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The map label for this gene is lpxK

Identifier: 89052890

GI number: 89052890

Start: 401012

End: 401998

Strand: Reverse

Name: lpxK

Synonym: Jann_0399

Alternate gene names: 89052890

Gene position: 401998-401012 (Counterclockwise)

Preceding gene: 89052891

Following gene: 89052886

Centisome position: 9.31

GC content: 67.98

Gene sequence:

>987_bases
ATGCGCGCGCCGGGGTTCTGGCATGAACCGGCGGGCGTGGCCTCGACCTTGCTGGCCCCCCTTGGCGCGCTTTACGCGGC
TGGCACAGCGCGACGCTTGCGGACCGGTCCTCGGGTACGCGTCGATGTCCCGGTGATCTGCATCGGCAATATCAATGCGG
GCGGCACCGGCAAGACGCCCACGGCCATCGCACTGGCGCAGCGCCTGCTTGCAAAAGGTGTGAAAGTGCACGCCGTGACG
CGCGGCTATGGCGGCGAGGTCGAGGGGCCACTCTGTGTGGAGGAGCGCACGCATACCGCGAAGCAGGTGGGGGATGAGGC
GTTGTTGCTCTCCGCCTTCCTGCCGACCTGGGTCTCCACGGACCGACAAGCGGGGGCACGGGCCGCCGTGGCGGACGGCG
CGGAGTGTCTGATCCTCGACGACGGTTTCCAGAACCCCGCGCTTGCCTATGACCTCTCCATCGTCGTCGTCGATGCGTGG
CGCGGGTTCGGCAACGGGCGCGTGATCCCGGCAGGGCCGTTGAGAGAACCGGTGGAGATCGGCCTGAAACGCGCGGATAT
CGTTCTGTCCATCGGGCCGGACGCAGCGCAGCAGCGCTTTGCGACCACCTGGGGCCGTCACATCGCCGTCCCGCATCTGA
CCGGCACGTTGCAGCCTTTGCCCACGGGCCTGCCGCTGGATGGTCTGCCTGTCCTGGCCTTCGCGGGCATCGGCCACCCG
GAGAAGTTCTTCCAGACCCTGCGCAGCCTCGGCGCGGACCTTCATGCCACCCACGCCCTTGCCGATCACCAGCCGTTGAC
GGATACGCTGATGATCCGCCTGCTGCGTGATGCGTCCATGCGTGGCGCGCAGGTGGTCACGACGGAGAAAGACGCCGTGC
GCCTCTCGCCGGAATTTCGCGCGCAGGTCATGACGGTGCCGGTCCGGCTGGAGGTCGACGATTGGGGGCCATTGGACAGC
GCGGTGGACAAGGTCCTAGGGCGCTGA

Upstream 100 bases:

>100_bases
TGGCGGCAGCGGCGTGGCAGGTGATCTCGGACGGTGCTGACGTGACGGATCGCGCCCTGGCGCTGATCATCGACACGTTG
GAAGAGGCAGAGACACCCTG

Downstream 100 bases:

>100_bases
CCCGGCATCCCCGCCCCGATCATAAAGCACACCCACCTCCGACGGTGCACCCGGCACCAAAATGATGCGGTACCGCTCAA
CATCATCACGCGCCGCCAGT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MRAPGFWHEPAGVASTLLAPLGALYAAGTARRLRTGPRVRVDVPVICIGNINAGGTGKTPTAIALAQRLLAKGVKVHAVT
RGYGGEVEGPLCVEERTHTAKQVGDEALLLSAFLPTWVSTDRQAGARAAVADGAECLILDDGFQNPALAYDLSIVVVDAW
RGFGNGRVIPAGPLREPVEIGLKRADIVLSIGPDAAQQRFATTWGRHIAVPHLTGTLQPLPTGLPLDGLPVLAFAGIGHP
EKFFQTLRSLGADLHATHALADHQPLTDTLMIRLLRDASMRGAQVVTTEKDAVRLSPEFRAQVMTVPVRLEVDDWGPLDS
AVDKVLGR

Sequences:

>Translated_328_residues
MRAPGFWHEPAGVASTLLAPLGALYAAGTARRLRTGPRVRVDVPVICIGNINAGGTGKTPTAIALAQRLLAKGVKVHAVT
RGYGGEVEGPLCVEERTHTAKQVGDEALLLSAFLPTWVSTDRQAGARAAVADGAECLILDDGFQNPALAYDLSIVVVDAW
RGFGNGRVIPAGPLREPVEIGLKRADIVLSIGPDAAQQRFATTWGRHIAVPHLTGTLQPLPTGLPLDGLPVLAFAGIGHP
EKFFQTLRSLGADLHATHALADHQPLTDTLMIRLLRDASMRGAQVVTTEKDAVRLSPEFRAQVMTVPVRLEVDDWGPLDS
AVDKVLGR
>Mature_328_residues
MRAPGFWHEPAGVASTLLAPLGALYAAGTARRLRTGPRVRVDVPVICIGNINAGGTGKTPTAIALAQRLLAKGVKVHAVT
RGYGGEVEGPLCVEERTHTAKQVGDEALLLSAFLPTWVSTDRQAGARAAVADGAECLILDDGFQNPALAYDLSIVVVDAW
RGFGNGRVIPAGPLREPVEIGLKRADIVLSIGPDAAQQRFATTWGRHIAVPHLTGTLQPLPTGLPLDGLPVLAFAGIGHP
EKFFQTLRSLGADLHATHALADHQPLTDTLMIRLLRDASMRGAQVVTTEKDAVRLSPEFRAQVMTVPVRLEVDDWGPLDS
AVDKVLGR

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=293, Percent_Identity=38.2252559726962, Blast_Score=137, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_JANSC (Q28VE6)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508341.1
- STRING:   Q28VE6
- GeneID:   3932840
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0399
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- PhylomeDB:   Q28VE6
- ProtClustDB:   PRK00652
- BioCyc:   JSP290400:JANN_0399-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 34806; Mature: 34806

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAPGFWHEPAGVASTLLAPLGALYAAGTARRLRTGPRVRVDVPVICIGNINAGGTGKTP
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCEEEEECCCCCCCCCCH
TAIALAQRLLAKGVKVHAVTRGYGGEVEGPLCVEERTHTAKQVGDEALLLSAFLPTWVST
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHCC
DRQAGARAAVADGAECLILDDGFQNPALAYDLSIVVVDAWRGFGNGRVIPAGPLREPVEI
CHHCCCCEEECCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEECCCCCCCHHHH
GLKRADIVLSIGPDAAQQRFATTWGRHIAVPHLTGTLQPLPTGLPLDGLPVLAFAGIGHP
CCEEEEEEEEECCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCHHHHEECCCCH
EKFFQTLRSLGADLHATHALADHQPLTDTLMIRLLRDASMRGAQVVTTEKDAVRLSPEFR
HHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEECHHHC
AQVMTVPVRLEVDDWGPLDSAVDKVLGR
EEEEEEEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MRAPGFWHEPAGVASTLLAPLGALYAAGTARRLRTGPRVRVDVPVICIGNINAGGTGKTP
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCEEEEECCCCCCCCCCH
TAIALAQRLLAKGVKVHAVTRGYGGEVEGPLCVEERTHTAKQVGDEALLLSAFLPTWVST
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHCC
DRQAGARAAVADGAECLILDDGFQNPALAYDLSIVVVDAWRGFGNGRVIPAGPLREPVEI
CHHCCCCEEECCCCEEEEEECCCCCCCEEEEEEEEEEEECCCCCCCEEECCCCCCCHHHH
GLKRADIVLSIGPDAAQQRFATTWGRHIAVPHLTGTLQPLPTGLPLDGLPVLAFAGIGHP
CCEEEEEEEEECCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCHHHHEECCCCH
EKFFQTLRSLGADLHATHALADHQPLTDTLMIRLLRDASMRGAQVVTTEKDAVRLSPEFR
HHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEECHHHC
AQVMTVPVRLEVDDWGPLDSAVDKVLGR
EEEEEEEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA