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The map label for this gene is lysA [H]

Identifier: 89052972

GI number: 89052972

Start: 479396

End: 480661

Strand: Reverse

Name: lysA [H]

Synonym: Jann_0481

Alternate gene names: 89052972

Gene position: 480661-479396 (Counterclockwise)

Preceding gene: 89052974

Following gene: 89052971

Centisome position: 11.13

GC content: 60.35

Gene sequence:

>1266_bases
ATGGATCATTTTCTCTACAAGAACGGCGCGCTCCACGCCGAAGATGTGCCCGTGGCCGACATCGCCGCCAGCGTCGGCAC
GCCCTTCTACGTCTATTCCACCGCCACCCTTACGCGCCACTTTCAGCTGTTTGAAGAGGCGCTGGGGGGTATGGATCACC
TCATCTGCTTTGCGGTGAAAAGCAATTCAAATCAAGCAGTTCTGTCCCATATGGCCATGCTCGGCGCGGGGATGGATGTG
GTGTCTGGCGGGGAGTATTTGCGCGCCAAGGCGGCGGGCGTGCCGGGTGACAAGATCGTCTTTTCCGGCATCGGTAAGAC
CGAAGATGAAATGCGCCTGGCGCTGAATGGCGGCATCCGTCAGTTCAACGTGGAATCGGAACCGGAGATGCACCGCTTAT
CCCGCGTTGCCACCGCGCTCGGCGTCACCGTCCCCATCACCGTGCGCGTGAACCCGGATGTGGATGCGAAGACCCACGCC
AAGATCGCCACGGGCCGGAAGGAGGACAAGTTCGGCATCCCGATTGCCCGTGCGCGGGAGGTCTACGCCCTCGCCGCCTC
CCTTCCCGGACTGCAAGTCATTGGAATCGATGTCCATATCGGGAGCCAACTGACCGATCTGGAACCTTTTGAGATCGCCT
ATGCCAAAGTCGCAGAACTGACCGAACAACTGCGCGAAGATGGCCATACCATTACCCGGCTCGATCTCGGCGGCGGGCTT
GGCATCCCCTATGAGCGTTCCAACTCCGCGCCGCCTCTGCCGATTGAATATGGGGAGGTCATCAAGCGCACCGTCGGTCA
TCTGGGCTGTGAGATCGAGATTGAACCGGGGCGTCTGATTTCCGGGAACGCGGGGCTTCTGGTGGCCTCAACTATCTACG
TAAAGCACGGAGAAGACAGAGATTTCTTGATCCTCGATGCGGCGATGAACGACCTGATCCGCCCCGCCATGTACGGCGCG
TATCACGACATCATTCCGGTGGTGGAGCCCGCGCCCGGCGCTGAACAATCGCCCTATGATATCGTCGGGCCGGTCTGCGA
AAGCGGCGACACCTTCGCCAAGCAGCGCGATCTGCCGCCCGTCAAAGAGGCCGATCTGATCGCCTTCCGCTCCGCCGGTG
CCTACGGCGCGGTGATGTCGTCGGAATACAACACACGGCCTCTCATCCCGGAGGTTCTGGTGAATGGCGATCAATTCGCC
GTCATCCGCGCGCGTCCATCGTTTGACGACATGATAAACCGCGATACACTCCCCCAATGGATGTAG

Upstream 100 bases:

>100_bases
GATAATCGCCGTCTTTGCCATTGGATTTCCCCCGAATTGCTTTGAACCCCATTGGATAGGTGCTAGGTCGCCGCGTGCAA
GACGATAAGGGGCGCGGGCC

Downstream 100 bases:

>100_bases
TGCGCGCTGGCGCCCTGGCAGATGGACCCACATGACCGAGGACAACGCCAATACCGGGCCAAAAACTGACGCGATCAGGT
GGCTGATCTGGCCGCTGCGG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDHFLYKNGALHAEDVPVADIAASVGTPFYVYSTATLTRHFQLFEEALGGMDHLICFAVKSNSNQAVLSHMAMLGAGMDV
VSGGEYLRAKAAGVPGDKIVFSGIGKTEDEMRLALNGGIRQFNVESEPEMHRLSRVATALGVTVPITVRVNPDVDAKTHA
KIATGRKEDKFGIPIARAREVYALAASLPGLQVIGIDVHIGSQLTDLEPFEIAYAKVAELTEQLREDGHTITRLDLGGGL
GIPYERSNSAPPLPIEYGEVIKRTVGHLGCEIEIEPGRLISGNAGLLVASTIYVKHGEDRDFLILDAAMNDLIRPAMYGA
YHDIIPVVEPAPGAEQSPYDIVGPVCESGDTFAKQRDLPPVKEADLIAFRSAGAYGAVMSSEYNTRPLIPEVLVNGDQFA
VIRARPSFDDMINRDTLPQWM

Sequences:

>Translated_421_residues
MDHFLYKNGALHAEDVPVADIAASVGTPFYVYSTATLTRHFQLFEEALGGMDHLICFAVKSNSNQAVLSHMAMLGAGMDV
VSGGEYLRAKAAGVPGDKIVFSGIGKTEDEMRLALNGGIRQFNVESEPEMHRLSRVATALGVTVPITVRVNPDVDAKTHA
KIATGRKEDKFGIPIARAREVYALAASLPGLQVIGIDVHIGSQLTDLEPFEIAYAKVAELTEQLREDGHTITRLDLGGGL
GIPYERSNSAPPLPIEYGEVIKRTVGHLGCEIEIEPGRLISGNAGLLVASTIYVKHGEDRDFLILDAAMNDLIRPAMYGA
YHDIIPVVEPAPGAEQSPYDIVGPVCESGDTFAKQRDLPPVKEADLIAFRSAGAYGAVMSSEYNTRPLIPEVLVNGDQFA
VIRARPSFDDMINRDTLPQWM
>Mature_421_residues
MDHFLYKNGALHAEDVPVADIAASVGTPFYVYSTATLTRHFQLFEEALGGMDHLICFAVKSNSNQAVLSHMAMLGAGMDV
VSGGEYLRAKAAGVPGDKIVFSGIGKTEDEMRLALNGGIRQFNVESEPEMHRLSRVATALGVTVPITVRVNPDVDAKTHA
KIATGRKEDKFGIPIARAREVYALAASLPGLQVIGIDVHIGSQLTDLEPFEIAYAKVAELTEQLREDGHTITRLDLGGGL
GIPYERSNSAPPLPIEYGEVIKRTVGHLGCEIEIEPGRLISGNAGLLVASTIYVKHGEDRDFLILDAAMNDLIRPAMYGA
YHDIIPVVEPAPGAEQSPYDIVGPVCESGDTFAKQRDLPPVKEADLIAFRSAGAYGAVMSSEYNTRPLIPEVLVNGDQFA
VIRARPSFDDMINRDTLPQWM

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=362, Percent_Identity=24.8618784530387, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI16506287, Length=399, Percent_Identity=23.3082706766917, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI22538418, Length=385, Percent_Identity=23.6363636363636, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI21361583, Length=385, Percent_Identity=23.6363636363636, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1789203, Length=440, Percent_Identity=33.6363636363636, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17562780, Length=414, Percent_Identity=22.7053140096618, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24586472, Length=364, Percent_Identity=25.5494505494505, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24586474, Length=367, Percent_Identity=25.3405994550409, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45505; Mature: 45505

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFLYKNGALHAEDVPVADIAASVGTPFYVYSTATLTRHFQLFEEALGGMDHLICFAVK
CCCEEECCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEE
SNSNQAVLSHMAMLGAGMDVVSGGEYLRAKAAGVPGDKIVFSGIGKTEDEMRLALNGGIR
CCCCHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCEEEECCCCCHHHEEEEECCCEE
QFNVESEPEMHRLSRVATALGVTVPITVRVNPDVDAKTHAKIATGRKEDKFGIPIARARE
EECCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHH
VYALAASLPGLQVIGIDVHIGSQLTDLEPFEIAYAKVAELTEQLREDGHTITRLDLGGGL
HHHHHHCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GIPYERSNSAPPLPIEYGEVIKRTVGHLGCEIEIEPGRLISGNAGLLVASTIYVKHGEDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEECCCCEEEEEEEEEEECCCC
DFLILDAAMNDLIRPAMYGAYHDIIPVVEPAPGAEQSPYDIVGPVCESGDTFAKQRDLPP
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCHHHCCCCHHHHHCCCCC
VKEADLIAFRSAGAYGAVMSSEYNTRPLIPEVLVNGDQFAVIRARPSFDDMINRDTLPQW
CCCCCEEEEECCCCCEEEECCCCCCCCCCHHHHCCCCEEEEEEECCCHHHHHCCCCCCCC
M
C
>Mature Secondary Structure
MDHFLYKNGALHAEDVPVADIAASVGTPFYVYSTATLTRHFQLFEEALGGMDHLICFAVK
CCCEEECCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCEEEEEEEE
SNSNQAVLSHMAMLGAGMDVVSGGEYLRAKAAGVPGDKIVFSGIGKTEDEMRLALNGGIR
CCCCHHHHHHHHHHHCCCCEECCCCEEEEECCCCCCCCEEEECCCCCHHHEEEEECCCEE
QFNVESEPEMHRLSRVATALGVTVPITVRVNPDVDAKTHAKIATGRKEDKFGIPIARARE
EECCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEECCCCCCCCCCCHHHHHH
VYALAASLPGLQVIGIDVHIGSQLTDLEPFEIAYAKVAELTEQLREDGHTITRLDLGGGL
HHHHHHCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
GIPYERSNSAPPLPIEYGEVIKRTVGHLGCEIEIEPGRLISGNAGLLVASTIYVKHGEDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCEEEECCCCEEEEEEEEEEECCCC
DFLILDAAMNDLIRPAMYGAYHDIIPVVEPAPGAEQSPYDIVGPVCESGDTFAKQRDLPP
CEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHCCHHHCCCCHHHHHCCCCC
VKEADLIAFRSAGAYGAVMSSEYNTRPLIPEVLVNGDQFAVIRARPSFDDMINRDTLPQW
CCCCCEEEEECCCCCEEEECCCCCCCCCCHHHHCCCCEEEEEEECCCHHHHHCCCCCCCC
M
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]