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The map label for this gene is hbdA [H]

Identifier: 89053034

GI number: 89053034

Start: 532303

End: 533181

Strand: Reverse

Name: hbdA [H]

Synonym: Jann_0543

Alternate gene names: 89053034

Gene position: 533181-532303 (Counterclockwise)

Preceding gene: 89053036

Following gene: 89053026

Centisome position: 12.35

GC content: 57.91

Gene sequence:

>879_bases
ATGGACATCGAGAGCATCGGAATTGTCGGCGCGGGCCAGATGGGAAATGGCATCGCCCATGTTTGCGCGCTCGCGGGGTA
TGAGGTGATCCTGTCGGACGTTAGTCAGGATGCGCTGGACAATGCGGTCGCCCTCATTGACCGAAATCTCGACCGTCAGG
TCAGCCGGGAAAAGATTTCGCAAACCGTCAAATCCGAAGCCATGGCACGGATCAGCACGACCCTGACCTTGTCCGATATC
GGCCCCACGGACCTGATCATCGAAGCTGCGACCGAACGTGAGACGGTAAAGCAGGCAATTTTCGAGGATCTTTTGCCGCA
TATCAAACCGAACACCATCCTGACTTCAAACACCTCGTCGATCTCGATCACACGGCTTGCCTCGCGCACCGACCGGCCTG
AGAAATTCATGGGGTTTCACTTCATGAATCCCGTCCCTGTCATGCAACTTGTGGAACTGATCCGGGGGATTGCCACCGAC
GAGCCAACCTTCAAGGCCTGCAAATCCGTCGTGGACCGGCTCGGCAAGACCGCCGCCACGGCCGAGGATTTCCCCGCATT
CATCGTCAACCGCATTCTGATGCCGATGATCAACGAGGCCGTCTATACGCTCTATGAAGGCGTCGGGAATGTGACCTCCA
TCGACATGGCCATGAAGCTGGGAACCAACCACCCGATGGGCCCGCTGGAGCTTGCGGATTTCATCGGCCTCGACACCTGT
CTTGCGATCATGAACGTGCTGCATGACGGCCTGGCCGATACCAAGTACCGCCCCTGTCCGCTGCTCACAAAATACGTGGA
GGCCGGGTGGCTTGGCCGAAAATCCCAGCGCGGGTTCTATGATTATCGCGGTGAAGGTGACCCCGTGCCAACGCGCTAA

Upstream 100 bases:

>100_bases
TGTACAATTCTTCGCAATCTTGTGCGAACCTGCTTTGGCTTGTGCCCACCCGTCAGCCGAGCCTATTCTACGCGCAATCA
ACCGCGCCGGAGGGACCCGC

Downstream 100 bases:

>100_bases
CCCAGCACGCAAGGTGGGACGCCGTCCCGTCATCCTGGCAAATATGACGCAATTCCCGCAGCACAACGCATGCCCGGATG
GGCAATGGGCGTTCTACTGG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MDIESIGIVGAGQMGNGIAHVCALAGYEVILSDVSQDALDNAVALIDRNLDRQVSREKISQTVKSEAMARISTTLTLSDI
GPTDLIIEAATERETVKQAIFEDLLPHIKPNTILTSNTSSISITRLASRTDRPEKFMGFHFMNPVPVMQLVELIRGIATD
EPTFKACKSVVDRLGKTAATAEDFPAFIVNRILMPMINEAVYTLYEGVGNVTSIDMAMKLGTNHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKSQRGFYDYRGEGDPVPTR

Sequences:

>Translated_292_residues
MDIESIGIVGAGQMGNGIAHVCALAGYEVILSDVSQDALDNAVALIDRNLDRQVSREKISQTVKSEAMARISTTLTLSDI
GPTDLIIEAATERETVKQAIFEDLLPHIKPNTILTSNTSSISITRLASRTDRPEKFMGFHFMNPVPVMQLVELIRGIATD
EPTFKACKSVVDRLGKTAATAEDFPAFIVNRILMPMINEAVYTLYEGVGNVTSIDMAMKLGTNHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKSQRGFYDYRGEGDPVPTR
>Mature_292_residues
MDIESIGIVGAGQMGNGIAHVCALAGYEVILSDVSQDALDNAVALIDRNLDRQVSREKISQTVKSEAMARISTTLTLSDI
GPTDLIIEAATERETVKQAIFEDLLPHIKPNTILTSNTSSISITRLASRTDRPEKFMGFHFMNPVPVMQLVELIRGIATD
EPTFKACKSVVDRLGKTAATAEDFPAFIVNRILMPMINEAVYTLYEGVGNVTSIDMAMKLGTNHPMGPLELADFIGLDTC
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKSQRGFYDYRGEGDPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=289, Percent_Identity=38.7543252595156, Blast_Score=200, Evalue=1e-51,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=37.4592833876222, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=31.095406360424, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI261878539, Length=290, Percent_Identity=29.6551724137931, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI68989263, Length=290, Percent_Identity=29.6551724137931, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI115430219, Length=230, Percent_Identity=26.9565217391304, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787661, Length=290, Percent_Identity=37.5862068965517, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1790281, Length=276, Percent_Identity=30.4347826086957, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=34.0740740740741, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17553560, Length=288, Percent_Identity=40.9722222222222, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17549919, Length=289, Percent_Identity=39.1003460207612, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17563036, Length=295, Percent_Identity=36.9491525423729, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI17558304, Length=287, Percent_Identity=32.404181184669, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17508953, Length=287, Percent_Identity=32.404181184669, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI25144276, Length=287, Percent_Identity=32.404181184669, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17508951, Length=287, Percent_Identity=32.404181184669, Blast_Score=143, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71985923, Length=290, Percent_Identity=29.3103448275862, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71985930, Length=291, Percent_Identity=27.4914089347079, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583077, Length=285, Percent_Identity=33.3333333333333, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24583079, Length=285, Percent_Identity=33.3333333333333, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI19921000, Length=285, Percent_Identity=33.3333333333333, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=27.0833333333333, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI20129993, Length=240, Percent_Identity=25.4166666666667, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31934; Mature: 31934

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIESIGIVGAGQMGNGIAHVCALAGYEVILSDVSQDALDNAVALIDRNLDRQVSREKIS
CCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
QTVKSEAMARISTTLTLSDIGPTDLIIEAATERETVKQAIFEDLLPHIKPNTILTSNTSS
HHHHHHHHHHHHHEEEECCCCCHHHEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
ISITRLASRTDRPEKFMGFHFMNPVPVMQLVELIRGIATDEPTFKACKSVVDRLGKTAAT
EEHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCC
AEDFPAFIVNRILMPMINEAVYTLYEGVGNVTSIDMAMKLGTNHPMGPLELADFIGLDTC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKSQRGFYDYRGEGDPVPTR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDIESIGIVGAGQMGNGIAHVCALAGYEVILSDVSQDALDNAVALIDRNLDRQVSREKIS
CCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
QTVKSEAMARISTTLTLSDIGPTDLIIEAATERETVKQAIFEDLLPHIKPNTILTSNTSS
HHHHHHHHHHHHHEEEECCCCCHHHEEEHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
ISITRLASRTDRPEKFMGFHFMNPVPVMQLVELIRGIATDEPTFKACKSVVDRLGKTAAT
EEHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCC
AEDFPAFIVNRILMPMINEAVYTLYEGVGNVTSIDMAMKLGTNHPMGPLELADFIGLDTC
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LAIMNVLHDGLADTKYRPCPLLTKYVEAGWLGRKSQRGFYDYRGEGDPVPTR
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]