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The map label for this gene is fadB [H]

Identifier: 89053167

GI number: 89053167

Start: 647428

End: 649491

Strand: Direct

Name: fadB [H]

Synonym: Jann_0676

Alternate gene names: 89053167

Gene position: 647428-649491 (Clockwise)

Preceding gene: 89053166

Following gene: 89053169

Centisome position: 14.99

GC content: 63.95

Gene sequence:

>2064_bases
ATGAGCGTCACGATGATCCGCGATGGGCTGACCGGGTTTGTCACCCTCGACAACCCGTCCGTGAACGCCATTGGCCGTGC
GATGCGCGAGGGGTTGATGGACGCCGTCGCCTGGGCGGAAACCGAAATGCTGGACCGCGTGATCGTGACGGGCGCGGGCC
GTGCCTTTGCGGCAGGCGCGGATGCCAAGGAGTTCGACGGCGCGGCGTTGGAGCCGTATTTGCCGGACGTTCTGGACGCG
ATTGAGCGCAGTTTCGTGCCATGGATCGCGGCGATCAACGGCGTGGCCTTGGGTGGCGGCGCAGAGATTGCGCTGGCCTG
CCGGATGCGGATCATGGGTCCGCGCGCGCAGATCGGCCTGCCGGAGGTGACGTTGGGCGTGATCCCCGGCGCGGGCGGAA
CGCAACGCGCGATGCGGCTCTGCGGCTTGGACACCGCGCTGGAGATGATCGCATACGGCAAACCTCTGGGCGCGAAAGCG
GCGCTTGCGACGGGCTTGGTCCATGCCGTCGAAGAAGATCCGGTCGACGCTGCCGACATGGTCAACAGTGAAGAACTGCT
TTGTATCGTGCCCACGTGGGAGCTGCCCGCCCCGGATATGAACGCCGATGCGTTCGCGAAAATCCGGGAGGGGTTGGCCA
AACGCTCGAAGGGTCAAGTGGCCCCGTTGAAGGCGGTGGAGGTGATCGAGGCCGGGCTGTCGATGGAATTTGCCGACGCC
ATGGCGCTGGAACGTGCGGCCTTCTTGGAGCTGAAAGCCGGCGATCAATCCCGCGCGCTTCGGCATATGTTCTTCAGTGA
ACGCGCCGCCAAGGCTCCGAATGACCTGCCGAAAGCGCCGGAAATCAGCAAGATCGCCATCGTCGGTGGGGGCACGATGG
GGGCAGGGATCGCATACGCCTGTTTGTCGGTCGGCTTGCCGGTGGTGCTGCTGGAAACCGACGCGGACGCCATCGCGCGG
GCGCAGCACAACATCGACACGTTAATCGGCGCGGGTCTCAAACGTGGCCGTCTTGATGACAGCGGGGCGGCGGCCCTTCG
GGATCGCCTGACCCTGACGGAGGATTACGCAGCCGCGTCCGATGCGACACTGGTCATTGAAGCGGCCTTCGAGTCGATGG
ACGTGAAAAAGGACATCTTCGCAAAACTCGATGCCGCCGTCTCACCCGACACGGTTCTGGCCACCAACACCTCCTATCTG
GATGTGGACGTGCTTGCGGCCAGCACCCGGGACCCGTCCCGCATCCTTGGTCTGCACTTCTTCGCGCCTGCGCATATCAT
GCGCCTGTTGGAGATCGTGACGGGGGCCGAGACGTCTGACCGGGCGTTGGCCACTGGCTACGCGCTGGCAAAACTGTTGA
AGAAAGTGCCCGTCCTGGCGGGTGTCTGCGACGGGTTCATCGGCAACCGCATCTTCTCGCGCTATAAGGAGGAGGCCGAT
ATCCTGCTGATGGACGGGGCCGTCCCGTGGGAGGTCGATGACGCGATGGAAGCGTTTGGATATGCCATGGGGCCGTTCGA
GGTGGGTGATCTCTCCGGCCTCGACATCGGGTTTGCCAATCGCCGCAGGCAGGACGCCACGCGCGATCCCAACCGGCGCT
ACATTCCCATTGCGGACCGGATGGTCAATGAGGGGCGTCTGGGACGGAAGGCCAGCGTGGGCTGGTATCGCTATCCCGGC
GGCGGCGGCAAGGTCATCGACCCGCTGATCGAGGATCTGATCGCGGAAGAAGCGCATTTCGCGGGTGCGACGCGCACCGA
AATTGCCGATGAGGTGGTGGTGGAAAGGCTGCTTCTGGCGATGATCAACGAGGCGGCGGATATCCTTGGCGAAGGCATCG
CGCGGTCTGCGGCAGATATCGATCTGGTCACGGTCTTTGGGTATGGCTTTCCCCGGTGGCGCGGCGGTTTGATGCACTAT
GCGGACACCCGGGGCGTGGCGCAGATTGTGGAAAAACTGCGGTCCCTAGAGGCGGTTGACCCGGTGATCTGGAAGGTGAG
CCCGGTTCTTTTGGACTGCGCGCAGACCGGCACCAAACTGGCCGACTGGCAGCGGACAACCTAA

Upstream 100 bases:

>100_bases
CCAATGCGGTGCTCGATACCGGCGGGCAAAGCGTCGATGCCTCGCTCGCGGGGTTGCTGTCACTGATCGAGCATCACAAT
TTCATAACAAAGGACCTGCC

Downstream 100 bases:

>100_bases
CGCTATCGCACTCGGATGGGCAGCGACGTCCATCCCCTGAACCGGGCAAGGCCAAGGCGCTCCCCCTCACCGGTCGCGGC
CAGCTTTGGGAACCGTTTGA

Product: short chain enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MSVTMIRDGLTGFVTLDNPSVNAIGRAMREGLMDAVAWAETEMLDRVIVTGAGRAFAAGADAKEFDGAALEPYLPDVLDA
IERSFVPWIAAINGVALGGGAEIALACRMRIMGPRAQIGLPEVTLGVIPGAGGTQRAMRLCGLDTALEMIAYGKPLGAKA
ALATGLVHAVEEDPVDAADMVNSEELLCIVPTWELPAPDMNADAFAKIREGLAKRSKGQVAPLKAVEVIEAGLSMEFADA
MALERAAFLELKAGDQSRALRHMFFSERAAKAPNDLPKAPEISKIAIVGGGTMGAGIAYACLSVGLPVVLLETDADAIAR
AQHNIDTLIGAGLKRGRLDDSGAAALRDRLTLTEDYAAASDATLVIEAAFESMDVKKDIFAKLDAAVSPDTVLATNTSYL
DVDVLAASTRDPSRILGLHFFAPAHIMRLLEIVTGAETSDRALATGYALAKLLKKVPVLAGVCDGFIGNRIFSRYKEEAD
ILLMDGAVPWEVDDAMEAFGYAMGPFEVGDLSGLDIGFANRRRQDATRDPNRRYIPIADRMVNEGRLGRKASVGWYRYPG
GGGKVIDPLIEDLIAEEAHFAGATRTEIADEVVVERLLLAMINEAADILGEGIARSAADIDLVTVFGYGFPRWRGGLMHY
ADTRGVAQIVEKLRSLEAVDPVIWKVSPVLLDCAQTGTKLADWQRTT

Sequences:

>Translated_687_residues
MSVTMIRDGLTGFVTLDNPSVNAIGRAMREGLMDAVAWAETEMLDRVIVTGAGRAFAAGADAKEFDGAALEPYLPDVLDA
IERSFVPWIAAINGVALGGGAEIALACRMRIMGPRAQIGLPEVTLGVIPGAGGTQRAMRLCGLDTALEMIAYGKPLGAKA
ALATGLVHAVEEDPVDAADMVNSEELLCIVPTWELPAPDMNADAFAKIREGLAKRSKGQVAPLKAVEVIEAGLSMEFADA
MALERAAFLELKAGDQSRALRHMFFSERAAKAPNDLPKAPEISKIAIVGGGTMGAGIAYACLSVGLPVVLLETDADAIAR
AQHNIDTLIGAGLKRGRLDDSGAAALRDRLTLTEDYAAASDATLVIEAAFESMDVKKDIFAKLDAAVSPDTVLATNTSYL
DVDVLAASTRDPSRILGLHFFAPAHIMRLLEIVTGAETSDRALATGYALAKLLKKVPVLAGVCDGFIGNRIFSRYKEEAD
ILLMDGAVPWEVDDAMEAFGYAMGPFEVGDLSGLDIGFANRRRQDATRDPNRRYIPIADRMVNEGRLGRKASVGWYRYPG
GGGKVIDPLIEDLIAEEAHFAGATRTEIADEVVVERLLLAMINEAADILGEGIARSAADIDLVTVFGYGFPRWRGGLMHY
ADTRGVAQIVEKLRSLEAVDPVIWKVSPVLLDCAQTGTKLADWQRTT
>Mature_686_residues
SVTMIRDGLTGFVTLDNPSVNAIGRAMREGLMDAVAWAETEMLDRVIVTGAGRAFAAGADAKEFDGAALEPYLPDVLDAI
ERSFVPWIAAINGVALGGGAEIALACRMRIMGPRAQIGLPEVTLGVIPGAGGTQRAMRLCGLDTALEMIAYGKPLGAKAA
LATGLVHAVEEDPVDAADMVNSEELLCIVPTWELPAPDMNADAFAKIREGLAKRSKGQVAPLKAVEVIEAGLSMEFADAM
ALERAAFLELKAGDQSRALRHMFFSERAAKAPNDLPKAPEISKIAIVGGGTMGAGIAYACLSVGLPVVLLETDADAIARA
QHNIDTLIGAGLKRGRLDDSGAAALRDRLTLTEDYAAASDATLVIEAAFESMDVKKDIFAKLDAAVSPDTVLATNTSYLD
VDVLAASTRDPSRILGLHFFAPAHIMRLLEIVTGAETSDRALATGYALAKLLKKVPVLAGVCDGFIGNRIFSRYKEEADI
LLMDGAVPWEVDDAMEAFGYAMGPFEVGDLSGLDIGFANRRRQDATRDPNRRYIPIADRMVNEGRLGRKASVGWYRYPGG
GGKVIDPLIEDLIAEEAHFAGATRTEIADEVVVERLLLAMINEAADILGEGIARSAADIDLVTVFGYGFPRWRGGLMHYA
DTRGVAQIVEKLRSLEAVDPVIWKVSPVLLDCAQTGTKLADWQRTT

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI68989263, Length=710, Percent_Identity=37.1830985915493, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI261878539, Length=623, Percent_Identity=37.3996789727127, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI20127408, Length=728, Percent_Identity=27.7472527472527, Blast_Score=265, Evalue=2e-70,
Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=31.3588850174216, Blast_Score=140, Evalue=6e-33,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=29.6052631578947, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI194097323, Length=270, Percent_Identity=30.7407407407407, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI213417737, Length=192, Percent_Identity=31.7708333333333, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI157694516, Length=192, Percent_Identity=31.7708333333333, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI157694520, Length=165, Percent_Identity=30.3030303030303, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1790281, Length=697, Percent_Identity=32.5681492109039, Blast_Score=293, Evalue=3e-80,
Organism=Escherichia coli, GI1788682, Length=667, Percent_Identity=34.3328335832084, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=36.6548042704626, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1787659, Length=164, Percent_Identity=39.0243902439024, Blast_Score=103, Evalue=4e-23,
Organism=Escherichia coli, GI221142681, Length=253, Percent_Identity=31.6205533596838, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=702, Percent_Identity=30.1994301994302, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17508951, Length=732, Percent_Identity=29.3715846994535, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17508953, Length=732, Percent_Identity=29.3715846994535, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71985923, Length=400, Percent_Identity=32.25, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71985930, Length=396, Percent_Identity=30.3030303030303, Blast_Score=225, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI25144276, Length=559, Percent_Identity=30.4114490161002, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=33.5616438356164, Blast_Score=154, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=35.7638888888889, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=294, Percent_Identity=34.6938775510204, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI25145438, Length=181, Percent_Identity=40.8839779005525, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17554946, Length=169, Percent_Identity=36.6863905325444, Blast_Score=96, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=181, Percent_Identity=33.1491712707182, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17560910, Length=187, Percent_Identity=30.4812834224599, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583077, Length=719, Percent_Identity=30.5980528511822, Blast_Score=241, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24583079, Length=719, Percent_Identity=30.5980528511822, Blast_Score=241, Evalue=2e-63,
Organism=Drosophila melanogaster, GI19921000, Length=719, Percent_Identity=30.5980528511822, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI20129971, Length=166, Percent_Identity=39.1566265060241, Blast_Score=109, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24653477, Length=166, Percent_Identity=39.1566265060241, Blast_Score=109, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24653139, Length=177, Percent_Identity=36.7231638418079, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=29.1666666666667, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR018376
- InterPro:   IPR012799
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =5.3.3.8; =1.1.1.35 [H]

Molecular weight: Translated: 73192; Mature: 73061

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTMIRDGLTGFVTLDNPSVNAIGRAMREGLMDAVAWAETEMLDRVIVTGAGRAFAAGA
CCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
DAKEFDGAALEPYLPDVLDAIERSFVPWIAAINGVALGGGAEIALACRMRIMGPRAQIGL
CCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEHHHHCCCCCCCCC
PEVTLGVIPGAGGTQRAMRLCGLDTALEMIAYGKPLGAKAALATGLVHAVEEDPVDAADM
CCEEEEEECCCCCHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
VNSEELLCIVPTWELPAPDMNADAFAKIREGLAKRSKGQVAPLKAVEVIEAGLSMEFADA
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHH
MALERAAFLELKAGDQSRALRHMFFSERAAKAPNDLPKAPEISKIAIVGGGTMGAGIAYA
HHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHH
CLSVGLPVVLLETDADAIARAQHNIDTLIGAGLKRGRLDDSGAAALRDRLTLTEDYAAAS
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHCCCC
DATLVIEAAFESMDVKKDIFAKLDAAVSPDTVLATNTSYLDVDVLAASTRDPSRILGLHF
CCEEEEEEHHHHCCHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHH
FAPAHIMRLLEIVTGAETSDRALATGYALAKLLKKVPVLAGVCDGFIGNRIFSRYKEEAD
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ILLMDGAVPWEVDDAMEAFGYAMGPFEVGDLSGLDIGFANRRRQDATRDPNRRYIPIADR
EEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECHHHH
MVNEGRLGRKASVGWYRYPGGGGKVIDPLIEDLIAEEAHFAGATRTEIADEVVVERLLLA
HHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MINEAADILGEGIARSAADIDLVTVFGYGFPRWRGGLMHYADTRGVAQIVEKLRSLEAVD
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHCCCCCEECCCCCHHHHHHHHHHHHHCC
PVIWKVSPVLLDCAQTGTKLADWQRTT
HHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SVTMIRDGLTGFVTLDNPSVNAIGRAMREGLMDAVAWAETEMLDRVIVTGAGRAFAAGA
CEEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCC
DAKEFDGAALEPYLPDVLDAIERSFVPWIAAINGVALGGGAEIALACRMRIMGPRAQIGL
CCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEECCCCCEEEEEHHHHCCCCCCCCC
PEVTLGVIPGAGGTQRAMRLCGLDTALEMIAYGKPLGAKAALATGLVHAVEEDPVDAADM
CCEEEEEECCCCCHHHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
VNSEELLCIVPTWELPAPDMNADAFAKIREGLAKRSKGQVAPLKAVEVIEAGLSMEFADA
CCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHH
MALERAAFLELKAGDQSRALRHMFFSERAAKAPNDLPKAPEISKIAIVGGGTMGAGIAYA
HHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCHHHHHHHH
CLSVGLPVVLLETDADAIARAQHNIDTLIGAGLKRGRLDDSGAAALRDRLTLTEDYAAAS
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHCCCC
DATLVIEAAFESMDVKKDIFAKLDAAVSPDTVLATNTSYLDVDVLAASTRDPSRILGLHF
CCEEEEEEHHHHCCHHHHHHHHHHCCCCCCEEEECCCCEEEEEEEEECCCCCHHHHHHHH
FAPAHIMRLLEIVTGAETSDRALATGYALAKLLKKVPVLAGVCDGFIGNRIFSRYKEEAD
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ILLMDGAVPWEVDDAMEAFGYAMGPFEVGDLSGLDIGFANRRRQDATRDPNRRYIPIADR
EEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECHHHH
MVNEGRLGRKASVGWYRYPGGGGKVIDPLIEDLIAEEAHFAGATRTEIADEVVVERLLLA
HHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
MINEAADILGEGIARSAADIDLVTVFGYGFPRWRGGLMHYADTRGVAQIVEKLRSLEAVD
HHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHCCCCCEECCCCCHHHHHHHHHHHHHCC
PVIWKVSPVLLDCAQTGTKLADWQRTT
HHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA