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The map label for this gene is sdhA

Identifier: 89053300

GI number: 89053300

Start: 768820

End: 770640

Strand: Reverse

Name: sdhA

Synonym: Jann_0809

Alternate gene names: 89053300

Gene position: 770640-768820 (Counterclockwise)

Preceding gene: 89053301

Following gene: 89053299

Centisome position: 17.85

GC content: 63.04

Gene sequence:

>1821_bases
ATGAAAGATACCACTTCCCCCGCCTACGCCCTGACCCACCACACCTATGACGTAGTGGTCGTGGGTGCCGGTGGCTCTGG
CTTGCGGGCAACGCTTGGCATGGCGGAACAAGGCCTGAAGACGGCCTGTATCTCCAAGGTGTTCCCGACCCGCTCCCACA
CCGTGGCCGCGCAAGGCGGCATCGCGGCGAGCCTTGGCAACATGGGTCCGGACCATTGGCACTGGCACATGTACGACACC
GTGAAGGGCTCGGACTGGTTGGGTGACACGGACGCGATGGAATACCTCGCGCGCGAAGCCCCCAAGGCGGTTTATGAGCT
GGAGCATTACGGCGTGCCGTTTTCCCGCACCGAAGAAGGCAAGATCTACCAGCGCCCCTTCGGCGGCCACACCACCGAAT
TCGGCGAAGGCCCCCCCGTGCAGCGCACCTGTGCCGCCGCCGACCGGACGGGGCACGCAATCCTGCACACGCTCTATGGC
CAATCCCTGAAGAACGACGCGGAATTCTTCATCGAATATTTCGCCACTGATCTGTTGATGGATGATGAAGGCCAATGCGT
CGGCGTCGTGGCCTGGAAACTGGACGACGGCACCATGCACGTCTTCCACTCCAAGATGACCGTTCTGGCGACGGGCGGTT
ATGGTCGTGCTTACTTCAGCGCCACAAGCGCCCATACCTGCACCGGCGACGGCGGCGGCATGGTCGCTCGGGCGGGTCTG
CCGCTCCAAGACATGGAATTCGTACAATTTCACCCCACCGGCATCTACGGCGCCGGCTGCCTGATCACCGAGGGCGCGCG
GGGCGAAGGCGGCTATCTGACGAACTCCGAGGGCGAGCGATTCATGGAACGCTATGCGCCCACCTACAAGGACCTCGCGT
CGCGCGATGTGGTGTCGCGTTGCATGACGATGGAGATCCGCGACGGCCGCGGCGTTGGCGAGAATGGGGATCACATCCAC
CTGCACCTCAACCACCTGCCGAAGGAAACGCTGGACCTGCGCCTGCCGGGGATCTCTGAGTCCGCGCGGATATTTGCGGG
GGTCGACCTGACGAAGGAACCGATCCCGGTTCTGCCGACGGTCCACTACAACATGGGCGGTATCCCCACGAATTATCTGG
GGGAGGTGCTGAACCCCACCGCCGATGATCCGATGAAGACCGTCCCCGGCCTGATGGCTGTGGGCGAGGCGGGCTGCGCA
AGCGTTCATGGGGCGAACCGTCTGGGCTCCAACTCGCTGATCGACCTAGTCGTCTTTGGCCGCGCCGCCGCGATCAAGGC
GGGTGAAATCGTCGATCCCAACGCCAAGAATCCCGACGTGCCCCAGCACCAGATCGACAAGGCGCTGGCGCGGTTTGACG
ACGTGCGCCATGCCGATGGCGGCACACCCACGGCGGAATTGCGGTTGGAGATGCAGAAGACCATGCAGGCCGATGCTGCC
GTCTTCCGCACCGACAAGACACTCGCCGAGGGGCTGGAAAAGATGACCGGTGTGGCGGGCAAGATGGACGATGTGGCCGT
CACCGACCGGTCGATGATCTGGAACTCCGACCTGATGGAGACGCTGGAGCTGACCAACCTGATGCCCAACGCTCTGGCCA
CGATTGCAGGTGCAGAGGCGCGCAAGGAAAGCCGGGGTGCCCATGCCCATGAGGATTATCCAGACCGTGACGACGTAGAC
TGGCGCAAGCATTCGCTGGCGATGGTCGATGGCAACAAGGTCGACCTCAGCTACCGTGACGTTGGCCTGTCCCCACTGAT
CGGCCATAATGAGGGCGGGATCGACATGGACAAGATCAAGCCCAAGGCGCGGGTCTATTGA

Upstream 100 bases:

>100_bases
ACCAAAAAGGTCTCGATCATCGTGACCACCATACTCAGCTACGGGCTGGCCGCTGGCGGCCTTGTGGCCCTGATGCAAAT
CGCGCTTTGAGGAGCTGACG

Downstream 100 bases:

>100_bases
TGCGCGCCATGGGGGTCCTTGCGTTGATCTGTACCACACCCGTGGCAGCGCAGCCCCTGCAACAGGCCGCGTTGGAGAGC
TTCTTGCGTCACAGCACGGA

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MKDTTSPAYALTHHTYDVVVVGAGGSGLRATLGMAEQGLKTACISKVFPTRSHTVAAQGGIAASLGNMGPDHWHWHMYDT
VKGSDWLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEGKIYQRPFGGHTTEFGEGPPVQRTCAAADRTGHAILHTLYG
QSLKNDAEFFIEYFATDLLMDDEGQCVGVVAWKLDDGTMHVFHSKMTVLATGGYGRAYFSATSAHTCTGDGGGMVARAGL
PLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTYKDLASRDVVSRCMTMEIRDGRGVGENGDHIH
LHLNHLPKETLDLRLPGISESARIFAGVDLTKEPIPVLPTVHYNMGGIPTNYLGEVLNPTADDPMKTVPGLMAVGEAGCA
SVHGANRLGSNSLIDLVVFGRAAAIKAGEIVDPNAKNPDVPQHQIDKALARFDDVRHADGGTPTAELRLEMQKTMQADAA
VFRTDKTLAEGLEKMTGVAGKMDDVAVTDRSMIWNSDLMETLELTNLMPNALATIAGAEARKESRGAHAHEDYPDRDDVD
WRKHSLAMVDGNKVDLSYRDVGLSPLIGHNEGGIDMDKIKPKARVY

Sequences:

>Translated_606_residues
MKDTTSPAYALTHHTYDVVVVGAGGSGLRATLGMAEQGLKTACISKVFPTRSHTVAAQGGIAASLGNMGPDHWHWHMYDT
VKGSDWLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEGKIYQRPFGGHTTEFGEGPPVQRTCAAADRTGHAILHTLYG
QSLKNDAEFFIEYFATDLLMDDEGQCVGVVAWKLDDGTMHVFHSKMTVLATGGYGRAYFSATSAHTCTGDGGGMVARAGL
PLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTYKDLASRDVVSRCMTMEIRDGRGVGENGDHIH
LHLNHLPKETLDLRLPGISESARIFAGVDLTKEPIPVLPTVHYNMGGIPTNYLGEVLNPTADDPMKTVPGLMAVGEAGCA
SVHGANRLGSNSLIDLVVFGRAAAIKAGEIVDPNAKNPDVPQHQIDKALARFDDVRHADGGTPTAELRLEMQKTMQADAA
VFRTDKTLAEGLEKMTGVAGKMDDVAVTDRSMIWNSDLMETLELTNLMPNALATIAGAEARKESRGAHAHEDYPDRDDVD
WRKHSLAMVDGNKVDLSYRDVGLSPLIGHNEGGIDMDKIKPKARVY
>Mature_606_residues
MKDTTSPAYALTHHTYDVVVVGAGGSGLRATLGMAEQGLKTACISKVFPTRSHTVAAQGGIAASLGNMGPDHWHWHMYDT
VKGSDWLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEGKIYQRPFGGHTTEFGEGPPVQRTCAAADRTGHAILHTLYG
QSLKNDAEFFIEYFATDLLMDDEGQCVGVVAWKLDDGTMHVFHSKMTVLATGGYGRAYFSATSAHTCTGDGGGMVARAGL
PLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTYKDLASRDVVSRCMTMEIRDGRGVGENGDHIH
LHLNHLPKETLDLRLPGISESARIFAGVDLTKEPIPVLPTVHYNMGGIPTNYLGEVLNPTADDPMKTVPGLMAVGEAGCA
SVHGANRLGSNSLIDLVVFGRAAAIKAGEIVDPNAKNPDVPQHQIDKALARFDDVRHADGGTPTAELRLEMQKTMQADAA
VFRTDKTLAEGLEKMTGVAGKMDDVAVTDRSMIWNSDLMETLELTNLMPNALATIAGAEARKESRGAHAHEDYPDRDDVD
WRKHSLAMVDGNKVDLSYRDVGLSPLIGHNEGGIDMDKIKPKARVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=625, Percent_Identity=59.84, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=592, Percent_Identity=51.1824324324324, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1790597, Length=564, Percent_Identity=40.6028368794326, Blast_Score=374, Evalue=1e-104,
Organism=Escherichia coli, GI1788928, Length=561, Percent_Identity=32.4420677361854, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17550100, Length=617, Percent_Identity=60.291734197731, Blast_Score=723, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=618, Percent_Identity=58.252427184466, Blast_Score=702, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=603, Percent_Identity=63.0182421227197, Blast_Score=762, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=610, Percent_Identity=63.1147540983607, Blast_Score=759, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=598, Percent_Identity=61.7056856187291, Blast_Score=736, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=598, Percent_Identity=61.7056856187291, Blast_Score=736, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=598, Percent_Identity=61.7056856187291, Blast_Score=736, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=594, Percent_Identity=56.5656565656566, Blast_Score=674, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65591; Mature: 65591

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDTTSPAYALTHHTYDVVVVGAGGSGLRATLGMAEQGLKTACISKVFPTRSHTVAAQGG
CCCCCCCCEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
IAASLGNMGPDHWHWHMYDTVKGSDWLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEG
CHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
KIYQRPFGGHTTEFGEGPPVQRTCAAADRTGHAILHTLYGQSLKNDAEFFIEYFATDLLM
CEEECCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHEE
DDEGQCVGVVAWKLDDGTMHVFHSKMTVLATGGYGRAYFSATSAHTCTGDGGGMVARAGL
CCCCCEEEEEEEEECCCEEEEEECCEEEEEECCCCEEEEECCCCCEEECCCCCEEEECCC
PLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTYKDLASRDVVSR
CCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCHHHHHHHHHCCHHHHHHHHHHHHH
CMTMEIRDGRGVGENGDHIHLHLNHLPKETLDLRLPGISESARIFAGVDLTKEPIPVLPT
HHEEEEECCCCCCCCCCEEEEEECCCCCCHHEEECCCCCCCCEEEEECCCCCCCCCCCCE
VHYNMGGIPTNYLGEVLNPTADDPMKTVPGLMAVGEAGCASVHGANRLGSNSLIDLVVFG
EECCCCCCCHHHHHHHCCCCCCCHHHHHCHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEC
RAAAIKAGEIVDPNAKNPDVPQHQIDKALARFDDVRHADGGTPTAELRLEMQKTMQADAA
CHHEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VFRTDKTLAEGLEKMTGVAGKMDDVAVTDRSMIWNSDLMETLELTNLMPNALATIAGAEA
HHHCCHHHHHHHHHHHCCCCCCCCEEECCCHHHCCHHHHHHHHHHHHCHHHHHHHHCHHH
RKESRGAHAHEDYPDRDDVDWRKHSLAMVDGNKVDLSYRDVGLSPLIGHNEGGIDMDKIK
HHHHCCCCCCCCCCCCCCCCHHHCEEEEECCCEEEEEECCCCCCCEECCCCCCCCHHHCC
PKARVY
CHHCCC
>Mature Secondary Structure
MKDTTSPAYALTHHTYDVVVVGAGGSGLRATLGMAEQGLKTACISKVFPTRSHTVAAQGG
CCCCCCCCEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCC
IAASLGNMGPDHWHWHMYDTVKGSDWLGDTDAMEYLAREAPKAVYELEHYGVPFSRTEEG
CHHHHCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCC
KIYQRPFGGHTTEFGEGPPVQRTCAAADRTGHAILHTLYGQSLKNDAEFFIEYFATDLLM
CEEECCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHEE
DDEGQCVGVVAWKLDDGTMHVFHSKMTVLATGGYGRAYFSATSAHTCTGDGGGMVARAGL
CCCCCEEEEEEEEECCCEEEEEECCEEEEEECCCCEEEEECCCCCEEECCCCCEEEECCC
PLQDMEFVQFHPTGIYGAGCLITEGARGEGGYLTNSEGERFMERYAPTYKDLASRDVVSR
CCCCCCEEEECCCCEEECCEEEECCCCCCCCEEECCHHHHHHHHHCCHHHHHHHHHHHHH
CMTMEIRDGRGVGENGDHIHLHLNHLPKETLDLRLPGISESARIFAGVDLTKEPIPVLPT
HHEEEEECCCCCCCCCCEEEEEECCCCCCHHEEECCCCCCCCEEEEECCCCCCCCCCCCE
VHYNMGGIPTNYLGEVLNPTADDPMKTVPGLMAVGEAGCASVHGANRLGSNSLIDLVVFG
EECCCCCCCHHHHHHHCCCCCCCHHHHHCHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEC
RAAAIKAGEIVDPNAKNPDVPQHQIDKALARFDDVRHADGGTPTAELRLEMQKTMQADAA
CHHEEECCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
VFRTDKTLAEGLEKMTGVAGKMDDVAVTDRSMIWNSDLMETLELTNLMPNALATIAGAEA
HHHCCHHHHHHHHHHHCCCCCCCCEEECCCHHHCCHHHHHHHHHHHHCHHHHHHHHCHHH
RKESRGAHAHEDYPDRDDVDWRKHSLAMVDGNKVDLSYRDVGLSPLIGHNEGGIDMDKIK
HHHHCCCCCCCCCCCCCCCCHHHCEEEEECCCEEEEEECCCCCCCEECCCCCCCCHHHCC
PKARVY
CHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA