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The map label for this gene is pip [H]

Identifier: 89052790

GI number: 89052790

Start: 305350

End: 306300

Strand: Direct

Name: pip [H]

Synonym: Jann_0299

Alternate gene names: 89052790

Gene position: 305350-306300 (Clockwise)

Preceding gene: 89052788

Following gene: 89052794

Centisome position: 7.07

GC content: 63.41

Gene sequence:

>951_bases
TTGTTTCCGCCGATCGACCCGTTCGATCAGCGCATTCTGGAGGTTGGCGACGGACACCACGTCTATGTGGAGCAATGCGG
CAACCCCCGCGGTGCGCCCGTTGTGGTGCTGCATGGCGGGCCCGGCGGCGGATGCAGTCCCGCGATGCGGCGGTATTTCG
ACCCTGAGGTGTGGCGCGTCATCCTGTTTGATCAACGTGGTTGCGGTCGGTCCCGCCCCCATGCGTCCACGCACGCCAAC
ACCACCTGGCACCTCGTCGCGGATATCGAGCGTATTCGGAACACGCTGGGGATTGAGCGCTGGGCTGTCTTCGGCGGCAG
CTGGGGCGCGACGCTTGGGCTCGTCTATGCCGAGGCGCATCCCAATGCGGTGGCCTTCCTCGCGTTGCGCGGTGTGTTCC
TTGCCATGCAACGAGAGCTGAATTGGTTCTACGGCGGCGGCGCGGGGCAATTCTGGCCCGACCAATGGCAGCGCTTCGTG
AATCTGGTGCCAGAGGAAGAACGGGGCGATCTGATCGCGGCGTATAACCGACGCCTGTTTTCCGGCGACCTGATGGTGGA
AACCCGCTTTGCGCGCGCCTGGGCGTCATGGGAAAATGCGCTGGCCAGCATGGAGAGTGATGGCCATGGCGGCGAAAGCC
CTGCGGATTATGCGCGCGCGTTTGCCCGGCTGGAGAACCATTACTTCGTCAATAAGGGTTTTCTGGAGGAAGACGGCCAG
ATCCTGCGCGACGTCCACCGCATCGCCCATATCCCCGGCATGATTGTGCAGGGGCGCTATGACATGATCTGCCCGCCGAT
TTCGGCCCATACTCTCGCGTCGAAATGGCCCGGTGGACGGCTGCACATGGTGCGCAGCGCTGGCCACGCGCTGAGCGAGG
TCGGGATCAGCCAGGAGCTTGTCCGCGTCATGCGCGCTGTTGGTGAAAAACGCCCGAAATACGGACTTTAG

Upstream 100 bases:

>100_bases
CTCACTCTCTTGCGACACTTCTCGTGCGGTTTTTTCAACTCACGCTCTATATAGGACCGGCATGGACAAGTTCTCGGGCC
AAAAGCGCGCAACCTCGCAT

Downstream 100 bases:

>100_bases
ACGCCGCGCGTCTCAGATGGGTCTTGCAGCCCGTCGTCTGAGAGAGTCCCCCCGGGCCGAGACGGAGGGCAGATGAGCCG
CAGACAAATTGATATAGCAT

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MFPPIDPFDQRILEVGDGHHVYVEQCGNPRGAPVVVLHGGPGGGCSPAMRRYFDPEVWRVILFDQRGCGRSRPHASTHAN
TTWHLVADIERIRNTLGIERWAVFGGSWGATLGLVYAEAHPNAVAFLALRGVFLAMQRELNWFYGGGAGQFWPDQWQRFV
NLVPEEERGDLIAAYNRRLFSGDLMVETRFARAWASWENALASMESDGHGGESPADYARAFARLENHYFVNKGFLEEDGQ
ILRDVHRIAHIPGMIVQGRYDMICPPISAHTLASKWPGGRLHMVRSAGHALSEVGISQELVRVMRAVGEKRPKYGL

Sequences:

>Translated_316_residues
MFPPIDPFDQRILEVGDGHHVYVEQCGNPRGAPVVVLHGGPGGGCSPAMRRYFDPEVWRVILFDQRGCGRSRPHASTHAN
TTWHLVADIERIRNTLGIERWAVFGGSWGATLGLVYAEAHPNAVAFLALRGVFLAMQRELNWFYGGGAGQFWPDQWQRFV
NLVPEEERGDLIAAYNRRLFSGDLMVETRFARAWASWENALASMESDGHGGESPADYARAFARLENHYFVNKGFLEEDGQ
ILRDVHRIAHIPGMIVQGRYDMICPPISAHTLASKWPGGRLHMVRSAGHALSEVGISQELVRVMRAVGEKRPKYGL
>Mature_316_residues
MFPPIDPFDQRILEVGDGHHVYVEQCGNPRGAPVVVLHGGPGGGCSPAMRRYFDPEVWRVILFDQRGCGRSRPHASTHAN
TTWHLVADIERIRNTLGIERWAVFGGSWGATLGLVYAEAHPNAVAFLALRGVFLAMQRELNWFYGGGAGQFWPDQWQRFV
NLVPEEERGDLIAAYNRRLFSGDLMVETRFARAWASWENALASMESDGHGGESPADYARAFARLENHYFVNKGFLEEDGQ
ILRDVHRIAHIPGMIVQGRYDMICPPISAHTLASKWPGGRLHMVRSAGHALSEVGISQELVRVMRAVGEKRPKYGL

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 35340; Mature: 35340

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPPIDPFDQRILEVGDGHHVYVEQCGNPRGAPVVVLHGGPGGGCSPAMRRYFDPEVWRV
CCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEE
ILFDQRGCGRSRPHASTHANTTWHLVADIERIRNTLGIERWAVFGGSWGATLGLVYAEAH
EEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCHHHHEEECCCCCCEEEEEEEECC
PNAVAFLALRGVFLAMQRELNWFYGGGAGQFWPDQWQRFVNLVPEEERGDLIAAYNRRLF
CCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCEEE
SGDLMVETRFARAWASWENALASMESDGHGGESPADYARAFARLENHYFVNKGFLEEDGQ
CCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEECCCCCCCCHH
ILRDVHRIAHIPGMIVQGRYDMICPPISAHTLASKWPGGRLHMVRSAGHALSEVGISQEL
HHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHHHHHCCCHHHH
VRVMRAVGEKRPKYGL
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFPPIDPFDQRILEVGDGHHVYVEQCGNPRGAPVVVLHGGPGGGCSPAMRRYFDPEVWRV
CCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHCCCCCEEE
ILFDQRGCGRSRPHASTHANTTWHLVADIERIRNTLGIERWAVFGGSWGATLGLVYAEAH
EEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCHHHHEEECCCCCCEEEEEEEECC
PNAVAFLALRGVFLAMQRELNWFYGGGAGQFWPDQWQRFVNLVPEEERGDLIAAYNRRLF
CCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEECCCEEE
SGDLMVETRFARAWASWENALASMESDGHGGESPADYARAFARLENHYFVNKGFLEEDGQ
CCCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEECCCCCCCCHH
ILRDVHRIAHIPGMIVQGRYDMICPPISAHTLASKWPGGRLHMVRSAGHALSEVGISQEL
HHHHHHHHHHCCCEEECCCCCCCCCCCCHHHHHHCCCCCEEEEHHHHHHHHHHCCCHHHH
VRVMRAVGEKRPKYGL
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]