Synonym: Jann_0937

Alternate gene names: 89053428

Gene position: 894759-893299 (Counterclockwise)

Preceding gene: 89053429

Following gene: 89053427

Centisome position: 20.72

GC content: 65.23

Gene sequence:

>1461_bases
ATGACGACCCGGTTCCTTCTGAACGGAGAGCCGCAGACAGTGGAGGCCGCGCCGACGCGCACGCTTCTGGACTGGCTGCG
GGAAGAGGCGCGACTGACCGGCACCAAAGAGGGCTGCAACGAAGGCGATTGCGGCGCGTGTACCGTCATGGTCACGAATG
CCGATGGCACAGCCCTCGCGCTCAACGCCTGCATTCTGTTCCTGCCCCAGCTGGAAGGCCGCGCCGTGCGCACCGTGGAG
GGCATCGCCGCACCCGATGGCACGCTGCATCCCGTGCAGCAGGCAATGGTCGACCATCACGGCAGCCAATGCGGCTTCTG
CACGCCGGGGTTTATCACCGCCATGGCGACAGCGCACCTCAACGGGGCCACGGACCATGAAGACCAGATCGCAGGCAACC
TCTGCCGCTGCACCGGTTACGCGCCCATCCTGCACGCCGCCCACGCCGCCGCCAATGCGCCTATCCCACCCCATATGGTT
CGGGACGCCGACCAGCTCTCTGCCCCATTCCCCGTTCCGGAAATATCCCAGGGGGAGTCCAACGGACGGGGGACAGCGTC
CCCCCGCCCTGCCGCGCAGGGCCAGAGTGACTCTTGCCCCGTCTGCCCAACCACGTCCGACGATCTGGCCACTTGGTATG
CCGCCCACCCCGACGCAACCTTGATTGCTGGGGCCACGGATGTCGGTCTGTGGGTCACCAAACAACACCGCAATCTGGGC
AAGGTCGCCTTCCTGAACCAATGCGCGGATTTGTACGGGGCCCACATCACCGGGGATACAATCCGCTTCGGGGCCATGAC
GTCCATGACCGACGTACTCGCCGCCATCGCCCCGCACTATCCCAGCTACGCCGAGATGATCCGTCGCTATGGCTCCGTCC
AGGTCCGCAATGCGGCGACGATTGGCGGGAATATCGCCAACGGATCGCCCATCGGCGACAACCCTCCGGCGCTGATCGCC
CTTGGCGCAACGCTGCATCTGCGCCATGGGGCCACCCGACGGGATCTGCTGCTGGAGGATTTCTTCCTCGACTACGGCAA
GCAGGATCTTGCGCCCGGGGAGTTTGTGGAGGCTGTGACGATCCCCATTCCAGGTGCGGGCGAGGACGACACCCTGCGCG
TCTACAAACTGTCCAAGCGCTTTGATCAGGACATCTCCGCTGTCTGCGGCGCATTCAATCTGACCGTCACCGACGGCACG
ATCGCCCAAGCGTGCATTGCCTGCGGCGGTATGGCAGGCATCCCGAAACGCGCCACGGCGGTGGAGGCGATGCTCCTCGG
CAAACCTCTTACGCAGGCGACGACGGACGCTGCCTTGCCCGCGTTTGCCGAGGATTTTGCGCCCCTCTCGGACATGCGCG
CGTCTGCCGGCTATCGGCTTGAGGCGGCGCAAAACATGCTCTTGCGCTACATGGCCGAGATGTCTGGCCAGGCAACCAGC
GTGCTGGAGGTGCGGCCATGA

Upstream 100 bases:

>100_bases
TTGTCCTATGCGTCAGGTCGTACAGTCTGGGCCGCCCTCTACGCCGCATCGAGGGCCGGATGACCACCCCAATCCCAGGT
AACGCGGTGGACATTGCCCT

Downstream 100 bases:

>100_bases
GCGTGCACAAACCCCTGCCCCATGATGCCGCCCGTCTGCATGTCACCGGGGCGGCCCGCTATGTGGATGACATTCCGACG
CCGCCCGATTGCCTGCACCT

Product: molybdopterin dehydrogenase

Products: NA

Alternate protein names: CO dehydrogenase subunit S; CO-DH S [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTTRFLLNGEPQTVEAAPTRTLLDWLREEARLTGTKEGCNEGDCGACTVMVTNADGTALALNACILFLPQLEGRAVRTVE
GIAAPDGTLHPVQQAMVDHHGSQCGFCTPGFITAMATAHLNGATDHEDQIAGNLCRCTGYAPILHAAHAAANAPIPPHMV
RDADQLSAPFPVPEISQGESNGRGTASPRPAAQGQSDSCPVCPTTSDDLATWYAAHPDATLIAGATDVGLWVTKQHRNLG
KVAFLNQCADLYGAHITGDTIRFGAMTSMTDVLAAIAPHYPSYAEMIRRYGSVQVRNAATIGGNIANGSPIGDNPPALIA
LGATLHLRHGATRRDLLLEDFFLDYGKQDLAPGEFVEAVTIPIPGAGEDDTLRVYKLSKRFDQDISAVCGAFNLTVTDGT
IAQACIACGGMAGIPKRATAVEAMLLGKPLTQATTDAALPAFAEDFAPLSDMRASAGYRLEAAQNMLLRYMAEMSGQATS
VLEVRP

Sequences:

>Translated_486_residues
MTTRFLLNGEPQTVEAAPTRTLLDWLREEARLTGTKEGCNEGDCGACTVMVTNADGTALALNACILFLPQLEGRAVRTVE
GIAAPDGTLHPVQQAMVDHHGSQCGFCTPGFITAMATAHLNGATDHEDQIAGNLCRCTGYAPILHAAHAAANAPIPPHMV
RDADQLSAPFPVPEISQGESNGRGTASPRPAAQGQSDSCPVCPTTSDDLATWYAAHPDATLIAGATDVGLWVTKQHRNLG
KVAFLNQCADLYGAHITGDTIRFGAMTSMTDVLAAIAPHYPSYAEMIRRYGSVQVRNAATIGGNIANGSPIGDNPPALIA
LGATLHLRHGATRRDLLLEDFFLDYGKQDLAPGEFVEAVTIPIPGAGEDDTLRVYKLSKRFDQDISAVCGAFNLTVTDGT
IAQACIACGGMAGIPKRATAVEAMLLGKPLTQATTDAALPAFAEDFAPLSDMRASAGYRLEAAQNMLLRYMAEMSGQATS
VLEVRP
>Mature_485_residues
TTRFLLNGEPQTVEAAPTRTLLDWLREEARLTGTKEGCNEGDCGACTVMVTNADGTALALNACILFLPQLEGRAVRTVEG
IAAPDGTLHPVQQAMVDHHGSQCGFCTPGFITAMATAHLNGATDHEDQIAGNLCRCTGYAPILHAAHAAANAPIPPHMVR
DADQLSAPFPVPEISQGESNGRGTASPRPAAQGQSDSCPVCPTTSDDLATWYAAHPDATLIAGATDVGLWVTKQHRNLGK
VAFLNQCADLYGAHITGDTIRFGAMTSMTDVLAAIAPHYPSYAEMIRRYGSVQVRNAATIGGNIANGSPIGDNPPALIAL
GATLHLRHGATRRDLLLEDFFLDYGKQDLAPGEFVEAVTIPIPGAGEDDTLRVYKLSKRFDQDISAVCGAFNLTVTDGTI
AQACIACGGMAGIPKRATAVEAMLLGKPLTQATTDAALPAFAEDFAPLSDMRASAGYRLEAAQNMLLRYMAEMSGQATSV
LEVRP

Specific function: Catalyzes the oxidation of carbon monoxide to carbon dioxide [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=462, Percent_Identity=31.1688311688312, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI71773480, Length=538, Percent_Identity=25.6505576208178, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1786480, Length=170, Percent_Identity=37.0588235294118, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1789232, Length=152, Percent_Identity=43.421052631579, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789231, Length=279, Percent_Identity=26.8817204301075, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=542, Percent_Identity=29.1512915129151, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17539860, Length=155, Percent_Identity=40.6451612903226, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=155, Percent_Identity=40, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI17737937, Length=487, Percent_Identity=31.6221765913758, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI24647199, Length=501, Percent_Identity=26.3473053892216, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24647197, Length=332, Percent_Identity=31.0240963855422, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24647195, Length=332, Percent_Identity=31.0240963855422, Blast_Score=128, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24647201, Length=526, Percent_Identity=24.7148288973384, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24647193, Length=525, Percent_Identity=24.3809523809524, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.2.99.2 [H]

Molecular weight: Translated: 51165; Mature: 51034

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRFLLNGEPQTVEAAPTRTLLDWLREEARLTGTKEGCNEGDCGACTVMVTNADGTALA
CCEEEEECCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCHH
LNACILFLPQLEGRAVRTVEGIAAPDGTLHPVQQAMVDHHGSQCGFCTPGFITAMATAHL
HHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
NGATDHEDQIAGNLCRCTGYAPILHAAHAAANAPIPPHMVRDADQLSAPFPVPEISQGES
CCCCCCHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCHHHHCCHHHHCCCCCCCCCCCCCC
NGRGTASPRPAAQGQSDSCPVCPTTSDDLATWYAAHPDATLIAGATDVGLWVTKQHRNLG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEECCCCCEEEECCCCCCEEEECCCCCCC
KVAFLNQCADLYGAHITGDTIRFGAMTSMTDVLAAIAPHYPSYAEMIRRYGSVQVRNAAT
HHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECEEE
IGGNIANGSPIGDNPPALIALGATLHLRHGATRRDLLLEDFFLDYGKQDLAPGEFVEAVT
ECCCCCCCCCCCCCCCEEEEECCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
IPIPGAGEDDTLRVYKLSKRFDQDISAVCGAFNLTVTDGTIAQACIACGGMAGIPKRATA
EECCCCCCCCCEEEEEHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHCCCCCCCCHHHH
VEAMLLGKPLTQATTDAALPAFAEDFAPLSDMRASAGYRLEAAQNMLLRYMAEMSGQATS
HHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEE
VLEVRP
EEEECC
>Mature Secondary Structure 
TTRFLLNGEPQTVEAAPTRTLLDWLREEARLTGTKEGCNEGDCGACTVMVTNADGTALA
CEEEEECCCCCCEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCCCHH
LNACILFLPQLEGRAVRTVEGIAAPDGTLHPVQQAMVDHHGSQCGFCTPGFITAMATAHL
HHHHHHEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
NGATDHEDQIAGNLCRCTGYAPILHAAHAAANAPIPPHMVRDADQLSAPFPVPEISQGES
CCCCCCHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCHHHHCCHHHHCCCCCCCCCCCCCC
NGRGTASPRPAAQGQSDSCPVCPTTSDDLATWYAAHPDATLIAGATDVGLWVTKQHRNLG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHEEEECCCCCEEEECCCCCCEEEECCCCCCC
KVAFLNQCADLYGAHITGDTIRFGAMTSMTDVLAAIAPHYPSYAEMIRRYGSVQVRNAAT
HHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCEEEECEEE
IGGNIANGSPIGDNPPALIALGATLHLRHGATRRDLLLEDFFLDYGKQDLAPGEFVEAVT
ECCCCCCCCCCCCCCCEEEEECCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
IPIPGAGEDDTLRVYKLSKRFDQDISAVCGAFNLTVTDGTIAQACIACGGMAGIPKRATA
EECCCCCCCCCEEEEEHHHHHHHHHHHHHCEEEEEEECCHHHHHHHHHCCCCCCCCHHHH
VEAMLLGKPLTQATTDAALPAFAEDFAPLSDMRASAGYRLEAAQNMLLRYMAEMSGQATS
HHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEE
VLEVRP
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721710; 2818128; 10430865; 12475995 [H]