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The map label for this gene is msrA2 [H]

Identifier: 89052831

GI number: 89052831

Start: 345842

End: 346522

Strand: Direct

Name: msrA2 [H]

Synonym: Jann_0340

Alternate gene names: 89052831

Gene position: 345842-346522 (Clockwise)

Preceding gene: 89052823

Following gene: 89052833

Centisome position: 8.01

GC content: 63.73

Gene sequence:

>681_bases
ATGCCCAGAAACCCGATCCATGAGACCGTCAAGGTCTTCACCCTGTCCATGGCGATCCTTGCGGGCATCGCGCTGCAAGG
TGGCCGCGCCCATGCCGAAGACATCCGCACGACCGTTGTTGCAGGCGGTTGCTTCTGGTGCGTCGAAAGCGATTTTGAGC
GGGTGGACGGCGTGATCGAGGTCGTGTCGGGTTTCGCCGGCGGCTCCGTACCCTACCCGGAATATCGCGACGTGGTGCGC
GGCGGGACCGGGCATCTGGAGGTCGTGCAGATCACCTATGATGCCGATGTGCTGCCTTATGCCGGGCTGTTGCGGCTGTT
CCTGCGGTCCATTGATCCGCTGGACGCGGGCGGTCAGTTCTGTGACCGCGGCGAAAGCTACACGACGGCAATTTTCGTGG
CTGACGAGCGCGAGCGGGACATCGCGCGCGGGGCCATTCTGGAAGCCGAGGGGAGCCTTGGGCAGAGCATCGTGACGCCA
GTCCGGGATGCCGCGCCGTTCTATGCGGCGGATGAGTATCACCAGGATTACTACCGCTCCAACGATCTGGTGATCACGCG
GTTTGGTCCCCGCCGGAAATCTGTGGCGTATGAGCTGTATCGCACGGCCTGCGGGCGGGACGCGCGCGTGCTGGAGGTCT
GGGGATCAGAAGCGCCGTTCGTCGCCGATCACCTGAATTGA

Upstream 100 bases:

>100_bases
CCCCGATGCTTTGGCGTTCATATATGCGTGAGATCACACCTCCGTGGCTTGCAATGCAAGCGCCCTTTGGGTGAGCGTCT
TGGCAACGCAGGAGGCCTCT

Downstream 100 bases:

>100_bases
TCTACCATTGATATACCTGCGGGGCGGACGATCTGGCGCTTACAGGAAGAGCGCCACATTGTTGCGCAAGATGATCTCGA
TCGCATAGACGCCAAGGATG

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MPRNPIHETVKVFTLSMAILAGIALQGGRAHAEDIRTTVVAGGCFWCVESDFERVDGVIEVVSGFAGGSVPYPEYRDVVR
GGTGHLEVVQITYDADVLPYAGLLRLFLRSIDPLDAGGQFCDRGESYTTAIFVADERERDIARGAILEAEGSLGQSIVTP
VRDAAPFYAADEYHQDYYRSNDLVITRFGPRRKSVAYELYRTACGRDARVLEVWGSEAPFVADHLN

Sequences:

>Translated_226_residues
MPRNPIHETVKVFTLSMAILAGIALQGGRAHAEDIRTTVVAGGCFWCVESDFERVDGVIEVVSGFAGGSVPYPEYRDVVR
GGTGHLEVVQITYDADVLPYAGLLRLFLRSIDPLDAGGQFCDRGESYTTAIFVADERERDIARGAILEAEGSLGQSIVTP
VRDAAPFYAADEYHQDYYRSNDLVITRFGPRRKSVAYELYRTACGRDARVLEVWGSEAPFVADHLN
>Mature_225_residues
PRNPIHETVKVFTLSMAILAGIALQGGRAHAEDIRTTVVAGGCFWCVESDFERVDGVIEVVSGFAGGSVPYPEYRDVVRG
GTGHLEVVQITYDADVLPYAGLLRLFLRSIDPLDAGGQFCDRGESYTTAIFVADERERDIARGAILEAEGSLGQSIVTPV
RDAAPFYAADEYHQDYYRSNDLVITRFGPRRKSVAYELYRTACGRDARVLEVWGSEAPFVADHLN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=153, Percent_Identity=32.0261437908497, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI208609995, Length=153, Percent_Identity=32.0261437908497, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=34.8684210526316, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17533973, Length=135, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=155, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=31.6901408450704, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=32.3529411764706, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24664631, Length=143, Percent_Identity=31.4685314685315, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 24854; Mature: 24723

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRNPIHETVKVFTLSMAILAGIALQGGRAHAEDIRTTVVAGGCFWCVESDFERVDGVIE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEECCEEEEECCHHHHHHHHHH
VVSGFAGGSVPYPEYRDVVRGGTGHLEVVQITYDADVLPYAGLLRLFLRSIDPLDAGGQF
HHHHCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHH
CDRGESYTTAIFVADERERDIARGAILEAEGSLGQSIVTPVRDAAPFYAADEYHQDYYRS
HHCCCCEEEEEEEECCCHHHHHHCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCC
NDLVITRFGPRRKSVAYELYRTACGRDARVLEVWGSEAPFVADHLN
CCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCC
>Mature Secondary Structure 
PRNPIHETVKVFTLSMAILAGIALQGGRAHAEDIRTTVVAGGCFWCVESDFERVDGVIE
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEECCEEEEECCHHHHHHHHHH
VVSGFAGGSVPYPEYRDVVRGGTGHLEVVQITYDADVLPYAGLLRLFLRSIDPLDAGGQF
HHHHCCCCCCCCHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCHH
CDRGESYTTAIFVADERERDIARGAILEAEGSLGQSIVTPVRDAAPFYAADEYHQDYYRS
HHCCCCEEEEEEEECCCHHHHHHCEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCC
NDLVITRFGPRRKSVAYELYRTACGRDARVLEVWGSEAPFVADHLN
CCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]